FOXL2 elisa kit | Canine Forkhead box protein L2 (FOXL2) ELISA Kit-NP 075555.1
... transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; positive regulation of ... Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. ... This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ... Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 3q23. Cellular Component: nucleus. ...https://www.mybiosource.com/prods/ELISA-Kit/Canine/Forkhead-box-protein-L2-FOXL2/FOXL2/datasheet.php?products_id=7200093
Transcription Factor Sox9 | Osteoarthritis Research Society International (OARSI)
To signup for our e-newsletter, please create an account. If you already have an account or are a Member of OARSI, you are already signed up to receive our e-newsletter.. Create an Account. ...https://oarsi.org/education/oarsi-resources/transcription-factor-sox9
SOX-9 - HMG-box - β-Scaffold Factors - Transcription Factors - Products
SOX-9. Sex-determining Region Y (SRY) box 9 (SOX-9; TF 4.7.1) is a member of a highly conserved family of transcription factors ... Role of SOX family of transcription factors in central nervous system tumors. Am. J. Cancer Res. 2014, 4, 312-324. ... SOX-9 is also expressed in a wide range of cancers, where it regulates cell proliferation. Functionally, SOX-9 knockdown ... Understanding the role of SOX9 in acquired diseases: lessons from development. Trends Mol. Med. 2011, 17, 166-174..  A.M. de ...https://www.axonmedchem.com/products/transcription-factors/scaffold-factors/hmg-box/sox-9
Embryonic transcription factor SOX9 drives breast cancer endocrine resistance.
We show that up-regulation of SOX9 is sufficient to cause relative endocrine resistance. The gain of SOX9 as an ER-regulated ... including most notably the stem cell factor SOX9, that promote proliferation and a metastatic phenotype. ... we have uncovered a role for an RUNX2-ER complex that stimulates the transcription of a set of genes, ...https://repository.icr.ac.uk/handle/internal/651
HKU Scholars Hub: Oncogenicity of the developmental transcription factor Sox9
Oncogenicity of the developmental transcription factor Sox9. Authors. Matheu, ACollado, MWise, CManterola, LCekaite, LTye, AJ ... SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles ... SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles ... Article: Oncogenicity of the developmental transcription factor Sox9. *Show simple item record ...http://hub.hku.hk/handle/10722/152631
Analysis of transcriptional targets of SOX9 during embryonic heart valve development reveals a critical network of...
... that are targeted by SOX9 are transcription factors and suggests that SOX9 may be regulating a network of transcription factors ... Interestingly, SOX9 targets that were down-regulated in the Sox9 cKO valves included numerous critical transcription factors ... A. Luciferase assays for SOX9 enhancer sites associated with the transcription factors Mecom and Nfia on HEK293T with SOX9 ... Since SOX4 is a direct target of SOX9, the ability of SOX4 to act as a co-factor of SOX9 would likely be dependent on SOX9- ...https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0220645
Events | UC Berkeley College of Natural Resources
A critical role of the transcription factor, Sox9, in early adipose development. ...https://nature.berkeley.edu/events/past
Activation of Wnt/β-catenin signalling affects differentiation of cells arising from the cerebellar ventricular zone.
0/Adenomatous Polyposis Coli Protein; 0/Biological Markers; 0/SOX9 Transcription Factor; 147336-22-9/Green Fluorescent Proteins ... Year: 2001) Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol152 ... that expressed Sox9 (Fig. 6A-C). Just 6.3% (±0.2%) of GFP+ cells in Apclox/lox embryos expressed Sox9, compared to 34.7% (±4.8 ... and Sox9 (E) revealed that the clear majority of β-gal+ cells also express Sox9 (F). The boxed region in the schematic ...http://www.biomedsearch.com/nih/Activation-Catenin-Signalling-Affects-Differentiation/22880037.html
Paweletz C[au] - PubMed - NCBI
Embryonic transcription factor SOX9 drives breast cancer endocrine resistance.. Jeselsohn R, Cornwell M, Pun M, Buchwalter G, ... Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Paweletz+C%5Bau%5D&dispmax=50
Ragnhild A Lothe - Institute of Clinical Medicine
Oncogenicity of the Developmental Transcription Factor Sox9. Cancer Research. ISSN 0008-5472. 72(5), s 1301- 1315 . doi: ... FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer. Genes, Chromosomes and Cancer. ISSN 1045- ... Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 ... Potential Downstream Target Genes of Aberrant ETS Transcription Factors Are Differentially Affected in Ewing's Sarcoma and ...https://www.med.uio.no/klinmed/english/people/aca/rlothe/index.html
Tissue specific expression of ar, sox9a, dmrt1, fig α, | Open-i
Basic Helix-Loop-Helix Transcription Factors/genetics. *Female. *Gene Expression Profiling. *Genetic Markers ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2500022_1477-7827-6-25-8&req=4
IJMS | Free Full-Text | Molecular Study of a Hoxa2 Gain-of-Function in Chondrogenesis: A Model of Idiopathic Proportionate...
