They are assembled to segregate chromosomes to the forming daughter cells (Movie 1). Our current understanding of spindle ... Mitotic spindles in mammalian cells Mitotic spindles are three-dimensional molecular machines. They are assembled to segregate ... This was recently achieved for the mitotic spindle in the early C. elegans embryo (Redemann et al., 2017). My intention is to ... My approach is to apply serial-section electron tomography (ET) to obtain large-scale reconstructions of mitotic spindles. For ...

Discovery Talk Questions and Answers: The Dynamic Mitotic Spindle. Please register as an Educator here. ...

During early prophase there is no antiactin staining associated with the mitotic centers, but by late prophase, as the spindle ... These results suggest that actin is a component of the mammalian mitotic spindle, that the distribution of actin differs from ... At metaphase the antiactin reveals a halo of ill-defined radius around each spindle pole and fibers that run from the poles to ... Cells fixed during cytokinesis show actin in the region of the cleavage furrow, while antitubulin reveals the fibrous spindle ...

... of spindles in PJ34 treated MDA-MB-231 cells (n = 20). Normal spindles, and chromosomes aligned in the spindle mid-zone were ... Mechanisms for focusing mitotic spindle poles by minus end directed motor proteins. J Cell Biol. 2005; 171:229-240. ... Simeonov DR, Kenny K, Seo L, Moyer A, Allen J, Paluh J. Distinct kinesin-14 mitotic mechanisms in spindle polarity. Cell Cycl. ... Compton D A, Luo C. Mutations in the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle ...

EML4 and NUDC in mitotic spindle formation (Drosophila melanogaster) EML4 and NUDC in mitotic spindle formation (Gallus gallus) ... EML4 and NUDC in mitotic spindle formation (Caenorhabditis elegans) EML4 and NUDC in mitotic spindle formation (Canis ... EML4 and NUDC in mitotic spindle formation (Plasmodium falciparum) EML4 and NUDC in mitotic spindle formation (Rattus ... Cell Cycle, Mitotic (Homo sapiens) * M Phase (Homo sapiens) * Mitotic Prometaphase (Homo sapiens) * EML4 and NUDC in mitotic ...

"Mitotic Spindle Apparatus" by people in this website by year, and whether "Mitotic Spindle Apparatus" was a major or minor ... "Mitotic Spindle Apparatus" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Mitotic Spindle Apparatus" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Mitotic Spindle Apparatus". ...

Here we combine the first large-scale serial electron tomography of whole mitotic spindles in early C. elegans embryos with ... A connection between centrosomes and chromosomes is a key feature of mitotic spindles. Here the authors generate 3D ... reconstructions of whole mitotic spindles in earlyC. elegansembryos and show that chromosomes are anchored by the entire ... We classify them as kinetochore (KMTs), spindle (SMTs) or astral microtubules (AMTs) according to their positions, and quantify ...

Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions *Ana Fernandez-Nicolas ... Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions *Ana Fernandez-Nicolas ...

Centrosome Size Sets Mitotic Spindle Length in Caenorhabditis elegans Embryos. In: Current Biology. 2010 ; Vol. 20, No. 4. pp. ... Centrosome Size Sets Mitotic Spindle Length in Caenorhabditis elegans Embryos. Garrett Greenan, Clifford P. Brangwynne, Steffen ... Centrosome Size Sets Mitotic Spindle Length in Caenorhabditis elegans Embryos. Current Biology. 2010 Feb 23;20(4):353-358. doi ... Centrosome Size Sets Mitotic Spindle Length in Caenorhabditis elegans Embryos. / Greenan, Garrett; Brangwynne, Clifford P.; ...

Lu, C. (2004). The roles of tubulins in caenorhabditis elegans meiotic and mitotic spindle formation (Doctoral thesis, ... The roles of tubulins in caenorhabditis elegans meiotic and mitotic spindle formation. ...

Mitotic spindle positioning edit Cytoplasmic dynein positions the spindle at the site of cytokinesis by anchoring to the cell ... "Disruption of mitotic spindle orientation in a yeast dynein mutant". Proceedings of the National Academy of Sciences of the ... Dynein is involved in the movement of chromosomes and positioning the mitotic spindles for cell division.[2][3] Dynein carries ... "Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex". The Journal of ...

As mitosis progresses, both centrosomes separate to generate the mitotic spindle. In this way, the mitotic spindle has two ... During this process, kinetochores that are attached to the mitotic spindle but that are not under tension trigger the spindle ... When sister kinetochores are properly attached to opposite spindle poles, forces in the mitotic spindle generate tension at the ... "Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption". Science. 273 (5277): 953-6. ...

... ... spindle apparatus epithelium time lapse imaging Time-Lapse Imaging Metadata. Show full item record ... Spindle orientation is critical for proper morphogenesis of organs and tissues as well as for the maintenance of tissue ... We show that FAKs role in spindle orientation is dependent on its ability to localize at focal adhesions and its interaction ...

initial mitotic spindle pole body separation (GO:0000073) regulation of mitotic spindle pole body separation is_a regulation of ... regulation of mitotic spindle pole body separation positive regulation of mitotic spindle pole body separation (GO:0010696) is_ ... GO:0010695 regulation of mitotic spindle pole body separation * GO:0010697 negative regulation of mitotic spindle pole body ... regulation of mitotic spindle pole body separation. Ontology. biological_process. Synonyms. regulation of SPB separation. ...

