SICB - 2012 meeting - Abstract Details
SoxE genes include a group of transcription factors (Sox8, Sox9, and Sox10) that are among key regulators of neural crest cell ... The functional redundancy among SoxE paralogs and orthologs suggests that a function of the ancestral SoxE gene was likely in ... 4 Expression of amphioxus and lamprey SoxE genes in zebrafish reveals ancient neural crest-specific roles in vertebrate ... and melanogenic roles of gnathostome SoxE genes originated in the ancestral SoxE prior to gene duplication, and that these ...http://www.sicb.org/meetings/2012/schedule/abstractdetails.php?id=519
Neural Crest Stem Cells/Progenitors and Their Potential Applications in Disease Therapies | MedCrave
Multiple molecules including signaling factors, transcription factors and components of migratory machinery are expressed at ... FoxD3 and SoxE family (mainly Sox9 and Sox10) [29-32]. Numerous functional studies in several species have revealed the ... 2001) The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev 15(1): 66-78. ... In response to the early inductive signals, neural plate border cells turn on a distinct set of transcription factors called ...http://googlescholar.medcraveonline.com/scholars/article_fulltext/4294
Genome duplications of early vertebrates as a possible chronicle of the evolutionary history of the neural crest
2. Transcription factors involved in the neural crest. Several transcription factors are known to be involved in neural crest ... although SoxE expression has not been examined in either ascidians or amphioxus, SoxE was likely involved in neural crest ... Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo. ... The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis ...http://www.ijbs.com/v02p0133.htm
ZFIN Publication: Mahalwar et al., 2014
PAX7 Transcription Factor/genetics; PAX7 Transcription Factor/metabolism; SOXE Transcription Factors/genetics; SOXE ... Transcription Factors/metabolism; Skin Pigmentation/genetics; Skin Pigmentation/physiology*; Time-Lapse Imaging; Zebrafish/ ...http://zfin.org/ZDB-PUB-140913-1
Nomura T[au] - PubMed - NCBI
NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer. ... Gotoh H, Wood WM, Patel KD, Factor DC, Boshans LL, Nomura T, Tesar PJ, Ono K, Nishiyama A. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Nomura+T%5Bau%5D&dispmax=50
Tesar PJ[au] - PubMed - NCBI
NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer. ... Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.. Miller TE, Liau BB, Wallace LC, Morton ... Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the ... Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Tesar+PJ%5Bau%5D&dispmax=50
The conditional allele DNMT3b−/− phenotype.Embryos | Open-i
SOXE Transcription Factors/genetics/metabolism. *Skull/embryology/enzymology. *Wnt1 Protein/genetics/metabolism ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3475715_pone.0047794.g002&req=4
Protocols and Video Articles Authored by Yuji Mishina (Translated to Hindi)
Dec, 2007 , Pubmed ID: 17905940 SOX8 is a transcription factor that belongs to the SoxE group of high mobility group (HMG) ... Analysis of transcription factors regulating SNS development shows that the basic helix-loop-helix factor Ascl1 is ... By deleting the type I BMP receptors or the transcription factor Smad4 in the limb bud mesenchyme, we find that loss of BMP- ... Feb, 2003 , Pubmed ID: 12524542 Zfp148 belongs to a large family of C2H2-type zinc-finger transcription factors. Zfp148 is ...https://www.jove.com/author/Yuji_Mishina?language=Hindi
Inflammation and NG2 Cell Differentiation - Akiko Nishiyama
2018) NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer. ... we have observed that deletion of the basic helix-loop-helix transcription factor Olig2 specifically in mature NG2 cells ... In Aim 2, we will determine whether the newly identified compounds that increase Olig2 transcription activate the Sonic ... We have also performed a high throughput screen to identify compounds that upregulate Olig2 transcription. We will use these ...http://grantome.com/grant/NIH/R01-NS073425-04
Neural development and regeneration: it's all in your spinal cord | Development
... the transcription factor effectors. Cell identities are determined by specific transcription factors expressed in restricted ... Michael Wegner (University of Erlangen-Nürnberg, Germany) presented a gene regulatory network involving SoxE factors that ... 2012). The transcription factor c-Maf controls touch receptor development and function. Science 335, 1373-1376. doi:10.1126/ ... 2013). The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating ...http://dev.biologists.org/content/142/5/811
SOX Transcription Factors | Harvard Catalyst Profiles | Harvard Catalyst
SOXB2 Transcription Factors. *SOXC Transcription Factors. *SOXD Transcription Factors. *SOXE Transcription Factors ... "SOX Transcription Factors" by people in Harvard Catalyst Profiles by year, and whether "SOX Transcription Factors" was a major ... Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. The numerous members of this family are ... "SOX Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical ...https://connects.catalyst.harvard.edu/Profiles/display/Concept/SOX%20Transcription%20Factors
Analysis of transcriptional targets of SOX9 during embryonic heart valve development reveals a critical network of...
