Similar to small regulatory RNAs such as microRNAs and snoRNAs, these functions often involve complementary base pairing with ... In eukaryotes, RNA transcription is a tightly regulated process. Noncoding RNAs act upon different aspects of this process, ... such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), ... and other short RNAs. Given that some lncRNAs have been reported to have the potential to encode small proteins or micro- ...

Our aim was to investigate these redox transcription factors in conjunction with redox-related microRNAs in naevi and melanoma ... MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by imperfect matching of mRNA [ ... A. S. Nikitina, E. I. Sharova, S. A. Danilenko et al., "Novel RNA biomarkers of prostate cancer revealed by RNA-seq analysis of ... Y. Zhao, L. Min, C. Xu et al., "Construction of disease-specific transcriptional regulatory networks identifies co-activation ...

... are small regulatory RNAs produced by Dicer proteins that regulate gene expression in development and adaptive responses to the ... Little is known about the selection of regulatory mechanisms for plant microRNAs. Now a Dicer partnering protein, DRB2, is ... environment1-4. In animals, the degree of base pairing between a miRNA and its target messenger RNA seems to determine whether ... Here we show that the form of regulatory action directed by a plant miRNA is determined by DRB2, a DICER-LIKE1 (DCL1) ...

RNA splicing, RNA stability and translation. Among the best studied ncRNAs are small interfering RNAs (siRNAs) and microRNAs ( ... miRNAs). Both of them regulate gene expression through the RNA interference (RNAi) pathway. It is currently estimated that ... The properties of gene regulatory networks such as feedback loops generated by the combinatorial action of TFs and miRNAs, ... MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous regulators of numerous target genes. Hundreds of human ...

... non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They can modulate various biochemical ... and physiological processes, including plant response and resistance to fungal pathogens, by regulating the... ... Small RNA isolation, library construction and sequencing. Small RNAs were isolated from 100 mg root tissue of both cultivars in ... In this dynamic and complex network of gene regulatory pathways during the immune response, short non-coding RNAs, so-called ...

tiny RNAs: See micro-RNAs trans-acting RNA: A Trans- Acting RNA as a Control Switch in Escherichia coli: DsrA Modulates ... small temporal RNA stRNA: Two ~ 21-nt RNAs regulate C. elegans temporal development, and we argue that one of these RNAs is ... al An abundant class of tiny RNAs with probably regulatory roles in Caenorhabditis elegans Science 294 (5543): 858- 862, 26 ... 2000 Broader term: microRNAs; Related term: RNA interference RNAi spliced leader RNA: The small RNAs which provide spliced ...

... is considered not only as a cytoprotective factor regulating the expression ... it could be easily predicted that these small regulatory RNA molecules serve important functions in modulating the Nrf2/HO-1 ... using ChIP-seq analysis identified several microRNAs which may potentially regulate Nrf2 activity [211]. The direct evidence of ... Seydoux G, Fire A (1994) Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans. Development ...

For example, microRNAs (miRNAs) and small interfering RNAs siRNAs are small regulatory RNA molecules about 22 nucleotides long ... Regulatory RNA (miRNAs and siRNAs). Some types of non-coding RNAs (RNAs that do not encode proteins) help regulate the ... messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), and regulatory RNAs. ... Still other RNA molecules, such as tiny microRNAs (miRNAs), act as regulators of other genes, and new types of non-protein- ...

A small fragment of RNA may regulate the expression of RORA, a gene implicated in many autism-related pathways, according to a ... Genetics: Regulatory RNAs found in autism risk regions by Jessica Wright / 16 April 2013 ... People with autism show differences from controls in the levels of microRNAs, small noncoding bits of RNA, in the social and ... In autism, RNA snippets vary little by brain region, age by Nicholette Zeliadt / 20 November 2014 ...

