Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms ...
Further support this, STAT5-deficiency impaired MPL W515L-induced CFU-Mk expansion. In vivo, MPL515/630 but not MPL515/625 or ... differential activation of the downstream signaling by four mutants was observed and constitutively active STAT5 or AKT instead ... An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994;371:221-6. ... STAT5-deficiency impairs MPL W515L-induced hyperproliferation of megakaryocytes. STAT5 is required for BCR-ABL to induced CML ...
Chronic Cardiovascular Disease-Associated Gene Network Analysis in Human Umbilical Vein Endothelial Cells Exposed to 2,3,7,8...
Finally, we found enhanced platelet-derived growth factor (PDGF) and signal transducer and activator of transcription 5 (Stat5 ... Finally, we found enhanced platelet-derived growth factor (PDGF) and signal transducer and activator of transcription 5 (Stat5 ... Finally, we found enhanced platelet-derived growth factor (PDGF) and signal transducer and activator of transcription 5 (Stat5 ... Finally, we found enhanced platelet-derived growth factor (PDGF) and signal transducer and activator of transcription 5 (Stat5 ...
Group Müller old - JAK Stat Monarchies
STAT Transcription Factors: Controlling All Aspects of NK Cell Biology.. In Jak-Stat Signaling: From Basics to Disease (Decker ... The different functions of Stat5 and chromatin alteration through Stat5 proteins.. Front Biosci 13:6237-54. [review] doi: dx. ... STAT1 and STAT3 Transcription Factors in Inflammation-Associated Colon Cancer.. In Jak-Stat Signaling: From Basics to Disease ... CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.. Immunity 38: 250-262. ...
IL-21 Is a Major Negative Regulator of IRF4-Dependent Lipolysis Affecting Tregs in Adipose Tissue and Systemic Insulin...
... transcription factor by using a mouse regulatory T-cell detection kit as directed by the manufacturers instructions (Miltenyi ... Stat5, and Stat6 (21-23). IL-21 expression in T cells can be regulated by IL-21 via an autocrine positive-feedback loop, ... high levels of expression of the transcription factor IRF4 and its targets lipe and pnpla2, particularly in the refeeding ... and the cells are characterized by the expression of the transcription factor Foxp3 and the nuclear receptor peroxisome ...
Faculty Collaboration Database - STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving...
STAT3 Transcription Factor. STAT5 Transcription Factor. Signal Transduction. Staining and Labeling. T-Lymphocytes, Cytotoxic. T ... Forkhead Transcription Factors. Humans. Immune Tolerance. Interleukin-2. Lymphocyte Activation. Mice. Phosphorylation. ... STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity. J Leukoc Biol 2014 ... Mechanistically, S3I-201 polarized the ratio of STAT phosphorylation in favor of STAT5 over STAT3 and also achieved a ...
CD4+ T Cell Model April 2012 | Nutritional Immunology and Molecular Medicine Laboratory
Cytokines TGF-beta and IL-4 induce the PU.1 transcription factor, which then upregulates IL-9. It also promotes IL-21 via the ... STAT-5 promotes BLIMP-1 phosphorylation, which, in turn, downregulates BCL-6. Conversely, BCL-6 is upregulated by STAT-3, which ... Also, activated transcription factors are now highlighted with a discontinued contour to be more easily detectable. Moreover, ... their shapes have been rearranged so now the transcription factors have a squared shape and the cytokines an oval one. ...
JAK2 is required for induction of the murine DUB-1 gene - Oxford Cardiovascular Science
A dominant-negative form of STAT5 (truncated at amino acid 650) inhibited the induction of GAS-luc but not DUB-1-luc. A ... hypothesize that IL-3 activates a JAK2/Raf-1 signaling pathway that is required for DUB-1 induction and is independent of STAT5 ... STAT transcription factors, and Raf-1 in transient transfection assays. In Ba/F3 cells, IL-3 induced a dose-dependent ... STAT transcription factors, and Raf-1 in transient transfection assays. In Ba/F3 cells, IL-3 induced a dose-dependent ...
Human/Mouse STAT5a/b Pan Specific Antibody AF2168: R&D Systems
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity ... Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is ... MGF; STAT5; STAT5A signal transducer and activator of transcription 5A ; STAT5a/b ... translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological ...
