GPCRs Signaling Directly Through Src-Family Kinases | Science Signaling
GPCRs Signaling Directly Through Src-Family Kinases Message Subject. (Your Name) has forwarded a page to you from Science ... Here, we discuss the evidence for direct interaction and activation of Src-family kinases by GPCRs and data that suggest that ... Several GPCRs directly interact with Src-family kinases. ... GPCRs Signaling Directly Through Src-Family Kinases. *Deirdre ... AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have ...http://stke.sciencemag.org/content/2007/392/pe35
Src Family Kinase Activity Is Required for Kit-mediated Mitogen-activated Protein (MAP) Kinase Activation, However Loss of...
Src Family Kinase Activity Is Required for Kit-mediated Mitogen-activated Protein (MAP) Kinase Activation, However Loss of ... which confirmed that Src family kinase activity is required for SCF-induced MAP kinase activation. The growth of cells that ... Our studies cannot distinguish between a requirement for Src kinase activation versus basal Src kinase activity, because it is ... Thus, it is apparent that PP1 cannot be used as a probe for Src family kinase function when class-III RTK function may also be ...http://cgd.aacrjournals.org/cgi/content/full/11/6/305
The Src family kinase c-Yes is required for maturation of West...
The Src family kinase c-Yes is required for maturation of West Nile virus particles.: The role of cellular genes in West Nile ... The Src family kinase c-Yes is required for maturation of West Nile virus particles.. Authors * Hirsch, Alec J ... of cellular transcripts upregulated during WNV infection revealed an increase in the expression of the src family kinase (SFK) ... RNA interference mediated knock-down of c-Yes, but not c-Src, and similarly reduced virus yield, specifically implicating c-Yes ...https://www.mysciencework.com/publication/show/src-family-kinase-c-yes-required-maturation-west-nile-virus-particles-5e828617
Identification of Tyrosine Residues on ELMO1 That Are Phosphorylated by the Src-Family Kinase Hck †
Identification of Tyrosine Residues on ELMO1 That Are Phosphorylated by the Src-Family Kinase Hck † ...https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi0500832
Targeting to C-Terminal Myosin Heavy Chain May Explain Mechanotransduction Involving Focal Adhesion Kinase in Cardiac Myocytes ...
Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases ... Phosphorylated Tyr397 recruits Src family kinases, which lead to phosphorylation of additional Fak tyrosine residues, which ... for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases ... Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src ...http://circres.ahajournals.org/content/96/1/73
Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1. - The Kennedy Institute of Rheumatology
Src family kinases (SFKs) are the largest nonreceptor tyrosine kinase family with nine members: Src, Hck, Lyn, Fyn, Fgr, Blk, ... Hck kinase mediates TLR4-induced transcription of both TNF and IL-6 by a mechanism that involves neither the NF-κB nor the MAPK ... As well as activating the NF-κB and MAPK pathways, TLR engagement leads to tyrosine kinase activation within minutes. ... the importance of Hck as an active component in LPS-induced TLR signaling and suggest the possibility of targeting this kinase ...https://www.kennedy.ox.ac.uk/publications/223546
pp60(c-src) and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions :: MPG.PuRe
... src-Family Kinases/antagonists & inhibitors/*metabolism; Titel: pp60(c-src) and related tyrosine kinases: a role in the ... Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions/drug effects/enzymology/metabolism; Gene ... Protein-Tyrosine Kinases/antagonists & inhibitors/metabolism; Proto-Oncogene Proteins/antagonists & inhibitors/metabolism; ... Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src)/antagonists &; inhibitors/ ...http://pubman.mpdl.mpg.de/pubman/faces/viewItemOverviewPage.jsp?itemId=escidoc:1813939
КИНАЗЫ (kinases): Topics by WorldWideScience.org
G proteins and Src-family protein tyrosine kinases in T lymphocytes:Regulation during differentation a.cell activation ... G proteins and Src-family protein tyrosine kinases in T cells:Regulation during differentiation and cell activation ... R/1966/144/1993 Pessa-Morikawa, T. G proteins and Src-family protein tyrosine kinases in T cells:Regulation during ... G proteins and Src-family protein tyrosine kinases in T lymphocytes:Regulation during differentation a.cell activation, Перейти ...https://worldwidescience.org/topicpages/multi/RU/k/kinases.html
News - Citation Spotlight: RhoA Activity Regulated by Src-Mediated Phosphorylation of ARHGAP42
... among other Rho family GTPases, on tyrosine residue 376 which results in activation of ARHGAP42 which in turn de-activates GTP- ... The non-receptor tyrosine kinase Src phosphorylates the newly discovered and described GTPase activating protein (GAP) ARHGAP42 ... Here, the authors characterized the functional regulation of ARHGAP42 by the non-receptor tyrosine kinase Src and the ... and is activated by Src-mediated phosphorylation of tyrosine residue 376. Following this Src-mediated activation, ARHGAP42 de- ...https://www.cytoskeleton.com/blog/rhoa-activity-regulated-by-src-mediated-phosphorylation-of-arhgap42/
