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Ceramide and sphingolipid metabolites quantification.. To measure sphingolipid metabolites, whole retinas were homogenized in ... Decreased ceramide mass suggests an alteration in sphingolipid metabolism, so additional sphingolipids were also measured. ... Diabetes Alters Sphingolipid Metabolism in the Retina. Todd E. Fox, Xianlin Han, Samuel Kelly, Alfred H. Merrill, Rex E. Martin ... Diabetes Alters Sphingolipid Metabolism in the Retina. Todd E. Fox, Xianlin Han, Samuel Kelly, Alfred H. Merrill, Rex E. Martin ...
http://diabetes.diabetesjournals.org/content/55/12/3573
*  Sphingolipid - Wikipedia
Sphingolipidoses, or disorders of sphingolipid metabolism, have particular impact on neural tissue. A sphingolipid with an R ... ISBN 0-7514-0253-2 Dickson RC (May 2008). "Thematic review series: sphingolipids. New insights into sphingolipid metabolism and ... Dickson RC (May 2008). "Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in ... Simple sphingolipids, which include the sphingoid bases and ceramides, make up the early products of the sphingolipid synthetic ...
https://en.wikipedia.org/wiki/Sphingolipid
*  Impact of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice | Arteriosclerosis,...
We then used LC/ESI/MS/MS to measure plasma membrane sphingolipid levels. As shown in Figure 2B and 2C, Sms1−/− macrophage ... Impact of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice. Zhiqiang Li, Yifan Fan, ... In this study, we focused on plasma and tissue sphingolipid metabolism and examined atherosclerosis in Ldlr-/- mice that were ... Sms1 deficiency dramatically increases glyco-sphingolipid levels, but that of Sms2 does not. We used enzymatic assays to ...
http://atvb.ahajournals.org/content/32/7/1577
*  C756 | Prosaposin (PSAP)- Cloud-Clone Corp.
Saposin is an acronym for Sphingolipid Activator PrO[S]teINs. Each domain of the precursor protein is approximately 80 amino ... "Simultaneous deficiency of sphingolipid activator proteins 1 and 2 is caused by a mutation in the initiation codon of their ... "Mutation in the sphingolipid activator protein 2 in a patient with a variant of Gaucher disease."FEBS Lett. 284:57-59(1991) [ ... "A non-glycosylated and functionally deficient mutant (N215H) of the sphingolipid activator protein B (SAP-B) in a novel case of ...
http://www.cloud-clone.com/items/C756.html
*  The ultrastructural effects and immunolocalisation of fumonisin B1 on cultured oesophageal cancer cells (SNO)
... of sphingolipids and the re-utilisation of sphingosine (So) derived from sphingolipid metabolism.36 As a result, FB1 causes an ... 37 Complex sphingolipids have been implicated in cell cell interactions.34 Therefore, a blockage of de novo sphingolipid ... Wang E., Norred W.P., Bacon C.W., Riley R.T. and Merrill A. (1991). Inhibition of sphingolipid biosynthesis by fumonisins. J. ... Merrill A.H., Schmelz E., Wang E., Dillehay D.L., Rice L.G., Meredith F. and Riley R.T. (1997). Importance of sphingolipids and ...
http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0038-23532009000300015&lng=en&nrm=iso&tlng=en
*  Two types of detergent-insoluble, glycosphingolipid/cholesterol-rich membrane domains from isolated myelin - Arvanitis - 2005 -...
Harder T. and Simons K. (1997) Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr. Opin. Cell Biol ... London E. and Brown D. A. (2000) Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/ ... Two different sphingolipid/cholesterol-enriched DIG fractions from melanoma cells could be separated by immunoprecipitation ( ... Nfasc155H and MAG are Specifically Susceptible to Detergent Extraction in the Absence of the Myelin Sphingolipid Sulfatide, ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2005.03331.x/full
*  Studies on Ceramide/Colipid Interactions in Complex Bilayers
Ceramide belongs to an important class of sphingolipids and it constitutes the hydrophobic backbone of all complex ... sphingolipids. Ceramide plays an important role in different biological processes such as cell signaling, proliferation, ...
http://www.doria.fi/handle/10024/144272
*  Abstract for TR-496 - Fumonisin B1 (CASRN 116355-83-0)
Fumonisin B1 is an inhibitor of ceramide synthase, resulting in an interruption of de novo sphingolipid synthesis. This enzyme ...
