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*  Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation
YY1 interacts with the conserved N-terminal Mad homology 1 domain of Smad4 and to a lesser extent with Smad1, Smad2, and Smad3 ... Smad proteins transduce transforming growth factor beta (TGF-beta) and bone morphogenetic protein (BMP) signals that regulate ... Protein Binding, Protein Structure; Tertiary, RNA; Small Interfering/metabolism, Research Support; Non-U.S. Gov't, Reverse ... Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:101622
*  Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts - Mori - 2003 - Arthritis &...
Protein and mRNA levels of SMAD3, but not of SMAD4 or SMAD7, were variably elevated in scleroderma fibroblasts compared with ... Next article in issue: Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and ... Next article in issue: Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and ... Intracellular compartmentalization of cellular SMAD proteins in the presence and absence of TGFβ was studied by antibody- ...
http://onlinelibrary.wiley.com/doi/10.1002/art.11157/abstract
*  Smad2 and Myocardin-Related Transcription Factor B Cooperatively Regulate Vascular Smooth Muscle Differentiation From Neural...
α-SMA and SM22α protein expression were detected by Western blot. F, Quantitative analysis of the protein expression in (E) by ... Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 1998;394:909-913. ... Smooth muscle α-actin (α-SMA) and SM22α protein expression was detected by Western blot. C, Quantification of protein ... Their protein expression was detected by Western blot (E). *P,0.01 compared with Ad-GFP group treated with TGF-β for both α-SMA ...
http://circres.ahajournals.org/content/113/8/e76
*  Smad4 - Mothers against decapentaplegic homolog 4 - Rattus norvegicus (Rat) - Smad4 gene & protein
Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to ... Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic ... Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a ... Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to ...
http://www.uniprot.org/uniprot/O70437
*  Anti-TGFBR1/Tgf Beta Receptor I Antibody
Total Protein Analysis. Electrophoresis/Gel Staining. Protein Transfer. Blocking Reagents. Chromogenic Development. ... Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is ... The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic ... Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. ...
https://www.bosterbio.com/anti-tgfbr1-antibody-pa1731.html
*  Immunolocalisation and expression of Smad2 and Smad4 proteins in dog testis during postnatal development. - Semantic Scholar
Smad2 and Smad4 proteins, was investigated in immature and mature dog testis. Cellular localisation of Smad2 and Smad4 proteins ... the expression of Smad2 and Smad4 proteins in the Sertoli cells of mature testis was higher than in the immature group (P , ... The temporospatial distribution of Smad2 and Smad4 proteins in testicular cells suggests that these two signalling molecules ... Smad2 and Smad4 were widely expressed in the testes, mainly immunolocalised in the cytoplasm of gonocytes, Leydig cells and ...
https://www.semanticscholar.org/paper/Immunolocalisation-and-expression-of-Smad2-and-Sma-Zhang-He/15bc10b8285fb524dc94e898387a34ce0ff70a84
*  SMAD4 (Human) Recombinant Protein (P01) - (H00004089-P01) - Products - Abnova
... recombinant protein with GST-tag at N-terminal. (H00004089-P01) - Products - Abnova ... Human SMAD4 full-length ORF ( AAH02379, 1 a.a. - 552 a.a.) ... AKT1 & SMAD4 Protein Protein Interaction Antibody Pair. *DI0415 ... Human SMAD4 full-length ORF ( AAH02379, 1 a.a. - 552 a.a.) recombinant protein with GST-tag at N-terminal. ... Best use within three months from the date of receipt of this protein. ...
http://www.abnova.com/products/products_detail.asp?catalog_id=H00004089-P01
*  Clinical significance of molecular markers in pancreatic cancer
Chapter 7 The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. * Chapter 8 Pancreatic Mucinous Cystic Neoplasms ...
http://dare.uva.nl/search?metis.record.id=198848
*  Safety of thalidomide and bevacizumab in patients with hereditary hemorrhagic telangiectasia | SpringerLink
SMAD4. Gene encoding the SMAD4 protein. SOC. System Organ Classification. TH. Thalidomide ... 91 (66.9%) had pathogenic variants in ACVRL1 (HHT type 2); 27 (19.9%) in ENG, and 3 (2.2%) in SMAD4. Each drug was prescribed ... For each agent, Centers were asked for the number, age, sex, and genotype (ENG, ACVRL1, SMAD4, or unknown) of HHT patients; and ... which encode proteins involved in the transforming growth factor ß pathway [2]. Clinical presentation varies greatly depending ...
https://link.springer.com/article/10.1186%2Fs13023-018-0982-4
*  JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming growth factor-β.