Establishment of tumor inflammasome clusters with distinct immunogenomic landscape aids immunotherapy
Gasiorek JJ, Blank V. Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells. ... Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib STAT5-and hypoxia-dependent upregulation ... An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti- ... Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors. Immunity. 2016;44:1255- ...
Molecular Chaperones | Profiles RNS
Маркеры Th1-поляризованных клеток Th17 (обзор литературы) | Куклина | Acta Biomedica Scientifica
Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev. 2014; 261(1): 141-156. doi ... Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity. 2007; 26(3): 371-381. doi: 10.1016/j.immuni ... Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. ... Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci. J Immunol. 2011; 187 ...
JAK Kinases in Health and Disease: An Update
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper ... At least 70% of patients with AML show evidence of STAT5 activation within the leukemic blast cells [108]. In view of the close ... In the mouse, the IL-7R is also critical for B cell development, in part due to its role in regulating the transcription factor ... Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor ...
In This Issue | Cancer Discovery | American Association for Cancer Research
... which engaged in multiple autoregulatory loops and was controlled by the transcription factor TEAD4 together with MYCN. TEAD4 ... Mechanistically, JAK3M511I activated downstream STAT5, and STAT5 and HOXA9 co-localized at sites across the genome in leukemia ... HOXA9 enhanced the transcriptional activity of STAT5, thereby increasing expression of STAT5 target genes including the PIM1 ... or by inhibiting the transcription factor NRF2, which drives the expression of an antioxidant transcriptional program. Having ...
Th17细胞标记 莱兹生物
Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational...
... from transcription to degradation. Finally, we contrast the regulatory properties of protein motifs and the regulatory elements ... a site for binding Transcription factor AP-2-alpha [174]; sites for Transcription factor E2F1 [175]; a Forkhead-binding site ... STAT3 and STAT5 dimers [165, 166]; three CDX-binding sites that bind homeobox protein CDX-2 [167]; a T-element that binds the T ... Bai YQ, Miyake S, Iwai T, Yuasa Y. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. ...
Edward Harhaj - Research output - Penn State
Role of the proteasome in the downregulation of transcription factors NFκB and C/EBP in macrophages from tumor hosts. Perry, G. ... Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells. Sun, S. C., Maggirwar, S. B., Harhaj, E. W. & Uhlik, ... Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway. Shembade, ... The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. ...
2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells<...
keywords = "2-Methoxyestradiol, Breast cancer, Progesterone receptor, STAT5, Tissue factor",. author = "Marisol Quezada and ... such as TF and signal transducer and activator of transcription 5. We further demonstrate that 2ME can alter the ... 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. Hormones and ... 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. In: Hormones ...
Search Results
... which includes the transcription factors GR, signal transducer and activator of transcription 5A (STAT5A) and retinoid X ... Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARγ J Endocrinol 235 (3) 223-235, ... The role of corticotropin-releasing factor in depression and anxiety disorders. *Post-transcriptional gene regulatory ...
Asher Bio to Unveil Two New Immunotherapy Programs, a CD8+ T Cell Targeted IL-21 and a Cis-Targeted IL-2 for Cell Therapy...
... a master transcription factor involved in a broad spectrum of adaptive and innate immune functions. Previously, wild-type IL-21 ... Both fusion molecules selectively induce phospo-STAT5 signaling resulting in greater than 100-fold preferential STAT5 activity ... all of which are complementary to the proliferation signal provided by IL-2 induced STAT5 activation. We believe AB821 could ...
BATF regulates collagen-induced arthritis by regulating T helper cell differentiation | Arthritis Research & Therapy | Full Text
... vascular endothelial growth factor, and receptor activator of NF-κB ligand (RANKL). Our findings indicate that BATF crucially ... The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat ... STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem. 2012;287(14):11234-9. ... BATF is known to regulate Th17 cell differentiation by modulating the expression of the transcription factor RORγt [16], and to ...
CAR T-Cells | Encyclopedia MDPI
Exploiting Transcription Factors and Specific Genes Pathways to Promote Potent Antitumor Activity of CAR T-Cells. Transcription ... IL7 enhances glucose uptake through the STAT5 activation pathway, increasing the survival of the CAR T-cells [41]. On the other ... metabolic program can also be improved using modified transcription factors as exemplified with the T-box transcription factor ... Transcription Factor IRF4 Promotes CD8(+) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic ...
