SKP Cullin F-Box Protein Ligases/chemistry*. *SKP Cullin F-Box Protein Ligases/genetics ... This review discusses the functions of a group of ubiquitin ligases, the SCF (SKP1-CUL1-F-box protein) family, in the ... b) The F-box protein β-TRCP controls DNA damage-induced cell cycle arrest, cessation of DNA damage signaling, and recovery from ... The SCF (SKP1/CUL1/F-box protein) complexes are assembled using a CUL1 scaffold. CUL1 recruits an E2 ubiquitin conjugating ...
SKP Cullin F-Box Protein Ligases / antagonists & inhibitors * Signal Transduction * Snail Family Transcription Factors ...
Cullins are proteins that function as scaffolds for modular ubiquitin ligases typified by the SCF (Skp1-Cul1-F-box) complex. ... Programmed destruction of regulatory proteins through the ubiquitin-proteasome system is a widely used mechanism for ... Cullin Proteins * Mel-26 protein, C elegans * SKP Cullin F-Box Protein Ligases ... and a member of the F-box family of proteins. F-box proteins bind Skp1 through the F-box motif, and substrates by means of ...
SKP Cullin F-Box Protein Ligases); EC 2.3.2.27 (Trim63 protein, mouse); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 2.7.1.- ( ... Prote nas Ligases SKP Culina F-Box/gen tica. Prote nas Ligases SKP Culina F-Box/metabolismo. Serina-Treonina Quinases TOR/ ... 0 (Insulin); 0 (Keto Acids); 0 (Muscle Proteins); 0 (Tripartite Motif Proteins); 0 (Valerates); 3F752311CD (beta- ... mTOR protein, rat); EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa); GMW67QNF9C (Leucine); IY9XDZ35W2 (Glucose). ...
SKP Cullin F-Box Protein Ligases); EC 2.3.2.27 (Trim63 protein, rat); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 3.6.1.- ( ... 0 (Microfilament Proteins); 0 (Muscle Proteins); 0 (Protein Isoforms); 0 (Synpo2l protein, mouse). ... Prote nas Ligases SKP Culina F-Box/metabolismo. Sepse/tratamento farmacol gico. Sepse/patologia. Prote nas com Motivo ... 0 (Bone Morphogenetic Protein 4); 0 (Intercellular Signaling Peptides and Proteins); 0 (Troponin T); 0 (Vitamins); IY9XDZ35W2 ( ...
Many F-box proteins are target recognition subunits of SCF (Skp, Cullin, F-box) ubiquitin-ligase complexes. fsn-1 functions in ... SKP Cullin F-Box Protein Ligases/chemistry*. *SKP Cullin F-Box Protein Ligases/genetics ... Here we report the identification of FSN-1, a novel F-box protein that is required in presynaptic neurons for the restriction ... An SCF-like ubiquitin ligase complex that controls presynaptic differentiation.. Liao EH1, Hung W, Abrams B, Zhen M. ...
Effects of neddylation and deneddylation on F-box proteins Slimb and Ago.(a) CSN5 clones generated in Drosophila third-instar ... SKP Cullin F-Box Protein Ligases/metabolism*. *Signal Transduction/physiology*. *Transcription Factors/metabolism* ... as the protein level of the Flag-conjugated F-box protein Archipelago (Flag-Ago) is unaltered in CSN5 cells (Fig. 1d), ... as the protein level of the Flag-conjugated F-box protein Archipelago (Flag-Ago) is unaltered in CSN5 cells (Fig. 1d), ...
Biotin ligase BirAG was obtained by removing a cryptic intron site in the BirA∗ gene when expressed in rice protoplasts. We ... Biotin ligase BirAG was obtained by removing a cryptic intron site in the BirA* gene when expressed in rice protoplasts. We ... By using this system, multiple proteins were identified that associated with and/or were proximate to OsFD2 in vivo. Our ... By using this system, multiple proteins were identified that associated with and/or were proximate to OsFD2 in vivo. Our ...
... it must first be recognized by an E3 ubiquitin ligase (18). One class of ubiquitin ligases, the SCF (Skp-Cullin-F box), is a ... the fly homolog of the human F-box protein β-TrCP (13, 22). Likewise, in Neurospora, the F-box protein FWD-1 regulates the ... The F-box protein Slimb controls the levels of clock proteins Period and Timeless. Nature 420 : 178-182. ... The F-box protein recognizes and binds a specific sequence within its cognate protein substrate (36). In flies, Slimb binds ...
... and jasmonate ZIM-domain protein (JAZ). COI1 acts as multi-component signaling hub that binds with each component. InsP is ... and jasmonate ZIM-domain protein (JAZ). COI1 acts as multi-component signaling hub that binds with each component. InsP is ... The jasmonate receptor is a multi-component complex, composed of Arabidopsis SKP-LIKE PROTEIN1 (ASK1), CORONATINE INSENSITIVE 1 ... The jasmonate receptor is a multi-component complex, composed of Arabidopsis SKP-LIKE PROTEIN1 (ASK1), CORONATINE INSENSITIVE 1 ...
