Models, MolecularMolecular Sequence DataAmino Acid SequenceProtein ConformationBinding SitesCrystallography, X-RayStructure-Activity RelationshipKineticsProtein Structure, SecondaryTime FactorsTreatment OutcomeMagnetic Resonance SpectroscopyProtein BindingSide-Population CellsHydrogen BondingDrug-Related Side Effects and Adverse ReactionsMolecular StructureProtein Structure, TertiaryMutagenesis, Site-DirectedFunctional LateralityDose-Response Relationship, DrugMutationSubstrate SpecificityBase SequenceEscherichia coliRecombinant ProteinsModels, ChemicalPeptidesHydrogen-Ion ConcentrationAmino AcidsMolecular ConformationThermodynamicsDouble-Blind MethodWaterModels, BiologicalAmino Acid SubstitutionNuclear Magnetic Resonance, BiomolecularSequence Homology, Amino AcidStereoisomerismHydrophobic and Hydrophilic InteractionsCatalysisAntipsychotic AgentsStatic ElectricityCattleCell MembraneLigandsCatalytic DomainMicroscopy, ElectronFollow-Up StudiesBacterial ProteinsBiological TransportComputer SimulationProtein FoldingRabbitsDrug Therapy, CombinationProspective StudiesProteinsAlanineHistidineAdministration, OralAntineoplastic AgentsAnalgesics, OpioidMembrane ProteinsCysteineCell LineLysineTryptophanPainClinical Trials as TopicRetrospective StudiesRats, Sprague-DawleyCircular DichroismPain MeasurementDrug Administration ScheduleFacial AsymmetryOxidation-ReductionTemperatureHemiplegiaAspartic AcidChromatography, High Pressure LiquidBiomechanical PhenomenaSequence AlignmentMagnetic Resonance ImagingAdministration, TopicalPeptide FragmentsSolutionsTomography, X-Ray ComputedOligopeptidesMandiblePhenylalanineRotationCloning, MolecularNauseaHydrolysisLipid BilayersDogsBrainMovementDNASolvents