Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor...
Shaker Superfamily of Potassium Channels/*chemistry/*metabolism Identifiers. URN: urn:nbn:se:su:diva-18687ISI: 000246599900015 ... Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor ...http://su.diva-portal.org/smash/record.jsf?pid=diva2:185210
Multiple Sclerosis; Sclerosis, Disseminated; Multiple Sclerosis, Acute Fulminating; MS (Multiple Sclerosis)
Shaker Superfamily of Potassium Channels. 1. + +. 263. Potassium Channels, Voltage-Gated. 1. + +. ...https://lookfordiagnosis.com/results.php?symptoms=Multiple+Sclerosis%3B%20Sclerosis%2C%20Disseminated%3B%20Multiple%20Sclerosis%2C%20Acute%20Fulminating%3B%20MS%20%28Multiple%20Sclerosis%29&lang=1&parent=%2F&mode=F&therapy_ap=1
Kcna6 (potassium voltage-gated channel, shaker-related, subfamily, member 6) - Rat Genome Database
INVOLVED IN potassium ion transmembrane transport (ortholog); FOUND IN axon; axon terminus; integral component of plasma ... ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); ... Superfamily-SCOP. BTB/POZ_fold. UniProtKB/Swiss-Prot. UniGene. Mm.62535. ENTREZGENE. ... potassium voltage gated channel, shaker related, subfamily, member 6; potassium voltage-gated channel subfamily A member 6; ...https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=62375
Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated...
... antibodies and their effects on potassium channel currents using human embryonic kidney cells expressing the potassium channel ... The remaining 18 sera were negative for potassium channel subunits and associated proteins by the methods employed. Of the 19 ... Surprisingly, only three of the patients had antibodies directed against the potassium channel subunits. By contrast, we found ... This study confirms that the majority of patients with high potassium channel antibodies have limbic encephalitis without ...https://www.neuroscience.ox.ac.uk/publications/241453
Patent US8129365 - Water-soluble, fluorescent compounds for detection of potassium ions - Google Patents
... the chromoionophore compounds further comprise a second chromophoric moiety which is insensitive to potassium binding by the ... Potassium channel subunits of the Shaker-like superfamily share a characteristic six transmembrane/1 pore domain structure. ... The Shaker-like channel family includes the voltage-gated potassium channels as well as the delayed rectifier type channels ... A second superfamily of potassium channels is composed of the inward rectifying channels (Kir). Kir channels have the property ...http://www.google.com/patents/US8129365?dq=6,073,142
A naturally occurring omega current in a Kv3 family potassium channel from a platyhelminth | BMC Neuroscience | Full Text
Recently, synthetic mutagenesis studies in the Drosophila melanogaster Shaker channel and analysis of human disease-causing ... highly selective pore typical of potassium channels. This channel has evolved to yield qualitatively different ion permeability ... The N.at-K v 3.2 potassium channel has an unusual weak inward rectifier phenotype. Several mutations of two amino acids in the ... The typical selectivity filter in potassium channels is formed by a tetrameric arrangement of the carbonyl groups of the ...https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-52
Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments | JGP
... to that of other ion channels in a large superfamily that includes voltage-gated calcium channels and Shaker potassium channels ... The transmembrane domains are illustrated using the homologous structure of the Shaker potassium channel (Long et al., 2005). ... Ankyrin repeats are also found in other TRP channels, including TRPA, TRPN, and TRPC channels. The TRPC and TRPV channels have ... including structures of vertebrate ion channels including Shaker channels produced in the yeast Pichia pastoris (Long et al., ...http://jgp.rupress.org/content/133/3/231
Kv1.2 Potassium Channel Summary Report | CureHunter
A delayed rectifier subtype of shaker potassium channels that is selectively inhibited by a variety of SCORPION VENOMS. ... Potassium Channels: 2108*Voltage-Gated Potassium Channels: 446*Shaker Superfamily of Potassium Channels*Kv1.2 Potassium Channel ... Potassium Channels: 2108*Voltage-Gated Potassium Channels: 446*Shaker Superfamily of Potassium Channels*Kv1.2 Potassium Channel ... Potassium Channels: 2108*Voltage-Gated Potassium Channels: 446*Delayed Rectifier Potassium Channels: 12*Kv1.2 Potassium Channel ...http://www.curehunter.com/public/keywordSummaryD051663-Kv1-2-Potassium-Channel.do
