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*  OriGene - SNRPN (NM 003097) cDNA Clone
... protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN ... The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame ( ... Synonyms : HCERN3; PWCR; PWS; RT-LI; SM-D; sm-N; SMN; SNRNP-N; SNURF-SNRPN. ... The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual ...
http://www.origene.com/human_cdna/NM_003097/SC118198.aspx
*  "Splicing of a critical exon of human Survival Motor Neuron is regulate" by Nirmal K. Singh, Natalia N. Singh et al.
Consistently, this oligonucleotide increased the levels of SMN protein in SMA patient-derived cells that carry only the SMN2 ... Considering that oligonucleotides annealing to intronic sequences do not interfere with exon-junction complex formation or mRNA ... SMN) gene, SMN1 and SMN2. In spinal muscular atrophy (SMA), SMN2 is not able to compensate for the loss of SMN1 due to ... Consistently, this oligonucleotide increased the levels of SMN protein in SMA patient-derived cells that carry only the SMN2 ...
https://escholarship.umassmed.edu/oapubs/1411/
*  Sporadic amyotrophic lateral sclerosis: is SMN-Gemins protein complex of importance for the relative resistance of oculomotor...
... hence the core of the SMN-Gemins complex was guessed to comprise only SMN and Gemin2; actually, the core of proteins ... this process requires apt functioning of a protein complex formed by the survival of motor neuron protein (SMN, or Gemin1), ... SMN) complex. J Biol Chem 2007; 282: 5825-5833. 40. Paushkin S, Gubitz AK, Massenet S, Dreyfuss G. The SMN complex, an ... A role for complexes of survival of motor neurons (SMN) protein with Gemins and profilin in neurite-like cytoplasmic extensions ...
https://www.termedia.pl/Sporadic-amyotrophic-lateral-sclerosis-is-SMN-Gemins-protein-complex-of-importance-for-the-relative-resistance-of-oculomotor-nucleus-motoneurons-to-degeneration-,20,34466,1,1.html
*  Investigation of the role of SMN1 and SMN2 haploinsufficiency as a risk factor for Hirayama's disease: clinical,...
0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 0/SMN Complex Proteins; 0/SMN1 protein, human; 0/SMN2 protein, human; 0/ ... RNA-Binding Proteins / genetics*. SMN Complex Proteins. Spain. Spinal Cord / pathology. Survival of Motor Neuron 1 Protein. ... 17452335 - Fukutin-related protein associates with the sarcolemmal dystrophin-glycoprotein complex.. 8242065 - Severe childhood ... Survival of Motor Neuron 1 Protein; 0/Survival of Motor Neuron 2 Protein ...
http://www.biomedsearch.com/nih/Investigation-role-SMN1-SMN2-haploinsufficiency/17850955.html
*  Comparative GO Graph (mouse, human, rat)
SMN complex. GEMIN4. IDA. Human. PMID:18984161. Cellular Component. GO:0034719. SMN-Sm protein complex. GEMIN4. IDA. Human. ... protein binding. GEMIN4. IPI. UniProtKB:Q8TEQ6. Human. PMID:11714716. Molecular Function. GO:0005515. protein binding. GEMIN4. ... protein binding. GEMIN4. IPI. UniProtKB:Q13137. Human. PMID:12869526. Molecular Function. GO:0005515. protein binding. GEMIN4. ... protein binding. GEMIN4. IPI. UniProtKB:O43609. Human. PMID:21988832. Molecular Function. GO:0005515. protein binding. GEMIN4. ...
http://www.informatics.jax.org/homology/GOGraph/69193
*  Strap - Serine-threonine kinase receptor-associated protein - Mus musculus (Mouse) - Strap gene & protein
Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the ... In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ... STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively ... Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that ...
http://www.uniprot.org/uniprot/Q9Z1Z2
*  SNRPE - Small nuclear ribonucleoprotein E - Homo sapiens (Human) - SNRPE gene & protein
Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that ... assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP ... SMN-Sm protein complex Source: UniProtKB ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the function ... section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes ...
http://www.uniprot.org/uniprot/P62304
*  Evgeny Makarov Introduction | Brunel University London
Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs'. Nucleic Acids ...
http://www.brunel.ac.uk/people/evgeny-makarov
*  Find Research Outputs - Discovery - the University of Dundee Research Portal
Composition of the Survival Motor Neuron (SMN) complex in Drosophila melanogaster. Matera, A. G., Raimer, A. C., Schmidt, C. A ... Climate change impact and adaptation for wheat protein. Asseng, S., Martre, P., Maiorano, A., Rötter, R. P., O'Leary, G. J., ... Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne RBR E3 ubiquitin ligases promotes cullin-RING ligase complex ...
