KCNC3 - Wikipedia
Potassium voltage-gated channel, Shaw-related subfamily, member 3 also known as KCNC3 or Kv3.3 is a protein that in humans is ... and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes ... "Entrez Gene: potassium voltage-gated channel". Haas M, Ward DC, Lee J, Roses AD, Clarke V, DEustachio P, Lau D, Vega-Saenz de ... Voltage-gated potassium channel GRCh38: Ensembl release 89: ENSG00000131398 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
KCNC4 - Wikipedia
Potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), also known as Kv3.4, is a human gene. The Shaker ... "Entrez Gene: KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4". Gutman GA, Chandy KG, Grissmer S, et al ... 1992). "Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, ... Voltage-gated potassium channel GRCh38: Ensembl release 89: ENSG00000116396 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
CNF-Sr3 - Wikipedia
The Shaker channel is a subtype of voltage-gated potassium channels. Inhibition of the Shaker channels by CNF-Sr3 is reversible ... This toxin does not block Shab, Shaw, Shal and Eag channels. Campos-Lira, Elba; Carrillo, Elissa; Aguilar, Manuel B. (2017). ... CNF-Sr3 is an inhibitor of the Shaker channel, a subtype of the voltage-gated potassium channels. CNF-Sr3 (conorfamide-Sr3) is ... The amino acid sequences of the conorfamides are displayed below:[1] CNF-Sr3 blocks Shaker K+ channels with a moderate affinity ...
Ergtoxin - Wikipedia
Asher, V.; Warren, A.; Shaw, R.; Sowter, H.; Bali, A.; Khan, R. (March 2011). "The role of Eag and HERG channels in cell ... This toxin targets hERG (human Ether- à -go-go-Related Gene) potassium channels. The toxin is derived from the venomous gland ... Warmke, J. W.; Ganetzky, B. (April 1994). "A family of potassium channel genes related to eag in Drosophila and mammals". Proc ... However, while hERG K+ channels are expressed by SK-OV-3 cancer cells, the specific mechanisms of channel function in ...
CmERG1 - Wikipedia
Shaw, Robert; Bali, Anish; Khan, Raheela (December 2010). "Eag and HERG potassium channels as novel therapeutic targets in ... Articles with short description, Short description with empty Wikidata description, Ion channel toxins, Potassium channel ... elimination of ionic channel current. Moreover, the blocking of potassium channels by CmERG1 is fast and reversible, resembling ... CmERG1 is part of the γ-KTx family, which binds selectively to hERG potassium channels. CmERG1 has a 90.5% homology with CnERG1 ...
KCNC1 - Wikipedia
1992). "The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells". J. ... "Entrez Gene: KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1". Kolodin YO (2008-04-27). "Ionic ... Potassium voltage-gated channel subfamily C member 1 is a protein that in humans is encoded by the KCNC1 gene. The Shaker gene ... Kv3.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCNC1+protein,+human at the U. ...
KCNB2 - Wikipedia
July 1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels ... Potassium voltage-gated channel subfamily B member 2 is a protein that in humans is encoded by the KCNB2 gene. The protein ... Kv2.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCNB2+protein,+human at the U. ... March 2004). "Expression of voltage-gated potassium channels in human and rhesus pancreatic islets". Diabetes. 53 (3): 597-607 ...
KCNV1 - Wikipedia
... a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): ... Potassium voltage-gated channel subfamily V member 1 is a protein that in humans is encoded by the KCNV1 gene. The protein ... Kv8.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCNV1+protein,+human at the U. ... Ebihara M, Ohba H, Kikuchi M, Yoshikawa T (2004). "Structural characterization and promoter analysis of human potassium channel ...
KCNA2 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 ... Kv1.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCNA2+protein,+human at the U. ...
KCNA3 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Calcium entry through the CRAC channel is promoted by potassium efflux through the Kv1.3 and KCa3.1 potassium channels. ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... "A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino ...
KCNAB2 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ... Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene. ... "Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2". Hoek KS, Schlegel NC, Eichhoff ...
KCNAB1 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene. Potassium channels ... "Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1". England SK, Uebele VN, Shear H, ... Schultz D, Litt M, Smith L, Thayer M, McCormack K (Mar 1997). "Localization of two potassium channel beta subunit genes, KCNA1B ...
Repolarization - Wikipedia
Jensen MØ, Jogini V, Borhani DW, Leffler AE, Dror RO, Shaw DE (April 2012). "Mechanism of voltage gating in potassium channels ... "SK channel" stands for a small conductance calcium activated potassium channel, and the channels are found in the heart. SK ... Another type of K+ channel that helps to mediate repolarization in the human atria is the SK channel, which are K+ channels ... Other voltage gated K+ channels which contribute to repolarization include A-type channels and Ca2+-activated K+ channels. ...
KCND1 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ... "Entrez Gene: KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1". Gutman GA, Chandy KG, Grissmer S, et al ... Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene. ...
KCND3 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ... Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the KCND3 ... "Entrez Gene: KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3". Oudit GY, Kassiri Z, Sah R, Ramirez RJ, ...
KCND2 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ... Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the KCND2 gene. It contributes ... Kv4.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCND2+protein,+human at the U. ...
KCNA4 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Voltage-gated potassium channel Voltage-gated potassium-channel Kv1.4 IRES GRCh38: Ensembl release 89: ENSG00000182255 - ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... Potassium voltage-gated channel subfamily A member 4 also known as Kv1.4 is a protein that in humans is encoded by the KCNA4 ...