Hongotoxin - Wikipedia
... targets are Shaker-type (Kv1) K+ channels. HgTX1 shows high affinity with Kv1.1, Kv1.2, Kv1.3 voltage-gated potassium channels ... Hongotoxin belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 2 subfamily. There ... Hongotoxin (HgTX) is an ion channel toxin, which blocks Shaker-type (Kv1) K+ channels. The toxin is derived from the venom of ... HgTX4 and HgTX5 are potent selective inhibitors of Kv1 voltage-gated potassium channels (By similarity). ND, not determined. ...https://en.wikipedia.org/wiki/Hongotoxin
Cation channel superfamily - Wikipedia
These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion ... Shaker-related: Kv1.4 (KCNA4) Kvα3.x - Shaw-related: Kv3.3 (KCNC3), Kv3.4 (KCNC4) Kvα4.x - Shal-related: Kv4.1 (KCND1), Kv4.2 ( ... The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. ... Durell SR, Guy HR (2001). "A family of putative Kir potassium channels in prokaryotes". BMC Evolutionary Biology. 1: 14. doi: ...https://en.wikipedia.org/wiki/Cation_channel_superfamily
Statistical Limits to the Identification of Ion Channel Domains by Sequence Similarity | JGP
... including the Shaker potassium channel (Kreusch et al., 1998) and, as an isolated domain, the Kv1.2 channel itself (Minor et al ... This superfamily includes members whose SCOP family is the "tetramerization domain of potassium channels." This structure, ... The assertions of the presence of the SCOP superfamilies "POZ domain" and "voltage-gated potassium channels" are the only two ... Crystal structure of the tetramerization domain of the Shaker potassium channel. Nature. 392:945-948. ...http://jgp.rupress.org/content/127/6/755
Kv1.1 Potassium Channel Summary Report | CureHunter
A delayed rectifier subtype of shaker potassium channels that is commonly mutated in human episodic ATAXIA and MYOKYMIA. ... Potassium Channels: 2108*Voltage-Gated Potassium Channels: 446*Shaker Superfamily of Potassium Channels*Kv1.1 Potassium Channel ... Potassium Channels: 2108*Voltage-Gated Potassium Channels: 446*Shaker Superfamily of Potassium Channels*Kv1.1 Potassium Channel ... Potassium Channels: 2108*Voltage-Gated Potassium Channels: 446*Delayed Rectifier Potassium Channels: 12*Kv1.1 Potassium Channel ...http://www.curehunter.com/public/keywordSummaryD051662-Kv1-1-Potassium-Channel.do
Potassium channel, voltage dependent, Kv3 (IPR003974) | InterPro | EMBL-EBI
Overlapping homologous superfamilies None.. Family relationships *Voltage-gated potassium channel (IPR028325) *Potassium ... Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.. Nature 331 137- ... Potassium channel, voltage dependent, Kv3.4 (IPR005405). *Potassium channel, voltage dependent, Shaw, invertebrate (IPR015572) ... Potassium channel, voltage dependent, Kv3 (IPR003974) *Potassium channel, voltage dependent, Kv3.1 (IPR005403) ...http://www.ebi.ac.uk/interpro/entry/IPR003974
Potassium channel, voltage dependent, Kv4 (IPR003975) | InterPro | EMBL-EBI
Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.. Nature 331 137- ... K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six ... Voltage-gated potassium channel (IPR028325) *Potassium channel, voltage dependent, Kv (IPR003968) *Potassium channel, voltage ... The Shal potassium channel was found in Drosophila melanogaster (Fruit fly). Several vertebrate potassium channels with similar ...http://www.ebi.ac.uk/interpro/entry/IPR003975
Mutagenesis studies of charged residues in the hERG K+ channel - UBC Library Open Collections
"Shaker Potassium Channel Gating. II: Transitions in the Activation Pathway." The Journal of General Physiology 103(2): 279-319 ... are highly conserved among the members of voltage-gated potassium superfamily, whereas three others (D411 in S1, D460 in S2 and ... The potassium channels are a diverse family of ion channels through which K+ preferentially permeates. Voltage-gated potassium ... "Voltage Sensitivity and Gating Charge in Shaker and Shab Family Potassium Channels." The Journal of General Physiology 114 ( ...https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0167204
GENTAUR antibody-antibodies.com The Marketplace for Antibodies : Molecular physiology of oxygen-sensitive potassium channels.
