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*  HKU Scholars Hub: EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third...
The MLL gene, the closest human homologue to the Drosophila trithorax gene, undergoes chromosomal translocation with a large number of different partner genes in both acute lymphoid and acute myeloid leukemias. We have identified a new partner gene, EEN, fused to MLL in a case of acute myeloid leukemia. The gene is located on chromosome 19p13, where two other MLL partner genes, ENL and ELL/MEN have also been identified. The deduced protein of 368 aa contains a central α-helical region and a C-terminal Src homology 3 (SH3) domain most similar to the C-terminal SH3 domain found in the Grb2/Sem-5/Drk family of genes. Sequence analysis of the fusion MLL/EEN transcript in our patient reveals that exon 6 of MLL is fused to the N- terminal end of EEN, a fusion that would create a chimeric protein that includes the major functional domain of EEN. EEN is expressed in a variety of tissue types and encodes a protein of approximately 46 kDa. The EEN protein is the human homologue of a ...
http://hub.hku.hk/handle/10722/48975
*  SH2B3 - Wikipedia
SH2B adapter protein 3 (SH2B3), also known as lymphocyte adapter protein (LNK), is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. SH2B adapter protein 3 is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. It is ubiquitously expressed in many tissues and cell types. LNK functions as a regulator in signaling pathways relating to hematopoiesis, inflammation, and cell migration. As a result, it is involved in blood diseases, autoimmune disorders, and vascular disease. The SH2B3 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. The SH2B3 gene resides on chromosome 12 at the band 12q24 and contains 12 exons. This protein belongs to the Src homology 2-B (SH2B) adapter family. LNK contains 3 functional domains: a C-terminal Src homology 2 (SH2) domain, a pleckstrin homology (PH) domain, and a dimerization domain. The SH2 ...
https://en.wikipedia.org/wiki/SH2B3
*  PLOS ONE: Versatile Membrane Deformation Potential of Activated Pacsin
Endocytosis is a fundamental process in signaling and membrane trafficking. The formation of vesicles at the plasma membrane is mediated by the G protein dynamin that catalyzes the final fission step, the actin cytoskeleton, and proteins that sense or induce membrane curvature. One such protein, the F-BAR domain-containing protein pacsin, contributes to this process and has been shown to induce a spectrum of membrane morphologies, including tubules and tube constrictions in vitro. Full-length pacsin isoform 1 (pacsin-1) has reduced activity compared to its isolated F-BAR domain, implicating an inhibitory role for its C-terminal Src homology 3 (SH3) domain. Here we show that the autoinhibitory, intramolecular interactions in pacsin-1 can be released upon binding to the entire proline-rich domain (PRD) of dynamin-1, resulting in potent membrane deformation activity that is distinct from the isolated F-BAR domain. Most strikingly, we observe the generation of small, homogenous ...
http://journals.plos.org/plosone/article/email?id=10.1371/journal.pone.0051628
*  The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcγRIIb1...
The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcγRIIb1-mediated inhibition of B cell receptor signaling Academic Article ...
http://vivo.med.cornell.edu/display/pubid0033548446
*  AID 242624 - Inhibition of fluorescent (GpYEEI) binding to Src protein tyrosine kinase SH2 domain - PubChem
BioAssay record AID 242624 submitted by ChEMBL: Inhibition of fluorescent (GpYEEI) binding to Src protein tyrosine kinase SH2 domain.
https://pubchem.ncbi.nlm.nih.gov/bioassay/242624
*  "Fast rebinding increases dwell time of Src homology 2 (SH2)-containing" by Dongmyung Oh, Mari Ogiue-Ikeda et al.
Receptor tyrosine kinases (RTKs) control a host of biological functions by phosphorylating tyrosine residues of intracellular proteins upon extracellular ligand binding. The phosphotyrosines (p-Tyr) then recruit a subset of ∼100 Src homology 2 (SH2) domain-containing proteins to the cell membrane. The in vivo kinetics of this process are not well understood. Here we use total internal reflection (TIR) microscopy and single-molecule imaging to monitor interactions between SH2 modules and p-Tyr sites near the cell membrane. We found that the dwell time of SH2 modules within the TIR illumination field is significantly longer than predictions based on chemical dissociation rate constants, suggesting that SH2 modules quickly rebind to nearby p-Tyr sites after dissociation. We also found that, consistent with the rebinding model, the effective diffusion constant is negatively correlated with the respective dwell time for different SH2 domains and the dwell time is ...
http://opencommons.uconn.edu/uchcres_articles/124/
*  A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is...