Sox9 and Wnt5a. These data confirm the impairment of chondrogenic differentiation by Hoxa2 overexpression. They also show a ... our results give an insight into understanding proportionate short stature pathogenesis by highlighting molecular factors whose ... here that the persistent expression of Hoxa2 in chondrogenic territories provokes a general down-regulation of the main factors ... Akiyama, H. Control of chondrogenesis by the transcription factor Sox9. Mod. Rheumatol 2008, 18, 213-219. [Google Scholar] ...http://mdpi.com/1422-0067/14/10/20386/htm
SMART: HMG domain annotation
Crystal structure of a HMG domain of transcription factor SOX-9 bound to DNA (SOX-9/DNA) from Homo sapiens at 2.77 A resolution ... MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in ... Transcription factor SOX-9 (P48436) (SMART). OMIM:114290: Campomelic dysplasia with autosomal sex reversal. ... transcription by RNA polymerase I; Abf2 yeast ARS-binding factor [(PUBMED:11779632)]; yeast transcription factors lxr1, Rox1, ...http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&DOMAIN=HMG
Finally the search identified the human transcription factor SOX-9. This protein recognizes the sequence CCTTGAG along with ... a transcription factor part of the ternary complex factor subfamily. This protein is the nuclear target for the Ras-Raf-MAPK ( ... A search was made for transcription factors located on the human chromosome X with high expression in ovary stromal cells, and ... This can be done in three different ways: (i) functional classes, such as kinases, transcription factors, or G-protein-coupled ...http://www.mcponline.org/content/7/10/2019
FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non...
Cheung, M. and Briscoe, J. (2003). Neural crest development is regulated by the transcription factor Sox9. Development 130,5681 ... The gene encoding the T-box factor Tbx2 is a target for the Microphthalmia-associated transcription factor in melanocytes. J. ... The transcription factors PAX3 and SOX10 cooperate to induce expression of MITF in nascent melanoblasts (Watanabe et al., 1998 ... Kos, R., Reedy, M. V., Johnson, R. L. and Erickson, C. A. (2001). The winged-helix transcription factor FoxD3 is important for ...http://dev.biologists.org/content/136/11/1849?ijkey=17f990c0d20aad0dae44cebf71f7f1c6e8a860fa&keytype2=tf_ipsecsha
Reactome | SOX9 [nucleoplasm]
Transcription factor SOX-9, SOX9_HUMAN Locations in the PathwayBrowser Expand all Gene expression (Transcription) (Homo sapiens ... RUNX2 binds SOX9 (Homo sapiens) * RUNX2:SOX9 [nucleoplasm] (Homo sapiens) * SOX9 [nucleoplasm] (Homo sapiens) ... RNA Polymerase II Transcription (Homo sapiens) * Generic Transcription Pathway (Homo sapiens) * Transcriptional regulation by ... CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens) * SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [ ...https://reactome.org/content/detail/R-HSA-3214954
ATF6a, a Runx2-activable transcription factor, is a new regulator of chondrocyte hypertrophy | Journal of Cell Science
2001). The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the ... 2014b). XBP1S, a BMP2-inducible transcription factor, accelerates endochondral bone growth by activating GEP growth factor. J. ... as a transcription factor, might modulate IHH and PTHrP transcription and expression through interacting with specific cis- ... a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in ...http://jcs.biologists.org/content/129/4/717.long
IJMS | Free Full-Text | Comparative Analysis of Osteogenic/Chondrogenic Differentiation Potential in Primary Limb Bud-Derived...
