Hongotoxin - Wikipedia
... targets are Shaker-type (Kv1) K+ channels. HgTX1 shows high affinity with Kv1.1, Kv1.2, Kv1.3 voltage-gated potassium channels ... Hongotoxin belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 2 subfamily. There ... Hongotoxin (HgTX) is an ion channel toxin, which blocks Shaker-type (Kv1) K+ channels. The toxin is derived from the venom of ... HgTX4 and HgTX5 are potent selective inhibitors of Kv1 voltage-gated potassium channels (By similarity). ND, not determined. ...
Cation channel superfamily - Wikipedia
These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion ... Shaker-related: Kv1.4 (KCNA4) Kvα3.x - Shaw-related: Kv3.3 (KCNC3), Kv3.4 (KCNC4) Kvα4.x - Shal-related: Kv4.1 (KCND1), Kv4.2 ( ... The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. ... Durell SR, Guy HR (2001). "A family of putative Kir potassium channels in prokaryotes". BMC Evolutionary Biology. 1: 14. doi: ...
KCNAB1 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... McCormack T, McCormack K (1995). "Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily". ... Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene. Potassium channels ... "Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1". England SK, Uebele VN, Shear H, ...
Tamulotoxin - Wikipedia
The primary targets consist of voltage-gated Shaker-related potassium channels, ether-a-go-go related gene (HERG) potassium ... TmTx belongs to the short scorpion toxin superfamily and the potassium channel inhibitor family. Adhering to the nomenclature ... calcium-activated potassium channel), respectively. Another suggested target is the Kv1.6 channel, a voltage-gated potassium ... It belongs to the group of alpha potassium toxins (α-KTx: alpha toxin affecting potassium channels). This group contains short- ...
Potassium channel tetramerisation domain - Wikipedia
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila". Nature. 331 ( ... K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six ... channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)- ... Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential, ...
Voltage-gated potassium channel - Wikipedia
Such genetic methods allowed the genetic identification of the "Shaker" K+ channel gene in Drosophila before ion channel gene ... at ualberta.ca UMich Orientation of Proteins in Membranes families/superfamily-8 - Spatial positions of voltage gated potassium ... potassium channel blocker and potassium channel opener. Ion channel Ion channel family Potassium channel tetramerisation domain ... Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in ...
KCNAB2 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... McCormack T, McCormack K (1995). "Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily". ... "Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2". Hoek KS, Schlegel NC, Eichhoff ... Gu C, Jan YN, Jan LY (2003). "A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels". Science ...
List of MeSH codes (D12.776.543) - Wikipedia
... shaker superfamily of potassium channels MeSH D12.776.543.550.425.750.900.500.124 - kv1.1 potassium channel MeSH D12.776. ... shaker superfamily of potassium channels MeSH D12.776.543.585.400.750.900.624.124 - kv1.1 potassium channel MeSH D12.776. ... shab potassium channels MeSH D12.776.543.550.425.750.900.249 - ether-a-go-go potassium channels MeSH D12.776.543.550.425.750. ... shab potassium channels MeSH D12.776.543.585.400.750.900.249 - ether-a-go-go potassium channels MeSH D12.776.543.585.400.750. ...
List of MeSH codes (D12.776.157) - Wikipedia
... shaker superfamily of potassium channels MeSH D12.776.157.530.400.600.900.500.124 - kv1.1 potassium channel MeSH D12.776. ... shab potassium channels MeSH D12.776.157.530.400.600.900.249 - ether-a-go-go potassium channels MeSH D12.776.157.530.400.600. ... kcnq potassium channels MeSH D12.776.157.530.400.600.900.124.249.500 - kcnq1 potassium channel MeSH D12.776.157.530.400.600. ... 900.124.249.750 - kcnq2 potassium channel MeSH D12.776.157.530.400.600.900.124.249.875 - kcnq3 potassium channel MeSH D12.776. ...
Hanatoxin - Wikipedia
The potassium channels that hanatoxin inhibits have huge diversity and are involved in a number of functions such as regulation ... Gonzalez, C. e.a. (2000). "Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker". Journal of General ... http://supfam.org/SUPERFAMILY/cgi-bin/search.cgi?search_field=hanatoxin, consulted 10th Oct. 2012. Swartz, K.J.; MacKinnon, R ... The toxin is mostly known for inhibiting the activation of voltage-gated potassium channels, most specifically Kv4.2 and Kv2.1 ...
Voltage-gated ion channel - Wikipedia
Potassium channels are the largest and most diverse class of voltage-gated channels, with over 100 encoding human genes. These ... Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE (March 2004). "A superfamily of voltage-gated sodium channels ... Webster SM, Del Camino D, Dekker JP, Yellen G (April 2004). "Intracellular gate opening in Shaker K+ channels defined by high- ... Voltage-gated ion-channels are usually ion-specific, and channels specific to sodium (Na+), potassium (K+), calcium (Ca2+), and ...
KcsA potassium channel - Wikipedia
... of other important voltage conducting proteins such as the drosophilla-derived Shaker and the human hERG potassium channel. ... "Overview of molecular relationships in the voltage-gated ion channel superfamily". Pharmacological Reviews. 57 (4): 387-95. doi ... Calcium channel Potassium channel Sodium channel Schrempf H, Schmidt O, Kümmerlen R, Hinnah S, Müller D, Betzler M, Steinkamp T ... KcsA (K channel of streptomyces A) is a prokaryotic potassium channel from the soil bacterium Streptomyces lividans that has ...
Two-pore channel - Wikipedia
... together forming the tetrameric channels pore, the new channel had just two Shaker-like repeats, each of which was equipped ... dimerise to form a functional channel. "Two P domain potassium channels". Guide to Pharmacology. Retrieved 2019-05-28. Rang, HP ... a protein superfamily specialized for electrical signaling and ionic homeostasis". Sciences STKE. 2004 (253): re15. doi: ... As implied by their name, TPC channels possess two pores and were named for their two Shaker-like repeats, which each have a ...
KCNA2 - Wikipedia
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ ... "Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2". Coleman SK, Newcombe J, Pryke J, Dolly ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ...
Ion channel - Wikipedia
Some potassium channels: Inward-rectifier potassium channels: These channels allow potassium ions to flow into the cell in an " ... Cyclic nucleotide-gated channels: This superfamily of channels contains two families: the cyclic nucleotide-gated (CNG) ... together forming the tetrameric channels pore, the new channel had just two Shaker-like repeats, each of which was equipped ... Potassium channels Voltage-gated potassium channels e.g., Kvs, Kirs etc. Calcium-activated potassium channels e.g., BKCa or ...