Obtusifoliol - Wikipedia
Obtusifoliol is a metabolic intermediate of sterols made by certain fungi. It can be converted to delta8,14-sterol by the ... "Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans". Archives of ...
Norcycloartenol - Wikipedia
"Rosa chinensis plant sterol biosynthesis II". pmn.plantcyc.org. v t e (Chemical articles without CAS registry number, Articles ... Hartmann, MA; Perret, AM; Carde, JP; Cassagne, C; Moreau, P (8 August 2002). "Inhibition of the sterol pathway in leek ... implications for sterol biosynthesis". Journal of Lipid Research. 42 (1): 128-36. doi:10.1016/S0022-2275(20)32344-0. PMID ... is a Metabolic intermediate of plant sterol biosynthesis. In the pathway, it is transformed from demethylation of cycloartenol ...
Miconazole - Wikipedia
British National Formulary 45 March 2003 Becher R, Wirsel SG (August 2012). "Fungal cytochrome P450 sterol 14α-demethylase ( ... Archived from the original on 14 August 2022. Retrieved 20 June 2023. "Miconazole Nitrate". The American Society of Health- ... Miconazole inhibits the fungal enzyme 14α-sterol demethylase, resulting in a reduced production of ergosterol. In addition to ... Lanosterol 14α-demethylase inhibitors, Otologicals, World Health Organization essential medicines, Wikipedia medicine articles ...
Induced cell cycle arrest - Wikipedia
Xu YJ, Singh A, Alter GM (November 2016). "Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α- ... Demethylase in the Ergosterol Biosynthesis Pathway". Genetics. 204 (3): 959-973. doi:10.1534/genetics.116.191536. PMC 5105871. ...
4,4'-Dihydroxybenzophenone - Wikipedia
... dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14α-demethylase (CYP51)". Journal of Biological ...
Beta-Sitosterol - Wikipedia
... sterol Δ14-reductase (E5), and sterol Δ8-Δ7-isomerase (E6). The last methyl group is removed by sterol demethylase (E7) to form ... Both of these steps are catalyzed by sterol C-24 methyltransferase (Step E1 in diagram). Compound 8 is then catalyzed by sterol ... While plant sterols are usually beneficial, there is a rare autosomal recessive genetic disorder phytosterolemia which causes ... Rudkowska I, AbuMweis SS, Nicolle C, Jones PJ (2008). "Cholesterol-lowering efficacy of plant sterols in low-fat yogurt ...
Viridin - Wikipedia
ISBN 978-0-470-74167-2. Hanson, James R.; OLeary, Margaret A.; Wadsworth, Harry J. (1980). "Fungal cleavage of the sterol side ... Loss of a hydrogen atom from C-15 during removal of the C-14 methyl group suggests a pathway similar to that of other steroid ... Analogous to the cholesterol pathway, the C-14 methyl group is lost as formic acid by action of sterol 14-demethylase. Though ... the loss of C-13 and C-14 methyl groups, aromatization of the C-ring, removal of the side chain, and oxidation of the A-ring. ...
Antifungal - Wikipedia
As a polyenes hydrophobic chain is shortened, its sterol binding activity is increased. Therefore, further reduction of the ... The polyene antimycotics bind with sterols in the fungal cell membrane, principally ergosterol. This changes the transition ... In ordinary circumstances membrane sterols increase the packing of the phospholipid bilayer making the plasma membrane more ... They inhibit the enzyme 14-alpha-sterol demethylase, a microsomal CYP, which is required for biosynthesis of ergosterol for the ...
ERG11 - Wikipedia
ERG11 or Sterol 14-demethylase is a fungal cytochrome P450 enzyme originally from Saccharomyces cerevisiae, belongs to family ... Mo C, Bard M (September 2005). "Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex". Journal of Lipid ... ERG11 catalyzes the C14-demethylation of lanosterol to 4,4-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first step ... v t e (Protein pages needing a picture, Cytochrome P450, EC 1.14.14, Saccharomyces cerevisiae genes, All stub articles, Enzyme ...
