Loading...
*  Genetics and clinical presentation of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
This conversion is mediated by 21-hydroxylase, the enzyme encoded by theCYP21A2gene.Patients with c ... Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man. Proc ... Mapping of steroid 21-hydroxylase genes adjacent to complement component C4 genes in HLA, the major histocompatibility complex ... Mutations of the steroid 21-hydroxylase gene in an Argentinian population of 36 patients with classical congenital adrenal ...
http://www.uptodate.com/contents/genetics-and-clinical-presentation-of-classic-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency
*  Experimental Factor Ontology - cholesterol - Classes | NCBO BioPortal
CYP8B1 has broad substrate specificity including 7-alpha-hydroxylated C27 steroids. P450 enzymes catalyze reactions involved in ... CYP8B1 has broad substrate specificity including 7-alpha-hydroxylated C27 steroids. P450 enzymes catalyze reactions involved in ... 7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase. InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13- ... 7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase. InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13- ...
http://bioportal.bioontology.org/ontologies/EFO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_16113
*  Mattammal MB[au] - PubMed - NCBI
Synthesis of analogs of 7 alpha-hydroxy-4-cholesten-3-one as substrates for hepatic steroid 12 alpha-hydroxylase. ... 12.. Thermospray high performance liquid chromatography/mass spectrometric identification of a bladder carcinogen metabolite ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Mattammal+MB%5Bau%5D&dispmax=50
*  Substantial contribution of genetic variation in the expression of transcription factors to phenotypic variation revealed by...
Oxidation-reduction process; nitrate assimilation; steroid 22-alpha hydroxylase activity (BR). 12 (4.67%) ... mathit{\log}\left({\lambda}_{ijk}\right)=\mu +{\alpha}_i+{\beta}_j+{o}_{ijk} $$ ... 2016;12:e1005767.View ArticlePubMedPubMed CentralGoogle Scholar. *. Yu J, Pressoir G, Briggs WH, Vroh Bi I, Yamasaki M, Doebley ... 2011;12:186.View ArticlePubMedPubMed CentralGoogle Scholar. *. Zheng W, Gianoulis TA, Karczewski KJ, Zhao H, Snyder M. ...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1328-6
*  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids. This gene encodes a member of ... Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 ... This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha ... The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which ...
https://pharos.nih.gov/idg/targets/CYP8B1
*  C-17 Hydroxylase Deficiency Treatment & Management: Medical Care, Surgical Care, Consultations
... known as 17-hydroxylase deficiency was first described in the 1960s in patients with sexual infantilism and hypertension. It ... Yanase T. 17 alpha-hydroxylase/17,20-lyase defects. J Steroid Biochem Mol Biol. 1995 Jun. 53(1-6):153-7. [Medline]. ... Disorders of steroid 17 alpha-hydroxylase deficiency. Endocrinol Metab Clin North Am. 1994 Jun. 23(2):341-57. [Medline]. ... Lin D, Black SM, Nagahama Y. Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and ...
https://emedicine.medscape.com/article/117140-treatment
*  C-17 Hydroxylase Deficiency Medication: Glucocorticoids, Estrogens, Progestogens, Androgens, Antihypertensive agents,...
... known as 17-hydroxylase deficiency was first described in the 1960s in patients with sexual infantilism and hypertension. It ... Yanase T. 17 alpha-hydroxylase/17,20-lyase defects. J Steroid Biochem Mol Biol. 1995 Jun. 53(1-6):153-7. [Medline]. ... Disorders of steroid 17 alpha-hydroxylase deficiency. Endocrinol Metab Clin North Am. 1994 Jun. 23(2):341-57. [Medline]. ... Lin D, Black SM, Nagahama Y. Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and ...
https://emedicine.medscape.com/article/117140-medication
*  CYP27A1 (Human) IP-WB Antibody Pair - (H00001593-PW1) - Products - Abnova
... steroid 27-hydroxylase, cerebrot ... 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26- ... hydroxylase,5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase,cholestanetriol 26-monooxygenase,cytochrome P- ... steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway ...
http://www.abnova.com/products/products_detail.asp?catalog_id=H00001593-PW1
*  Congenital Adrenal Hyperplasia (CAH) due to 21-Alpha-Hydroxylase Deficiency (CYP21A2) - Sema4
Approximately 95% of cases of CAH are caused by defects in the CYP21A2 gene, which leads to a deficiency of the steroid 21- ... Congenital Adrenal Hyperplasia (CAH) due to 21-Alpha-Hydroxylase Deficiency (CYP21A2). Congenital adrenal hyperplasia (CAH) is ... Treatment for CAH usually includes steroids to replace the low hormones. The long-term prognosis for individuals with CAH is ... Approximately 1 in 12 individuals is a carrier of CAH. Symptoms of CAH vary based on the form of CAH, the age of diagnosis, and ...
