Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review | Calcified Tissue...
... reduced muscle mass and strength (sarcopenia), and increased adiposity (obesity) in mid ... Myostatin inhibits myoblast proliferation and thus acts as a negative regulator of skeletal muscle mass. ... Myokines are involved in communication pathways from skeletal muscle to bone [123]. Myostatin (growth differentiation factor-8 ... Sarcopenia, is a progressive and generalized skeletal muscle disorder, which can be detected as low muscle strength and ...
Science-based policy: targeted nutrition for all ages and the role of bioactives | European Journal of Nutrition
... "much smaller than the role of fat mass and muscle strength". These conclusions that the loss of skeletal muscle mass, per se, ... and this includes those genes which are specifically responsible for cellular proliferation, differentiation and apoptosis [53 ... of the total body creatine pool is sequestered in skeletal muscle and that creatine is turned over in muscle through the ... as a surrogate assessment of muscle mass has resulted in erroneous conclusions on the importance of skeletal muscle in ...
Acne and Genetics | SpringerLink
Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 ... Expression of perilipin A on the surface of lipid droplets increases along with the differentiation of hamster sebocytes in ... Indentification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ... Ppar gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 1999;4:611-7. ...
Cellular stress response mechanisms of Rhizoma coptidis: a systematic review | Chinese Medicine
Effect of berberine on the insulin resistance and TLR4/IKKbeta/NF-kappaB signaling pathways in skeletal muscle of obese rats ... Low levels of ROS/RNS are necessary for cell proliferation and differentiation. Excessive levels of ROS/RNS directly destruct ... Effect of acute activation of 5′-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle. J Appl ... Sustained postexercise increases in AS160 Thr642 and Ser588 phosphorylation in skeletal muscle without sustained increases in ...
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity | Acta...
... consistent with previous reports in mitochondria isolated from heart and skeletal muscle tissue from ClpP null mice [29] and in ... in neuronal differentiation medium. Neuronal differentiation medium contained Neurobasal and DMEM/F12 (1:3), B27, N2, GlutaMax ... of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation. ... The quantitative data from each of independent differentiation batch are shown in Suppl Fig. 1e. The Students t test. All data ...
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues | Diabetologia
Schulz TJ, Huang TL, Tran TT et al (2011) Identification of inducible brown adipocyte progenitors residing in skeletal muscle ... Anatomical localisation influences adipogenesis in both humans and rodents with respect to proliferation and differentiation of ... terminal differentiation and mature adipocytes. The first step of white adipocyte differentiation is the generation of pre- ... is the result of white adipocyte trans-differentiation or differentiation of specific precursors is still a matter of debate ...
TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms | Cellular and Molecular Life...
a IFM analysis of the expression of the proliferation marker KI67 and formation of primary cilia (arrows), labeled with anti- ... Ezratty EJ, Stokes N, Chai S et al (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during ... Cortés CR, McInerney-Leo AM, Vogel I et al (2016) Mutations in human C2CD3 cause skeletal dysplasia and provide new insights ... signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin. PLoS One 9:e94801. ...
Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development | Cellular and Molecular Life Sciences
Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells. Dev Dyn 237(4):1144-1152. doi: ... Liu J, Sato C, Cerletti M, Wagers A (2010) Notch signaling in the regulation of stem cell self-renewal and differentiation. ... Kingsley DM, Bland AE, Grubber JM, Marker PC, Russell LB, Copeland NG, Jenkins NA (1992) The mouse short ear skeletal ... Noseda M, Fu Y, Niessen K, Wong F, Chang L, McLean G, Karsan A (2006) Smooth Muscle alpha-actin is a direct target of Notch/CSL ...
Evolving Role of Vitamin D in Immune-Mediated Disease and Its Implications in Autoimmune Hepatitis | SpringerLink
The effects of 1,25-dihydroxyvitamin D3 on human T lymphocyte activation and proliferation: a cell cycle analysis. J Immunol. ... Bhat M, Ismail A. Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis. J Steroid ... Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol. 2007;179:1634-1647. ... Targeted ablation of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme: evidence for skeletal, reproductive, and immune ...