Phase I Safety and Tolerability Study of Staphylococcal Protein A in Adult Patients With Chronic ITP - Full Text View -...Phase I Safety and Tolerability Study of Staphylococcal Protein A in Adult Patients With Chronic ITP - Full Text View -...

Phase I Safety and Tolerability Study of Staphylococcal Protein A in Adult Patients With Chronic ITP. The safety and scientific ... Drug: PRTX-100 (Staphylococcal protein A) 4 weekly IV (in the vein) doses of 1 of the 3 following PRTX-100 dose levels:. * ... The primary purpose of this study is to evaluate the safety of multiple doses of Staphylococcal protein A (PRTX-100) in adult ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00571467

Actions - H.R.5549 - 112th Congress (2011-2012): To suspend temporarily the duty on recombinant staphylococcal protein A (56kDa...Actions - H.R.5549 - 112th Congress (2011-2012): To suspend temporarily the duty on recombinant staphylococcal protein A (56kDa...

To suspend temporarily the duty on recombinant staphylococcal protein A (56kDa). ... H.R.5549 - To suspend temporarily the duty on recombinant staphylococcal protein A (56kDa).112th Congress (2011-2012). Bill. ...
more infohttps://www.congress.gov/bill/112th-congress/house-bill/5549/all-actions?overview=closed

Engineering of Fc(1) and Fc(3) from human immunoglobulin G to analyse subclass specificity for staphylococcal protein A.Engineering of Fc(1) and Fc(3) from human immunoglobulin G to analyse subclass specificity for staphylococcal protein A.

The interactions to Staphylococcal protein A (SpA), a bacterial Fc receptor, that interacts with human IgG-Fc(1), but not with ... Engineering of Fc(1) and Fc(3) from human immunoglobulin G to analyse subclass specificity for staphylococcal protein A.. ... Production levels in E. coli of 1-10 mg/l of secreted Fc proteins, covalently linked as dimers, were routinely obtained. SpA- ...
more infohttp://kth.diva-portal.org/smash/record.jsf?pid=diva2:499017

Tandem repeat sequence analysis of staphylococcal protein A (spa) gene in methicillin-resistant Staphylococcus pseudintermedius...Tandem repeat sequence analysis of staphylococcal protein A (spa) gene in methicillin-resistant Staphylococcus pseudintermedius...

A putative staphylococcal protein A (spa) gene was discovered in the genome of Staphylococcus pseudintermedius and used for ... Tandem repeat sequence analysis of staphylococcal protein A (spa) gene in methicillin-resistant Staphylococcus pseudintermedius ... Tandem repeat sequence analysis of staphylococcal protein A (spa) gene in methicillin-resistant Staphylococcus pseudintermedius ... Tandem repeat sequence analysis of staphylococcal protein A (spa) gene in methicillin-resistant Staphylococcus pseudintermedius ...
more infohttps://espace.library.uq.edu.au/view/UQ:327598

A Phase 1, Randomized, Double-Blind, Placebo-Controlled Multiple-Dose Study of Intravenous Staphylococcal Protein A in Patients...A Phase 1, Randomized, Double-Blind, Placebo-Controlled Multiple-Dose Study of Intravenous Staphylococcal Protein A in Patients...

This phase Ib trial investigated multiple escalating doses of staphylococcal protein A [PRTX 100] + methotrexate in patients ... A Phase 1, Randomized, Double-Blind, Placebo-Controlled Multiple-Dose Study of Intravenous Staphylococcal Protein A in Patients ... A Phase 1, Randomized, Double-Blind, Placebo-Controlled Multiple-Dose Study of Intravenous Staphylococcal Protein A in Patients ...
more infohttp://adisinsight.springer.com/trials/700048713

Environmental Health Perspectives   -  The Prevalence of Antibiotic-Resistant Staphylococcus aureus Nasal Carriage among...Environmental Health Perspectives - The Prevalence of Antibiotic-Resistant Staphylococcus aureus Nasal Carriage among...