Posaconazole - Wikipedia
It does this by blocking the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of ... methylated sterol precursors. Posaconazole is significantly more potent at inhibiting 14-alpha demethylase than itraconazole. ... Lanosterol 14α-demethylase inhibitors, Merck & Co. brands, Orphan drugs, Piperazines, Phenylethanolamine ethers, Schering- ...
Withaferin A - Wikipedia
The biosynthesis of withaferin A uses enzymes such as squalene epoxidase (SQE), cycloartenol synthase (CAS), sterol methyl ... demethylase (ODM). To produce withaferin A from 24-methylene cholesterol, the molecule undergoes several functional changes ...
Penicillium digitatum - Wikipedia
The mechanism of P. digitatum resistance to imazalil is suggested to lie in the over-expression of the sterol 14α-demethylase ( ... After 14 days at room temperature, the reverse is colourless to light brown. Penicillium digitatum is found in the soil of ...
29-Norlanosterol - Wikipedia
"Rosa chinensis plant sterol biosynthesis II". pmn.plantcyc.org. v t e (Chemical articles without CAS registry number, Articles ... is a Metabolic intermediate of plant sterol biosynthesis. In the pathway, it is transformed from ring-opening reactions of ... a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals". The Plant Journal. 11 (2): ... Bak, S; Kahn, RA; Olsen, CE; Halkier, BA (February 1997). "Cloning and expression in Escherichia coli of the obtusifoliol 14 ...
Sterol 14-demethylase - Wikipedia
... lanosterol 14alpha-demethylase, and sterol 14alpha-demethylase. This enzyme participates in biosynthesis of steroids. These are ... Lepesheva GI, Waterman MR (March 2007). "Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms ... and other types of sterols in plants. These sterols localize to the plasma membrane of cells, where they play an important ... In enzymology, a sterol 14-demethylase (EC 1.14.13.70) is an enzyme of the Cytochrome P450 (CYP) superfamily. It is any member ...
Lanosterol 14 alpha-demethylase - Wikipedia
Lepesheva GI, Waterman MR (March 2007). "Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms ... "Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) ... This demethylation step is regarded as the initial checkpoint in the transformation of lanosterol to other sterols that are ... Becher R, Wirsel SG (August 2012). "Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and ...
List of EC numbers (EC 1) - Wikipedia
... thebaine 6-O-demethylase EC 1.14.11.32: codeine 3-O-demethylase EC 1.14.11.33: DNA oxidative demethylase EC 1.14.11.34: Now EC ... Δ14-sterol reductase EC 1.3.1.71: Δ24(241)-sterol reductase EC 1.3.1.72: Δ24-sterol reductase EC 1.3.1.73: 1,2- ... trimethyl-LL-lysine4 demethylase * EC 1.14.11.68: [histone H3]-trimethyl-L-lysine27 demethylase * EC 1.14.11.69: [histone H3]- ... dimethyl-L-lysine9 demethylase * EC 1.14.11.66: [histone H3]-trimethylL-lysine9 demethylase * EC 1.14.11.67: [histone H3]- ...
Ketoconazole - Wikipedia
Experimentally, resistance usually arises as a result of mutations in the sterol biosynthesis pathway. Defects in the sterol 5- ... As azole antifungals all act at the same point in the sterol pathway, resistant isolates are normally cross-resistant to all ... While ketoconazole blocks the synthesis of the sterol ergosterol in fungi, in humans, at high dosages (>800 mg/day), it ... This enzyme participates in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. Lower doses of ...
VNI (molecule) - Wikipedia
"Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human ... The molecule acts by inhibiting Trypanosoma cruzi sterol 14α-desmethylase activity in vitro. It exhibits no toxicity in mouse ... 14 (24): 6322-5. doi:10.1021/ol303092v. PMC 3528807. PMID 23214987. (Articles without KEGG source, Articles containing ...
