STAT5 phospho Y694 Antibody 200-301-A45S
Stat5) belongs to a family of cytoplasmic transcription factors that can be activated (phosphorylated) by a cell surface ... Stat5 has two isoforms, Stat5 alpha and Stat5 beta. Aberrant Stat5 activation has been implicated in the pathogenesis of ... Stat5 is localized in the cytoplasm and upon phosphorylation at Y694 is translocated to the nucleus. Ideal for Cancer, ... Phosphorylation at Tyr694 is obligatory for Stat5 activation. ... Stat5 has two isoforms, Stat5 alpha and Stat5 beta. Aberrant ...https://rockland-inc.com/Product.aspx?id=33795
Response to interferons and antibacterial innate immunity in the absence of tyrosine‐phosphorylated STAT1 | EMBO Reports
Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner AC, Sepuri NB (2013) The import of the transcription factor STAT3 into ... Lee JE, Yang YM, Liang FX, Gough DJ, Levy DE, Sehgal PB (2012) Nongenomic STAT5‐dependent effects on Golgi apparatus and ... These heterodimers associate with interferon regulatory factor 9 (IRF9) to form the IFN‐stimulated gene factor 3 (ISGF3). After ... CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity 38: 250-262. ...http://embor.embopress.org/content/17/3/367
New Strategy to Target Transcription Factor STAT5 to Combat Leukaemia
Health Care New Strategy to Target Transcription… Published: February 23, 2018.Released by University of Veterinary Medicine - ... Transcription factors like STAT5 are similar to genetic light switches and capable of turning genes on and off. But previous ... New Strategy to Target Transcription Factor STAT5 to Combat Leukaemia. / no comments ... it subsequently also disrupts STAT5 activation, nuclear translocation, and STAT5-dependent gene transcription. Bettina ...http://healthmedicinet.com/new-strategy-to-target-transcription-factor-stat5-to-combat-leukaemia/
Constitutive activation of the transcription factor Stat5 in hematopoietic stem/progenitor cells - Role of adrenergic receptors...
Constitutive activation of the transcription factor Stat5 in hematopoietic stem/progenitor cells. January 23, 2018. ... Constitutive activation of the transcription factor Stat5 in hematopoietic stem/progenitor cells leads to several hematopoietic ... These properties are reliant on constitutive account activation of the transcription aspect Stat5 and can end up being ... Amazingly, an 11-residue Stat5-holding peptide (residues 988-998) covered up Stat5 activity in Ba/Y3 cells and growth and ...http://researchreportone.com/?p=4166
Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene...
We have investigated the activity of a mammary gland-specific transcription factor (MGF), which mediates hormonal influences at ... The role of Stat5 transcription factors as tumor suppressors or oncogenes.. *Gerardo Ferbeyre, Richard Moriggl ... We have investigated the activity of a mammary gland-specific transcription factor (MGF), which mediates hormonal influences at ... Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene ...https://www.semanticscholar.org/paper/Developmental-and-environmental-regulation-of-a-for-SCHMITT-NEY-Happ/bcaa298b4b72813dac82adacc5809652101b2721
Organic Chemistry and Chemical Biology
The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation The ... Here, the authors use STAT5 protein to assemble its own small molecule inhibitors via Mannich ligation (three-component- ... oncogene STAT5 is involved in cancer cell proliferation. ...http://www.nature.com/collections/wdzvyhgxft?error=cookies_not_supported&code=6fcd1389-9639-4a0c-9dc9-b4b5ee6b1791
Cancer News - Health News, Medicine News, Cancer
New strategy to target transcription factor STAT5 to combat leukaemia. Acute myeloid leukaemia is the most common type of acute ... Add broken DNA repair to the list of inherited colorectal cancer risk factors. An analysis of nearly 3,800 colorectal cancer ... HealthDay)-Cancer history has an important impact on mortality independent of cardiovascular risk factors (CVRFs), according to ...https://medicalxpress.com/cancer-news/
Growth hormone signal transduction.