https://sema4.com/products/expandedcarrierscreen/diseases-screened/congenital-adrenal-hyperplasia/
*  List of MeSH codes (D08) - Wikipedia
... steroid 16-alpha-hydroxylase MeSH D08.244.453.915.748 --- steroid 17-alpha-hydroxylase MeSH D08.244.453.915.760 --- steroid 21- ... steroid 16-alpha-hydroxylase MeSH D08.811.682.690.708.170.915.748 --- steroid 17-alpha-hydroxylase MeSH D08.811.682.690.708.170 ... steroid 16-alpha-hydroxylase MeSH D08.811.682.690.708.783.745 --- steroid 17-alpha-hydroxylase MeSH D08.811.682.690.708.783.760 ... 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH D08.811.682.690.708.783.720 --- steroid 11-beta-hydroxylase MeSH D08.811.682.690. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  List of MeSH codes (D12.776) - Wikipedia
... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... Type XII collagen MeSH D12.776.860.300.250.600 - procollagen MeSH D12.776.860.300.250.700 - tropocollagen MeSH D12.776.860.300. ... 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH D12.776.422.220.453.915.720 - steroid 11-beta-hydroxylase MeSH D12.776.422.220. ... alpha 1-antichymotrypsin MeSH D12.776.377.715.085.085 - alpha 1-antitrypsin MeSH D12.776.377.715.085.100 - alpha-macroglobulins ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
*  Human Metabolome Database: Showing Protein 3-oxo-5-beta-steroid 4-dehydrogenase (HMDBP00550)
Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency ... The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as ... Showing Protein 3-oxo-5-beta-steroid 4-dehydrogenase (HMDBP00550). IdentificationBiological propertiesGene propertiesProtein ... Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta- ...
http://www.hmdb.ca/proteins/HMDBP00550
*  Vitamin D status has a linear association with seasonal infections and lung function in British adults | British Journal of...
2004) Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol Cell Endocrinol 215, 31-38. ... J Steroid Biochem Mol Biol 103, 558-562.. 33 Song, Y, Qi, H & Wu, C (2007) Effect of 1,25-(OH)2D3 (a vitamin D analogue) on ... 2010) Vitamin D levels, lung function and steroid response in adult asthma. Am J Respir Crit Care Med 181, 699-704. ... 12 Black, PN & Scragg, R (2005) Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national ...
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/vitamin-d-status-has-a-linear-association-with-seasonal-infections-and-lung-function-in-british-adults/1BB18F6DED43D7E4B7032F58BE58BF95
*  Plus it
... alpha (17 alpha-hydroxylase/C17-20 lyase). J Steroid Biochem Mol Biol 1994; 50: 267-73. ... Because abiraterone suppressed both 17-alpha-hydroxylase and C-17,20-lyase CYP17 activity ( Fig. 1A), its continuous ... 9) or with daily low dose steroids that suppress ACTH. Importantly, abiraterone suppressed downstream C-21 androgenic steroids ... 17 alpha hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis. Clinical trials have confirmed that specific ...
http://cancerres.aacrjournals.org/content/69/12/4937
*  Browse In 17-alpha hydroxylase/17,20 lyase deficiency, Hydrocortisone | EDM Case Reports
Treatment was commenced with steroid replacement and puberty induction with estradiol. The index case had surgical tumor ... Combined 17α-hydroxylase/17,20-lyase deficiency is a rare condition but might be underdiagnosed. It should be considered in ... 17-hydroxylase/17,20-lyase deficiency due to a R96Q mutation causing hypertension and poor breast development ... Combined17α-hydroxylase/17,20-lyase deficiency is a rare cause of congenital adrenal hyperplasia and hypogonadism. Hypertension ...
https://edm.bioscientifica.com/browse?pageSize=10&sort=datedescending&t=condition_0&t_1=medication_173
*  Vitamin D and Physical Performance | SpringerLink
Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 2005;29(1):21-30.PubMedGoogle ... J Steroid Biochem Mol Biol. 2004;89-90(1-5):557-60.PubMedGoogle Scholar ... J Steroid Biochem Mol Biol. 2004;89-90:595-600.PubMedGoogle Scholar ... 24-Hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs. Am J Physiol Endocrinol Metab. 2003;284:E505-13 ...
https://link.springer.com/article/10.1007/s40279-013-0036-y
*  Molecular Pathways: Inhibiting Steroid Biosynthesis in Prostate Cancer | Clinical Cancer Research
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J Steroid Biochem ... Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the ... Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci 2008;99:81- ... effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J Steroid ...