Staphylococcal protein A (spa) typing was performed by amplifying the spa gene as described above. PCR products were sequenced ... Staphylococcal manipulation of host immune responses. Nat Rev Microbiol 13(9):529-543. ...
more infohttps://ehp.niehs.nih.gov/ehp35/

Potential Associations between Hematogenous Complications and Bacterial Genotype in Staphylococcus aureus InfectionPotential Associations between Hematogenous Complications and Bacterial Genotype in Staphylococcus aureus Infection

For MRSA isolates, the staphylococcal chromosomal cassette mec (SCCmec) element was also typed. Three clinical categories were ... Role of Platelet Microbicidal Protein Killing and agr Genotypes. Moise, Pamela A.; Forrest, Alan; Bayer, Arnold S.; Xiong, Yan ... Vancomycin susceptibility, the accessory gene global regulator (agr) genotype and function, staphylococcal cassette chromosome ... SCC) mec type, and susceptibility to cationic thrombin-induced platelet microbicidal protein 1 (tPMP-1) have been individually ...
more infohttp://connection.ebscohost.com/c/articles/26240117/potential-associations-between-hematogenous-complications-bacterial-genotype-staphylococcus-aureus-infection

Methicillin Resistant Staphylococcus AureusMethicillin Resistant Staphylococcus Aureus

The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS. ... Staphylococcal Pneumonia Staphylococcus aureus Osteomyelitis Management Skin Infection Linezolid Necrotizing Soft Tissue ... Staphylococcal Scalded Skin Syndrome Penicillin Allergy Health Care Associated Infection ...
more infohttp://www.fpnotebook.com/ID/Emerging/MthclnRstntStphylccsArs.htm

Protein A Antigen | Staphylococcal Protein A | ProSpecProtein A Antigen | Staphylococcal Protein A | ProSpec

Recombinant Staphylococcal Protein A produced in E.Coli is a non-glycosylated, Polypeptide chain containing 434 amino acids (37 ... Immunoglobulin G-binding protein A, IgG-binding protein A, Staphylococcal protein A, SPA. ... Recombinant Staphylococcal Protein A produced in E.Coli is a non-glycosylated, Polypeptide chain containing 434 amino acids (37 ... The recombinant protein A is produced by expressing a modified protein A gene in E.coli. A specific purification process with ...
more infohttps://www.prospecbio.com/protein_a_434aa

RCSB PDB 









- 1Q2N: REFINED Solution NMR structure of the Z domain of STAPHYLOCOCCAL PROTEIN A Literature Report PageRCSB PDB - 1Q2N: REFINED Solution NMR structure of the Z domain of STAPHYLOCOCCAL PROTEIN A Literature Report Page

Validation of helical tilt angles in the solution NMR structure of the Z domain of Staphylococcal protein A by combined ... REFINED Solution NMR structure of the Z domain of STAPHYLOCOCCAL PROTEIN A. *DOI: 10.2210/pdb1q2n/pdb ... IMMUNOGLOBULIN G BINDING PROTEIN A A 58 Staphylococcus aureus Fragment: residues 212-269 Mutation: A1V, G29A Gene Name(s): spa ...
more infohttp://www.rcsb.org/pdb/explore/litView.do?structureId=1Q2N

Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant
         of functional plasticity.Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity.

Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity. ... The Staphylococcus aureus virulence factor staphylococcal protein A (SpA) is a major contributor to bacterial evasion of the ... These include monomeric λ repressor, the B domain of protein A (BdpA) and various regulator of G-protein signalling (RGS) ... Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity. Structure, ...
more infohttps://dukespace.lib.duke.edu/dspace/handle/10161/11167

Recombinant Staphylococcal Protein A Human rh-EGF Cosmetic Materials CAS 62253-63-8 of item 108890765Recombinant Staphylococcal Protein A Human rh-EGF Cosmetic Materials CAS 62253-63-8 of item 108890765

Latest Recombinant Staphylococcal Protein A Human rh-EGF Cosmetic Materials CAS 62253-63-8 from Quality EGF Epidermal Growth ... Recombinant Staphylococcal Protein A Human rh-EGF Cosmetic Materials CAS 62253-63-8 Product Name: Recombinant Staphylococcal ... Recombinant Staphylococcal Protein A Human rh-EGF Cosmetic Materials CAS 62253-63-8 ... Recombinant Staphylococcal Protein A Human rh-EGF Cosmetic Materials CAS 62253-63-8 ...
more infohttp://www.spintoband.com/pz6986744-cz58a9d79-recombinant-staphylococcal-protein-a-human-rh-egf-cosmetic-materials-cas-62253-63-8.html

WO2013025834 COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN AWO2013025834 COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN A

In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA). ... EN) COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN A. (FR) COMPOSITIONS ET PROCÉDÉS LIÉS AUX ... In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).. (FR) Des ... 1. (WO2013025834) COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN A ...
more infohttps://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013025834