Apart from lineage-specific marker genes, pluripotency factors (Nanog and Sox2) were also expressed in these models, reflecting ... cells of both models expressed mRNA transcripts for major cartilage-specific marker genes including Sox9, Acan, Col2a1, Snorc, ... Sox9 codes for the main chondrogenic transcription factor; Acan and Col2a1 are cartilage-specific ECM components; Hapln1 codes ... The Runt-related transcription factor-2 (Runx2; also known as Cbfa-1), the key transcription factor associated with osteoblast ...http://www.mdpi.com/1422-0067/14/8/16141/htm
2002) The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is ... 2012) Oncogenicity of the developmental transcription factor Sox9. Cancer Res 72:1301-1315. ... Sox9 is expressed in the brain and is a conserved transcription factor involved in central nervous system development (Esain et ... 2001) Two Sox9 genes on duplicated zebrafish chromosomes: expression of similar transcription activators in distinct sites. Dev ...http://molpharm.aspetjournals.org/content/91/6/609
Role of noggin as an upstream signal in the lack of neuronal derivatives found in the avian caudal-most neural crest |...
Cheung, M. and Briscoe, J. (2003). Neural crest development is regulated by the transcription factor Sox9. Development 130,5681 ... and Sox9 (G,G′), and cross-sections caudally to the level of somite 47 (s47) (C″,D″,E″,F″,G″). All transcription factors, ... Kos, R., Reedy, M. V., Johnson, R. L. and Erickson, C. A. (2001). The winged-helix transcription factor FoxD3 is important for ... Cheng, Y., Cheung, M., Abu-Elmagd, M. M., Orme, A. and Scotting, P. J. (2000). Chick sox10, a transcription factor expressed in ...http://dev.biologists.org/content/136/10/1717
Downstream genes of Sox8 that would affect adult male fertility. - PubMed - NCBI
Sox8 encodes a high mobility group transcription factor closely related to Sox9 and Sox10. Sertoli cells produceSOX8 protein, ...https://www.ncbi.nlm.nih.gov/pubmed/19339814
Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation |...
2003) The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev 17:1677-1689. doi: ... 2014) Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis. PLoS One 9:e87646. doi ... C, D, Relative fluorescence intensities of Meis1 in Sox9-negative (C) and Sox9-positive cells (D) of control and Meis1 cKO ... Myeloid ectopic viral integration site 1 homolog (Meis1) is a transcription factor of the three amino acid loop extension (TALE ...http://www.jneurosci.org/content/38/5/1277
2003) The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev 17:1677-1689. ... 2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306:2111-2115. ... 2002) The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109:61-73. ... The bHLH (basic helix-loop-helix) transcription factor Mash1 is best known for its role in the regulation of neurogenesis. ...http://www.jneurosci.org/content/27/16/4233
ZFIN Publication: Yan et al., 2002
SOX9 Transcription Factor; Transcription Factors/genetics*; Transcription Factors/physiology; Zebrafish/embryology*; Zebrafish/ ... one of two zebrafish orthologs of the human transcription factor SOX9. A mutation induced by ethyl nitrosourea changed a ... A zebrafish sox9 gene required for cartilage morphogenesis. Yan, Y.-L., Miller, C.T., Nissen, R.M., Singer, A., Liu, D., Kirn, ... A zebrafish sox9 gene required for cartilage morphogenesis. Development (Cambridge, England). 129(21):5065-5079. ...http://zfin.org/ZDB-PUB-021030-1
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. | Sigma-Aldrich
Sox9 is a transcription factor of the SRY family required for several steps of chondrogenesis. It activates the expression of ... Tip60 enhances acetylation of Sox9 mainly through K61, 253, 398 residues; however, the K61/253/398A mutant of Sox9 still ... but the mechanisms and role of cofactors involved in Sox9-regulated gene transcription are not fully understood. Here, we ... Gel shift assays showed the presence of a complex containing Sox9, Tip60 and the DNA of an enhancer region of the Col2a1 ...https://www.sigmaaldrich.com/catalog/papers/18390577