Hypophosphatemia: Practice Essentials, Background, Pathophysiology
Hypophosphatemia is defined as a phosphate level of less than 2.5 mg/dL (0. ... 12] In the proximal tubule, phosphate reabsorption by type 2 sodium phosphate cotransporters is regulated by dietary phosphate ... Several sodium-coupled transport proteins have been identified that enable intracellular uptake of phosphate by taking ... Any of the following three pathogenic mechanisms can cause hypophosphatemia:. * Inadequate intake ...
Sodium-dependent phosphate transport protein 2A - Wikipedia
This gene encodes a member of the type II sodium-phosphate cotransporter family. The sodium/phosphate cotransporter is a ... Sodium-dependent phosphate transport protein 2A, also known as Na+-Pi cotransporter 2a (NaPi-2a), is a protein in humans that ... Sodium-Phosphate+Cotransporter+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e ( ... Alternatively it can move dihydrogen phosphate (H2PO4− along with 2 sodium ions. For both movements the net charge is +1. Once ...
Pharmacology - Mangelsdorf Lab - Research output - University of Texas Southwestern Medical Center
Type III Sodium-Phosphate Cotransporter Proteins 100% * Endosomal Sorting Complexes Required for Transport 75% ... Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ... Katner, S. N., Bredhold, K. E., Steagall, K. B., Bell, R. L., Neal-Beliveau, B. S., Cheong, M. C. & Engleman, E. A., Jun 3 2019 ... Wang, Z., Schaffer, N. E., Kliewer, S. A. & Mangelsdorf, D. J., Apr 3 2017, In: Journal of Clinical Investigation. 127, 4, p. ...
FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa
Slc34a1 protein, mouse * Sodium-Phosphate Cotransporter Proteins * Sodium-Phosphate Cotransporter Proteins, Type IIa ... FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa ... The renal phosphate wasting in the transgenic mice was accompanied by the reduced expression of sodium phosphate cotransporter ... Sodium-Phosphate Cotransporter Proteins * Sodium-Phosphate Cotransporter Proteins, Type IIa * Symporters / biosynthesis ...
SLC34A1 Polyclonal Antibody (OSS00415W-100UL)
Sodium-dependent phosphate transport protein 2A; Sodium-phosphate transport protein 2A; sodium/phosphate co-transporter; Sodium ... Protein Aliases: Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; Na+-phosphate cotransporter type II; ... sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1; Solute carrier family ... inorganic phosphate transmembrane transporter activity sodium:phosphate symporter activity protein binding sodium-dependent ...
Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia...
... primary transport protein responsible for phosphate reabsorption in the kidney is the type II sodium-phosphate cotransporter ( ... In TIO most tumors overexpress the protein fibroblast growth factor-23 (FGF-23) inhibiting renal phosphate reabsorption in the ... The level of phosphate was slightly decreased with 2.14 mg/dL, and an oral substitution was restarted. The level of phosphate ... A 24-hour urine sample revealed an increased phosphate clearance of 44.7 mL/min (normal range: 5-16 mL/min). Fractional ...
Role of pyrophosphate in vascular calcification in chronic kidney disease | Nefrología
Subsequent studies have shown43 that PFA is not an effective inhibitor of sodium-phosphate co-transporter type III (Pit1 and ... The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. ... Phosphate transport. The main phosphate transporter family is the sodium-dependent phosphate cotransporter, also known as NaPi ... Pi are recovered from the extracellular space by the sodium-phosphate transporter type III (Pit1/2). To close the cycle of ...
SLC34A2 Polyclonal Antibody | G-AB-02855 | Gentaur Antibodies
Sodium-dependent phosphate transport protein 2B, Sodium-phosphate transport protein 2B, Sodium/phosphate cotransporter 2B, ... Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three ... Category Type: Polyclonal Antibody. Research Areas: Metabolism, Signal Transduction. Synonyms: Na (+) -dependent phosphate ... Overview: The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. ...
MeSH Browser
Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704] * Sodium-Phosphate Cotransporter Proteins, Type III ... Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829] * Sodium-Phosphate Cotransporter Proteins, Type III ... Proteins [D12.776] * Carrier Proteins [D12.776.157] * Membrane Transport Proteins [D12.776.157.530] * Solute Carrier Proteins [ ... Proteins [D12.776] * Membrane Proteins [D12.776.543] * Membrane Transport Proteins [D12.776.543.585] * Solute Carrier Proteins ...
Bone Mineralization and Related Disorders: Practice Essentials, Vitamin D Metabolism, Pathophysiology
Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/type IIc sodium-phosphate cotransporter: presentation ... a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 (DMP1), ... Dysfunctions in tubular phosphate reabsorption via the sodium-phosphate cotransporter, endocytotic reabsorption of the vitamin ... which encodes the renal type IIc sodium-phosphate cotransporter (NaPi-IIc). The typical presentation is severe rickets, ...
Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease | Kidney and Blood Pressure Research | Karger Publishers
... sodium-glucose co-transporter 2; NaPi-IIa/c, sodium-phosphate co-transporter IIa/c; GLUT2, glucose transporter 2. ... PTC, proximal tubule cell; VDBP, vitamin D binding protein; SGLT2, sodium-glucose co-transporter 2; NaPi-IIa/c, sodium- ... Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: cardiovascular and renal benefits in patients with chronic ... Furthermore, (iii) CYP27B1 activity is decreased probably due to increased FGF23 levels - simultaneously increasing CYP24A1 ...
MeSH Browser
Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704] * Sodium-Phosphate Cotransporter Proteins, Type III ... Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829] * Sodium-Phosphate Cotransporter Proteins, Type III ... Proteins [D12.776] * Carrier Proteins [D12.776.157] * Membrane Transport Proteins [D12.776.157.530] * Solute Carrier Proteins [ ... Proteins [D12.776] * Membrane Proteins [D12.776.543] * Membrane Transport Proteins [D12.776.543.585] * Solute Carrier Proteins ...
SLC34A1 gene: MedlinePlus Genetics
... which plays a role in the regulation of phosphate levels in the body (phosphate homeostasis). Learn about this gene and related ... The SLC34A1 gene provides instructions for making a protein called sodium-dependent phosphate transporter 2A (NaPi-IIa), ... solute carrier family 34 (sodium phosphate), member 1. *solute carrier family 34 (type II sodium/phosphate cotransporter), ... The SLC34A1 gene provides instructions for making a protein called sodium-dependent phosphate transporter 2A (NaPi-IIa), which ...
Halothane Decreases Na,K-ATPase, and Na Channel Activity in Alveolar Type II Cells | Anesthesiology | American Society of...
Clerici C, Soler P, Saumon G: Sodium-dependent phosphate and alanine transports but sodium-independent hexose transport in type ... Brown SES, Kim KJ, Goodman BE, Wells JR, Crandall ED: Sodium-amino acid cotransporter by type II alveolar epithelial cells. J ... Uptake of phosphate, alanine, Na, and Rb was expressed as nanomoles per milligram of protein. For evaluation of the recovery, ... Data represent the means +/- SD of three experiments done in triplicate. Values obtained for each concentration of halothane ...
Genetics of kidney stone disease | Nature Reviews Urology
... a G protein-coupled receptor) signalling pathway; and the metabolic pathways for vitamin D, oxalate, cysteine, purines and uric ... the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate ... Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J. Biol. Chem. 276, 9206-9213 (2001). ... Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a possible risk factor for idiopathic calcium oxalate ...
MeSH Browser
Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704] * Sodium-Phosphate Cotransporter Proteins, Type III ... Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829] * Sodium-Phosphate Cotransporter Proteins, Type III ... Sodium-Glucose Transport Proteins [D12.776.543.585.450.625.562] * Sodium-Phosphate Cotransporter Proteins [D12.776.543.585. ... Sodium, Potassium, Chloride-Cotransporter Sodium-Potassium-Chloride Cotransporter Sodium-Potassium-Chloride Cotransporters ...
MH DELETED MN ADDED MN
Type IIc D12.776.157.530.937.704.500 D12.776.543.585.937.829.500 Sodium-Phosphate Cotransporter Proteins, Type III D12.776. ... Sodium-Phosphate Cotransporter Proteins, Type II D12.776.157.530.937.704 D12.776.543.585.937.829 Sodium-Phosphate Cotransporter ... Sodium-Phosphate Cotransporter Proteins, Type IIb D12.776.157.530.937.704.249 D12.776.543.585.937.829.249 Sodium-Phosphate ... ELAV Proteins D12.776.641.520 D12.776.631.520 ELAV-Like Protein 2 D12.776.641.520.500 D12.776.631.520.500 ELAV-Like Protein 3 ...
MH DELETED MN ADDED MN
Type IIc D12.776.157.530.937.704.500 D12.776.543.585.937.829.500 Sodium-Phosphate Cotransporter Proteins, Type III D12.776. ... Sodium-Phosphate Cotransporter Proteins, Type II D12.776.157.530.937.704 D12.776.543.585.937.829 Sodium-Phosphate Cotransporter ... Sodium-Phosphate Cotransporter Proteins, Type IIb D12.776.157.530.937.704.249 D12.776.543.585.937.829.249 Sodium-Phosphate ... ELAV Proteins D12.776.641.520 D12.776.631.520 ELAV-Like Protein 2 D12.776.641.520.500 D12.776.631.520.500 ELAV-Like Protein 3 ...
MH DELETED MN ADDED MN
Type IIc D12.776.157.530.937.704.500 D12.776.543.585.937.829.500 Sodium-Phosphate Cotransporter Proteins, Type III D12.776. ... Sodium-Phosphate Cotransporter Proteins, Type II D12.776.157.530.937.704 D12.776.543.585.937.829 Sodium-Phosphate Cotransporter ... Sodium-Phosphate Cotransporter Proteins, Type IIb D12.776.157.530.937.704.249 D12.776.543.585.937.829.249 Sodium-Phosphate ... ELAV Proteins D12.776.641.520 D12.776.631.520 ELAV-Like Protein 2 D12.776.641.520.500 D12.776.631.520.500 ELAV-Like Protein 3 ...
