Chemokine Expression in Human Astrocytes in Response to Shiga Toxin 2Chemokine Expression in Human Astrocytes in Response to Shiga Toxin 2

A. D. OBrien and R. K. Holmes, "Shiga and Shiga-like toxins," Microbiological Reviews, vol. 51, no. 2, pp. 206-220, 1987. View ... "Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells," Journal ... P. B. Eisenhauer, M. S. Jacewicz, K. J. Conn et al., "Escherichia coli Shiga toxin 1 and TNF-α induce cytokine release by human ... Chemokine Expression in Human Astrocytes in Response to Shiga Toxin 2. Naomi Kioka, Koichi Minami, Akira Tamura, and Norishige ...
more infohttps://www.hindawi.com/journals/iji/2012/135803/ref/

Purification and Characterization of Shiga Toxin 2f, an Immunologically Unrelated Subtype of Shiga Toxin 2Purification and Characterization of Shiga Toxin 2f, an Immunologically Unrelated Subtype of Shiga Toxin 2

Stx2f was also much more stable at low pH and high temperature compared to Stx2a, suggesting the toxin itself may survive ... Background Shiga-like toxin 2 (Stx2) is one of the most important virulence factors in enterohaemorrhagic Escherichia coli (E. ... Toxins Is the Subject Area "Toxins" applicable to this article? Yes. No. ...
more infohttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059760

Toxins  | Free Full-Text | An Improved Method for the Sensitive Detection of Shiga Toxin 2 in Human Serum | HTMLToxins | Free Full-Text | An Improved Method for the Sensitive Detection of Shiga Toxin 2 in Human Serum | HTML

Shiga toxins (Stx) released by Stx-producing E. coli (STEC) are virulence factors that are most closely associated with ... Purification and characterization of Shiga toxin 2f, an immunologically unrelated subtype of shiga toxin 2. PLoS ONE 2013, 8, ... Villysson, A.; Tontanahal, A.; Karpman, D. Microvesicle involvement in Shiga toxin-associated infection. Toxins 2017, 9, 376. [ ... H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. Eur. J. Biochem. 1988, 171, 45-50. [ ...
more infohttps://www.mdpi.com/2072-6651/10/2/59/htm

Toxins | Free Full-Text | Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase...Toxins | Free Full-Text | Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase...

HGEC and HK-2 were pretreated with OUA and then incubated with the toxins. OUA protected the HGEC viability from Stx2 and SubAB ... The protective action of OUA on HGEC and HK-2 was associated with a decrease in apoptosis and an increase in cell proliferation ... The majority of cases are associated with Shiga toxin (Stx)-producing Escherichia coli (STEC). In Argentina, HUS is endemic and ... STEC strains expressing Stx type 2 (Stx2) are responsible for the most severe cases of this pathology. Subtilase cytotoxin ( ...
more infohttp://www.mdpi.com/2072-6651/9/7/226

Characterization of the Escherichia coli O157:H7 Outbreak Strain Whose Shiga Toxin 2 Gene Is Inactivated by IS1203v Insertion.Characterization of the Escherichia coli O157:H7 Outbreak Strain Whose Shiga Toxin 2 Gene Is Inactivated by IS1203v Insertion.

H7 Outbreak Strain Whose Shiga Toxin 2 Gene Is Inactivated by IS1203v Insertion. Jpn J Infect Dis. 2013;66(3):201-6 Authors: ... Characterization of the Escherichia coli O157:H7 Outbreak Strain Whose Shiga Toxin 2 Gene Is Inactivated by IS1203v Insertion. ...
more infohttps://medworm.com/7281250/characterization-of-the-escherichia-coli-o157h7-outbreak-strain-whose-shiga-toxin-2-gene-is-inactiv/

Bovine Non-O157 Shiga Toxin 2-Containing Escherichia coli Isolates Commonly Possess stx2-EDL933 and/or stx2vhb Subtypes |...Bovine Non-O157 Shiga Toxin 2-Containing Escherichia coli Isolates Commonly Possess stx2-EDL933 and/or stx2vhb Subtypes |...

