SOXF transcription factors in cardiovascular development.
... 2016: Semin. Cell Dev. Biol.. Journal. Seminars in Cell & ... Understanding how SOXF factors are regulated, as well as their downstream transcriptional target genes, will be important for ... In this review we discuss the various reported roles of the SOXF factors: SOX7, SOX17 and SOX18 in cardiac, vascular and ... SOXF factors have pleiotropic roles during these processes, and there is significant redundancy and functional compensation ...https://christie.openrepository.com/handle/10541/619928
The copy number analysis of chromosome 8.(A) Ideogram o | Open-i
SOXF Transcription Factors/genetics*. *beta-Defensins/genetics*. Minor. *Adult. *Child. *Chromosome Deletion ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3757027_pone.0072515.g002&req=4
Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality | JEM
SoxF transcription factors are positive feedback regulators of VEGF signaling. Circ. Res. 119:839-852. doi:10.1161/CIRCRESAHA. ... SoxF transcription factors consisting of Sox7, Sox17, and Sox18 are expressed specifically in endothelial cells (ECs) and ... Similarly, transcription factor HIF-1α-deficient HGG cells elicit different vessel changes depending on the implantation site, ... Likewise, homologous transcription factors Irx3 and Irx5 have a cooperative role in embryonic cardiac morphogenesis but an ...http://jem.rupress.org/content/215/3/963
Inhibition of miR-184 reduces the proliferation of HCC | Open-i
SOXF Transcription Factors/genetics*. Minor. *Base Sequence. *Carcinogenesis/genetics. *Cell Cycle/genetics ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3928300_pone.0088796.g003&req=4
ZFIN Publication: Kikuchi et al., 2000
SOXF Transcription Factors. *Signal Transduction. *Stem Cells/cytology*. *Stem Cells/metabolism. *Transcription Factors* ...https://zfin.org/ZDB-PUB-000616-3
ZFIN Publication: Lunde et al., 2004
Octamer Transcription Factor-3; SOX Transcription Factors; SOXF Transcription Factors; Signal Transduction*; Transcription ... Factors/metabolism*; Zebrafish/embryology*; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/metabolism PubMed:. ...https://zfin.org/ZDB-PUB-040109-3
ZFIN Publication: Alexander et al., 1999
Transforming Growth Factor beta*; SOXF Transcription Factors; Signal Transduction; Transcription Factors*; Transforming Growth ... Overexpression of a constitutively active form of the type I transforming growth factor beta (TGF-beta) receptor TARAM-A also ... Factor beta/genetics; Transforming Growth Factor beta/metabolism; Zebrafish/embryology*; Zebrafish/genetics*; Zebrafish/ ... a member of the Cripto/FRL-1/Cryptic family of epidermal growth factor related proteins (EGF-CFC); and the product of the ...https://zfin.org/ZDB-PUB-991102-6
Immunofluorescence for Epigenetic Modifications and Mod | Open-i
SOXF Transcription Factors/metabolism*. Minor. *Animals. *Antigens, CD38/metabolism. *Cell Line, Tumor ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4310934_figs3&req=4
Cyclin D1 expression is induced by Sox17.(A-B) Immuno | Open-i
SOXF Transcription Factors/metabolism*. *Signal Transduction*. *Smad3 Protein/metabolism*. *Stem Cells/cytology*/metabolism ... The Sry-related high mobility group box transcription factor Sox17 is required for diverse developmental processes including ... The Sry-related high mobility group box transcription factor Sox17 is required for diverse developmental processes including ... Sox17 decreased the expression of transforming growth factor-beta (TGF-beta)-responsive cell cycle inhibitors in the adult ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2682659_pone.0005711.g006&req=4
SRY-Box 18 - CAGS
... which consists of several other transcription factors, including two other members of the SOXF family, Sox7 and Sox17. Within ... The SOX18 gene codes for a member of the SRY related HMG Box (SOX) family of transcription factors. These transcription factors ...http://cags.org.ae/ctga/details.aspx?id=2213&se=Latest
Recent publications - Ludwig Institute for Cancer Research
Genetic disruption of SoxF binding sites established a clear requirement for members of this group of transcription factors ( ... Using a combination of targeted mutagenesis of transcription factor-binding sites and gene silencing of transcription factors, ... These findings position SoxF transcription factors directly upstream of Notch receptor expression during the acquisition of ... Osteogenic-angiogenic coupling is promoted by the hypoxia-inducible factor 1-alpha (HIF-1α) transcription factor, provoking ...https://www.ludwig.ox.ac.uk/selected-recent-publications
GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos. - Radcliffe Department of Medicine
All three GATA factors were induced by activin, although GATA4 and 6 required lower concentrations. GATA MOs inhibited ... Induction of HNF3beta by all three GATA factors was abolished when protein synthesis was inhibited, showing that these ... these observations identify GATA6 as the predominant GATA factor in the maintenance of endodermal gene expression by TGFbeta ... The individual contributions of the three vertebrate GATA factors to endoderm formation have been unclear. Here we detail the ...https://www.rdm.ox.ac.uk/publications/106537
Search | eLife
A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact ... on other members of the SoxF family. Insight Jan 31, 2017. Available as: *HTML ...https://elifesciences.org/search?for=lymphatics
Search | eLife
A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact ... on other members of the SoxF family. Insight Jan 31, 2017. Available as: *HTML ... A membrane protein complex in the endoplasmic reticulum is a key factor for the biogenesis of multi-pass transmembrane proteins ... Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices. ...https://elifesciences.org/search?for=SMC%20proteins
Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease | Genome Medicine |...
We identified SOX17 as a novel candidate risk gene (p = 5.5e−7). SOX17 is highly constrained and encodes a transcription factor ... Transcription factor pathways and congenital heart disease. Curr Top Dev Biol. 2012;100:253-77.View ArticlePubMedPubMed Central ... SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development. ... Association analysis identifies transcription factor SOX17 as a new candidate PAH-CHD risk gene. To identify novel risk genes ...https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-018-0566-x
Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing...
Through computational analysis, we recognized putative binding sites for transcription factors downstream of these pathways ... Sox15 or SoxF), Enhancer of split (E(spl)) and Medea (Med). SoxF codes for a transcription factor involved in the Wg signalling ... 12861_2010_571_MOESM2_ESM.PDF Additional file 2: List of transcription factors in C24→C72. For each transcription factor we ... For example, we found the Krüppel-like transcription factor cabut (cbt) [47, 48], the Collagen type IV (Cg25C) gene related to ...https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-10-94
SOX17 links gut endoderm morphogenesis and germ layer segregation. - PubMed - NCBI
SOXF Transcription Factors/biosynthesis. *SOXF Transcription Factors/metabolism*. Substances. *Cadherins. *Extracellular Matrix ... We show that the transcription factor SOX17, which is activated in prospective DE cells before intercalation, is necessary for ...https://www.ncbi.nlm.nih.gov/pubmed/25419850?access_num=25419850&link_type=MED&dopt=Abstract
lymphedema gene sox18 [Lymphedema People]
Sox7, -17 and -18 constitute the Sox subgroup F (SoxF) of HMG box transcription factor genes, which all are co-expressed in ... Sox7, Sox17 and Sox18 constitute group F of the Sox family of HMG box transcription factor genes. Dominant-negative mutations ... The testis-determining gene SRY (480000) encodes a transcription factor characterized by a DNA-binding motif known as the HMG ( ... SOX proteins are called transcription factors on the basis of this action. ...http://iphone.lymphedemapeople.com/wiki/doku.php?id=lymphedema_gene_sox18
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching | PNAS
SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling. *. Sympathetic Innervation Promotes Arterial ... Flt-1 (Vascular Endothelial Growth Factor Receptor-1) Is Essential for the Vascular Endothelial Growth Factor-Notch Feedback ... Filopodia extension in dll4+/− retinal vessels required the vascular growth factor VEGF and was inhibited when VEGF signaling ... Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina ...http://www.pnas.org/content/104/9/3225
Welcome to CDC stacks | Population Based Model of Human Embryonic Stem Cell (hESC) Differentiation during Endoderm Induction -...