https://discovery.dundee.ac.uk/en/publications/?format=&page=2
*  Loss of PLS3 orthologs enhances SMN loss of function de | Open-i
Loss of PLS3 orthologs enhances SMN loss of function defects in invertebrates.Previous studies in vertebrates suggested that ... Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular ... Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular ... Drosophila melanogaster and Caenorhabditis elegans each have a single gene encoding a protein orthologous to human SMN; ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2965752_pgen.1001172.g005&req=4
*  miRNA Entry for MI0007606
... of a group of 40 other miRNAs and two key proteins that make up a ribonucleic protein analogous to the SMN protein complex.[2] ... Deletions and loss of function to the SMN complex has been correlated with the neurodegenerative disease spinal muscular ... The miR-92 microRNAs are short single stranded non-protein coding RNA fragments initially discovered incorporated into an RNP ... As there is a relatively small number of miRNAs encoded in the human genome compared with the number of protein coding genes, ...
http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007606
*  Mir-92 microRNA precursor family - Wikipedia
... of a group of 40 other miRNAs and two key proteins that make up a ribonucleic protein analogous to the SMN protein complex. SWN ... Deletions and loss of function to the SMN complex has been correlated with the neurodegenerative disease spinal muscular ... As there is a relatively small number of miRNAs encoded in the human genome compared with the number of protein coding genes, ... Also present in the same cosediment peak was the eIF2C2 protein belonging to the family Argonaute. The Argonautes are involved ...
https://en.wikipedia.org/wiki/Mir-92_microRNA_precursor_family
*  Gem-associated protein 4 - Wikipedia
... a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631-6. doi:10.1074/jbc ... Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene. The product of this gene is part of the SMN ... The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced ... "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of ...
https://en.wikipedia.org/wiki/Gem-associated_protein_4
*  ASMscience | Translation and Protein
IRESs exhibit distinct requirements in terms of functional RNA-protein associations. Ribonucleoprotein complexes assembled on ... The presence of 3C and 3C-like proteinase domains in a wide range of positive-stranded RNA virus poly proteins argues strongly ... The study of IRES-ribonucleoprotein complexes in living cells has been addressed using reagents that are permeable to the cell ... Picornavirus genomes are tightly packed; the RNA encodes a single poly protein whose translation is governed by the internal ...
http://www.asmscience.org/content/book/10.1128/9781555816698.ch09
*  ISG20 Gene - GeneCards | ISG20 Protein | ISG20 Antibody
Protein Coding), Interferon Stimulated Exonuclease Gene 20, including: function, proteins, disorders, pathways, orthologs, and ... Associates with PML and SP100 in the PML NB complex. Associates with survival motor neuron protein (SMN)-containing ... Protein Symbol:. Q96AZ6-ISG20_HUMAN. Recommended name:. Interferon-stimulated gene 20 kDa protein. Protein Accession:. Q96AZ6. ... bodies and is associated with nuclear SMN protein-containing complexes. (PMID: 16514659) Espert L … Mechti N (Journal of ...
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ISG20
*  JW Jenkinson Memorial Lecture - Library Publishing Media
... the SMN protein complex, and miRNA based post-transcriptional silencing. The identification of a specific human disorder of ... this might equally be taken to indicate that their roles are less crucial than their protein counterparts, else there is much ... The bantam locus does not express a protein of known identity, but a ~90nt 3' region of extensive nucleotide homology to ...
http://libpubmedia.co.uk/jw-jenkinson-memorial-lecture/
*  SMART: Secondary literature for Fibrillarin domain
Immuno-sedimentation of the epitope-tagged SMN protein complex from HeLa cells expressing CFP-SMN showed that the SMN protein ... SMN is part of a multi-protein complex that includes Gemin2, Gemin3, and Gemin4. The SMN complex plays an important role in the ... The SMN complex contains the SMN protein Gemin2 and several additional Gemins that participate in snRNP biosynthesis. SMN was ... SMN) protein, a protein best known for its housekeeping role in the SMN-Gemin multiprotein complex involved in spliceosomal ...