Bovine Non-O157 Shiga Toxin 2-Containing Escherichia coli Isolates Commonly Possess stx2-EDL933 and/or stx2vhb Subtypes. Kim N ... Detection of Shiga-like toxin (stx1 and stx2), intimin (eaeA), and enterohaemorrhagic Escherichia coli (EHEC) hemolysin (EHEC ... Stx2 subtyping of Shiga toxin-producing Escherichia coli isolated from cattle in France: detection of a new stx2 subtype and ... A new Shiga toxin 2 variant (Stx2f) from Escherichia coli isolated from pigeons. Appl. Environ. Microbiol. 66:1205-1208. ...
more infohttps://jcm.asm.org/content/41/6/2716?ijkey=11464d6429bfffbbf41d51848da53edb341ee441&keytype2=tf_ipsecsha

Frontiers | Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine...Frontiers | Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine...

... that of the infant rabbit expresses the Shiga toxin receptor Gb3. We also demonstrate that Shiga toxin treatment of the infant ... that of the infant rabbit expresses the Shiga toxin receptor Gb3. We also demonstrate that Shiga toxin treatment of the infant ... However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking. One of ... However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking. One of ...
more infohttps://www.frontiersin.org/articles/10.3389/fcimb.2012.00135/full

Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates com by Kim Brett, Michael A Hornitzky et al."Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates com" by Kim Brett, Michael A Hornitzky et al.

stx2 genes from 138 Shiga toxin-producing Escherichia coli (STEC) isolates, of which 127 were of bovine origin (58 serotypes) ... 2 isolates contained stx2vhb only. Although 7 of 11 (63.6%) human O113:H21 isolates associated with diarrhea possessed stx2- ... Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx2-EDL933 and/or stx2vhb subtypes ... Brett, K. N., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. & Djordjevic, S. P. (2003). Bovine non-O157 Shiga toxin 2- ...
more infohttps://ro.uow.edu.au/smhpapers/1971/

Structure of Shiga Toxin Type 2 (Stx2) from <i>Escherichia coli</i> O by Marie E. Fraser, Masao..."Structure of Shiga Toxin Type 2 (Stx2) from <i>Escherichia coli</i> O" by Marie E. Fraser, Masao...

To investigate the differences among the Stxs, which are all AB5 toxins, the crystal structure of Stx2 from E. coli O157:H7 was ... Any of these structural differences might result in different mechanisms of action of the two toxins and the development of ... Several serotypes of Escherichia coli produce protein toxins closely related to Shiga toxin (Stx) from Shigella dysenteriae ... Several serotypes of Escherichia coli produce protein toxins closely related to Shiga toxin (Stx) from Shigella dysenteriae ...
more infohttps://digitalcommons.unl.edu/usuhs/109/

Lysogeny with Shiga Toxin 2-Encoding Bacteriophages Represses Type III Secretion in Enterohemorrhagic Escherichia coli -...Lysogeny with Shiga Toxin 2-Encoding Bacteriophages Represses Type III Secretion in Enterohemorrhagic Escherichia coli -...

Typical EHEC strains are defined by the expression of a type III secretion (T3S) system, the production of Shiga toxins (Stx) ... Lysogenisation of Shiga toxin-encoding bacteriophage represses cell motility.. *Shoichi Mitsunaka, Naoki Sudo, Yasuhiko Sekine ... Cumulative effect of prophage burden on Shiga toxin production in Escherichia coli.. *Paul C. M. Fogg, J. R. Saunders, Alan J. ... Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization.. *Cory Robinson, James F. ...
more infohttps://www.semanticscholar.org/paper/Lysogeny-with-Shiga-Toxin-2-Encoding-Bacteriophages-Xu-McAteer/611b6912a1817795542475e40d7bdc626f4b6cde

Effects of Antibiotics on Shiga Toxin 2 Production and Bacteriophage Induction by Epidemic Escherichia coli O104:H4 Strain |...Effects of Antibiotics on Shiga Toxin 2 Production and Bacteriophage Induction by Epidemic Escherichia coli O104:H4 Strain |...

Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice. J. Infect. Dis. 181:664- ... Toxin gene expression by Shiga toxin-producing Escherichia coli: the role of antibiotics and the bacterial SOS response. Emerg ... Rifaximin does not induce toxin production or phage-mediated lysis of Shiga toxin-producing Escherichia coli. Antimicrob. ... Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany-preliminary report. N. Engl. J. Med. 365 ...
more infohttps://aac.asm.org/content/56/6/3277

Virulence of the Shiga Toxin Type 2-Expressing Escherichia coli O104:H4 German Outbreak Isolate in Two Animal Models |...Virulence of the Shiga Toxin Type 2-Expressing Escherichia coli O104:H4 German Outbreak Isolate in Two Animal Models |...

Virulence of the Shiga Toxin Type 2-Expressing Escherichia coli O104:H4 German Outbreak Isolate in Two Animal Models. Tonia ... Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N. Engl. J. Med. 365:1771-1780. ... Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization. Proc. Natl. Acad. Sci. U. S. A ... Two copies of Shiga-like toxin II-related genes common in enterohemorrhagic Escherichia coli strains are responsible for the ...
more infohttps://iai.asm.org/content/81/5/1562

Human Antibody against Shiga Toxin 2 Administered to Piglets after the Onset of Diarrhea Due to Escherichia coli O157:H7...Human Antibody against Shiga Toxin 2 Administered to Piglets after the Onset of Diarrhea Due to Escherichia coli O157:H7...

ODtoxin + HuMAb − ODtoxin only)/(ODno toxin − ODtoxin only)] × 100, where the ODs were determined for plates containing toxin ... Purification of Shiga toxin and Shiga-like toxins I and II by receptor analog affinity chromatography with immobilized P1 ... Virulence of Shiga toxin-producing Escherichia coli (STEC) in orally-infected mice correlates with the type of toxin produced ... Variants of Shiga-like toxin II constitute a major toxin component in Escherichia coli O157 strains from patients with ...
more infohttps://iai.asm.org/content/73/8/4607?ijkey=a50f51f4daee981e88633a03de7f424c1fc4cd21&keytype2=tf_ipsecsha

Detection and characterization of E. coli O157:H7 and induced shiga toxin-2 coding bacteriophagesDetection and characterization of E. coli O157:H7 and induced shiga toxin-2 coding bacteriophages

... Login ... Muller, EE 2002, Detection and characterization of E. coli O157:H7 and induced shiga toxin-2 coding bacteriophages, MSc ... Detection and characterization of E. coli O157:H7 and induced shiga toxin-2 coding bacteriophages. en. ... H7 using repetitive sequence analysis and induction of shiga toxin (Stx)¬converting phages which carry the genes coding for Stx ...
more infohttps://repository.up.ac.za/handle/2263/29049?show=full

Table 2 - Prevalence of Non-O157:H7 Shiga Toxin-Producing Escherichia coli in Diarrheal Stool Samples from Nebraska - Volume 6,...Table 2 - Prevalence of Non-O157:H7 Shiga Toxin-Producing Escherichia coli in Diarrheal Stool Samples from Nebraska - Volume 6,...

We determined the prevalence of Shiga-toxin producing Escherichia coli (STEC) in diarrheal stool samples from Nebraska by three ... 2 polymerase chain reaction (PCR). Fourteen (4.2%) of 335 specimens were positive by at least one method (CT-SMAC culture [6 of ... 14], EHEC enzyme immunoassay [13 of 14], stx1,2 PCR [14 of 14]). Six contained serogroup 0157, while non-0157 were as prevalent ... Prevalence of Non-O157:H7 Shiga Toxin-Producing Escherichia coli in Diarrheal Stool Samples from Nebraska Paul D. Fey*. , R.S. ...
more infohttps://wwwnc.cdc.gov/eid/article/6/5/00-0513-t2

Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks | BMC Microbiology | Full TextPhylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks | BMC Microbiology | Full Text

These data could indicate that Shiga toxins are experiencing purifying selection. ... Stx1 and Stx2 are genetically and immunologically distinct but share the same compound toxin structure, method of entry and ... Shiga toxins 1 and 2 (Stx1 and Stx2) are bacteriophage-encoded proteins that have been associated with hemorrhagic colitis, ... Similarity of Shiga Toxin 1 A and B subunit genes. The Shiga Toxin 1 A and B subunit genes showed very little difference in ...
more infohttps://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-7-109

RCSB PDB - Protein Feature View 









 - Shiga-like toxin 2 subunit A - P09385 (STXA BP933)RCSB PDB - Protein Feature View - Shiga-like toxin 2 subunit A - P09385 (STXA BP933)

Shiga-like toxin contains a single A subunit and multiple copies of a B subunit. UniProt ... P09385 - Enterobacteria phage 933W 2 * Q9R398 - Enterobacteria phage 933W no matching PDB entries ...
more infohttp://www.rcsb.org/pdb/protein/P09385

Multiplex PCR for the simultaneous detection of the Enterobacterial gene wecA , the Shiga Toxin genes ( stx 1 and stx 2 ) and...Multiplex PCR for the simultaneous detection of the Enterobacterial gene wecA , the Shiga Toxin genes ( stx 1 and stx 2 ) and...

Two important virulence factors are the Shiga toxin (Stx) and the E. coli outer membrane protein (Eae) or intimin, encoded by ... Characterization of Shiga toxin subtypes and virulence genes in porcine Shiga toxin-producing Escherichia coli. Front Microbiol ... Heijnen L, Medema G. Quantitative detection of E. coli, E. coli O157 and other Shiga toxin producing E. coli in water samples ... The common ovine Shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d ...
more infohttps://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3457-8

Ingested shiga toxin 2 (stx2) causes histopathological changes in kidney, spleen, and thymus tissues and mortality in mice<...Ingested shiga toxin 2 (stx2) causes histopathological changes in kidney, spleen, and thymus tissues and mortality in mice<...

Ingested shiga toxin 2 (stx2) causes histopathological changes in kidney, spleen, and thymus tissues and mortality in mice. / ... Ingested shiga toxin 2 (stx2) causes histopathological changes in kidney, spleen, and thymus tissues and mortality in mice. In ... Rasooly, R., Do, P. M., Griffey, S. M., Vilches-Moure, J. G., & Friedman, M. (2010). Ingested shiga toxin 2 (stx2) causes ... N2 - The Shiga toxin (Stx)-producing bacterial strain, Escherichia coli O157:H7, colonizes the distal small intestine and the ...
more infohttps://ucdavis.pure.elsevier.com/en/publications/ingested-shiga-toxin-2-stx2-causes-histopathological-changes-in-k

Mouse in Vivo Neutralization of Escherichia coli Shiga Toxin 2 with Monoclonal Antibodies - pdf descargarMouse in Vivo Neutralization of Escherichia coli Shiga Toxin 2 with Monoclonal Antibodies - pdf descargar

Mouse in Vivo Neutralization of Escherichia coli Shiga Toxin 2 with Monoclonal Antibodies. . Biblioteca virtual para leer y ... Shiga toxin-producing E. coli; toxicokinetics monoclonal antibodies; neutralization of Shiga toxins; Shiga toxin-producing E. ... Aflatoxin, Fumonisin and Shiga Toxin-Producing Escherichia coli Infections in Calves and the Effectiveness of Celmanax®- ... Abstract Shiga toxin-producing Escherichia coli STEC food contaminations pose serious health concerns, and have been the ...
more infohttp://libros.duhnnae.com/2017/jun6/1497620905100-Mouse-in-Vivo-Neutralization-of-Escherichia-coli-Shiga-Toxin-2-with-Monoclonal-Antibodies.php