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain Academic Article ...
http://vivo.med.cornell.edu/display/pubid0029961705
*  Human SH3PX1 peptide (ab23266) | Abcam
Buy our Human SH3PX1 peptide. Ab23266 is a blocking peptide for ab15709 and has been validated in BL. Abcam provides free protocols, tips and expert support…
http://www.abcam.com/human-sh3px1-peptide-ab23266.html
*  Recombinant Human SH3GL2 protein (ab116742) | Abcam
Buy our Recombinant Human SH3GL2 protein. Ab116742 is a protein fragment produced in Wheat germ and has been validated in WB, ELISA, SDS-PAGE. Abcam provides…
http://www.abcam.com/recombinant-human-sh3gl2-protein-ab116742.html
*  Recombinant Human SH3BGRL protein (ab114874) References
References for Abcam's Recombinant Human SH3BGRL protein (ab114874). Please let us know if you have used this product in your publication
http://www.abcam.com/recombinant-human-sh3bgrl-protein-ab114874-references.html
*  SHC1 (SHC (Src homology 2 domain containing) transforming protein 1)
... , Authors: Lucilla Luzi, Enrica Migliaccio, Pier Giuseppe Pelicci. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/SHC1ID42287ch1q21.html
*  Plus it
In light of the Scansite prediction and these data, we tested the potential of these proteins to interact with an inactive mutant of caspase-8-to prevent apoptosis induction-in transfected cells. P85 strongly interacted with caspase-8 ( Fig. 2B). This interaction depended on the integrity of the Y380 site but was independent of another phosphorylation site, Y334, identified independently by proteomics ( 12). The interaction was also dependent on cotransfected, activated c-src (Y527F or Δ92-95) or c-fyn (Y531F), which were more effective than wild-type c-src or kinase-inactive c-src (K295M). The phosphorylation of caspase-8 by these src constructs correlated with the magnitude of the caspase-8-p85 interaction. Deletion of the COOH-terminal SH2 domain of p85 abolished the interaction ( Fig. 2C), implicating this SH2 domain in the caspase-8 interaction. Other candidates identified from the Panomics screen (Nck-2, c-fyn, SHP-2) interacted more ...
http://cancerres.aacrjournals.org/content/67/24/11505
*  CiNii 論文 - 関節リウマチの根治的治療を目指して-Epstein-Barr ウイルスと感染制御遺伝子(SAP)の応用の可能性
Epstein-Barrウイルス(EBV)はヘルペスウイルス群に属し,感染後潜在化し,一生を終わる.免疫抑制剤などで再活性化し,生体に重篤な状態を起こす.EBV関連疾患群である難病の病態に再活性化を起こし関与している可能性がある.関節リウマチ(RA)滑膜炎でのEBVの関与について最初に述べ,根治的治療の可能性について考察する.新たな治療戦略のキーワードは我々が発見し,クローニングしたSAP (signaling lymphocytic-activation molecule associated protein)または,SH2D1A (Src homology 2 domain-containing protein)である.SAP (SH2D1A)はSrc homology 2 (SH2)を持つアダプター分子として免疫細胞で働き,EBVの感染防御,液性免疫に深く関与し,SLEの原因遺伝子としても注目されている.SAP遺伝子の異常はEBVの致死的な感染を起こすX-linked lymphoproliferative (XLP) syndrome (Duncan ...
https://ci.nii.ac.jp/naid/10021242594
*  DSpace@MIT: Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions
We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells ...
https://dspace.mit.edu/handle/1721.1/86182
*  SHC SH2 domain-binding protein 1
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells ...
