Timeline for Superfamily a.90.1: Transcription factor STAT-4 N-domain: *Superfamily a.90.1: Transcription factor STAT-4 N- ... Transcription factor STAT-4 N-domain [48093] (1 protein). More info for Superfamily a.90.1: Transcription factor STAT-4 N- ... Transcription factor STAT-4 N-domain [48091] (1 superfamily). *. Superfamily a.90.1: Transcription factor STAT-4 N-domain [ ... Lineage for Superfamily a.90.1: Transcription factor STAT-4 N-domain. *Root: SCOP 1.55 *. Class a: All alpha proteins [46456] ( ...

The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose ... "Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation ... The key Th2 transcription factors are STAT6 and GATA3. IL-4 is the positive feedback cytokine for Th2 cells differentiation. ... The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells ADCC to ...

The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to ... The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to ... Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell- ... URL of this page: https://medlineplus.gov/genetics/gene/stat4/ STAT4 gene. signal transducer and activator of transcription 4 ...

... independently of well-established transcription factors. In the presence of NAD+, the frequency of T-bet−/− CD4+IFNγ+ T cells ... Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation ... The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12, 450-459 (2011). ... More importantly, T-bet and GATA3, two transcription factors that regulate CD4+ T cell Th1/Th2 fate decision were downregulated ...

T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper ... Expression of active STAT-4, another crucial transcription factor for Th1 T cell development and regulation, did not ... 12 Transcription factors such as STAT-1 and STAT-4 are associated with IFN-γ production and play a major role in Th1 specific ... C) Representative blot showing phosphorylation of STAT-4 on tyrosine groups (p-Tyr-STAT-4) (top blot) and total STAT-4 (bottom ...

Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper ... The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest ( ... Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell- ... Th1 differentiation is initiated and stabilized by transcription factors signal transducer and activator of transcription (STAT ...

Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis ... Induction of nuclear factor-kappaB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic β cells ... Susceptibility to T1D is linked to genetic factors, but T1D-predisposing genes have low penetrance and only a small proportion ... This suggests that local IFN production may interact with a genetic factor (PTPN2) to induce aberrant proapoptotic activity of ...

... signal transducers of activation and transcription factor (STAT)-4, and T-bet, each of which exhibits defective Th1 immune ... Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Mol. Cell. Biol. 17, 2360- ...

The T-box transcription factors T-bet and Eomesodermin (Eomes) instruct discrete stages in NK cell development. However, their ... IL-12 and STAT4 upregulate T-bet in NK cells during MCMV infection. To gain insight into when T-box transcription factors may ... T-box transcription factors are dispensable for NK cell homeostasis. To investigate the role of individual T-box transcription ... Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. ...

... mice deficient in the transcription factors T-bet, STAT4, STAT3, RORγt, GM-CSF-promoting factor Bhlhe40, and cytokines GM-CSF, ... Signal transducer and activator of transcription 1 (STAT1) is a transcription factor that predominantly mediates signaling ... The transcription factor STAT1 plays a critical role in modulating the differentiation of CD4+ T cells producing IL-17 and GM- ... Effector CD4+ T cell subsets have been defined based on their secretion of cytokines, as well as based on transcription factors ...

Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation ... Fiore, M., Chaldakov, G. N., & Aloe, L. (2009). Nerve growth factor as a signaling molecule for nerve cells and also for the ... Galazios, G., Papazoglou, D., Tsikouras, P., & Kolios, G. (2009). Vascular endothelial growth factor gene polymorphisms and ... Fibrosis and subsequent cytopenias are associated with basic fibroblast growth factor-deficient pluripotent mesenchymal stromal ...

rOnIL-12 not only elevated the mRNA expression level Th1 cell-associated transcription factor T-bet in lymphocytes, but also ... Moreover, the mRNA and phosphorylation levels of STAT1, STAT3, STAT4 and STAT5 were enhanced by rOnIL-12. These findings will ... γ signaling in neurons results in differential activation of its downstream transcription factor, signal transducer and ... The transforming growth factor-ß-activated kinase 1 (TAK1) phosphorylation promotes inflammation occurrence. Meanwhile, TAK1 ...

Inactivation of the Transcription Factor STAT-4 Prevents Inflammation-Driven Fibrosis in Animal Models of Systemic Sclerosis. ... The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic ... Malignancies associated with tumour necrosis factor inhibitors in registries and prospective observational studies: a ...

Differentially methylated genes in pathogenic SIV infection were enriched for Th1-signaling (e.g., RUNX3, STAT4, NFKB1) and ... Moreover, several key transcription factors in this pathway were differentially methylated: STAT4, RUNX3 and NFKB1. This is in ... The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. J ... These included genes encoding cytokines and transcription factors, such as LTA (lymphotoxin alpha), FOXP1 (forkhead box protein ...

STAT4 Transcription Factor. A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN- ... CulturedInterferon Regulatory FactorsReceptor, Interferon alpha-betaSTAT1 Transcription FactorCell LineTumor Necrosis Factor- ... Interferon Regulatory Factors. A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind ... An interferon regulatory factor that represses transcription of TYPE I INTERFERONS and activates transcription of HISTONE H4.. ...

... transcription prediction showed that mutation of these 6 SNPs might alternate the binding of particular transcription factors. ... STAT4, signal transducers and activators of transcription; TF, transcription factor; FOXP3, forkhead box P3; AR, androgen ... Site-specific DNA-binding proteins or CAAT box transcription factor. E2F-1:. Adenovirus E2 gene promoter region binding factor ... Abbreviations: NF, nuclear factor; CTF, site-specific DNA-binding proteins or CAAT box transcription factor; E2F-1, adenovirus ...