Lysogeny with Shiga Toxin 2-Encoding Bacteriophages Represses Type III Secretion in Enterohemorrhagic Escherichia coli - CORELysogeny with Shiga Toxin 2-Encoding Bacteriophages Represses Type III Secretion in Enterohemorrhagic Escherichia coli - CORE

Lysogeny with Shiga Toxin 2-Encoding Bacteriophages Represses Type III Secretion in Enterohemorrhagic Escherichia coli By ... Typical EHEC strains are defined by the expression of a type III secretion (T3S) system, the production of Shiga toxins (Stx) ...
more infohttps://core.ac.uk/display/8728891

Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks | BMC Microbiology | Full TextPhylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks | BMC Microbiology | Full Text

These data could indicate that Shiga toxins are experiencing purifying selection. ... Stx1 and Stx2 are genetically and immunologically distinct but share the same compound toxin structure, method of entry and ... Shiga toxins 1 and 2 (Stx1 and Stx2) are bacteriophage-encoded proteins that have been associated with hemorrhagic colitis, ... Similarity of Shiga Toxin 1 A and B subunit genes. The Shiga Toxin 1 A and B subunit genes showed very little difference in ...
more infohttps://0-bmcmicrobiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2180-7-109

Characterization of shiga toxin type 2 variant B-subunit in Escherichia coli strains from asymptomatic human carriers by PCR...Characterization of shiga toxin type 2 variant B-subunit in Escherichia coli strains from asymptomatic human carriers by PCR...

Shiga toxin types and further virulence-associated factors have to be investigated. ... The high Stx2d prevalence in asymptomatic carriers was conspicuous and may indicate a reduced pathogenicity of these toxin ... Subtyping of shiga toxin type 2 variant B-subunit in 35 non-O157 and two O157 strains isolated from 37 asymptomatic human ... Shiga toxin subtypes associated with Shiga toxin-producing Escherichia coli strains isolated from red deer, roe deer, chamois, ...
more infohttps://www.semanticscholar.org/paper/Characterization-of-shiga-toxin-type-2-variant-in-Stephan-Hoelzle/a51506ad6f458765fc7d2707a6ad9e1c1d628269

Immunization with a chimera between the B subunit of Shiga toxin type 2 and Brucella Lumazine Synthase confers total protection...Immunization with a chimera between the B subunit of Shiga toxin type 2 and Brucella Lumazine Synthase confers total protection...

Immunization with a chimera between the B subunit of Shiga toxin type 2 and Brucella Lumazine Synthase confers total protection ... The striking feature of Enterohemorrhagic Escherichia coli (EHEC) infections is the production of Shiga toxins (Stx) implicated ... Immunization with a chimera between the B subunit of Shiga toxin type 2 and Brucella Lumazine Synthase confers total protection ... against Shiga toxins in mice. Mejias, María Pilar. ; Ghersi, Giselle. ; Craig, Patricio Oliver. ; Panek, Cecilia Analía. ; ...
more infohttps://ri.conicet.gov.ar/handle/11336/20877

Immunization with a Chimera Consisting of the B Subunit of Shiga Toxin Type 2 and Brucella Lumazine Synthase Confers Total...Immunization with a Chimera Consisting of the B Subunit of Shiga Toxin Type 2 and Brucella Lumazine Synthase Confers Total...

Immunization with a Chimera Consisting of the B Subunit of Shiga Toxin Type 2 and Brucella Lumazine Synthase Confers Total ... The striking feature of enterohemorrhagic Escherichia coli (EHEC) infections is the production of Shiga toxins (Stx) implicated ... Immunization with a Chimera Consisting of the B Subunit of Shiga Toxin Type 2 and Brucella Lumazine Synthase Confers Total ... Protection against Shiga Toxins in Mice.. Mejias, Maria Pilar. ; Ghersi, Giselle. ; Craig, Patricio Oliver. ; Panek, Cecilia ...
more infohttps://ri.conicet.gov.ar/handle/11336/7774