The CSN positively regulates Ci155 protein stability in wing discs.(a) CSN5 clones are revealed by the absence of GFP (green) ... SKP Cullin F-Box Protein Ligases/metabolism*. *Signal Transduction/physiology*. *Transcription Factors/metabolism* ... Protein levels of Ci-Myc detected by the anti-Myc antibody (red) are reduced in CSN4 mutant clones (arrow). (d) The ci-lacZ ... Protein levels of Ci-Myc detected by the anti-Myc antibody (red) are reduced in CSN4 mutant clones (arrow). (d) The ci-lacZ ...
Chen, B B; Glasser, J R; Coon, T A; Mallampalli, R K (August 2013). "Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates ... 2004). "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model". ... Aurora B has been shown to bind to end-binding protein 1 (EB1), a protein that regulates microtubule dynamics. Indirect ... including the type-III intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein (GFAP). In general ...
SINA also participates in an Skp Cullin F-Box-like complex (Santelli et al., 2005). Plant SINA families comprise highly ... yellow fluorescent protein. GFP. green fluorescent protein. CFP. cyan fluorescent protein. GUS. β-glucuronidase. DAI. days ... the Lotus japonicus CERBERUS and orthologous Medicago truncatula LIN genes encoding E3 ligase U box proteins, which are ... 2009). LIN, a novel type of U-box/WD40 protein, controls early infection by rhizobia in legumes. Plant Physiol. 151: 1239-1249. ...
... and Skp2 Skp-F-box-cullin (SCF) E3 ubiquitin ligases, which degrade and suppress steady-state LT protein levels. Knockdown of ... Protein-mediated viral latency through cellular SCF E3 ligase targeting of viral replication proteins is a unique form of ... Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence. Hyun Jin Kwun, Yuan Chang, and ... MCV can sense stresses in its intracellular environment, such as nutrient loss, through SCF E3 ligase activities, and responds ...
... skp cullin f-box protein ligases MeSH D08.811.464.938.750.750.500 - cullin proteins MeSH D08.811.464.938.750.875 - von hippel- ... ubiquitin-protein ligases MeSH D08.811.464.938.750.186 - fanconi anemia complementation group l protein MeSH D08.811.464.938. ... valine-tRNA ligase MeSH D08.811.464.267.500 - coenzyme a ligases MeSH D08.811.464.267.500.200 - acetate-coa ligase MeSH D08.811 ... 500.600 - succinate-coa ligases MeSH D08.811.464.754.600 - dna ligases MeSH D08.811.464.754.720 - rna ligase (atp) MeSH D08.811 ...
... a Cullin homolog (Kipreos et al. 1996); SKR-1/-2, Skp homologs (Nayak et al. 2002); and PROM-1, an F-box protein (Jantsch et al ... We previously identified the F-box protein, PROM-1, as well as the SCF E3 ubiquitin-ligase complex proteins, SKR-1/-2 and CUL-1 ... Ubiquitin is then added to an F-box protein-bound substrate protein by the action of an E3 ubiquitin ligase, and further ... PROM-1 is homologous to human F-box protein FBXO47, with sequence conservation across the full length of the protein, and ...
Skp, Cullin, F-box containing complex) ubiquitin ligase complex.11 Fbxo32 was primarily identified as a vital effector involved ... 10 Another antihypertrophic E3 ligase is the muscle-specific F-box protein, Fbxo32, which is a component of the SCF ( ... AMP-activated protein kinase regulates E3 ligases in rodent heart. Circ Res. 2011;109:1153-1161. doi: 10.1161/CIRCRESAHA. ... Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A. 2001;98:14440- ...
... classically act as adapter components that confer substrate specificity to SKP Cullin F-box E3 ubiquitin-protein ligase ... The target proteins recognized by the F-box protein are typically polyubiquitinated and subsequently degraded by the 26S ... SMAX1 has weak similarity to the ClpB protein HSP101/HOT1. ClpB proteins are typically involved in disaggregating proteins, ... 2011) F-box protein MAX2 has dual roles in karrikin and strigolactone signaling in Arabidopsis thaliana. Proc Natl Acad Sci USA ...
... which is part of the Skp-Cullin-F-box complex SCFCOI1, an E3 ubiquitin ligase that ubiquitinates proteins and targets them for ... including the JAZ proteins themselves). A third study by Yan et al. also identified JAZ proteins as repressors of jasmonate ... encoded a member of a family of ZIM-domain-containing proteins (JAZ proteins). Like Thines et al., they showed that ... Jasmonate stimulated the COI1- and proteasome-dependent degradation of a fusion protein encoding JAZ1 or JAZ6 linked to β- ...
In C. elegans motor neurons, another F-box protein, FSN-1, forms an SCF complex with the Skp and Cullin homologs SKR-1 and CUL- ... Cullin, F-box containing) ubiquitin ligase complexes that target proteins for proteasomal degradation (Kipreos and Pagano 2000 ... Complexes that target proteins for degradation often contain F-box proteins. Here we characterize MEC-15, an F-box protein with ... T01E8.4 encodes a protein with an F-box domain and WD repeats. Both motifs are involved in protein-protein interactions and ...