0/ID2 protein, human; 0/Inhibitor of Differentiation Protein 2; 0/Proto-Oncogene Proteins c-jun; 0/Smad4 Protein; 0/ ... Proto-Oncogene Proteins c-jun / genetics, metabolism*. Signal Transduction / physiology. Smad4 Protein / genetics, metabolism. ... The study found JunB in Smad4 immune complexes and Smad4 in JunB precipitates (Fig. 2 E), indicating that JunB and Smad4 are ... 4 B). Depletion of JunB reduced phospho-Tyr levels in 120-130- and 60-70-kD proteins (Fig. 4 B). Pax is a 68-kD protein that ...
http://www.biomedsearch.com/nih/JunB-contributes-to-Id2-repression/22391036.html
*  Molecular Imaging with MRI: Potential Application in Pancreatic Cancer
F. Liu, "SMAD4/DPC4 and pancreatic cancer survival. Commentary re: M. Tascilar et al., The SMAD4 protein and prognosis of ... Additionally, some protein markers have newly been discovered. CEACAM-1 [68, 69], CEACAM-6 [70-72], CD133 [73-75], S100A4 [76- ... Y.-F. Ji, H. Huang, F. Jiang, R.-Z. Ni, and M.-B. Xiao, "S100 family signaling network and related proteins in pancreatic ... These related proteins and highly expressed genes in malignant tumors are the design foundation of functionally targeted ...
https://www.hindawi.com/journals/bmri/2015/624074/
*  Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer | Clinical Cancer Research
Results: SMAD4 protein expression was informative in 1,381/1,564 cases. SMAD4 loss was found in 293/1,381 (21%) cases. Of 1,088 ... SMAD4 protein expression was validated by assessing mRNA expression using available expression array data. SMAD4 expression was ... SMAD4 mRNA expression. To assess to what extent SMAD4 expression by IHC reflects SMAD4 mRNA expression, we used previously ... SMAD4 IHC expression correlates with SMAD4 mRNA expression. Expression of SMAD4 mRNA showed a gradual decrease from strong ...
http://clincancerres.aacrjournals.org/content/22/12/3037
*  Uterine glands | definition of uterine glands by Medical dictionary
IMMUNOLOCALIZATION OF THE SMAD4 PROTEIN IN POSTNATAL PORCINE UTERUS. The finger-like villi of trophectoderm which penetrate ... Roles of conceptus secretory proteins in establishment and maintenance of pregnancy in ruminants ...
http://medical-dictionary.thefreedictionary.com/uterine+glands
*  AKT1 polyclonal antibody - (PAB11177) - Products - Abnova
AKT1 & MAPK14 Protein Protein Interaction Antibody Pair. *DI0011. * AKT1 & SMAD4 Protein Protein Interaction Antibody Pair ... RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase ... The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and ...
http://www.abnova.com/Products/products_detail.asp?Catalog_id=PAB11177&SL=EN
*  AKT1 Validated Chimera RNAi - (H00000207-R01V) - Products - Abnova
AKT1 & MAPK14 Protein Protein Interaction Antibody Pair. *DI0011. * AKT1 & SMAD4 Protein Protein Interaction Antibody Pair ... RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase ... The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and ...
https://www.abnova.com/Products/products_detail.asp?Catalog_id=H00000207-R01V
*  AKT1 polyclonal antibody - (PAB12948) - Products - Abnova
AKT1 & MAPK14 Protein Protein Interaction Antibody Pair. *DI0011. * AKT1 & SMAD4 Protein Protein Interaction Antibody Pair ... RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase ... The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and ... Mechanism of activation of protein kinase B by insulin and IGF-1.. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, ...