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Researchers probe the physical forces involved in creating the mitotic spindle Many millions of times per day, football-shaped ... structures called mitotic spindles form within the bodys cells as they prepare to divide. The process is routine but ...

... and syncytial blastoderm mitotic cell cycle. Located in nucleus and spindle midzone. Colocalizes with mitotic spindle. Is ... involved_in mitotic chromosome movement towards spindle pole IMP Inferred from Mutant Phenotype. more info ... Involved in several processes, including midbody abscission; mitotic chromosome movement towards spindle pole; ... involved_in mitotic cell cycle phase transition IBA Inferred from Biological aspect of Ancestor. more info ...

... cells assemble a spindle that captures the kinetochores and pulls them towards opposite poles ... Here, we compared mitotic and meiotic spindles in fission yeast. We show that, even though mitotic and meiotic spindles ... Home Kinesin-14 family proteins and microtubule dynamics define S. pombe mitotic and meiotic spindle assembly, and elongation ... Kinesin-14 family proteins and microtubule dynamics define S. pombe mitotic and meiotic spindle assembly, and elongation. ...

When mitotic chromosomes were transferred into enucleated or intact mouse GV oocytes, the first bipolar meiotic spindles were ... The spindle formation and polar body extrusion suggest that the first meiotic spindle was functional, and the chromosome ... This research employed a unique model in the mouse, mitotic chromosomes transferred to meiotic cytoplasts to investigate ... whether a meiotic oocytes microtubule apparatus can effectively separate mitotic metaphase chromosomes, and whether a spindle ...

The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. In: ... The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. ... Dive into the research topics of The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic ... The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. / ...

... in interacting with both the NPC and the mitotic spindle. However, comparative genomics suggests that TbNup92 and Mlp/Tpr may ... Touching from a distance: Evolution of interplay between the nuclear pore complex, nuclear basket, and the mitotic spindle. ... Touching from a distance: Evolution of interplay between the nuclear pore complex, nuclear basket, and the mitotic spindle. ... Mlp, Trypanosoma brucei, chromosome segregation, mitosis, mitotic spindle, nuclear basket, nuclear evolution, nuclear pore ...

Mehta, S., Yang, X. M., Jayaram, M., & Velmurugan, S. (2005). A novel role for the mitotic spindle during DNA segregation in ... Mehta, S, Yang, XM, Jayaram, M & Velmurugan, S 2005, A novel role for the mitotic spindle during DNA segregation in yeast: ... A novel role for the mitotic spindle during DNA segregation in yeast: Promoting 2μm plasmid-cohesin association. Molecular and ... Dive into the research topics of A novel role for the mitotic spindle during DNA segregation in yeast: Promoting 2μm plasmid- ...

The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle ... is_active_in mitotic spindle microtubule IBA Inferred from Biological aspect of Ancestor. more info ... located_in mitotic spindle microtubule IDA Inferred from Direct Assay. more info ... FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. Zhu H, et ...

A. mitotic spindles. B. kinetochores. C. antibodies. D. tumor suppressors. Definition. D. tumor suppressors. ...

Mechanisms of Golgi division by the mitotic spindle. Joachim Seemann, Dallas/USA. Host: Volker Gerke, Cells-in-Motion Cluster ...

The mitotic rate varies but is frequently brisk. Biphasic synovial sarcoma includes a spindle cell component as in the ... Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) ... 3, 8, 9] However, the mesothelial marker D2-40 is occasionally positive in the spindle cells of SFT. [73] CD117 is usually ... DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. [3, 8] The ...

Disruption of centrosomes and mitotic spindles would result in monopolar, tripolar, and quadrapolar divisions of chromosomes. ... such as the mitotic spindle, as well as the motor proteins that separate the chromosomes during cell division. ... mutation and errors in chromosome number as well as mitotic spindle disruption. The physical properties of the carbon nanotubes ...

The findings will also contribute to understanding how the mitotic spindle is perturbed by drugs that target microtubules and ... filaments responsible for organizing the mitotic spindle -- provides novel insight into the dynamic architecture of this ... The division of a cell in two requires the assembly of the mitotic spindle, an extremely complex structure, which is the result ... A large part of the time that a cell requires to divide is devoted to assembling the mitotic spindle, which, superficially, ...

Regulation of mitotic progression by the spindle assembly checkpoint. Lischetti, T. & Nilsson, Jakob, 2015, In: Molecular & ... Can sequestering of mitotic spindle proteins cause aneuploidy? (Comment on DOI 10.1002/bies.201400175). Nilsson, Jakob, Mar ...

Mitotic kinases (including Cdks, Polo, aurora).. • Microtubule reorganisation (including spindle formation and regulation). ...