Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosaSubstrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa

... Krämer, Andreas; Herzer, Jan ... Its ability to deacetylate synthetic acetylated lysine substrates points to a protein deacetylation functionality with yet ... but only PA1409 and much more efficiently PA3774 can also process the plain acetylated lysine substrate. P. aeruginosa is able ...
more infohttps://publikationen.bibliothek.kit.edu/1000062791

Molecular determinants of metalloproteinase substrate specificity | SpringerLinkMolecular determinants of metalloproteinase substrate specificity | SpringerLink

Molecular determinants of metalloproteinase substrate specificity. Matrix metalloproteinase substrate binding domains, modules ... substrate specificity, and tissue inhibitor of metalloproteinase interaction. J. Biol. Chem. 272, 7608-7616.PubMedCrossRef ... cDNA cloning and deprivation of protein substrate specificity by autolytic degradation. Biochemistry 36, 7225-7238.PubMed ... identification of regions responsible for substrate specificity and general proteinase activity. Proc. Natl. Acad. Sci. USA. 90 ...
more infohttps://link.springer.com/article/10.1385%2FMB%3A22%3A1%3A051

Redesigning trypsin: alteration of substrate specificity.  - PubMed - NCBIRedesigning trypsin: alteration of substrate specificity. - PubMed - NCBI

... they showed enhanced substrate specificity relative to the native enzyme. This increased specificity was achieved by the ... Redesigning trypsin: alteration of substrate specificity.. Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, ... Computer graphic analysis suggested that these substitutions would differentially affect arginine and lysine substrate binding ... at position 226 exhibited an altered conformation that may be converted to a trypsin-like structure upon binding of a substrate ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/3838593

Determinants for Substrate Specificity of Protein Phosphatase 2ADeterminants for Substrate Specificity of Protein Phosphatase 2A

... Andrew M. Slupe, Ronald A. Merrill, and Stefan Strack ... Andrew M. Slupe, Ronald A. Merrill, and Stefan Strack, "Determinants for Substrate Specificity of Protein Phosphatase 2A," ...
more infohttps://www.hindawi.com/journals/er/2011/398751/cta/

WikiGenes - Substrate SpecificityWikiGenes - Substrate Specificity

Anatomical context of Substrate Specificity. *The strict substrate specificity of this reaction suggests that L-arginine is the ... Gene context of Substrate Specificity. *The substrate specificity of the truncated RAD2 protein implicates branched DNA ... Disease relevance of Substrate Specificity. *Altered substrate specificity of herpes simplex virus thymidine kinase confers ... Substrate specificity and affinity of a protein modulated by bound water molecules. Quiocho, F.A., Wilson, D.K., Vyas, N.K. ...
more infohttps://www.wikigenes.org/e/mesh/e/593.html

Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.  - PubMed - NCBISubstrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. - PubMed - NCBI

Kinetic analysis reveals that the major source of the substrate specificity lies in changes in K(m) for the various substrates ... Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.. Burgis NE1, Cunningham RP. ... possess deoxyribonucleoside triphosphate pyrophosphohydrolase activity and that all four RdgB homologs have high specificity ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17090528

Substrate Specificity - Semantic ScholarSubstrate Specificity - Semantic Scholar

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule ... Substrate Specificity. Known as: Specificities, Substrate, Specificity, Substrate, Substrate Specificities A characteristic ... Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. ... Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin.. *Derek Parsonage, P. Andrew Karplus, Leslie B. ...
more infohttps://www.semanticscholar.org/topic/Substrate-Specificity/137114

Analysis of AtZDP substrate specificityAnalysis of AtZDP substrate specificity

... Valsecchi, Isabel Uppsala University, Disciplinary Domain of Medicine and Pharmacy, ... All substrates were dephosphorylated by AtZDP, assuming that this enzyme could potentially be involved in double-strand DNA ...
more infohttp://uu.diva-portal.org/smash/record.jsf?pid=diva2:172212

Substrate specificity of protein kinases - Patent # 5532167 - PatentGeniusSubstrate specificity of protein kinases - Patent # 5532167 - PatentGenius

The invention also provides peptide substrates for protein kinase A, cell cycle control kinases, src family kinases, the EGF ... peptides within the library which are substrates for the kinase are converted to phosphopeptides and the phosphopeptides are ... When the substrate is a substrate for a protein-serine/threonine kinase, Xaa5 is Ser or Thr, whereas whenthe substrate is a ... This invention pertains to the substrate specificity of protein kinases and to peptides which are substrates for protein ...
more infohttp://www.patentgenius.com/patent/5532167.html