https://pharos.nih.gov/idg/targets/Q8NEM2
*  Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemsoctrans.org/content/25/2/374
*  SH2D2A purified MaxPab mouse polyclonal antibody (B01P) - (H00009047-B01P) - Products - Abnova
Mouse polyclonal antibody raised against a full-length human SH2D2A protein. SH2D2A (AAH12107, 1 a.a. ~ 389 a.a) full-length human protein. (H00009047-B01P) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00009047-B01P
*  SH2D3A purified MaxPab mouse polyclonal antibody (B01P) - (H00010045-B01P) - Products - Abnova
Mouse polyclonal antibody raised against a full-length human SH2D3A protein. SH2D3A (AAH06281, 1 a.a. ~ 576 a.a) full-length human protein. (H00010045-B01P) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00010045-B01P
*  Produktübersicht anti-LIM Domain Binding 1 Protein Antikörper
Monoklonale und polyklonale LIM Domain Binding 1 Protein Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für LIM Domain Binding 1 Protein Antikörper. Hier bestellen.
http://www.antikoerper-online.de/stem-cell-maintenance-pathway-61/lim-domain-binding-1-protein-antibody-26409/
*  SH3BGRL Gene - GeneCards | SH3L1 Protein | SH3L1 Antibody
Complete information for SH3BGRL gene (Protein Coding), SH3 Domain Binding Glutamate Rich Protein Like, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=SH3BGRL
*  PH and SEC7 domain-containing protein 3
MEGRSAAAETFVWVNNASAHSQSVAKAKYEFLFGRSEGKAPDTSDHGGSTLLPPNVTNEFPEYGTMEEGG 1 - 70 EGLRASLEFDGEALPCHPQEQQGVQPLTGCHSGLDSVTEGPKDVREAPSQSHLKEQSLQPIDSLISALKA 71 - 140 TEARIISGTLQATKVLDQDAVSSFSVQQVEKELDTASRKTQRVNKTLPAGQKNLPEIPLSAEVTTEESFY 141 - 210 LSIQKDLTALLTGDTQAEISQIMNNGRKGAVCVQEPSCPLASLGSSAVTCHSAGSVGFLKEQRSALGREH 211 - 280 PGGCDRSSSMGRPGRVKHVEFQGVEILWTGGDKRETQHPIDFETSLQRTASPDSKESSKVPRHLISSAGL 281 - 350 CNSSSLTENVWDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQENKQHLEKTPKPERDRERISEQEEH 351 - 420 VKGEDEDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGG 421 - 490 QFLERTSGGGHQDILSVSADGGIVMGYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEM 491 - 560 GSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGM 561 - 630 TLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHVNIGKK 631 - 700 MTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGS 701 - 770 TTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEE 771 - 840 ...
https://pharos.nih.gov/idg/targets/Q9NYI0
*  GRAM domain-containing protein 1B
MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSG 1 - 70 RSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYS 71 - 140 NIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLC 141 - 210 PKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKK 211 - 280 SITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPT 281 - 350 ELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEE 351 - 420 NGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVA 421 - 490 RNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTT 491 - 560 VRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCV 561 - 630 ICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREII 631 - 700 KSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH 701 - 738 ...
https://pharos.nih.gov/idg/targets/Q3KR37
*  SRC3抗体|Abcam中国|Anti-SRC3抗体(ab10313)
SRC3兔多克隆抗体(ab10313)可与人样本反应并经WB, IP实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
http://www.abcam.cn/src3-antibody-ab10313.html
*  重组人Src蛋白(ab51424)|Abcam中国
购买我们的重组人Src蛋白。Ab51424为有活性的全长蛋白,在大肠杆菌中生产并经过Functional Studies, SDS-PAGE实验验证。中国80%以上现货。
http://www.abcam.cn/recombinant-human-src-protein-ab51424.html
*  Vitamina B1
... ,roli i vitamines B1,vitaminat b1,vitamina,vitaminat,rendesia e vitamines B1,vitamina b1 shqip,vitaminat shqip,vitamina shqip Shëndetësi, Vitaminat, Vitamina B1, Tiamina, Karboksilaza, Kokarboksilaza, Oksidimi, Acidi piruvik, Dekarboksilimi, Karbohidratet, Acidi laktik,
http://rapitful.blogspot.com/2012/02/vitainina-b1-ose-tiamina.html