Fibroblast Growth Factor 2 Flow Cytometry Humans Models, Biological Receptors, CXCR4 Research Article Reverse Transcriptase ... Embryonic stem cells are conventionally differentiated by modulating specific growth factors in the cell culture media. ... basic fibroblast growth factor (FGF2) and bone morphogenetic protein 4 (BMP4)). The differentiating cell population is analyzed ... performed experimentally with exposure to Activin A and Activin A supplemented with growth factors ( ...https://stacks.cdc.gov/view/cdc/22769
Analysis of transcriptional targets of SOX9 during embryonic heart valve development reveals a critical network of...
SOX transcription factors are known to bind in complexes with other SOXs or other transcription factors in order to efficiently ... all of the SOXE TFs have roles involved in neural crest cell development and SOXF factors have important functions in the ... Transcription factor TGFβ- Transforming growth factor beta TSS- Transcriptional start site TTS- Transcription termination site ... that are targeted by SOX9 are transcription factors and suggests that SOX9 may be regulating a network of transcription factors ...https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0220645
Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. -...
SOXF Transcription Factors. *Signal Transduction/physiology. *TCF Transcription Factors/genetics. *TCF Transcription Factors/ ... We report a novel mechanism by which the Sox family of transcription factors regulate the canonical Wnt signaling pathway. We ... Different Sox factors are antagonists or agonists of the canonical Wnt pathway and are expressed in the normal and neoplastic ... Transfection with Sox factors without β-catenin(S37A) did not result in significant TOP-flash activity (data not shown). ...https://www.ncbi.nlm.nih.gov/pubmed/17875931
SOX gene family - Wikipedia
SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes ... SOX10 SoxF: SOX7, SOX17, SOX18 SoxG: SOX15 SoxH: SOX30 Homeobox Pax genes Evolutionary developmental biology Body plan Bowles, ... transcription factors". Int. J. Biochem. Cell Biol. 39 (12): 2195-214. doi:10.1016/j.biocel.2007.05.019. PMC 2080623 . PMID ... J; Schepers G; Koopman P. (November 2000). "Phylogeny of the SOX family of developmental transcription factors based on ...https://en.wikipedia.org/wiki/SOX_gene_family
Expression of multiple Sox genes through embryonic development in the ctenophore Mnemiopsis leidyi is spatially restricted to...
... and SoxF (MleSox5), with one unclassified gene (MleSox6). We investigated the expression of five out of six Mnemiopsis Sox ... a family of transcription factors characterized by the presence of a high mobility group (HMG) box domain, are among the ... Evolutionary history of the of Sox transcription factor family. According to our analyses and within the context of the animal ... The Sox genes, a family of transcription factors characterized by the presence of a high mobility group (HMG) box domain, are ...https://evodevojournal.biomedcentral.com/articles/10.1186/2041-9139-5-15
Potential application of cell reprogramming techniques for cancer research | SpringerLink
For example, during SCLC progression to metastasis, the expression of the transcription factor nuclear factor 1b (Nfib) ... Among the known reprogramming factors, the SOX family members, especially those of the SOXB, SOXE, and SOXF subclasses, are ... TGF-β and the tumor necrosis factor-α, WNT, NOTCH, SHH signals and ECM stiffness, and some CSC-related transcription factors) [ ... 3 can interact with other factors on OCT4 target loci and potentiate DR conversion with multiple types of transcription factors ...https://link.springer.com/article/10.1007%2Fs00018-018-2924-7