"Discovery and Characterization of a Novel Progesterone Sensitive Bacterial Transcription Factor". and. "Factors Affecting RNA ... "Hepatocyte STAT3-Dependent Mechanisms of Limiting Pneumonia Susceptibility During Sepsis". 10. Qualifying Exam Seminar. Bukola ... "Investigating the Role of Novel HIV-2 Transcription Factors". 29. Journal Club. Fumiaki Aihara. Onder, L. et al. 2017. ... "Profiling Transcription Factor and Cofactor Recruitment Utilizing a Novel Array-Based Approach". Heather Hook, Siggers Lab. and ...
The signal transducer and activator of transcription factor 3 (STAT3) was observed to be phosphorylated also 30 min after ... hepatocyte growth factor; HIF-1, hypoxia-inducible factor-1; IGF, insulin-like growth factor; IGFR, insulin-like growth factor ... signal transducer and activator of transcription; TCF, T-cell factor; TGF-β, transforming growth factor beta; TKB-1, tank- ... nuclear-factor kappa-light-chain-enhancer of activated B cell; Nrf2, Nuclear factor E2 related factor 2; NSB1, Nijmegen ...
... and STAT3, respectively, and converge on the induction of RORt, a MCHr1 antagonist 2 lineage-specific transcription factor for ... and additional transcription factors (e.g., STAT3, ROR, BATF, c-Rel) also facilitate Th17 cell induction under certain ... complex chromatin remodeling responses that control the accessibility of transcription Mouse monoclonal to HDAC4 factors to ... This process is transcriptionally regulated and involves the induction of lineage-specific transcription factors MCHr1 ...
... one can assume that the transcription factor STAT3 is one of the major participant factors in tran scription activation. It is ... BRG1 is the ß-catenin co-factor in the processes of the regulation of transcription of the genes associated with the Wnt- ... As a result, the interaction between pRB and the E2F transcription factor is disrupted. E2F is activated, triggering the ... The proteins TRF1, TRF2 (te-lomeric repeat binding factor 1 and 2) and POT1 (protection of telomeres protein 1) are bound to ...
NGS and PCR array data submitted to the Gene Ontology project also predicted the role of transcription factors modulated by put ... STAT3). In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was ... In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression ... In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression ...
A mutation in the transcription factor STAT3 has been associated with the most common form of this disease. Cellectis has ... may change as a result of various factors, including factors currently unknown to us. Furthermore, many other important factors ... developed a strategy applicable in HSCs and T-cells, to insert a corrected version of the STAT3 gene into the patients genome ...
... and apoptosis-related factor production as well as immune cell activation and infiltration. Reduced inflammation may have led ... Activation of nuclear factor-κB (NF-κB) signaling pathway has been shown to be associated with inflammatory response induced by ... its expression is also associated with transcription factors STAT-3 [9, 14], NF-κB [4], and JNK [15]. While it has been shown ... Inflammation in the spotlight-clinical relevance of genetic variants affecting nuclear factor kappaB and tumor necrosis factor ...
... which is the key factor during wound healing. In this study, we aim to test whether the supernatant of MSCs pretreated with IT ... secretion of growth factors, phagocytosis, cell proliferation, and collagen deposition in wound, ... STAT3 and STAT6 are key transcription factors that induce polarization of macrophages toward the M2 phenotype. Moreover, IL-6 ... Activation of M2 has been shown to be associated with multiple transcription factors, among which STAT3 and STAT6 are the key ...
... various intracellular regions of HER3 were fused to the DNA binding domain of the yeast transcription factor Gal4 (Gal4DBD) and ... TADs of transcription factors often contain proline and acidic amino acid rich regions that help recruit proteins necessary for ... 2005) Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 7: 575-589. * View Article ... The specific transcription factors that associate with nuclear HER3 is under current investigation, but we speculate that HER3 ...
Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) ... Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. Cancer Discov. 2014 ... The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor beta-induced gene expression ... The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-kappaB positive feedback loop in peripheral T-cell ...
STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity. Circulation. 2013 ...
Transcription factors that are known to maintain normal stem cell pluripotency also regulate stemness properties of liver CSCs ... Thus, Twist2 regulates liver cancer stem-like cell self-renewal via the CD24-STAT3-NANOG axis (Liu et al., 2014). Pluripotency ... Transcription factors that are known to maintain normal stem cell pluripotency also regulate stemness properties of liver CSCs ... In addition to the identification of developmental pathways and transcription factors implicated in regulating stem cell ...
... a transcription factor known as STAT3 has been a major therapeutic target in the treatment of cancer. But STAT3 has largely ... A potent and selective degrader of the transcription factor STAT3 offers a new approach to a previously "undruggable" target. ... For decades, a transcription factor known as STAT3 has been a major therapeutic target in the treatment of cancer. But STAT3 ...
... ginseng suppresses inflammation by reducing the STAT3 transcription factor phosphorylation and decreasing Th17 cell counts ( ...
Finally, we found that SCARA5 could suppress STAT3, PI3K, and AKT phosphorylation. Therefore, SCARA5 was related to STAT3 and ... SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT ... Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin ... b-d) The ratio of p-STAT3/STAT3, p-AKT/AKT and p-PI3K/PI3K. (e). Western blot analysis of the expression of p-STAT3, STAT3, p- ...
... activation of the inflammatory transcription factor NF-κB. Metformin strongly delays cellular transformation in a manner ... Metformin preferentially inhibits nuclear translocation of NF-κB and phosphorylation of STAT3 in cancer stem cells compared ...
... which is clearly inhibited by either expression of a dominant-negative form of a transcription factor, signal transducer and ... signal transducer and activator of transcription 3 (STAT3) or by a nucleotide-substitution in the STAT3-binding element within ... signal transducer and activator of transcription 3 (STAT3) or by a nucleotide-substitution in the STAT3-binding element within ... signal transducer and activator of transcription 3 (STAT3) or by a nucleotide-substitution in the STAT3-binding element within ...
... transcription factor). And it does so in a way which bypasses the multifactorial activation of STAT3, directly and ... WP1066 is designed to defeat cancer by modulating cancer progression transcription factors (WP1066), while WP1122 has been ... Not only is this factor the leading cause of having to limit the dose, tumor cells also have a tendency (via the phenomena ... due to factors such as a growing geriatric population and increasing rates of obesity, smoking, and excessive alcohol ...
Vascular endothelial growth factor:2,,transcription factors:2,,transcriptional regulation:2,,Mitosis:2,,hypoxia:2,,MAPK:2,, ... STAT3:2,,CIP2A:2,,histidine biosynthesis genes:2,,homeobox gene:2,,Saccharomyces cerevisiae:2,,Mitochondria:2,,Peritoneal ... microphthalmiaassociated transcription factor (MITF):1,,migration:1,,mitochondria:1,,mitochondrial mediated apoptosis:1,, ... apoptosisinducing factor:2,,DNase I sensitivity:2,,methionine:2,,PP2A:2,,MicroRNA:2,,heat shock:2,,DNA topoisomerase:1,,DNA ...
Moreover, Cdc42 is essential for G1-S progression and mitosis, and it also regulates transcription factors SRF, STAT3, and NFkB ... Meanwhile, Cdc42 promotes the expression of β1 integrin by activating a transcription factor called SRF. Persistent active ... forms of transcription factors can also insert endothelium into cancer cells lacking Cdc42. Nonetheless, the therapy targeting ...
This transcription factor recruits the androgen receptor to lineage-specific genomic loci to turn on prostate gene expression, ... 4 Other biological markers are associated with neuroendocrine differentiation such as IL-8 and IL-6 in association with STAT3.5 ... The FOXA1 transcription factor is a necessary molecule for the development and differentiation of epithelial cells in the ...
Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription Factors ... "STAT3 Protein ... "Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway ... aquaporin 0 expression in rat lens epithelia explants requires fibroblast growth factor-induced ERK and JNK signaling.." J Biol ... polarized vascular endothelial growth factor secretion, and gene expression pat." Stem Cells 29(5).May (2011): 825-35. ...
STAT3: sign transducer and activator of transcription 3; VEGF: vascular endothelial development factor. Open up in another ... Moreover, the activation of RTKs may result in the stimulation of nuclear factor-kappaB (NF-B) that in turn can induce the ... vascular endothelial growth factor. Sofalcone Open in another window Fig. 4 Proposed style of potential transforming events ... hypoxia-inducible factors; IAP: inhibitor of apoptosis protein; IL-6: interleukin-6; MAPK: mitogen-activated protein kinase; ...
Previous studies have frequently reported that over-activation of STAT3, as a transcription factor involved in various ... A synergistic interaction between transcription factors nuclear factor-kappaB and signal transducers and activators of ... STAT3) signaling pathway in cancer, and the IL-6/STAT3 pathway is considered as the most promising new target for cancer ... protein expression of STAT3 and p-STAT3 was measured by western blotting (D) ...
STAT3, signal transducer and activator of transcription 3; TGF-β, transforming growth factor-beta; TNF, tumor necrosis factor. ... IL-6/STAT3 signaling mediated Forkhead box M1 activation. Promotes hepatocyte proliferation [8]. ... Epinephrine (EPI) and norepinephrine (NE) induce the production of collagen-1α2 (COL1A2), transforming growth factor-beta (TGF- ... inhibits expression of tumor necrosis factor (TNF) and IL-6 through activation of Src kinase by acting on the α7AChR of KCs, ...
Prediction and experimental validation of a putative non-consensus binding site for transcription factor STAT3 in serum amyloid ... Predicting conformational ensembles and genome-wide transcription factor binding sites from DNA sequences. Scientific Reports, ... Molecular Basis for SUMOylation-dependent Regulation of DNA Binding Activity of Heat Shock Factor 2. Journal of Biological ... Distinct transcriptional regulatory modules underlie STAT3s cell type-independent and cell type-specific functions. Nucleic ...
Although IL 6 can activate multiple transcription factors, in CNS cells activation of the IL 6 recep tor upregulates STAT3 ... a basic helix loop helix transcription factor, and Rosea1, a R2R3 MYB type transcription factor, showed that F35H expres sion ... Experiments with expression of the Inhibitors,Modulators,Libraries snapdragon tran scription factor genes Delila, ... Introduction of these transcription factors under control of the fruit specific E8 promoter increased the expression of most of ...
... belong to a large group of zinc finger-containing transcription factors with amino acid sequences resembling the Drosophila gap ... Currently, 17 murine and human KLFs are known to play crucial roles in the regulation of transcription, cell proliferation, ... mediated by transcription factor KLF4 and DNA methylation ameliorates osteoarthritis progression via inactivation of JAK2/STAT3 ... Crucial transcription factors, including SRY-box transcription factor 9 (SOX9), runt-related transcription factor 2 (RUNX2), ...
38] proposed that IL-6 promotes T cell proliferation due to low-level expression of the ROR-γt transcription factor under ... Jones et al [37]. reported that IL-6-mediates Th17 subset maturation and attributed it to the role of STAT3 also Li et al. [ ... NF-κB, nuclear factor kappa light chain enhancer of activated B cells; TNF-α, tumor necrosis factor-α; PPAR-γ, peroxisome ... NF-κB, nuclear factor kappa light chain enhancer of activated B cells; TNF-α, tumor necrosis factor-α; PPAR-γ, peroxisome ...
STAT3 Transcription Factor. *Oligodeoxyribonucleotides. *DNA, Bacterial. *Toll-Like Receptor 9. *Lung. *CpG Islands ...