SOX transcription factors are known to bind in complexes with other SOXs or other transcription factors in order to efficiently ... Haldin, C.E. and LaBonne, C. (2010) SoxE factors as multifunctional neural crest regulatory factors. Int J Biochem Cell Biol, ... Transcription factor TGFβ- Transforming growth factor beta TSS- Transcriptional start site TTS- Transcription termination site ... that are targeted by SOX9 are transcription factors and suggests that SOX9 may be regulating a network of transcription factors ...https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0220645
Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest | Development
The Transcription Factor Activator Protein 2 (Tfap2) was duplicated in the chordate lineage and is essential for development of ... We show that in neural crest cells Tfap2 directly activates expression of sox10, which encodes a transcription factor essential ... The appearance of this regulatory interaction is likely to have coincided with that of the neural crest, because AP2 and SoxE ... Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest ...http://dev.biologists.org/content/early/2012/01/12/dev.071308
Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem...
Using a profiling approach, preferential limbal expression was found for SoxE and SoxF genes, particularly for Sox9, which ... Understanding transcription factor (TF) regulation of limbal epithelial stem/progenitor cells (LEPCs) may aid in using non- ... Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/ ... Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/ ...https://cris.fau.de/converis/portal/Publication/208944278?auxfun=%E2%8C%A9=en_GB
Sox8 is a critical regulator of adult Sertoli cell function and male fertility - UQ eSpace
Sox8 encodes a high-mobility group transcription factor that is widely expressed during development. Sox8, -9 and -10 form ... In contrast to other SoxE genes, the role of Sox8 is unclear and Sox8 mouse mutants reportedly showed only idiopathic weight ...https://espace.library.uq.edu.au/view/UQ:173969
SOX gene family - Wikipedia
SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes ... SOX13 SoxE: SOX8, SOX9, SOX10 SoxF: SOX7, SOX17, SOX18 SoxG: SOX15 SoxH: SOX30 Homeobox Pax genes Evolutionary developmental ... transcription factors". Int. J. Biochem. Cell Biol. 39 (12): 2195-214. doi:10.1016/j.biocel.2007.05.019. PMC 2080623 . PMID ... "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Dev. Biol. 227 ...https://en.wikipedia.org/wiki/SOX_gene_family
76 HD ZIP III lost the HD: e volution of a transcription factor regulator Miles NW 1 Soltis D E 1,2 Soltis P S 2 1 Department ... data presented here demonstrate that invertebrate cartilage is collagen based and chondrogenesis is probably regulated by SoxE ... Induction of gst 4 is via the SKN 1 transcription factor. We examined w hether heat stress impairs the response to juglone ... 52 ECM, for instance, and the Coll agen2A1 gene is directly regulated by Sox9, Sox5 and Sox6 transcription factors. Signaling ...http://ufdc.ufl.edu/IR00001363/00001
Comparative analysis of histologically classified oligodendrogliomas reveals characteristic molecular differences between...