ZEITLUPE (ADO1/ZTL) is the F-box protein that associates with the SCF (for Skp/Cullin/F-box) E3 ubiquitin ligase that is ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q9LKL2. A0A178UC73. Arabidopsis thaliana (Mouse- ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q9LKL2. A0A178UC73. D7MUK2. UPI000A29DC1C. ...
Skp-Cullin-F-box) complex, is composed of four major components: Skp1, Cul1/Cdc53, Roc1/Rbx1/Hrt1, and an F-box protein. The F- ... Gcm binds to 2 F-box proteins, Supernumerary limbs (Slimb) and Archipelago (Ago), adaptors of SCF E3 ubiquitin ligases. ... Here we discuss the importance of F-box proteins by providing a general overview and examples of how F-box proteins function in ... the F-box motif of the F-box protein while it associates with phosphorylated substrates through its second protein-protein ...
... shown to accelerate c-Jun degradation by allowing its recognition by the E3 ligase Fbw7-containing Skp/Cullin/F-box protein ... The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A 2006; 103: 12753-8. ... protein-protein interaction. Introduction. WWOX encodes a WW domain-containing oxidoreductase tumor suppressor that spans the ... WW domain class I recognizes and binds to the short PY oligopeptide motif PPxY to mediate protein-protein interactions ( 8). ...
The TIR1 gene encodes an F-box protein, one of the four subunits of the ubiquitin protein ligase (SCF complex) that confers ... The other subunits are the scaffold components Skp-like proteins (ASK), Cullin (CUL), and the RBX protein. ... FAS1 and FAS2 proteins interact with AtMSI1, a WD-40 repeat protein, and together they show replication-dependent nucleosome ... and the ubiquitin protein ligase (E3), which in the case of mitotic cyclin is thought to be the anaphase-promoting complex (APC ...
Skp-Cullin-F-box) ubiquitin ligases which are involved in tagging proteins for degradation in the proteasome. ... Skp-Cullin-F-box) ubiquitin ligases and thereby regulates the degradation of potent oncogenes such as cyclin E, Myc, c-Jun and ... Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature. 2001 ;413(6853 ... Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. Embo J. 2004 ;23(10):2116-25 ...
... component of the Skp, Cullin, F-box (SCFβ-TrCP) E3 ubiquitin ligase by Vpu leads to proteasome-dependent degradation of newly ... the viral protein(s) responsible for peroxisome loss had not been identified. As a first step in determining which HIV protein( ... protein assay kit (Thermo Fisher Scientific, Waltham, MA). Equivalent amounts of total protein (20 μg) were resolved by SDS- ... and the amounts of NEFAs relative to the protein content in the sample (measured using a Bio-Rad protein assay kit) were ...
Alcat1 is a labile protein that is lysosomally degraded by the ubiquitin E3 ligase Skp-Cullin-F-box containing the Fbxo28 ... an inhibitor of Cullin-RING E3 ubiquitin ligases. Thus, LPS increases HDAC2-mediated Alcat1 deacetylation and facilitates SCF- ... Calcium/calmodulin-dependent Protein Kinase (CaMK) Ialpha Mediates the Macrophage Inflammatory Response to Sepsis Journal of ... The primary goal of this study was to identify soluble proteins in plasma that associate with the severity of airflow ...
SKP)-cullin-F box ubiquitin ligase: the S-phase kinase-associated protein 2 (SKP2) and CDC28 protein kinase b1 (CKS1) complex. ... and S-phase kinase-associated protein 2 (SKP2)/CDC28 protein kinase 1b (CKS1) ubiquitin ligase complex in human hepatocellular ... Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci U S A 2001; 98: 2515-20. ... As a consequence, some differences in protein levels may be underestimated. Proteins were then transferred onto nitrocellulose ...
An E3 ubiquitin ligase Skp, Cullin, F-box-containing complex including the F-box protein ZTL is crucial for clock-regulated ... rapa ZTL protein and the transgenic Arabidopsis ZTL-GFP fusion protein. ZTL protein was detected at only slightly increased ... 2003) Circadian phase-specific degradation of the F-box protein ZTL is mediated by the proteasome. Proc Natl Acad Sci USA 100: ... 2004) The F-box protein ZEITLUPE confers dosage-dependent control on the circadian clock, photomorphogenesis, and flowering ...
ZEITLUPE (ZTL) is the F-box protein that associates with the SCF (Skp/Cullin/F-box) E3 ubiquitin ligase that is responsible for ... Arabidopsis Proteins/metabolism/*physiology, Arabidopsis/enzymology/*physiology, Circadian Rhythm/*physiology, Cullin Proteins ... Home » CUL1 regulates TOC1 protein stability in the Arabidopsis circadian clock. CUL1 regulates TOC1 protein stability in the ... physiology, Movement, Plant Leaves/physiology, Seasons, Seedling/physiology, Sunlight, Temperature, Ubiquitin-Protein Ligases/ ...