Human IgA and IgG F(ab)2 that bind to staphylococcal protein A belong to the VHIII subgroup. | The Journal of ImmunologyHuman IgA and IgG F(ab')2 that bind to staphylococcal protein A belong to the VHIII subgroup. | The Journal of Immunology

Staphylococcal protein A (SPA) is a bacterial membrane protein that possesses, in addition to its Fc gamma-binding activity, a ... Human IgA and IgG F(ab)2 that bind to staphylococcal protein A belong to the VHIII subgroup.. E H Sasso, G J Silverman and M ... Human IgA and IgG F(ab)2 that bind to staphylococcal protein A belong to the VHIII subgroup. ... Human IgA and IgG F(ab)2 that bind to staphylococcal protein A belong to the VHIII subgroup. ...
more infohttps://www.jimmunol.org/content/147/6/1877?ijkey=28a459acd4588dd08f26378f6ba19839ca48cf9a&keytype2=tf_ipsecsha

Frontiers | Essential Domain-Dependent Roles Within Soluble IgG for in vivo Superantigen Properties of Staphylococcal Protein A...Frontiers | Essential Domain-Dependent Roles Within Soluble IgG for in vivo Superantigen Properties of Staphylococcal Protein A...

Recent reports have highlighted the contributions of staphylococcal protein A (SpA). This small oligomeric secreted protein ... This small oligomeric secreted protein contains 4-5 homologous domains with two distinct immunoglobulin-binding sites; one for ... Recent reports have highlighted the contributions of staphylococcal protein A (SpA). ... Recent reports have highlighted the contributions of staphylococcal protein A (SpA). This small oligomeric secreted protein ...
more infohttps://www.frontiersin.org/articles/10.3389/fimmu.2018.02011/full

Preparation and characterization of Staphylococcal protein A adsorbent by Samuel C. Crowley"Preparation and characterization of Staphylococcal protein A adsorbent" by Samuel C. Crowley

The retained proteins were then eluted by a step change to pH 3. The retention characteristics of the Protein A column were ... The suitability of the PD model for the study of protein-protein interactions as well as high affinity biocomplexes (K[ ... Coupling yields for small amines and for several proteins were found to be relatively insensitive to buffer and pH over the ... Columns were prepared by immobilizing Protein A from Staphylococcus aureus on 10 m diol-bonded silica. Immunoglobulin (Ig)- ...
more infohttps://lib.dr.iastate.edu/rtd/9333/

Staphylococcal protein A - Protalex - AdisInsightStaphylococcal protein A - Protalex - AdisInsight

PRTX 100 is a highly purified form of staphylococcal protein A (Spa) that is in development with Protalex for the treatment of ... Staphylococcal protein A - Protalex Alternative Names: PRTX-001; PRTX-100 Latest Information Update: 19 Jul 2019 ... Class Antirheumatics; Bacterial proteins; Immunotherapies * Mechanism of Action B cell inhibitors; Immunomodulators; Macrophage ...
more infohttps://adisinsight.springer.com/drugs/800016619?error=cookies_not_supported&code=f3095105-0733-4c92-a555-ecaf2fcabe4c

Allosteric inhibition of complement function by a staphylococcal immune evasion protein.  - PubMed - NCBIAllosteric inhibition of complement function by a staphylococcal immune evasion protein. - PubMed - NCBI

Allosteric inhibition of complement function by a staphylococcal immune evasion protein.. Chen H1, Ricklin D, Hammel M, Garcia ... Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A. 2010 Oct 12; ... Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A. 2010 Oct 12; ... Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A. 2010 Oct 12; ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/20876141

A SENSITIVE ENZYME-LINKED-IMMUNOSORBENT-ASSAY (ELISA) FOR THE DETECTION OF STAPHYLOCOCCAL PROTEIN-A (SPA) PRESENT AS A TRACE...A SENSITIVE ENZYME-LINKED-IMMUNOSORBENT-ASSAY (ELISA) FOR THE DETECTION OF STAPHYLOCOCCAL PROTEIN-A (SPA) PRESENT AS A TRACE...