... and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). However, whether ... Luciferase reporter assay and RNA pull-down assay were carried out to detect the interaction between miR-383 and LncRNA PTTG3P ... In this study, we found that PTTG3P was up-regulated in HCC tissues and cells. Functional experiments demonstrated that ... acting as a competing endogenous RNA (ceRNA). The PTTG3P-miR-383-CCND1/PARP2 axis modulated HCC phenotypes. Moreover, PTTG3P ...

miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of ... The collective findings indicate that miR-21 plays a regulatory role in host-pathogen interactions through IRAK4-mediated NF-κB ... Furthermore, we demonstrated that miR-21 regulates inflammatory responses through NF-κB signaling pathways. The collective ... Furthermore, we demonstrated that miR-21 regulates inflammatory responses through NF-κB signaling pathways. ...

N2 - MicroRNAs (miRNAs) are small non-coding RNAs that function in transcriptional and post-transcriptional regulation of gene ... Several miRNAs have been implicated in regulating prostate cancer (PCa) progression. Deregulations of miRNA regulatory networks ... Small Untranslated RNA Medicine & Life Sciences 18% * Gene Expression Regulation Medicine & Life Sciences 15% ... AB - MicroRNAs (miRNAs) are small non-coding RNAs that function in transcriptional and post-transcriptional regulation of gene ...

24 selected miRs in IFN-β-treated Huh-7 cells and in three different clones of Huh-7 cells carrying a self-replicating HCV RNA ... To date, the effect produced by HCV on the expression of microRNAs (miRs) involved in the interferon-β (IFN-β) antiviral ... The present findings reveal that 3 IFN-β-regulated miRs and 37 genes, which are likely their functional targets, were commonly ... it has been proposed that also microRNAs (miRs), a class of small non-coding regulatory RNAs, are involved in the antiviral ...

MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level. Proteoglycans are ... RESULTS: Whole transcriptome profiles of the mouse dental epithelium and mesenchyme were investigated by RNA sequencing (RNA- ... We screened for microRNA with immune-regulatory functions against M.tb by next generation sequencing of peripheral blood ... Next generation sequencing reveals miR-431-3p/miR-1303 as immune-regulating microRNAs for active tuberculosis. ...

In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and ... Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation ... Small non-coding RNAs, represented by RNA molecules smaller than 200 nucleotides, include microRNAs, snoRNAs, piRNAs and tRNAs ... Wang, C.; Yao, N.; Lu, C.-L.; Li, D.; Ma, X. Mouse microRNA-124 regulates the expression of Hes1 in P19 cells. Front. Biosci. ...

The Keane lab will explore how the structural configurations of large RNAs control the production of smaller regulatory RNA ... The Keane lab will explore how the structural configurations of large RNAs control the production of smaller regulatory RNA ... Among these regulatory RNAs, microRNAs play critical roles in the control of gene expression. These microRNAs are encoded in ... human genome revealed the surprising existence of a vast assortment of small RNA molecules that have the ability to regulate ...

... on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. Non (protein)-coding RNAs are ... Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different ... Amongst these, long non-coding RNAs (lncRNAs) are species of 200 bp to ,100 K bp in length, that recognize, and bind unique and ... Amongst these, long non-coding RNAs (lncRNAs) are species of 200bp to ,100K bp in length, that recognize and bind unique and ...

... are a group of small non-coding RNAs that regulate gene expression at the RNA level. MicroRNAs have positive regulatory effects ... are a group of small non-coding RNAs that regulate gene expression at the RNA level. MicroRNAs have positive regulatory effects ... MicroRNAs (miRNAs) are, small (roughly 19-25 nucleotides in length), conserved, non-coding, single-stranded, and functional RNA ... of all genes and the majority of genetic pathways are regulated by microRNAs. In general, microRNAs and their target molecules ...

The changes in the G1-to-S cell cycle pathway showed that 1,25(OH)2D3 down-regulates the genes influencing the G1-to-S phase ... Adding microRNA regulation to the network enabled the identification of gene targets of significantly expressed microRNAs after ... Moreover, after 1,25(OH)2D3 treatment the gene expression in several cancer-related processes was down-regulated. The more ... Network algorithms were used to (1) identify active network modules and (2) integrate microRNA regulation in the network. ...

USF1 can also regulate long non-coding (lnc)RNA and micro (mi)RNA that are involved in cancer development and other diseases ( ... RNAs, indicating the regulatory function of USF1. It was also demonstrated that USF1 directly binds to the promoter region of ... 4B). There was a variety of gene types in these 2,718 genes, including protein coding genes, lincRNA, microRNA, small nucleolar ... thus forming a multiple-level regulatory network of USF1; this regulatory network was reflected in the RNA-seq data of USF1. In ...