https://ntp.niehs.nih.gov/results/pubs/longterm/reports/longterm/tr400499/abstracts/tr496/index.html
*  Fumonisin B1 Is Hepatotoxic and Nephrotoxic in Milk-Fed Calves : Toxicological Sciences - oi
Keywords: fumonisin; sphingosine; sphinganine; sphingolipid; hepatotoxicity; cholesterol; nephrotoxicity; proximal renal ... This is the first report of fumonisin B1-induced renal injury and organ sphingolipid alterations in cattle. ... Fumonisins are a group of mycotoxins that alter sphingolipid biosynthesis and induce leukoencephalomalacia in horses and ... Fumonisins are a group of mycotoxins that alter sphingolipid biosynthesis and induce leukoencephalomalacia in horses and ...
http://oxfordindex.oup.com/view/10.1093/toxsci/60.2.385
*  Sphingolipids in Disease | SpringerLink
Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling ... Sphingolipids in Inflammation, Infection and Lung Diseases. * Front Matter Pages 199-199 ... Sphingolipids in Neuro-psychiatry and Muscle Diseases. * Front Matter Pages 403-403 ... Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling ...
https://link.springer.com/book/10.1007/978-3-7091-1511-4
*  Sphingolipids | Cayman Chemical
Ceramide is the simplest of the sphingolipids: with hydrogen as its 'head' group, it is a diol. Like the other sphingolipids, ... The enigmatic sphingolipids and their derivates are, like the Great Sphinx, beginning to reveal their secrets. Some of the most ... Consider the sphingolipids, whose name reveals little about their structure or function. They can be as mysterious to the ... And like the sphinx, the different sphingolipids have different head groups. While Egyptologists would prefer to delve more ...
https://www.caymanchem.com/news/sphingolipids
*  Sphingolipids in Inflammation: From Bench to Bedside
describe sphingolipid metabolism and signaling in IBD and discuss the potential of sphingolipid-targeted molecules as ... Sphingolipids in Inflammation: From Bench to Bedside. Kazuyuki Kitatani,1 Kazuhisa Iwabuchi,2 Ashley Snider,3,4 and Laura ... Sphingolipids have been appreciated as bioactive lipids that regulate a diverse range of cellular responses [1, 2]. In recent ... review roles of sphingolipid in the pathobiology of lung inflammation.. Three research articles discuss novel findings for S1P ...
https://www.hindawi.com/journals/mi/2016/7602526/
*  sphingolipid
The article presents a definition for the term "sphingolipid," which refers to a lipid containing one of several long-chain ... Here we show that the sphingolipid metabolic pathway is highly activated in the deciduum during pregnancy and disturbance of ... Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. Mizugishi, Kiyomi; Cuiling Li; Olivera ... Sphingolipids, including monohexosylceramides (mainly glucosylceramide), dihexosylceramides (mainly lactosylceramide), ...
http://connection.ebscohost.com/c/reference-entries/21246241/sphingolipid
*  Sphingolipids - Lipids in Cell Signaling | Sigma-Aldrich
The core of a sphingolipid is an amino alcohol called sphingosine. Complex sphingolipids located in the plasma membrane of ... Sphingolipids are involved in diseases including diabetes, cancer, microbial infections, neurological syndromes, and ... Types of Sphingolipids include Ceramides, Phytoceramide, Sphingomyelins, Glycosphingolipids, Gangliosides, Cerebrosides, and ... Sigma-Aldrich has a variety of products to aid sphingolipid research. ...
https://www.sigmaaldrich.com/life-science/cell-biology/cell-biology-products.html?TablePage=9560519
*  Sphingolipid delta4-desaturase (IPR011388) | InterPro | EMBL-EBI
This group represents sphingolipid delta-4 desaturase (DEGS), an integral membrane protein required for sphingosine ... Identification and characterization of a sphingolipid delta 4-desaturase family.. J. Biol. Chem. 277 25512-8 2002 ... Identification and characterization of a sphingolipid delta 4-desaturase family.. J. Biol. Chem. 277 25512-8 2002 ... Delta4-desaturated sphingolipids provide an early signal that triggers the entry into both meiotic and spermatid ...
http://www.ebi.ac.uk/interpro/entry/IPR011388
*  Journal News | JLR | Sphingolipids connected to corneal disease
Sphingolipids are specialized fat molecules important in cell-membrane structure, cellular processes and molecular signaling. ... The investigators found that three types of TGF-β, known as 1, 2 and 3, differentially regulated sphingolipid levels in ... These results open the door to possible treatments for keratoconus based on the sphingolipid pathway. Mandal explains, "These ... Moreover, the investigators discovered that TGF-β treatment also changed the expression of sphingolipid-production genes in ...