Four sequence-related potassium channel genes, shaker, shaw, shab, an. 0.1 mg. ... ACCN4 belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. ... Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1 ... Potassium channel subfamily K member 5 - Acid-sensitive potassium channel protein TASK-2; TWIK-related acid-sensitive K(+) ...http://www.antibody-antibodies.com/pubmed-11510795-Molecular_physiology_of_oxygensensitive_potassium_channels.html
October | 2009 | Markus Library News
The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current. JOURNAL OF ... Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ ... ion channels, K+, KV1, potassium, Shaker , Leave a reply Recommended Readings: Stephen J. Elledge Ph.D. Friday Oct 16, 2009. ... Recent Studies of Potassium Channels and Calcium-activated Chloride Channels. Lily Jan, Ph.D.,. Jack and Delores Change Endowed ...http://librarynews.rockefeller.edu/?m=200910
The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current. JOURNAL OF ... Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ ... ion channels, ion conduction, Potassium channels Neuroscientists Learn How Channels Fine-Tune Neuronal Excitability. Posted on ... ion channels, K+, KV1, potassium, Shaker , Leave a reply Related Readings: A. James Hudspeth, M.D., Ph.D.. Posted on October 27 ...http://librarynews.rockefeller.edu/?tag=ion-channels
Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons
Clustering of neuronal potassium channels is independent of their interaction with PSD-95. J Cell Biol. 2002;159:663-672. [PMC ... At this site, Shaker-like Kv1.1 and Kv1.2 K+ channels are localized (Wang et al., 1993), and associated with an axonal cell ... a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ ... Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M. Clustering of Shaker-type K+ channels by interaction with a family of ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2859216/
IMP: Integrative Multi-species Prediction
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia). 0.012. ... tumor necrosis factor receptor superfamily, member 13B. 0.012. SLC26A3. solute carrier family 26, member 3. 0.012. ...http://imp.princeton.edu/predictions/process/human-context-global/5250/?gene=21093
Tissue-specific transcriptome assemblies of the marine medaka Oryzias melastigma and comparative analysis with the freshwater...
A) Specific expression of gap junction beta-1 protein (CXB1) and potassium voltage-gated channel, shaker-related subfamily, ... superfamily, whose members interact with membrane-bound receptors to exert their biological functions . Analysis of BMP10- ... Additionally, cardiac channels such as potassium voltage-gated channel subfamily D member 2 (KCND2) and plakophilin-2 (PKP2) ... Our results demonstrated that gap junction beta-1 protein (CXB1) and potassium voltage-gated channel subfamily A member 2 ( ...https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1325-7
Timothy Jegla - Penn State University Department of Biology
Expanded functional diversity of Shaker K+ channels in cnidarians is driven by gene expansion. Jegla T, Marlow HQ, Chen B, ... Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr. Martinson A.S., van Rossum D.B., Diatta ... External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor. Kazmierczak M, ... Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Zhang X., Bertaso F., Yoo J., ...http://bio.psu.edu/directory/tjj3/
Synchrotron radiation circular dichroism spectroscopy-defined structure of the C-terminal domain of NaChBac and its role in...
1992) Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science 257: ... 2004) A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem 279:9532-9538. ... The prokaryotic sodium channel NaChBac shows strong sequence homology to 6TM bacterial and eukaryotic potassium channels; in ... Previous studies with KIR and EAG potassium channels demonstrated the necessity of a tetramerization domain for channel ...https://www.pnas.org/content/107/32/14064
Molecular characterization of the cyclic nucleotide-gated cation channel of bovine rod outer segments - UBC Library Open...
1.3.3 Potassium channels The first potassium channel to be cloned was the K channel Shaker from Drosophila + (Papazian et al, ... A superfamily of ion channels. Nature 345 672. Jay, S.D., Ellis, S.B., Kahl, S.D., McCue, A.E., Williams, M.E., Vedvick, T.S., ... 1.3.2 Calcium channels 15 1.3.3 Potassium channels 18 1.3.4 Cyclic nucleotide-gated channels 19 1.4 The bovine rod CNG channel ... YPEIRLNRLLRISRMFEFFQRTETRT channel Shaker Na* channel Ca * channel 1st 2nd 3rd 4th 1st 2nd 3rd 4 th LAILRVIRLVRVFRIFKLSRHSKGLQ ...https://open.library.ubc.ca/cIRcle/collections/ubctheses/831/items/1.0094703
The sequence of human chromosome 21 and implications for research into Down syndrome
Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel ... DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of ... Overexpression of one potassium channel gene has been shown to disregulate expression of other channel genes, affecting ...http://pubmedcentralcanada.ca/pmcc/articles/PMC138845/?lang=en-ca