MicroRNAs (miRNAs) are highly conserved small non-coding RNAs that regulate gene expression with post-transcriptional silencing ... Four ng of RNA collected from plasma and urine and 25 ng of RNA collected from the tissue samples were reverse-transcribed ... Taking into account the important regulatory roles that miRNAs have in cancer development, by acting either as oncogenes or as ... The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis. Br J Cancer. ...

... and the RNA-dependent RNA polymerase. However, none of the CASS components is orthologous to its apparent eukaryotic functional ... is a mechanism of defense against invading phages and plasmids that functions analogously to the eukaryotic RNA interference ( ... including the double-stranded RNA-specific helicase-nuclease (dicer), the endonuclease cleaving target mRNAs (slicer), ... distinct forms of regulatory small RNAs involved in eukaryotic gene silencing: small interfering (si) RNAs and micro (mi) RNAs ...

... has studied microRNAs, a class of small RNAs. Molecule) Regulatory Genes and COVID-19 Severity in 259 Unvaccinated COVID-19 ... investigated the association between microRNAs, a class of small RNA molecules that regulate genes, and COVID-19 severity among ...

In general, microRNAs, a class of small (~21 nucleotide) non-coding RNAs, negatively regulate the expression of their target ... an increasing number of reports have implicated a new class of small regulatory RNA molecules, termed microRNAs (miRNAs), in ... small, non-coding RNAs that negatively regulate gene expression in vertebrates through multiple mechanisms, such as ... a large number of studies have revealed that microRNAs constitute effective regulatory networks and can regulate approximately ...

... small noncoding RNAs have emerged as key elements of the circuitry involved in regulating epididymal function and hence sperm ... Although the regulatory network responsible for spatial coordination of epididymal function remains unclear, recent evidence ... RNA/methods",. author = "Brett Nixon and Stanger, {Simone J.} and Mihalas, {Bettina P.} and Reilly, {Jackson N.} and Anderson ... small noncoding RNAs have emerged as key elements of the circuitry involved in regulating epididymal function and hence sperm ...

MicroRNAs (miRNAs) are regulatory small non-coding RNAs that can regulate gene expression by binding to gene elements, such as ... Overexpression of Long Non-Coding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma. Bo Wang, Yun Su, Qun ... MicroRNAs (miRNAs) are regulatory small non-coding RNAs that can regulate gene expression by binding to gene elements, such as ... MicroRNA-590-5p Regulates Proliferation and Invasion in Human Hepatocellular Carcinoma Cells by Targeting TGF-β RII. Xiaofeng ...

However, he thought the gene lin-4 expressed a regulatory protein that inhibited the expression of the gene lin-14. Until 1993 ... refer to such small regulatory RNAs. In this article, we will introduce this small but important guy, micro ribonucleic acid, ... RNA, except that their expression patterns are often inconsistent with the role of regulating developmental time. This suggests ... Lin-4 RNA is the first small RNA found. In 2000, a second small RNA, let-7 RNA was discovered, which inhibits lin-41 to promote ...

... functions as a competing endogenous RNA to regulate target genes expression by sponging microRNAs (miRs) to play cancer- ... Small interfering RNAs of AFAP1-AS1 (siAFAP1-AS1) were transfected into the (CD44v6)(+) cells. The levels of AFAP1-AS1 were ... However, the regulatory mechanism of AFAP1-AS1 in cervical cancer (CC) stem cells is unknown. The present study aimed to ... BACKGROUND@#Long non-coding RNA (lncRNA) actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) ...

MicroRNAs (miRNAs) are endogenous small noncoding RNAs that negatively regulate the expression of target genes through mRNA ... Review: MicroRNAs and their regulatory roles in plant-environment interactions (Annu Rev Plant Bio) ($). March 29, 2019. ... Some of these effectors suppress the host RNA silencing pathway, which is mediated by a diverse… ... MicroRNAs and their regulatory roles in plant-environment interactions (Annu Rev Plant Bio) ($). ...