A Silent Polymorphism in the MDR1 Gene Changes Substrate Specificity | ScienceA "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity | Science

A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity. By Chava Kimchi-Sarfaty, Jung Mi Oh, In-Wha Kim, Zuben ... A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity. By Chava Kimchi-Sarfaty, Jung Mi Oh, In-Wha Kim, Zuben ... A Silent Polymorphism in the MDR1 Gene Changes Substrate Specificity Message Subject. (Your Name) has forwarded a page to you ... mammalian membrane transport protein alters the substrate specificity. We hypothesize that when frequent codons are changed to ...
more infohttps://science.sciencemag.org/content/315/5811/525?ijkey=10cca3d2f1243c4564539e3a10a669b21ba179f9&keytype2=tf_ipsecsha

188af) Exploring and Enhancing the Activity and Substrate Specificity of Amine Dehydrogenases | AIChE188af) Exploring and Enhancing the Activity and Substrate Specificity of Amine Dehydrogenases | AIChE

188af) Exploring and Enhancing the Activity and Substrate Specificity of Amine Dehydrogenases. ... have increased activity across the board without affecting substrate. specificity. Finally, we have demonstrated for the first- ... chimeric amine dehydrogenase shows altered substrate specificity compared to. its parent enzymes. Chem Commun. (Camb) 2014, 50 ... ammonia, ketone, and NADH as substrates and release an (R)-amine, NAD+,. and water as products as seen in the reaction scheme ...
more infohttps://www.aiche.org/conferences/aiche-annual-meeting/2018/proceeding/paper/188af-exploring-and-enhancing-activity-and-substrate-specificity-amine-dehydrogenases

Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variantsFuraldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants

... Laadan, B. ... resulting in Adh1p-variants with different substrate specificities. ... Kinetic characterization with both aldehydes and the in vivo primary substrate acetaldehyde also enabled to correlate the ... of both native and mutated ADH1 genes was performed in order to identify the key amino acids involved in this substrate shift, ...
more infohttp://www.diva-portal.org/smash/record.jsf?pid=diva2:738158

Diversity and Substrate Specificity in the Structures of Steroidogenic Cytochrome P450 EnzymesDiversity and Substrate Specificity in the Structures of Steroidogenic Cytochrome P450 Enzymes

Japans largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
more infohttps://www.jstage.jst.go.jp/article/bpb/35/6/35_b212001/_article

Defining Substrate Specificities for Lipase and Phospholipase Candidates | ProtocolDefining Substrate Specificities for Lipase and Phospholipase Candidates | Protocol

... lipases are poorly characterized with regard to their substrate specificities and physiological functions. Here ... ... Presently, it seems more feasible to explore substrate specificities for groups of enzymes where at least one substrate is ... Defining Substrate Specificities for Lipase and Phospholipase Candidates. Diana X. Sahonero-Canavesi1, Maritza Zavaleta-Pastor1 ... The definition of substrate specificities for new enzymes, often provides hypotheses for a potential physiological role of ...
more infohttps://www.jove.com/video/54613/defining-substrate-specificities-for-lipase-phospholipase

A Silent Polymorphism in the MDR1 Gene Changes Substrate Specificity | ScienceA "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity | Science

A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity. By Chava Kimchi-Sarfaty, Jung Mi Oh, In-Wha Kim, Zuben ... A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity. By Chava Kimchi-Sarfaty, Jung Mi Oh, In-Wha Kim, Zuben ... A Silent Polymorphism in the MDR1 Gene Changes Substrate Specificity Message Subject. (Your Name) has forwarded a page to you ... mammalian membrane transport protein alters the substrate specificity. We hypothesize that when frequent codons are changed to ...
more infohttps://science.sciencemag.org/content/315/5811/525?ijkey=5496bc6fee992d37be001fcef9191da0480fb161&keytype2=tf_ipsecsha

Chemoenzymatic synthesis of prodigiosin analogues-exploring the substrate specificity of PigC - Chemical Communications (RSC...Chemoenzymatic synthesis of prodigiosin analogues-exploring the substrate specificity of PigC - Chemical Communications (RSC...

analogues-exploring the substrate specificity of PigC Suresh R. Chawrai,a Neil R. Williamson,b George P. C. Salmond*b and ... analogues-exploring the substrate specificity of PigC S. R. Chawrai, N. R. Williamson, G. P. C. Salmond and F. J. Leeper, Chem ...
more infohttp://pubs.rsc.org/en/Content/ArticleLanding/2008/CC/b719353j

Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr. | Journal of BacteriologyMutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr. | Journal of Bacteriology

Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr.. K A Klyachko, S Schuldiner, A A ... Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr.. K A Klyachko, S Schuldiner, A A ... Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr.. K A Klyachko, S Schuldiner, A A ... Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr. Message Subject (Your Name) has ...
more infohttps://jb.asm.org/content/179/7/2189?ijkey=38ee12993d8ccf993bd32401080f8fe794080337&keytype2=tf_ipsecsha

Crystal structure of the FTO protein reveals basis for its substrate specificity. | Sigma-AldrichCrystal structure of the FTO protein reveals basis for its substrate specificity. | Sigma-Aldrich

Crystal structure of the FTO protein reveals basis for its substrate specificity.. [Zhifu Han, Tianhui Niu, Junbiao Chang, ... Taken together, these results provide a structural basis for understanding FTO substrate-specificity, and serve as a foundation ...
more infohttps://www.sigmaaldrich.com/catalog/papers/20376003

Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase | SpringerLinkSubstrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase | SpringerLink

Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase. ... Daubner S.C., Melendez J., Fitzpatrick P.F. (2002) Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of ... These substrate specificities are determined by the C domains (11). The goal of the experiments described here was to identify ... these enzymes differ in their substrate specificities. PheH is very specific for phenylalanine; although it can hydroxylate ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4615-0945-5_21

The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity.The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity.

... Ilari A., ... Accordingly, a 15 fold increase in k(cat) and 100 fold decrease in K(m) for sarcosine as substrate has been achieved in MTOX ... The analysis of the substrate binding site highlights the structural determinants that favour the accommodation of the bulky N- ... located at the entrance of the active site appears to play a key role for the recognition of the amino acid substrate side ...
more infohttps://www.uniprot.org/citations/18186483

YscP and YscU Regulate Substrate Specificity of the Yersinia Type III Secretion SystemYscP and YscU Regulate Substrate Specificity of the Yersinia Type III Secretion System

... Edqvist, Petra Umeå University, Faculty ... These results suggest that YscP and YscU coordinately regulate the substrate specificity of the Yersinia type III secretion ... A range of putative Yersinia Tat substrates were predicted in silico, which together with the Tat system itself may be ... YscP and YscU act upstream of the cell contact sensor YopN as well as the inner gatekeeper LcrG in the pathway of substrate ...
more infohttp://umu.diva-portal.org/smash/record.jsf?pid=diva2%3A144010&c=15&searchType=SIMPLE&language=en&query=&af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%221663%22%7D%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all

The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis | Biochemical JournalThe substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis | Biochemical Journal

The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis Message Subject (Your Name) has forwarded a ... The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis. G. H. Sloane-Stanley ...
more infohttp://www.biochemj.org/content/44/3/373

YscP and YscU Regulate Substrate Specificity of the Yersinia Type III Secretion System | Journal of BacteriologyYscP and YscU Regulate Substrate Specificity of the Yersinia Type III Secretion System | Journal of Bacteriology

YscP and YscU Regulate Substrate Specificity of the Yersinia Type III Secretion System. Petra J. Edqvist, Jan Olsson, Moa ... YscP regulates the substrate specificity of the Yersinia TTSS. (A) Surface localization of YscF in the yscP-null strain. The ... These results suggest that YscP and YscU coordinately regulate the substrate specificity of the Yersinia type III secretion ... Domain structure of Salmonella FlhB, a flagellar export component responsible for substrate specificity switching. J. Bacteriol ...
more infohttps://jb.asm.org/content/185/7/2259?ijkey=15839259dd3710b60317af9c3e10bbf1765bffb5&keytype2=tf_ipsecsha

Evolution, substrate specificity and subfamily classification of glycoside hydrolase family 5 (GH5)Evolution, substrate specificity and subfamily classification of glycoside hydrolase family 5 (GH5)

... Aspeborg, Henrik KTH, ... In this thesis, the evolution, substrate specificity and subfamily classification of the most important GH family, i.e., ... With the objective of improving the differentiation of enzyme specificities in a knowledge-based context, and to obtain new ...
more infohttp://kth.diva-portal.org/smash/record.jsf?pid=diva2%3A583951&c=1&searchType=SIMPLE&language=en&query=&af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%221969%22%7D%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all

Browsing Biochemistry and Molecular Biophysics by Subject Substrate SpecificityBrowsing Biochemistry and Molecular Biophysics by Subject "Substrate Specificity"

... K-REx Repository. Search K-REx. This ... Defining the extreme substrate specificity of Euonymus alatus diacylglycerol acetyltransferase, an unusual membrane-bound O- ...
more infohttps://krex.k-state.edu/dspace/handle/2097/12219/browse?type=subject&value=Substrate+Specificity