Moreover, we revealed characteristic expression differences of several HOX and SOX transcription factors suggesting the ... b Ranking of transcription factors by out-degree for the CNV + EXP network. Only very few transcription factors have high out- ... SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006; 11: ... Hallier M. The transcription factor Spi-1/PU,1 interacts with the potential splicing factor TLS. J Biol Chem. 1998; 273(9):4838 ...https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4251-7
Olig1 and Sox10 Interact Synergistically to Drive Myelin Basic Protein Transcription in Oligodendrocytes | Journal of...
Transcription factor binding sites in the mbp promoter region. A, Alignment of the mbp promoter sequences from human, mouse, ... 2006) SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell 11: ... 2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306:2111-2115. ... Several transcription factors including OLIG1, OLIG2, NKX2.2, SOX10, and OCT6 are known to regulate the development of OLPs ( ...http://www.jneurosci.org/content/27/52/14375
TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila. - preLights
A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural ... For organisms such as Drosophila, these factors can vary considerably during larval development. How then do fly larvae achieve ...https://prelights.biologists.com/highlights/torc1-modulation-adipose-tissue-required-organismal-adaptation-hypoxia-drosophila/
Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling -...
A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural ... PYGO complex seems to control the expression of a specific subgroup of Wnt target genes including key transcription factors ... BCL9 proteins and their interaction partners PYGO1/2 have been shown to act as co-factors of nuclear ß-catenin in the context ... The preprint from Cantù and colleagues identifies BCL9 and PYGO as essential tissue-specific co-factors of ß-catenin that ...https://prelights.biologists.com/highlights/mutations-bcl9-pygo-genes-cause-congenital-heart-defects-tissue-specific-perturbation-wnt%CE%B2-catenin-signaling/
Expression of multiple Sox genes through embryonic development in the ctenophore Mnemiopsis leidyi is spatially restricted to...
SoxE (MleSox3, MleSox4), and SoxF (MleSox5), with one unclassified gene (MleSox6). We investigated the expression of five out ... a family of transcription factors characterized by the presence of a high mobility group (HMG) box domain, are among the ... Evolutionary history of the of Sox transcription factor family. According to our analyses and within the context of the animal ... The Sox genes, a family of transcription factors characterized by the presence of a high mobility group (HMG) box domain, are ...https://evodevojournal.biomedcentral.com/articles/10.1186/2041-9139-5-15
Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus | Molecular Brain |...
... family of transcription factors. AP-2δ is restricted to specific regions of the CNS, including a subset of ganglion cells in ... The transcription factor Bhlhb4 is required for rod bipolar cell maturation. Neuron. 2004;43(6):779-93.PubMedView ArticleGoogle ... Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest. Development. 2012; ... Eckert D, Buhl S, Weber S, Jager R, Schorle H. The AP-2 family of transcription factors. Genome Biol. 2005;6(13):246.PubMed ...https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-016-0244-0
An SRY-related sequence on the marsupial X chromosome: implications for the evolution of the mammalian testis-determining gene....
The male-determining gene SRY is a hybrid of DGCR8 and SOX3, and is regulated by the transcription factor CP2 ... Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development? ... Sox3: A transcription factor for Cyp19 expression in the frog Rana rugosa ... Co-option of Sox3 as the male-determining factor on the Y chromosome in the fish Oryzias dancena ...https://www.pnas.org/content/91/5/1927/tab-article-info
Mortlock Lab - Labnodes - The Vanderbilt Research Network
... genetics Peptides RNA Interference RNA Polymerase II SOXE Transcription Factors Stromal Cells Syndrome transcription factors ... which may be critical for its crucial role as a signaling factor in osteoblast differentiation. We will dissect the factors ... Dynamics and cellular localization of Bmp2, Bmp4, and Noggin transcription in the postnatal mouse skeleton. Pregizer SK, ...https://labnodes.vanderbilt.edu/community/profile/id/36