Topical antifungal drugs - Wikipedia
By blocking the sterol synthesis in fungal cells and cell extracts, the integrity of fungal cell membranes will be interrupted ... It is a sterol, which is important in maintaining proper membrane fluidity and normal functions of the cell membrane. ... Mechanism of action Azole antifungal drugs exert their effects by inhibiting the synthesis of the sterol components of the ... This inhibition results in decreased amounts of sterols, causing cell death and the disruption of the fungal cell wall ...
P450-containing systems - Wikipedia
The sterol demethylase system from Mycobacterium tuberculosis contains flavoprotein reductase A (FprA), bacterial-type Fe3S4 ... "Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their ... 14: 29-56. doi:10.1016/S1569-2558(08)60339-2. ISBN 9780762301133. McLean, K.J.; Sabri, M.; Marshall, K.R.; Lawson, R.J.; Lewis ...
Ergosterol - Wikipedia
Ergosterol (ergosta-5,7,22-trien-3β-ol) is a sterol found in fungi, and named for ergot, the common name of members of the ... Ergosterol (ergosta-5,7,22-trien-3β-ol) is a sterol found in cell membranes of fungi and protozoa, serving many of the same ... Lv QZ, Yan L, Jiang YY (August 2016). "The synthesis, regulation, and functions of sterols in Candida albicans: Well-known but ... Roberts CW, McLeod R, Rice DW, Ginger M, Chance ML, Goad LJ (February 2003). "Fatty acid and sterol metabolism: potential ...
Aspergillus fumigatus - Wikipedia
Two highly characterized sterol-regulatory element binding proteins, SrbA and SrbB, along with their processing pathways, have ... Dhingra S, Cramer RA (2017). "Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: ... "A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and ... "The signal peptide peptidase SppA is involved in sterol regulatory element-binding protein cleavage and hypoxia adaptation in ...
Steroidogenesis inhibitor - Wikipedia
They may inhibit the production of cholesterol and other sterols, sex steroids such as androgens, estrogens, and progestogens, ... "Inhibitors of sterol synthesis. Metabolism of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one after intravenous administration to ... a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in ... Schroepfer GJ, Parish EJ, Kisic A, Jackson EM, Farley CM, Mott GE (1982). "5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, ...
Terconazole - Wikipedia
In a double-blind study by Slavin in 1992, terconazole showed a 75% mycological cure over a short-term period (7-14 days) and ... This occurs by transforming lanosterol into 4,4-dimethyl cholesta-8,14,24-triene-3-β-ol. This stops respiration by prohibiting ... Within a normal yeast cell, lanosterol is demethylated using 14α-demethylation. This process creates zymosterol: a major ... "Selective inhibition of 14 alpha-desmethyl sterol synthesis in Candida albicans by terconazole, a new triazole antimycotic". ...
Clotrimazole - Wikipedia
It binds to phospholipids in the cell membrane and inhibits the biosynthesis of ergosterol and other sterols required for cell ... Clotrimazole is usually used five times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for skin infections, ... Retrieved 14 April 2014. "Clotrimazole (Oral)". Lexicomp Online. Archived from the original on 23 January 2015. Retrieved 17 ... Archived from the original on 14 September 2016. World Health Organization (2019). World Health Organization model list of ...
Cyproconazole - Wikipedia
... a particular step in the synthesis of a component of the fungal cell wall called sterol. This means it affects fungal growth, ... New York State Department of Environmental Conservation (July 14, 2009). "Registration of Alto 100 SL (EPA Reg. No. 100-1226) ...
List of EC numbers (EC 3) - Wikipedia
... sterol esterase EC 3.1.1.14: chlorophyllase EC 3.1.1.15: L-arabinonolactonase EC 3.1.1.16: deleted, mixture of EC 5.3.3.4 ( ... 4-dinitroanisole O-demethylase * EC 3.3.2.15: trans-2,3-dihydro-3-hydroxyanthranilic acid synthase * *No Wikipedia article EC ... 14)-fucoidanase EC 3.2.1.45: glucosylceramidase EC 3.2.1.46: galactosylceramidase EC 3.2.1.47: Now known to be catalyzed by EC ...