http://clincancerres.aacrjournals.org/content/19/13/3353?ijkey=2807e1611a2dfd4db44b05765d06ede3ce860be1&keytype2=tf_ipsecsha
*  Recent Progress in Hormone Research - Volume 49, Volume 49 - 1st Edition
Alpha 1 and Beta 1 Thyroid Hormone Receptors on Human Granulosa Cells. Dopaminergic Stimulation of Estrogen Receptor Binding in ... Steroid Receptors and Other Transcription Factors in Ecdysone Response. Protein Phosphatases. Prenylation and G Protein ... Molecular Genetic Prenatal Diagnosis of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency By Allele-Specfic ... The Molecular Genetics of Steroid 5 Reductases. 5 Reductases Inhibitors for the Treatment of Benign Prostatic Hyperplasia. ...
https://www.elsevier.com/books/recent-progress-in-hormone-research-volume-49/bardin/978-0-12-571149-4
*  Cytochrome P450 - Wikipedia
steroid biosynthesis. 2 subfamilies, 3 genes. CYP11A1, CYP11B1, CYP11B2 CYP17. steroid biosynthesis, 17-alpha hydroxylase. 1 ... found in the inner mitochondrial membrane of adrenal cortex has steroid 11β-hydroxylase, steroid 18-hydroxylase, and steroid 18 ... has steroid 11β-hydroxylase, steroid 18-hydroxylase, and steroid 18-methyloxidase activities. ... steroid 20α-hydroxylase, steroid 22-hydroxylase, cholesterol side-chain scission).. *CYP11B1 (encoding the protein P450c11β) ...
https://en.wikipedia.org/wiki/CYP450
*  Plus it
2006) Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids 71:849-856. ... 1991) Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli. Proc Natl Acad ... 2004) Identification of a novel rat microsomal vitamin D3 25-hydroxylase. J Biol Chem 279:22848-22856. ... Further, they replenished the BHA in their cell media frequently during their induction (at 6, 12, 18, 24, and 48 hours), ...
http://dmd.aspetjournals.org/content/41/12/2087
*  PAR-domain protein 1
1999). Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse ... The Cyp2a4 gene, encoding the cytochrome P450 steroid 15alpha-hydroxylase, is a novel circadian expression gene. This enzyme ... Thus, HLF43 stimulates transcription from the cholesterol 7 alpha-hydroxylase promoter much more efficiently than from the ... transcription factors that bind similar sites on the promoters of albumin and cholesterol 7 alpha hydroxylase genes. However, C ...
http://www.sdbonline.org/sites/fly/dbzhnsky/pardmp11.htm
*  3 Overview of Vitamin D | Dietary Reference Intakes for Calcium and Vitamin D | The National Academies Press
Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. Journal of Steroid Biochemistry and Molecular ... 1 alpha-hydroxyvitamin D2 is less toxic than 1 alpha-hydroxyvitamin D3 in the rat. Proceedings of the Society for Experimental ... Regulation of 25-hydroxyvitamin D-1alpha-hydroxylase by epidermal growth factor in prostate cells. Journal of Steroid ... Pharmacokinetics and systemic effect on calcium homeostasis of 1 alpha,24-dihydroxyvitamin D2 in rats. Comparison with 1 alpha, ...
https://www.nap.edu/read/13050/chapter/5
*  Repro-Stuff Missed Flashcards by A Fleary | Brainscape
17-hydroxylase deficiency results in decreased secretion of cortisol and sex steroids and increased level of mineralcorticoids ... 5-alpha reductase.. 5-alpha reductase converts testosterone to DHT.. DHT is reponsible for EXTERNAL male genitalia ...
https://www.brainscape.com/flashcards/repro-stuff-missed-845297/packs/1473017
*  HPGD | Cancer Genetics Web
J Steroid Biochem Mol Biol. 2014; 144 Pt A:91-5 [PubMed] Free Access to Full Article Related Publications ... Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα) are proinflammatory cytokines that play a critical role in ... Using quantitative RT-PCR, we analyzed mRNA expression of genes activating and catabolizing 1,25-D3 (1α-hydroxylase (CYP27B1), ... 24-hydroxylase (CYP24A1)), expression of several vitamin D target genes, as well as expression of cyclooxygenase 2 (COX-2) and ...
http://www.cancerindex.org/geneweb/HPGD.htm
*  Publications - Mayo Clinic
Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues ... Antihypertensive efficacy of alpha-methyldopa, chlorothiazide and Supres-150 (alpha-methyldopa-chlorothiazide). CMAJ: Canadian ... J Steroid Biochem. 1977 Mar; 8(3):221-8. View PubMed. * Zachariah PK, Liston J. Temperature sensitive cell membrane of a ... Steroids. 1975 Nov; 26(5):571-8. View PubMed. * Juchau MR, Namkung MJ, Berry DL, Zachariah PK. Oxidative biotransformation of 2 ...
http://www.mayo.edu/research/SearchPublications/Publications?authid=10277099