http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=Fibrillarin
*  GEMIN5 Gene - GeneCards | GEMI5 Protein | GEMI5 Antibody
Protein Coding), Gem Nuclear Organelle Associated Protein 5, including: function, proteins, disorders, pathways, orthologs, and ... This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays ... Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the ... Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=GEMIN5
*  Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? - PubMed - NCBI
Sm proteins are released from pICln-PRMT5 complex and bind the SMN complex.. B1) The SMN complex is composed of SMN, Gemins2-8 ... the snRNA is brought into the Sm protein-bound SMN complex by binding to Gemin5.. C) The SMN complex places the Sm proteins ... allowing the SMN complex with the snRNA to bind snurportin and importin, which mediates transport of the SMN complex with an ... leading to reduced SMN protein levels and a selective dysfunction of motor neurons. SMN, together with partner proteins, ...
https://www.ncbi.nlm.nih.gov/pubmed/19584893?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2
*  Table of Contents | Journal of Cell Science
A role for protein phosphatase PP1γ in SMN complex formation and subnuclear localization to Cajal bodies Benoît Renvoisé, ... The SEC6 protein is required for contractile vacuole function in Chlamydomonas reinhardtii Karin Komsic-Buchmann, Lisa Marie ... Role of LRP1 in transport of CCN2 protein in chondrocytes Kazumi Kawata, Satoshi Kubota, Takanori Eguchi, Eriko Aoyama, ... The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis Chao-Wen Wang, Shu-Chuan Lee ...
http://jcs.biologists.org/content/125/12
*  Medical Home Portal - Spinal Muscular Atrophy
The SMN protein complex appears to be involved in the biogenesis of specific ribonucleoproteins that control regulation of gene ... Missing or defective motor neuron survival protein (SMN protein) results in SMA. This protein is coded for by the SMN1 gene, ... Copy number of the SMN 2 gene appears to control severity of SMA by a complex mechanism allowing some production of the ... Congenital bone fractures in spinal muscular atrophy: functional role for SMN protein in bone remodeling.. J Child Neurol. 2007 ...
https://www.medicalhomeportal.org/diagnoses-and-conditions/spinal-muscular-atrophy
*  Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing | PNAS
... increasing the binding affinity between Sm proteins and SMN-complex to promote U snRNP assembly (44). Although direct evidence ... and WD repeat protein/MEP50 (13-15). In this complex, U1, 2, 4, 5 snRNP Sm proteins Sm B/B′, D1, D3, and U6 snRNP-specific Sm- ... and the Sm-like protein LSm4, and their interaction with the SMN protein. RNA 7:1531-1542. ... 2001) Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln. Curr Biol 11: ...
http://www.pnas.org/content/107/44/19114?ijkey=a256d52ccb84460fc8c45fe7647fe543af8854c1&keytype2=tf_ipsecsha
*  SMN1 gene - Genetics Home Reference - NIH
This protein is one of a group of proteins called the SMN complex, which is important for the maintenance of specialized nerve ... The SMN complex helps to assemble the cellular machinery needed to process pre-mRNA. The SMN complex is also important for the ... The SMN1 gene provides instructions for making the survival motor neuron (SMN) protein. The SMN protein is found throughout the ... A small amount of SMN protein is produced from a gene similar to SMN1 called SMN2. Several different versions of the SMN ...
https://ghr.nlm.nih.gov/gene/SMN1
*  Gideon Dreyfuss | Members | Institute for Translational Medicine and Therapeutics | Perelman School of Medicine at the...
We are now particularly interested in a large multi-protein complex, the Survival of Motor Neurons Protein (SMN) complex, that ... and functions of the SMN complex. To assemble RNPs, the SMN complex must recognize and bring together their protein and RNA ... We are engaged in determining the specific features in the RNAs and the proteins that mediate their binding to the SMN complex ... The Survival of Motor Neurons (SMN) complex -RNA-binding proteins -Spinal Muscular Atrophy/neurogenerative disease -Assembly ...
https://www.med.upenn.edu/apps/faculty/index.php/g5455356/p17458
*  Biogenesis of small nuclear RNPs | Journal of Cell Science
In the cytoplasm, the survival of motor neurons (SMN) protein complex facilitates the assembly of pre-snRNA with a ... Paushkin, S., Gubitz, A. K., Massenet, S. and Dreyfuss, G. (2002). The SMN complex, an assemblyosome of ribonucleoproteins. ... to form the snRNP core complex (Paushkin et al., 2002). The Sm proteins bind to the conserved Sm-binding site (Sm, consensus ... Binding of the Lsm protein complex is essential for targeting of U6 snRNA to the nucleolus and, afterward, to the Cajal body ( ...
http://jcs.biologists.org/content/117/25/5949?ijkey=e334ebbb14903bafc66323782c154e25207465c9&keytype2=tf_ipsecsha