MH DELETED MN ADDED MN
Type IIc D12.776.157.530.937.704.500 D12.776.543.585.937.829.500 Sodium-Phosphate Cotransporter Proteins, Type III D12.776. ... Sodium-Phosphate Cotransporter Proteins, Type II D12.776.157.530.937.704 D12.776.543.585.937.829 Sodium-Phosphate Cotransporter ... Sodium-Phosphate Cotransporter Proteins, Type IIb D12.776.157.530.937.704.249 D12.776.543.585.937.829.249 Sodium-Phosphate ... ELAV Proteins D12.776.641.520 D12.776.631.520 ELAV-Like Protein 2 D12.776.641.520.500 D12.776.631.520.500 ELAV-Like Protein 3 ...
MH DELETED MN ADDED MN
Type IIc D12.776.157.530.937.704.500 D12.776.543.585.937.829.500 Sodium-Phosphate Cotransporter Proteins, Type III D12.776. ... Sodium-Phosphate Cotransporter Proteins, Type II D12.776.157.530.937.704 D12.776.543.585.937.829 Sodium-Phosphate Cotransporter ... Sodium-Phosphate Cotransporter Proteins, Type IIb D12.776.157.530.937.704.249 D12.776.543.585.937.829.249 Sodium-Phosphate ... ELAV Proteins D12.776.641.520 D12.776.631.520 ELAV-Like Protein 2 D12.776.641.520.500 D12.776.631.520.500 ELAV-Like Protein 3 ...
TCDB » SEARCH
2002). The nptA gene of Vibrio cholerae encodes a functional sodium-dependent phosphate cotransporter homologous to the type II ... 2001). Interaction of the type IIa Na/P. i cotransporter with PDZ proteins. J. Biol. Chem. 276: 9206-9213. 11099500 ... 2016). Characterizing and evaluating the expression of the type IIb sodium-dependent phosphate cotransporter (slc34a2) gene and ... 2012). Molecular cloning and functional characterization of swine sodium dependent phosphate cotransporter type II b (NaPi-IIb ...
Organic Anion Transport Protein 1 | Colorado PROFILES
Sodium-Phosphate Cotransporter Proteins, Type II. *Sodium-Phosphate Cotransporter Proteins, Type III ... Organic Anion Transporters, Sodium-Independent [D12.776.157.530.450.074.500.781]. *Organic Anion Transport Protein 1 [D12.776. ... Organic Anion Transporters, Sodium-Independent [D12.776.543.585.450.074.500.875]. *Organic Anion Transport Protein 1 [D12.776. ... Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 ...
Hypophosphatemic Rickets: Practice Essentials, Etiology, Epidemiology
Hypophosphatemic rickets is a form of rickets that is characterized by low serum phosphate levels and resistance to treatment ... This phenomenon is secondary to defective regulation of the sodium-phosphate cotransporter in the epithelial cell brush border. ... from proteolysis through formation of a zinc-dependent protein-protein interaction. A mutated PHEX gene could result in failure ... A study by Zheng et al indicated that in X-linked hypophosphatemic rickets, the specific type of mutation, ie, truncating or ...
Pesquisa | Portal Regional da BVS
Sodium-glucose cotransporter 2 (SGLT2) inhibitor is a new oral antidiabetic drug that has greatly improved the cardiovascular ... and identified that the energy metabolism-related proteins and senescence-related proteins were disturbed. In vivo experiments ... Empagliflozin mitigates high phosphate-induced calcification in mouse VSMCs through the Nrf2/HO-1 anti-inflammatory pathway by ... Acute myeloid leukemia (AML), a very rare type of cancer, generally affects patients over 50 years old. While clinical drugs to ...
Frontiers | Endocrine Diseases of Newborn: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome "Current Insights Into...
The bone minerals calcium, phosphate and magnesium are all maintained at higher concentrations in utero to achieve adequate ... This article will guide clinicians through an updated review of calcium and phosphate physiology, then review specific ... This article will guide clinicians through an updated review of calcium and phosphate physiology, then review specific ... and hormone regulation factors have changed the understanding of calcium and phosphate homeostasis in the fetus and the newborn ...
Amino Acid Transport System y+L | Palmetto Profiles
MeSH Browser
Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704] * Sodium-Phosphate Cotransporter Proteins, Type III ... Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829] * Sodium-Phosphate Cotransporter Proteins, Type III ... Proteins [D12.776] * Carrier Proteins [D12.776.157] * Membrane Transport Proteins [D12.776.157.530] * Solute Carrier Proteins [ ... Proteins [D12.776] * Membrane Proteins [D12.776.543] * Membrane Transport Proteins [D12.776.543.585] * Solute Carrier Proteins ...
December | 2022 | MiRna21
Electroneutral sodium-bicarbonate co-transporter (NBCn1) will be indicated inside inactive osteoclasts, however its physical ... Propylene glycerin should not be see more employed in whey protein-based high-protein intermediate-moisture meals because it ... No less than three statistics are involved in individual management in the hospital: the actual health care oncologist, the ... The consequence of coaching using Weightlifting Finding or Pulling Types on Lift Bounce and Countermovement Hop Force-Time ...