Janus kinase 1; Janus kinase 2; Janus kinase 3; JTK1; JTK9; L-JAK; LCK; LSK; LYN; MATK; Ntk; p60c-src protein tyrosine kinase; ... 1. Robinson, D.R., Wu, Y.M. and Lin, S.F. The protein tyrosine kinase family of the human genome. Oncogene 19 (2000) 5548-5557 ... Src protein-tyrosine kinase structure and regulation. Biochem. Biophys. Res. Commun. 324 (2004) 1155-1164. [PMID: 15504335]. [ ... In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [ ...http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC2/7/10/2.html
Small Molecule Tyrosine Kinase Inhibitors with BCR-ABL and C-Kit as Targets | OncoLink
Src, c-Kit and PDGFR and is more than 300 times more potent than imatinib against cells expressing wild type bcr-abl( ... Genetics & Family History * Medications, Health History and Cancer Risk * Prevention & Screening * Sexual History & Human ... Small Molecule Tyrosine Kinase Inhibitors with BCR-ABL and C-Kit as Targets. Neha Vapiwala, MD and Geoffrey Geiger, MD ... Rather than tyrosine kinase inhibition, as in CML, imatinib fights GISTs through inhibition of this pathway. Following the ...https://www.oncolink.org/cancer-treatment/therapies/targeted/small-molecule-tyrosine-kinase-inhibitors-with-bcr-abl-and-c-kit-as-targets
Src family kinase - Wikipedia
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the ... a tyrosine kinase domain, and C-terminal tail. Src family kinases interact with many cellular cytosolic, nuclear and membrane ... Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker ... Zhang S, Yu D (March 2012). "Targeting Src family kinases in anti-cancer therapies: turning promise into triumph". Trends in ...https://en.wikipedia.org/wiki/Src_family_kinase
Cellular functions regulated by Src family kinases. - PubMed - NCBI
Src family protein tyrosine kinases are activated following engagement of many different classes of cellular receptors and ... This chapter reviews the evidence implicating Src family kinases in specific receptor pathways and describes the mechanisms ... Cellular functions regulated by Src family kinases.. Thomas SM1, Brugge JS. ... While several of these kinases have evolved to play distinct roles in specific receptor pathways, there is considerable ...https://www.ncbi.nlm.nih.gov/pubmed/9442882?dopt=Abstract
New Src-Family Kinase Activator | Science Signaling
Members of the Src family show interactions between protein domains that are thought to control kinase activity. In fact, the ... Thus, Unc119 may represent a new class of regulatory protein for Src family kinases. ... Members of the Src familiy of protein kinases contribute to signals emanating from various receptors on the cell membrane, but ... Now Cen et al. have discovered a new activator of Src-like kinases, Unc119, that appears to work in a similar manner. Unc119 ...https://stke.sciencemag.org/content/2003/173/tw101
An integrative dynamic systems approach to understanding Src family kinase signalling by Hendrik Fuß (Paperback) - Lulu
Buy An integrative dynamic systems approach to understanding Src family kinase signalling by Hendrik Fuß (Paperback) online at ... A further study addressed issues relating to the interface between Src family kinases and several receptor tyrosine kinases. ... An integrative dynamic systems approach to understanding Src family kinase signalling By Hendrik Fuß ... The model serves as a coherent and quantifiable description of Src family kinase signalling events and makes novel, ...http://www.lulu.com/shop/hendrik-fu%C3%9F/an-integrative-dynamic-systems-approach-to-understanding-src-family-kinase-signalling/paperback/product-2424614.html
The role of Src family kinases in mediating M-CSF receptor signaling and monocytic cell survival
... p38MAPK and Erk1/2 kinases. Here, we found that Src family kinases were upstream of these kinases and played a central role in ... These findings indicated that Src family kinases mediate monocyte survival through the regulation of receptor phosphorylation ... Thus, we predict that targeting Src family kinases may have therapeutic implication in inflammatory diseases. ... We observed that M-CSF promoted c-Src activation in monocytes and MDMs in a time-dependent manner. Src inhibitors reduced M-CSF ...http://www.scirp.org/journal/papercitationdetails.aspx?PaperID=22548&JournalID=164
VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation | JEM
VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. Alessandro Fantin, Anastasia ... VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation ...http://jem.rupress.org/content/early/2017/03/10/jem.20160311/tab-article-info
Activation of Src-Family Kinases in Spinal Microglia Contributes to Mechanical Hypersensitivity after Nerve Injury | Journal of...