http://www.abnova.com/products/products_detail.asp?Catalog_id=PAB12948
*  AKT1/AKT3 (Human) Cell-Based ELISA Kit - (KA2566) - Products - Abnova
AKT1 & MAPK14 Protein Protein Interaction Antibody Pair. *DI0011. * AKT1 & SMAD4 Protein Protein Interaction Antibody Pair ... RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase ... OTTHUMP00000037911,OTTHUMP00000037912,RAC-gamma serine/threonine protein kinase,protein kinase B gamma,serine threonine protein ... The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases ...
http://www.abnova.com/products/products_detail.asp?catalog_id=KA2566
*  AKT1 polyclonal antibody - (PAB4548) - Products - Abnova
AKT1 & MAPK14 Protein Protein Interaction Antibody Pair. *DI0011. * AKT1 & SMAD4 Protein Protein Interaction Antibody Pair ... RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase ... The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and ... Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta- ...
https://www.abnova.com/products/products_detail.asp?Catalog_id=PAB4548
*  AKT1 polyclonal antibody - (PAB9932) - Products - Abnova
AKT1 & MAPK14 Protein Protein Interaction Antibody Pair. *DI0011. * AKT1 & SMAD4 Protein Protein Interaction Antibody Pair ... RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase ... The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and ... Western blot using AKT1 polyclonal antibody (Cat # PAB9932) shows detection of endogenous protein in whole cell extracts from H ...
https://www.abnova.com/products/products_detail.asp?Catalog_id=PAB9932&SL=
*  AKT1 monoclonal antibody (M19), clone 4E2 - (H00000207-M19) - Products - Abnova
AKT1 (AAH00479.1, 127 a.a. ~ 200 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00000207- ... AKT1 & MAPK14 Protein Protein Interaction Antibody Pair. *DI0011. * AKT1 & SMAD4 Protein Protein Interaction Antibody Pair ... RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase ... The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and ...
http://www.abnova.com/products/products_detail.asp?catalog_id=H00000207-M19
*  DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res. 2001;7:4115-4121. [PubMed] ... Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- ... DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma. J Clin Oncol. 2002;20:4531-4542. [PubMed] ... Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2668706/?lang=en-ca
*  WikiGenes
Loss of Smad4 protein expression occurs infrequently in endometrial carcinomas.. Smad4 is a member of the Smad proteins, which ... Loss of Smad4 protein expression occurs infrequently in endometrial carcinomas. Liu, F.S., Chen, J.T., Hsieh, Y.T., Ho, E.S., ... Diffusely positive expression of Smad4 protein was detected in all 20 cases of endometrial hyperplasia and in most of the ... Smad4 is also a tumor suppressor gene for cancers of the pancreas, colon, and lung. The aim of this study was to investigate ...
https://www.wikigenes.org/e/ref/e/14501814.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
When the TGF-? pathway is activated, SMAD proteins, including the common mediator SMAD4, are subsequently translocated into the ... Luciferase reporter and SMAD4-knockdown experiments demonstrated that specific SMAD4 binding to the SBE located at -3790 bp to ... The SMAD4 protein has been identified as a mediator of transforming growth factor-? (TGF-?) superfamily signaling, which ... The K-RAS protein is associated with mitochondria, and induces a rapid suppression of respiratory chain complex-I and a ...
https://www.jove.com/visualize?author=Paul%20J%20Chiao%20
*  Wounded confluent MDCK monolayers express LM-332. (A) W | Open-i
Recombinant Proteins/pharmacology. *Signal Transduction. *Smad2 Protein/metabolism. *Smad4 Protein/metabolism. *Transcription, ... Laminin (LM)-332 is an extracellular matrix protein that plays a structural role in normal tissues and is also important in ... Laminin (LM)-332 is an extracellular matrix protein that plays a structural role in normal tissues and is also important in ... and the Smad2-Smad4 complex.Significantly, we show that expression of LM-332 in MDCK cells is an autocrine response to ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2965683_zmk0211096250008&req=4
*  CIPSM - Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells
Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells. ... Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing ... Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of ... Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to ...
http://cipsm.de/publications/research-area-f/adult-neurogenesis-requires-smad4-mediated-bone-morphogenic-protein-signaling-in-stem-cells/