0/STAT5 Transcription Factor; 0/Trans-Activators; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; EC ... STAT5 Transcription Factor. Sex Characteristics. Signal Transduction / physiology*. Trans-Activators / physiology. Grant ... Insulin-Like Growth Factor I / physiology. Islets of Langerhans / physiology. Janus Kinase 2. Liver / metabolism. Milk Proteins ... 10537136 - Dissociation of janus kinase 2 and signal transducer and activator of transcription 5 a.... 24951756 - The atypical ...http://www.biomedsearch.com/nih/Growth-hormone-signal-transduction/12099386.html
Mitogen-Activated Protein Kinase 8 Summary Report | CureHunter
STAT5 Transcription Factor 7. Proliferating Cell Nuclear Antigen (PCNA) 8. sorafenib (BAY 43-9006) ... 09/01/2009 - "c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human ... tumour necrosis factor alpha) and activation of JNK1/2 (c-Jun N-terminal kinase 1/2). ". ... and attenuated the activation of nuclear factor-kappa B (NF-kappaB) in the kidneys subjected to ischemia. ". 01/18/2002 - " ...http://www.curehunter.com/public/keywordSummaryD048055.do
Research - CheckOrphan
New strategy to target transcription factor STAT5 to combat leukaemia Thursday, February 22, 2018 ...http://www.checkorphan.org/news/research?b_start:int=50
Wip1-knockout animals have reduced alveolar development | Open-i
... insulin-like growth factor 2), paracrine stimulators of alveolar development.In the MMTV-neu model, HER2/neu activates STAT5 in ... Bottom Line: In the absence of Wip1, hormone-receptor-positive cells have significantly reduced transcription of RANKL ( ... insulin-like growth factor 2), paracrine stimulators of alveolar development.In the MMTV-neu model, HER2/neu activates STAT5 in ... insulin-like growth factor 2), paracrine stimulators of alveolar development. In the MMTV-neu model, HER2/neu activates STAT5 ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3672744_bcr3381-1&req=4
WT Treg Cannot Completely Protect against LAG-3 KO Tres | Open-i
... we found that IL-2 and STAT5 are critical for LAG-3 function. Similarly, LAG-3 blockade was ineffective in the absence of ... we found that IL-2 and STAT5 are critical for LAG-3 function. Similarly, LAG-3 blockade was ineffective in the absence of ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4220939_pone.0109080.g007&req=4
Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone | PNAS
GH signals by inducing phosphorylation of the transcription factor STAT-5 (21). Immunoblotting revealed elevated phospho-STAT-5 ... The plot reveals a strong correlation between LC3-II level and p-STAT5 level (R2 = 0.90). Inasmuch as p-STAT5 is produced by GH ... E) Relationship between the amounts of LC3II and p-STAT5. The relative amounts of LC3II (normalized to GAPDH) and p-STAT5 ( ... and there were corresponding decreases in p-STAT5 and LC3-II. We found a striking correlation between p-STAT5 and LC3-II levels ...https://www.pnas.org/content/112/4/1226?ijkey=a53767fe4374643f404d174788085f5edf5bf219&keytype2=tf_ipsecsha
NADPH Oxidase Nox2 Is Required for Hypoxia-Induced Mobilization of Endothelial Progenitor Cells | Circulation Research
EPO signaling involves the STAT5 transcription factor. EPO-induced STAT5-dependent reporter gene expression was absent in Nox2- ... The EPO-induced proliferation of EPCs required the transcription factor STAT5: Antisense oligonucleotides directed against ... STAT5) is recruited and activated. STAT5 subsequently dimerizes, translocates into the nucleus, and induces transcription.5 ... proangiogenic factors like vascular endothelial growth factor (VEGF) or stromal-cell derived factor-1α (SDF-1α, CXCL12),2 ...http://circres.ahajournals.org/content/105/6/537
Earlier Detection of Heart Problems Needed in Cancer Patients - Healthcanal.com : Healthcanal.com
New strategy to target transcription factor STAT5 to combat leukaemia 02/22/2018 Cancers ... Female sex not a protective factor against heart disease in type 1 diabetes ...https://www.healthcanal.com/cancers/15809-earlier-detection-of-heart-problems-needed-in-cancer-patients.html
"Reprogrammed" Treatment-resistant Lymphomas Respond to Cancer Drugs - Healthcanal.com : Healthcanal...
