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*  K252b | CAS#99570-78-2 | staurosporine analog | PKC inhibitor | DNA synthesis suppressor | MedKoo
K252b is a staurosporine analog and PKC inhibitor that suppresses DNA synthesis. It also inhibits microbial ectoprotein kinases ... 19: Pollack S, Young L, Bilsland J, Wilkie N, Ellis S, Hefti F, Broughton H, Harper S. The staurosporine-like compound L- ... Description: K252b is a staurosporine analog and PKC inhibitor that suppresses DNA synthesis. It also inhibits microbial ... Neuronal differentiation by analogs of staurosporine. Neurochem Int. 2010 Mar;56(4):554-60. doi: 10.1016/j.neuint.2009.12.018. ...
http://www.medkoo.com/products/15158
*  Patent US6015892 - Oligonucleotide modulation of protein kinase C - Google Patents
Staurosporine, an alkaloid product of Streptomyces sp., and its analogs, are the most potent in vitro inhibitors of PKC ...
http://www.google.com.au/patents/US6015892
*  High Pressure Induces Superoxide Production in Isolated Arteries Via Protein Kinase C-Dependent Activation of NAD(P)H Oxidase |...
... staurosporine (10−6 mol/L, an inhibitor of PKC), Tiron (10 mmol/L, a O2·− scavenger), or losartan (10−6 mol/L) or in the ... staurosporine (Stauro; 10−6 μmol/L), or Tiron (10 mmol/L) or in the absence of extracellular Ca2+. C, O2·− production in rat ...
http://circ.ahajournals.org/content/108/10/1253
*  Staurosporine - DrugBank
Staurosporine. PDB Entries. 1aq1 / 1byg / 1e8z / 1nvr / 1nxk / 1oky / 1q3d / 1qpd / 1qpj / 1sm2 … ... Staurosporine. Accession Number. DB02010 (EXPT02970, EXPT02972) Type. Small Molecule. Groups. Experimental. Description. An ... Staurosporine may decrease the excretion rate of Acetyldigoxin which could result in a higher serum level. ... Budworth J, Davies R, Malkhandi J, Gant TW, Ferry DR, Gescher A: Comparison of staurosporine and four analogues: their effects ...
https://www.drugbank.ca/drugs/DB02010
*  Staurosporine | Biotium
Staurosporine Staurosporine is a potent and cell-permeable inhibitor of a wide variety of protein kinases (1,2) including ... Staurosporine is a potent and cell-permeable inhibitor of a wide variety of protein kinases (1,2) including protein kinase C ( ... IC50 = 0.7 nM), protein kinase A (IC50 = 7 nM), and protein kinase G (IC50 = 8.5 nM). Staurosporine induces apoptosis in human ... protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50 = 7 nM), and protein kinase G (IC50 = 8.5 nM). Staurosporine induces ...
https://biotium.com/product/staurosporine/
*  Adhesion to type V collagen enhances staurosporine-induced apoptosis of adrenocortical cancer cells | SpringerLink
... and type I-III collagens didn't modify staurosporine-induced apoptosis. Staurosporine-treated H295R cells showed an increase of ... Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V collagen didn't modify Akt activation ... Adrenocortical cancer Type V collagen Apoptosis Staurosporine This is a preview of subscription content, log in to check access ... H295R cells grown on plastic showed a low responsiveness to staurosporine, with an apoptotic rate of 24 %, as compared to ...
https://link.springer.com/article/10.1007/s13277-014-2281-6
*  Staurosporine | CAS 62996-74-1 | SCBT - Santa Cruz Biotechnology
Buy Staurosporine (CAS 62996-74-1), an antifungal inhibitor of many different enzymes, from Santa Cruz. Purity: >99%, MF: ...
https://www.scbt.com/scbt/product/staurosporine-62996-74-1/
*  Staurosporine - Wikipedia
Staurosporine is in the non-halogenated class. Staurosporine is the precursor of the novel protein kinase inhibitor midostaurin ... This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. Staurosporine is a ... staurosporine induces specific cell cycle effects arresting cells in G1 or G2 phases of the cycle. Staurosporine is an ... also called staurosporine aglycone). In the natural biosynthetic pathway, K252c is a precursor of staurosporine. The ...