S-EPMC4702595 - Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional...
This integrative analysis of liver lincRNA chromatin states, transcription factor occupancy, and growth hormone regulation ... STAT5, hepatocyte nuclear factor 6 [HNF6], FOXA1, and FOXA2) and transcriptional repressors (CUX2 and BCL6). Repression of ... are more highly species conserved and have a significantly higher frequency of proximal binding by liver transcription factors ... transcription factor binding, and epigenetic states. To investigate the potential for functionality, we focused on the ...
Reference Detail
... with autophosphorylation of FLT3 and activated the downstream targets signal transducer and activator of transcription 5 (STAT5 ... CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/ ... All AML/MDS patients with identified CBL mutants belonged to the core binding factor and 11q deletion AML subtypes. ... Expression of CBLDeltaexon8 and CBLDeltaexon8+9 in FLT3-WT-Ba/F3 cells induced growth factor-independent proliferation ...
Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in...
Molecular Dynamics Control Intramolecular Communication in the Signal Transducers and Activators of Transcription Factor STAT5 ... The Notch intracellular domain represses CRE-dependent transcription. * Troy, a tumor necrosis factor receptor family member, ... The Notch intracellular domain represses CRE-dependent transcription. * Troy, a tumor necrosis factor receptor family member, ... Molecular Dynamics Control Intramolecular Communication in the Signal Transducers and Activators of Transcription Factor STAT5 ...
Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of...
Molecular Dynamics Control Intramolecular Communication in the Signal Transducers and Activators of Transcription Factor STAT5 ... The Notch intracellular domain represses CRE-dependent transcription. * Troy, a tumor necrosis factor receptor family member, ... The Notch intracellular domain represses CRE-dependent transcription. * Troy, a tumor necrosis factor receptor family member, ... Molecular Dynamics Control Intramolecular Communication in the Signal Transducers and Activators of Transcription Factor STAT5 ...
WikiGenes - STAT1 - signal transducer and activator of...
STAT1 is a founding member of the Signal Transducers and Activators of Transcription family of transcription factors. ... The activation of STAT5 cannot be excluded, so the IL-2-activated complexes most probably include at least one novel STAT [51]. ... Alteration of transcription factors NF-kappaB and STAT1 in Alzheimers disease brains. Kitamura, Y., Shimohama, S., Ota, T., ... In this model, both signal transducer and activator of transcription factor 1 (STAT1) and STAT3 are activated in the liver [50] ...
Page 1 | Search Results | Blood | American Society of Hematology
ISMARA results: Foxf2
... tool that recognizes most important transcription factors that are changing their activity in a set of samples. ... transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010). ... PID IL2 STAT5 PATHWAY. IL2 signaling events mediated by STAT5. 0.2. 3.3. PID CIRCADIAN PATHWAY. Circadian rhythm pathway. ... Signaling events mediated by Stem cell factor receptor (c-Kit). 0.0. 3.4. PID HIF1 TFPATHWAY. HIF-1-alpha transcription factor ...
15,16-Dihydrotanshinone I inhibits the proliferation of MV4-11 by means of apoptosis via antagonizing FLT3-ITD/STAT5/Mcl-1...
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood 2003; ... Activation of FLT3, STAT5, and Mcl-1 expression was analyzed by western blotting. The results showed that MV4-11 was sensitive ... 15,16-Dihydrotanshinone I inhibits the proliferation of MV4-11 by means of apoptosis via antagonizing FLT3-ITD/STAT5/Mcl-1 ... "15,16-Dihydrotanshinone I Inhibits the Proliferation of MV4-11 by Means of Apoptosis via Antagonizing FLT3-ITD/STAT5/Mcl-1 ...
November | 2021 | Pdgfr Inhibitors
upon broad epigenetic mechanisms in addition to master transcription factors. This review considers epigenetic regulation in ... G129R was superior at blocking STAT3 and STAT5 activation. G129R was also able to directly inhibit the HER2 phosphorylation. ... The factors associated with low HAZ in 2010 were: wealth index, the situation of living with biological parents, maternal ... Associated factors were identified by hierarchical multiple logistic regression analysis. Results: The prevalence of low HAZ ( ...