https://www.asbmb.org/asbmbtoday/201705/JournalNews/JLRSphingolipids/
*  Sphingolipids: A Potential Molecular Approach to Treat Allergic Inflammation
... Wai Y. Sun1,2,3 and Claudine S. Bonder1,2,3,4 ... Herein, we review the current knowledge of allergic inflammation and discuss the role of sphingolipids as potential targets to ...
https://www.hindawi.com/journals/ja/2012/154174/abs/
*  Sphingolipids Summary | CureHunter Mobile
Sphingolipids Summary Description: A class of membrane lipids that have a polar head and two nonpolar tails. They are composed ... Key Diseases for which Sphingolipids is Relevant. * Neoplasms (Cancer) : 2 outcomes 12 studies in 127 results ...
http://www.curehunter.com/m/keywordSummaryD013107.do
*  Sphingolipids in essential hypertension and endothelial dysfunction
... Supervisors. E.S.G. Stroes. J.G.R. de Mey. ... Chapter 2: Sphingolipids and the orchestration of endothelium-derived vasoactive factors: When endothelial function demands ... Chapter 3: Hypertension is associated with marked alterations in sphingolipid biology: A potential role for ceramide. ... Chapter 4: Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats. ...
http://dare.uva.nl/search?metis.record.id=393001
*  Sphingolipids in Inflammation: Roles and Implications | BenthamScience
Sphingolipids in Inflammation: Roles and Implications. Author(s): B. J. Pettus, C. E. Chalfant, Y. A. Hannun. Department of ... Abstract: Sphingolipids, historically described as potential reservoirs for bioactive lipids, presently define a new family of ... Sphingolipids, historically described as potential reservoirs for bioactive lipids, presently define a new family of cellular ... Sphingolipid metabolism is clearly involved in the regulation of cell growth, differentiation, and programmed cell death. ...
http://www.eurekaselect.com/62133/article
*  The Role of Sphingolipids in Cancer Development and Therapy, Volume 117 - 1st Edition
Purchase The Role of Sphingolipids in Cancer Development and Therapy, Volume 117 - 1st Edition. Print Book & E-Book. ISBN ... The Role of Sphingolipids in Cancer Development and Therapy, Volume 117 1st Edition. Write a review ... This thematic volume looks at 'The Role of Sphingolipids in Cancer Development and Therapy' ... This thematic volume looks at 'The Role of Sphingolipids in Cancer Development and Therapy' ...
https://www.elsevier.com/books/the-role-of-sphingolipids-in-cancer-development-and-therapy/norris/978-0-12-394274-6
*  My journey into the world of sphingolipids and sphingolipidoses
Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
https://www.jstage.jst.go.jp/article/pjab/88/10/88_PJA8810B-03/_article
*  Sphingolipids - Chemistry LibreTexts
Sphingolipids are a second type of lipid found in cell membranes, particularly nerve cells and brain tissues. They do not ... Sphingolipids are named after the sphinx in Greek mythology, part woman and part lion, who devoured all who could not answer ... Sphingolipids are a second type of lipid found in cell membranes, particularly nerve cells and brain tissues. They do not ...
https://chem.libretexts.org/Core/Biological_Chemistry/Lipids/Non-glyceride_Lipids/Sphingolipids
*  Sphingolipid Ceramide N-Deacylase | SCDase | Sphingolipid Hydrolysis
Sphingolipid Hydrolysis: Sphingolipid Ceramide N-Deacylase (SCDase) Sphingolipid ceramide N-deacylase (SCDase) is derived from ... Pseudomonas and hydrolyzes the N-acyl linkage between fatty acids and sphingosine bases in ceramides of various sphingolipids. ...
http://www.clontech.com/US/Products/Glycobiology/Glycobiology_Enzymes_and_Reagents/SCDase
*  Sphingolipids Metabolites: A New Class of Second Messengers in the Regulation of Cell Growth | SpringerLink
Y.A. Hanrun and R.M. Bell, Functions of sphingolipids and sphingolipid breakdown products in cellular regulation, Science 243: ... the sphingolipids. All sphingolipids, including ceramide, sphingomyelin, cerebrosides, gangliosides, and sulfatides, contain (1 ... Spiegel S. (1994) Sphingolipids Metabolites: A New Class of Second Messengers in the Regulation of Cell Growth. In: Hu V.W. ( ... A.H. Merrill, Cell regulation by sphingosine and more complex sphingolipids, J. Bioenerg. Biomembr. 23: 83 (1991).PubMedGoogle ...
https://link.springer.com/chapter/10.1007/978-1-4615-2421-2_12