A SENSITIVE ENZYME-LINKED-IMMUNOSORBENT-ASSAY (ELISA) FOR THE DETECTION OF STAPHYLOCOCCAL PROTEIN-A (SPA) PRESENT AS A TRACE ... FOR THE DETECTION OF STAPHYLOCOCCAL PROTEIN-A (SPA) PRESENT AS A TRACE CONTAMINANT OF MURINE IMMUNOGLOBULINS PURIFIED ON ... PROTEIN-A LEAKAGE, CHROMATOGRAPHY, AFFINITY, MONOCLONAL ANTIBODY, MURINE, ANTIBODY, CHICKEN, ELISA, CHICKEN EGG-YOLK, ... IMMOBILIZED PROTEIN-A JOURNAL OF IMMUNOLOGICAL METHODS, 149 (1). pp. 21-27. ...
more infohttp://epubs.surrey.ac.uk/834187/

Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3) | PNASStructural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3) | PNAS

Among these secreted virulence factors are the staphylococcal superantigen-like proteins (SSLs), a family of 14 proteins ... 2012) Evasion of Toll-like receptor 2 activation by staphylococcal superantigen-like protein 3. J Mol Med (Berl) 90(10):1109- ... 2010) Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain. J Immunol 184(11):6283-6292. ... One of these, staphylococcal superantigen-like protein 3 (SSL3), disrupts an important component of our innate immune system: ...
more infohttps://www.pnas.org/content/112/35/11018

Staphylococcal Protein A as a Pharmacological Treatment for Autoimmune Disorders | AbstractStaphylococcal Protein A as a Pharmacological Treatment for Autoimmune Disorders | Abstract

Staphylococcal protein A (SpA) is a key virulence factor that enables Staphylococcus aureus to evade host innate and adaptive ... Staphylococcal Protein A as a Pharmacological Treatment for Autoimmune Disorders Staphylococcal protein A (SpA) is a key ...
more infohttp://autoimmunediseases.imedpub.com/abstract/staphylococcal-protein-a-as-a-pharmacological-treatment-for-autoimmune-disorders-19971.html

Buy Recombinant Staphylococcal Protein A 434 a.a Protein (pro-686)Buy Recombinant Staphylococcal Protein A 434 a.a Protein (pro-686)

ProteoGenix provides you the best Recombinant proteins. Shop now from our 200 000 + products. ... Buy online Recombinant Staphylococcal Protein A 434 a.a Protein from Prospec cat# pro-686. ... More info about Recombinant Staphylococcal Protein A 434 a.a Protein. Catalog#: pro-686. ... Data sheet of Recombinant Staphylococcal Protein A 434 a.a Protein. Brand. Prospec. ...
more infohttps://www.proteogenix-products.com/4429-spa-434aa.html

Isolation and characterisation of a 17-kDa staphylococcal heparin-binding protein with broad specificityIsolation and characterisation of a 17-kDa staphylococcal heparin-binding protein with broad specificity

... Fallgren, Corina; Utt ... Isolation and characterisation of a 17-kDa staphylococcal heparin-binding protein with broad specificity}, volume = {50}, year ... The staphylococcal heparin-binding component(s) were purified by affinity chromatography on heparin-Sepharose and a major ... heparin-binding protein, here designated HBP, was identified by immunoblot in these two coagulase-negative staphylococcal (CNS ...
more infohttps://lup.lub.lu.se/search/publication/132604

Snd1 - Staphylococcal nuclease domain-containing protein 1 - Mus musculus (Mouse) - Snd1 gene & proteinSnd1 - Staphylococcal nuclease domain-containing protein 1 - Mus musculus (Mouse) - Snd1 gene & protein

Staphylococcal nuclease domain-containing protein 1Add BLAST. 909. Amino acid modifications. Feature key. Position(s). ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q78PY7. A0A0P6CJ96. A0A0P6CY62. Daphnia magna. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q78PY7. Q7KZF4. A0A140VK49. B2R5U1. A0A2K5J3W6. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q78PY7. Q7KZF4. A0A140VK49. B2R5U1. A0A2K5J3W6. ...
more infohttp://www.uniprot.org/uniprot/Q78PY7

The influence of pH on the binding of immunoglobulin G to staphylococcal protein AThe influence of pH on the binding of immunoglobulin G to staphylococcal protein A

... ... The interaction between protein A and immunoglobulin G (IgG) was studied at a variety of pH values using a surface plasmon ... This study was carried out due to the large scale use of Protein A affinity chromatography for the purification of IgG for ... A multiple site model seems intuitively correct given the six different binding sites that Protein A has for interaction with ...
more infohttps://ir.canterbury.ac.nz/handle/10092/7952