New strategy to target transcription factor STAT5 to combat leukaemia 02/22/2018 Cancers ... Female sex not a protective factor against heart disease in type 1 diabetes ...https://www.healthcanal.com/cancers/41979-reprogrammed-treatment-resistant-lymphomas-respond-to-cancer-drugs.html
Hypoxic Tumor Kinase Signaling Mediated by STAT5A in Development of Castration-Resistant Prostate Cancer
... substrate microarray method we revealed high kinase activity mediated by signal transducer and activator of transcription 5A ( ... STAT5 belongs to the STAT gene family of transcription factors . STAT5 comprises two highly homologous isoforms; the 94 kDa ... 2008) Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells. Cancer Res 68: 236-248. * View ... 2003) Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells. J Biol Chem 278: 27287-27292 ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063723
Molecular Pathways and Mechanisms Regulating the Recombination of Immunoglobulin Genes during B-Lymphocyte Development |...
Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. ... Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999; 401(6753):556-562.CrossRefPubMed ... Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes. Nat ... Transcription factor EBF restricts alternative lineage options and promotes B-cell fate commitment independently of Pax5. Nat ...https://link.springer.com/chapter/10.1007/978-1-4419-0296-2_11
Ovarian cancer survival rates improve in study. ecancer - News
New strategy to target transcription factor STAT5 to combat leukaemia (23 Feb 2018) ... New strategy to target transcription factor STAT5 to combat leukaemia ...http://ecancer.org/news/10760-ovarian-cancer-survival-rates-improve-in-study.php
Diabetes drug metformin inhibits multidrug-resistant breast cancer. ecancer - News
New strategy to target transcription factor STAT5 to combat leukaemia (23 Feb 2018) ... New strategy to target transcription factor STAT5 to combat leukaemia ...http://ecancer.org/news/12950-diabetes-drug-metformin-inhibits-multidrug-resistant-breast-cancer.php
The Ets-1 transcription factor controls the development and function of natural regulatory T cells | JEM
IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in ... The STAT5 transcription factor, which is activated by the IL-2-Jak3 signaling pathway, plays a key role by directly activating ... regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor ... Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor ...http://jem.rupress.org/content/early/2010/09/15/jem.20092153
STAT5-Induced Lunatic Fringe during Th2 Development Alters Delta-like 4-Mediated Th2 Cytokine Production in Respiratory...
Critical role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity 36: 586 ... and the two most important transcription factors are GATA3 and STAT5 (33). Although early Th2 differentiation requires GATA3, ... proteins and the transcription factor CSL/RBP-Jk (encoded by Rbpj) to induce target gene transcription HES genes in mammals. ... at least in part due to Notch-induced transcription of Gata3, a Th2-specific transcription factor (11, 13). The activation of ...http://www.jimmunol.org/content/192/3/996
STAT5 is a transcription factor involved in signal transduction pathways inducing anti-apoptotis and proliferation. From ... 3 and 5 expression in melanoma metastasis by immunohistochemistry and evaluate activation of the transcription factors by the ... Recent publications revealed that neoantigens of the tumor might be one of the main factors to lead to recognition by the ... In interferon resistant melanoma cell lines we found a high expression of STAT5 and a low expression of STAT1. Hence, this ...https://www.klinikum.uni-heidelberg.de/hautklinik-zentrum/hauttumorzentrum/forschung/wissenschaftliche-projekte/
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis | JEM
... and Stat5, a transcription factor downstream of GM-CSF signaling (Mui et al., 1995; Kimura et al., 2009) which has been ... The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis. Blood. 114:4721-4728. doi:10.1182/blood-2009-04- ... 1 H), the gene which codes for Blimp-1, which is an essential transcription factor in plasma cell generation (Shapiro-Shelef et ... Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs ...http://jem.rupress.org/content/early/2014/05/06/jem.20131471
ZFIN Publication: Li et al., 2012
STAT5 Transcription Factor/metabolism. *Zebrafish/genetics*. PubMed:. 21888874 Full text @ J. Hepatol. ... Using the Tet-on system for liver-specific expression of fish oncogene xmrk, a hyperactive version of epidermal growth factor ... When the tumors regressed, there were decreased phosphorylated Erk and Stat5 accompanied with an increase of apoptosis, ... Our zebrafish model demonstrates the potential of a hyperactivated epidermal growth factor receptor pathway in initiating ...http://zfin.org/ZDB-PUB-110907-29