The Src family of protein tyrosine kinases includes Src, Lck, and Lyn. To investigate which Src-family kinase is activated in ... were cut in a cryostat and processed for phosphorylated-Src family (Tyr416; p-Src family), p-Src, p-Lck, p-Lyn, p-ERK1/2, p-p38 ... Src and other Src-family kinases (SFKs) are expressed widely throughout the mammalian CNS and have been implicated in ... Marked activation of Src family in the spinal dorsal horn after L5 spinal nerve injury. A, E, p-Src family immunostaining in ...http://www.jneurosci.org/content/26/34/8680
The Src family kinase c-Yes is required for maturation of West Nile virus particles. - PubMed - NCBI
The Src family kinase c-Yes is required for maturation of West Nile virus particles.. Hirsch AJ1, Medigeshi GR, Meyers HL, ... The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles ... The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles ... The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles ...https://www.ncbi.nlm.nih.gov/pubmed/16140770
Src-Family Kinases Stabilize the Neuromuscular Synapse In Vivo via Protein Interactions, Phosphorylation, and Cytoskeletal...
We examined the role of Src-family kinases (SFKs) in vivo. Electroporation of kinase-inactive Src constructs into soleus ... Such dominant-negative Src constructs interfere with many members of the Src family (e.g., Src, Fyn, and Yes), not just Src ... We first used a kinase-inactive Src expression construct, Src-AM, in this approach. Src-AM harbors two mutations, K295M and ... Thomas SM, Brugge JS (1997) Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13: 513-609. ...http://www.jneurosci.org/content/25/45/10479
A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE...
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood 110: 2511- ... Src family kinases (SFK) are critical for initiating and regulating the response of mast cells activated by engagement of the ... A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE ... A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE ...https://www.jimmunol.org/content/184/1/84
Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. | JCB
Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.. C A ... Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. ... 45:217-311.) To directly test whether these functional responses are dependent on the Src family kinases p59/61hck and p58c-fgr ... This is the first direct genetic evidence of the importance of Src family kinases in integrin signaling within leukocytes, and ...http://jcb.rupress.org/content/133/4/895
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish | JCB
extracellular signal-regulated kinase. MO. morpholino. pSFK. phosphorylated SFK. ROS. reactive oxygen species. SFK. Src family ... Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. Sa Kan ... rabbit antiphospho-Src family (Tyr416) antibody (#2101; Cell Signaling Technology) at 1:300, rabbit antiphospho-Src family ( ... Previously, we found that the Src family kinase (SFK) Lyn functions as a redox sensor in leukocytes that detects H2O2 at wounds ...http://jcb.rupress.org/content/199/2/225.long
KAKEN - Research Projects | Novel mechanisms of Src-family kinase regulation by CD45 (KAKENHI-PROJECT-14570292)
CD45 is a key tyrosine phosphatase regulating Src-family kinases (Src-PTKs) in lymphocytes ; precisely how it exerts its effect ... Publications] Shrivastava P: 'Dynamic regulation of Src-family kinases by CD45 in B cells.'Blood. 103. 1425-1432 (2004). *. ... Publications] Shrivastava P: 'Dynamic regulation of Src-family kinases by CD45 in B cells.'Blood. 103. 1425-1432 (2004). *. ... CD45 / Src-family kinases / GEM / lipid raft / tyrosine phosphatase / tyrosine phosphorylation / GEM(ラフト) / B細胞 / マスト細胞 / 基質. ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14570292/
Abstract 2377: The AML linked Src family kinase Fgr is uncoupled from SH2 and SH3 domain regulation and drives oncogenic...
Phosphorylation of the homologous tyrosines in c-Src, Hck and other Src-family members by the regulatory kinase Csk causes ... The AML linked Src family kinase Fgr is uncoupled from SH2 and SH3 domain regulation and drives oncogenic transformation [ ... Taken together, our data show that Fgr is a unique Src family member in that its kinase domain is not subject to regulatory ... Fgr is a member of the Src family of non-receptor protein-tyrosine kinases, which are over-expressed and constitutively active ...http://cancerres.aacrjournals.org/content/77/13_Supplement/2377