STAT1 Transcription Factor / genetics * STAT1 Transcription Factor / metabolism * STAT3 Transcription Factor / genetics ... Y510 efficiently mediated IL-21-induced phosphorylation of Stat1 and Stat3, but not of Stat5, and CD8(+) T cells from Stat1/ ...
STAT1 Transcription Factor / metabolism Substances * Galactosylceramides * Inflammation Mediators * STAT1 Transcription Factor ...
... proteins are latent cytoplasmic transcription factors that become activated by tyrosine phosphorylation in response to cytokine ... STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic transcription factors that become ... PIAS1, but not other PIAS proteins, blocked the DNA binding activity of Stat1 and inhibited Stat1-mediated gene activation in ... The in vivo PIAS1-Stat1 interaction requires phosphorylation of Stat1 on Tyr-701. These results identify PIAS1 as a specific ...
... on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation was examined using RAW 264.7 macrophage- ... and signal transducer and activator of transcription (STAT1) expression. Moreover, PQQ reduced the expression level of c-Fos ... PQQ inhibited the activation of nuclear factor of activated T cells (NFATc1), a key transcription factor of osteoclastogenesis ... The effect of pyrroloquinoline quinine (PQQ) on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast ...
... were identified in the last decade as transcription factors which were critical in mediating virtually all cytokine driven ... Stat1 plays an important role in growth arrest, in promoting apoptosis and is implicated as a tumor suppressor; while Stats 3 ... The STAT proteins (Signal Transducers and Activators of Transcription), were identified in the last decade as transcription ... enter the nucleus and working coordinately with other transcriptional co-activators or transcription factors lead to increased ...
STAT Transcription Factors * Janus Kinases * Protein Kinase C-delta * Extracellular Signal-Regulated MAP Kinases ... The reverse-phase protein arrays (RPPA) technique was employed to identify STAT3, STAT1, JAK1, JAK2, PKCδ and ERK1/2 ... In conclusion, T lymphocyte signal transduction pathway mapping revealed an enhanced activation of JAK1/STAT3/STAT1 and PKCδ ... STAT1 and PKCδ phosphoproteins were found in SF T cells of PsA patients, compared with PB of HC. The expansion of T CD4(+)IL- ...