https://en.wikipedia.org/wiki/Staurosporine
*  Staurosporine Induces Platelet Apoptosis Through p38 Mitogen-Activated Protein Kinase Signaling Pathway. | Sigma-Aldrich
Staurosporine (STS), a microbial alkaloid and potent PKC inhibitor, has become one of the most promising anti-cancer drugs. STS ... Staurosporine Induces Platelet Apoptosis Through p38 Mitogen-Activated Protein Kinase Signaling Pathway.. [Lili Zhao, Guoyuan ...
https://www.sigmaaldrich.com/catalog/papers/26299070
*  Increase of reduced nicotinamide adenine dinucleotide fluorescence lifetime precedes mitochondrial dysfunction in staurosporine...
In one of our previous studies, staurosporine (STS)-induced apoptosis in HeLa cells was used as the model of the mitochondria- ... I. Kruman, Q. Guo, and M. P. Mattson, "Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial ... We have previously observed the NADH fluorescence lifetime change is associated with staurosporine (STS)-induced mitochondria- ... Increase of reduced nicotinamide adenine dinucleotide fluorescence lifetime precedes mitochondrial dysfunction in staurosporine ...
https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-16/issue-03/036008/Increase-of-reduced-nicotinamide-adenine-dinucleotide-fluorescence-lifetime-precedes-mitochondrial/10.1117/1.3560513.full?SSO=1
*  Bruno, S., Ardelt, B., Skierski, J.S., Traganos, F. and Darzynkiewicz, Z. (1992) Different Effects of Staurosporine, an...
Different Effects of Staurosporine, an Inhibitor of Protein Kinases, on the Cell Cycle and Chromatin Structure of Normal and ... TITLE: Staurosporine-Induced Cell Death in Trypanosoma brucei and the Role of Endonuclease G during Apoptosis ... KEYWORDS: Trypanosoma brucei, Endonuclease, EndoG, Staurosporine, Programmed Cell Death, Apoptosis JOURNAL NAME: Open Journal ... In the work presented here, we studied the effects of prostaglandin D2 and staurosporine induced cell death in blood-forms of ...
https://www.scirp.org/reference/ReferencesPapers.aspx?ReferenceID=1170761
*  Gentaur Molecular :Biotium \ STAUROSPORINE \ 00025
STAUROSPORINE \ 00025 for more molecular products just contact us ... 29562261] Staurosporine targets the Hippo pathway to inhibit cell growth.. [29558119] Bioactive Indolocarbazoles from the ... ISR1 YPR106W] Serine/threonine-protein kinase ISR1 (EC 2.7.11.1) (Inhibition of staurosporine resistance protein 1). [ZAP70 SRK ...
http://www.antibody-antibodies.com/product_det.php?id=1184130&supplier=search&name=STAUROSPORINE
*  Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and...
EGF induces EMT in the breast cancer cell line PMC42-LA and the kinase inhibitor staurosporine (ST) induces EMT in embryonic ... Staurosporine combined with EGF led to an enhanced EMT with a switch from Snail2 to Snail1 signalling. EGF plays an important ... Staurosporine and EMT. We have proposed that ST-induced EMT of neural epithelia was initiated rapidly due chiefly to inhibition ... Staurosporine mediated effects on ECM cellular attachment. A reduction in focal contact size mediated by ST may have achieved ...
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-235
*  Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44+/CD24-) in MCF-7 by Upregulating Mucin1 and EpCAM
Gescher A. Staurosporine analogues - pharmacological toys or useful antitumour agents?. Crit Rev Oncol Hematol. 2000;34:127-35 ... Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44+/CD24-) in MCF-7 by Upregulating Mucin1 and EpCAM Na ... Zhou N, Wang R, Zhang Y, Lei Z, Zhang X, Hu R, Li H, Mao Y, Wang X, Irwin DM, Niu G, Tan H. Staurosporine Induced Apoptosis May ... Staurosporine (STS) was purchased from Merck (Darmstadt, Germany).. Generation of acute apoptotic MCF-7, STS-1-R and STS-2-R. ...
http://www.jcancer.org/v06p1049.htm
*  Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44+/CD24-) in MCF-7 by Upregulating Mucin1 and EpCAM ...
Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44+/CD24-) in MCF-7 by Upregulating Mucin1 and EpCAM Na ... Zhou N, Wang R, Zhang Y, Lei Z, Zhang X, Hu R, Li H, Mao Y, Wang X, Irwin DM, Niu G, Tan H. Staurosporine Induced Apoptosis May ... were enhanced after recovery from apoptosis induced by two pulses of staurosporine (STS). The distribution of cells in the cell ...
http://www.jcancer.org/v06p1049
*  Leicester Research Archive: Comparison of staurosporine and four analogues: Their effects on growth, rhodamine 123 retention...
Comparison of staurosporine and four analogues: Their effects on growth, rhodamine 123 retention and binding to P-glycoprotein ...
https://lra.le.ac.uk/handle/2381/26620
*  Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine -...
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine ... The OAG-induced aggregation, however, was strongly inhibited by H-7 or staurosporine but not by polymyxin B. In contrast, ... H-7 and staurosporine. Biochemical and biophysical research communications 151 (1), pp. 542-547. ... or staurosporine, all being potent inhibitors of PKC in vitro. ...
https://epub.uni-regensburg.de/23269/
*  Staurosporine - MDM2 antagonists targeting fundamental oncogenic signaling pathways
Blog MYH9, Staurosporine Clinical Wire Blood (CB) Hematopoietic Cell Transplantation (HCT) has progressed well. February 11, ... Staurosporine RNA-binding proteins (RBPs) facilitate post-transcriptional control of eukaryotic gene expression at. September 4 ... Blog Rabbit Polyclonal to FOXC1/2, Staurosporine Background Despite the large numbers of published documents analyzing the ... The advantages of CB for HCT include the ease of collection Staurosporine of the CB at the birth of the baby, with no problems ...
http://healthconnectionsvt.org/tag/staurosporine/
*  The Four Most Asked Questions About Staurosporine - Hemoroizi Forum
When the fibrinogen is discovered to get Staurosporine lower than 100?mg/dL, the particular test had been looked at for ...
http://hemoroiziforum.ro/discussion/80/kupit-v-onlayn-magazine-bosonozhki-inario
*  Staurosporine inhibits apoptotic blebbing in PC12 and | Open-i
Staurosporine inhibits apoptotic blebbing in PC12 and COS-7 cells. Serum removal and z-VAD-FMK treatment were performed as ... Figure 4: Staurosporine inhibits apoptotic blebbing in PC12 and COS-7 cells. Serum removal and z-VAD-FMK treatment were ... Figure 4: Staurosporine inhibits apoptotic blebbing in PC12 and COS-7 cells. Serum removal and z-VAD-FMK treatment were ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2140178_JCB32958.f4&req=4
*  Staurosporine - Targeting prostate cancer cell lines with polo-like kinase inhibitors
Posted in Gonadotropin-Releasing Hormone ReceptorsTagged CCNF, Staurosporine Search for: Recent Posts. * Levodopa (L-dopa) may ... Tag: Staurosporine. Objective To measure the effectiveness and security of abatacept in biological-naive. Posted on November 23 ...
http://www.ecologicalsgardens.com/tag/staurosporine/
*  Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via...
Staurosporine (stsp) is a kinase inhibitor which induces cornified envelope assembly and terminal differentiation in normal and ... Staurosporine (stsp) is a kinase inhibitor which induces cornified envelope assembly and terminal differentiation in normal and ...
http://oxfordindex.oup.com/view/10.1093/carcin/17.6.1259
*  NAVER Academic | Inhibitory effects of 1,25-dihydroxyvitamin D3 and its low-calcemic analogues on staurosporine-induced...
Inhibitory effects of 1,25-dihydroxyvitamin D3 and its low-calcemic analogues on staurosporine-induced apoptosis.. Author. ...
https://academic.naver.com/article.naver?doc_id=146489598