Lawrence B. Salkoff - Wikipedia
Cloning of the extended family of potassium channel genes. The structure of potassium channels which shape the electrical ... Covarrubias, M; Wei, AA; Salkoff, L (November 1991). "Shaker, Shal, Shab, and Shaw express independent K+ current systems". ... "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family". EMBO ... family of high conductance potassium channels. The discovery of a high conductance sperm¬specific potassium channel turned out ...
Cation channel superfamily - Wikipedia
These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion ... Shaw-related: Kv3.3 (KCNC3), Kv3.4 (KCNC4) Kvα4.x - Shal-related: Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3) Kvα10.x: Kv10.2 ( ... Durell SR, Guy HR (2001). "A family of putative Kir potassium channels in prokaryotes". BMC Evolutionary Biology. 1: 14. doi: ... This also includes the 2-TM inward-rectifier potassium channels (Pfam PF01007) found primarily in eukaryotes. There are ...
KCNB1 - Wikipedia
... a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". The EMBO Journal ... Potassium channels are among the most diverse of all ion channels in eukaryotes. With over 100 genes coding numerous functions ... Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ... This general sequence comprises the selectivity of the potassium channel. Depending on the channel, the alpha subunits are ...
Thyrotoxic periodic paralysis - Wikipedia
Furthermore, mutations have been reported in the genes coding for potassium voltage-gated channel, Shaw-related subfamily, ... sodium and potassium) across cell membranes. The main ones are the L-type calcium channel α1-subunit and potassium inward ... The abnormality in the channel is thought to lead to shifts of potassium into cells, under conditions of high thyroxine ( ... Potassium is not in fact lost from the body, but increased Na+/K+-ATPase activity (the enzyme that moves potassium into cells ...
Potassium channel tetramerisation domain - Wikipedia
Williams JB, Luneau C, Smith JS, Wiedmann R (1991). "Shaw-like rat brain potassium channel cDNAs with divergent 3 ends". FEBS ... Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential, ... the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ ... Sansom MS (2000). "Potassium channels: watching a voltage-sensor tilt and twist". Curr. Biol. 10 (5): R206-9. doi:10.1016/S0960 ...
Voltage-gated potassium channel - Wikipedia
Shaw-related: Kv3.1 (KCNC1), Kv3.2 (KCNC2) Kvα7.x: Kv7.1 (KCNQ1) - KvLQT1, Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 ( ... potassium channel blocker and potassium channel opener. Ion channel Ion channel family Potassium channel tetramerisation domain ... Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in ... Channels at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "Voltage-Gated Potassium Channels". IUPHAR ...
Scaffold protein - Wikipedia
... of the Drosophila Discs Large Tumor Suppressor Binds to p56 lck Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T ... Burack, W Richard; Shaw, Andrey S (April 2000). "Signal transduction: hanging on a scaffold". Current Opinion in Cell Biology. ... Locasale, Jason W.; Shaw, Andrey S.; Chakraborty, Arup K. (14 August 2007). "Scaffold proteins confer diverse regulatory ... Such as type 4 collagen Shaw, Andrey S.; Filbert, Erin L. (January 2009). "Scaffold proteins and immune-cell signalling". ...
KCNC2 - Wikipedia
The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2). Kv3.1 and Kv3.2 channels are prominently ... "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711-5. doi:10.1007/ ... Kv3.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCNC2+protein,+human at the U. ... Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene. ...
ZG16 - Wikipedia
"KCNIP3 potassium voltage-gated channel interacting protein 3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. ... Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of ...
List of MeSH codes (D12.776.543) - Wikipedia
... shal potassium channels MeSH D12.776.543.550.425.750.900.500.750 - shaw potassium channels MeSH D12.776.543.550.425.875 - ... shal potassium channels MeSH D12.776.543.585.400.750.900.624.750 - shaw potassium channels MeSH D12.776.543.585.400.875 - ... shab potassium channels MeSH D12.776.543.550.425.750.900.249 - ether-a-go-go potassium channels MeSH D12.776.543.550.425.750. ... shab potassium channels MeSH D12.776.543.585.400.750.900.249 - ether-a-go-go potassium channels MeSH D12.776.543.585.400.750. ...
Action potential - Wikipedia
This is followed by the opening of potassium ion channels that permit the exit of potassium ions from the cell. The inward flow ... Caldwell PC, Hodgkin AL, Keynes RD, Shaw TL (July 1960). "The effects of injecting energy-rich phosphate compounds on the ... Potassium channels are then activated, and there is an outward current of potassium ions, returning the electrochemical ... At the same time, the raised voltage opens voltage-sensitive potassium channels; the increase in the membranes potassium ...
List of MeSH codes (D12.776.157) - Wikipedia
... shal potassium channels MeSH D12.776.157.530.400.600.900.500.750 - shaw potassium channels MeSH D12.776.157.530.400.875 - ... shab potassium channels MeSH D12.776.157.530.400.600.900.249 - ether-a-go-go potassium channels MeSH D12.776.157.530.400.600. ... kcnq potassium channels MeSH D12.776.157.530.400.600.900.124.249.500 - kcnq1 potassium channel MeSH D12.776.157.530.400.600. ... 900.124.249.750 - kcnq2 potassium channel MeSH D12.776.157.530.400.600.900.124.249.875 - kcnq3 potassium channel MeSH D12.776. ...
Cardiac excitation-contraction coupling - Wikipedia
As well as this, in the SAN, the G-protein activates specific potassium channel, that opposes action potential initiation (see ... Shaw, R.M., Institute, C.-S.H., Center, C.-S.M., Angeles, L., California and Angeles, C.L. (2017) Cardiac T-Tubule ... Activated DHPRs open, forming a channel, that allows Ca2+ to pass into the cell. This increase in Ca2+, then binds to and ... Firstly, it binds to the intracellular side of the DHPR, signalling the channels to close and preventing further influx of Ca2+ ...