STAT4 Transcription Factor Medicine & Life Sciences 100% * Phosphorylation Medicine & Life Sciences 40% ... To characterize the role of the STAT4 N-terminal domain in mediating STAT4 biological function, we have generated STAT4- ... To characterize the role of the STAT4 N-terminal domain in mediating STAT4 biological function, we have generated STAT4- ... To characterize the role of the STAT4 N-terminal domain in mediating STAT4 biological function, we have generated STAT4- ...

... mediated activation of the STAT4 transcription factor in cancer cells. KDM5D-dependent chromatin mark and transcriptome changes ... mediated activation of the STAT4 transcription factor in cancer cells. KDM5D-dependent chromatin mark and transcriptome changes ...

Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation ... 592C/A of the IL-10 gene promoter is located near a number of transcription factor binding sites. This SNP has been reported to ... Moore EE, Wark JD, Hopper JL, et al (2012) The roles of genetic and environmental factors on risk of cervical cancer: a review ... Du G-H, Wang J-K, Richards JR, Wang J-J (2019) Genetic polymorphisms in tumor necrosis factor alpha and interleukin-10 are ...

Secondly, the transcription factor STAT4 of Klotho was identified by bioinformatic analysis. Double luciferase reporter gene ... two key transcription factors responsible for the activation of IL-8 transcription. Kaempferol was identified as one of the key ... Moreover, we found CIP significantly enhanced the expression of STAT4. Knockdown STAT4 suppressed Klotho up-regulation after ... However, the factors affecting fungal community formation are unclear. This study is the first to utilize "mini-community" ...

48092 - Transcription factor STAT-4 N-domain. *47655 - STAT. *49417 - p53-like transcription factors. 0.00618. INHERITED FROM: ... 48092 - Transcription factor STAT-4 N-domain. *47655 - STAT. *49417 - p53-like transcription factors. 0.00618. Inherited. ... Transcription factor STAT-4 N-domain. *47655 - STAT. 0.00618. Inherited. 49417,55550. *49417 - p53-like transcription factors. ... 48092 - Transcription factor STAT-4 N-domain. *47655 - STAT. 0.00618. INHERITED FROM: abnormal endocrine pancreas secretion ,, ...

STAT4 is a target of the hematopoietic zinc‐finger transcription factor Ikaros in T cells (2005). (46) ... Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast (1994). (157) ... The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair ... Subunit Interactions in Yeast Transcription/Repair Factor TFIIH (2000). (27). *. Improvements in the Epstein-Barr-based shuttle ...

They screened 54 different transcription factors and found that one, known as STAT4, was 10 times higher in the white carneau ... The groups aim was to see if certain transcription factors might be found in altered amounts in the smooth muscle cells of ... "Interfering with these factors and the signaling pathways involving STAT4 may be potentially important in atherosclerosis ... He said that by finding the transcription factor, researchers can concentrate on modifying its pathway, and wont need to know ...

Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper ... In the mouse, the IL-7R is also critical for B cell development, in part due to its role in regulating the transcription factor ... Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor ... The identification of the STAT family of transcription factors (STAT1-5a, 5b and 6) was complementary to the discovery of JAKs ...

... suggests that these defects are acquired through prolonged exposure to proinflammatory cytokines such as tumour necrosis factor ... The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway. Proc Natl Acad Sci U S ... transcription factor specific for Th2 cells; ERM, transcription factor specific for Th1 cells; GATA-3, transcription factor ... c-Maf = a transcription factor specific for Th2 cells; ERM = a transcription factor specific for Th1 cells; ICRAC = calcium- ...

... the ILCs also express many key transcription factors that are found in Th cells, suggesting that a given transcription factor ... At present, the master regulators of Th lineages that have been identified include T-bet/Stat4 (Th1), GATA-3/Stat5 (Th2), RORγt ... the functions of known key transcription factors, including GATA3 and T-bet, and novel, potentially critical transcription ... Yu F, Sharma S, Jankovic D, Gurram RK, Su P, Hu G, Li R, Rieder S, Zhao K, Sun B, Zhu J. The transcription factor Bhlhe40 is a ...

Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many ... N2 - Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of ... AB - Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of ... abstract = "Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of ...

48092 - Transcription factor STAT-4 N-domain. *47655 - STAT. *49417 - p53-like transcription factors. 0.0002182. DIRECT. ... 48092 - Transcription factor STAT-4 N-domain. *47655 - STAT. *49417 - p53-like transcription factors. 0.0002182. Direct. ... 49417 - p53-like transcription factors. *55550 - SH2 domain. 0.0002182. DIRECT. 48092,47655. *48092 - Transcription factor STAT ... 49417 - p53-like transcription factors. *55550 - SH2 domain. 0.0002182. Direct. 48092,47655. *48092 - Transcription factor STAT ...

... a crucial transcription factor involved with Th17 differentiation (11,12). On the other hand, IL-12 promotes Th1 polarization ... In focus on cells, both cytokines activate Tyk2, Jak2, and STAT4 signaling (5,7C10). IL-23 promotes Th17 extension as well as ... not only to sense the presence of extracellular growth factors but also to interpret the complex dynamic growth factor patterns ... Known factors mixed up in regulation of mitochondrial morphology are absent in and spp virtually., which are in charge of ...

Cytoprotection by CD40 involves activation of protective genes mediated by NF-kappa B transcription factors; however, its basis ... Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated ... Induction of endothelial cell decay-accelerating factor by vascular endothelial growth factor: a mechanism for cytoprotection ... Induction of endothelial cell decay-accelerating factor by vascular endothelial growth factor: a mechanism for cytoprotection ...