"Saposins: structure, function, distribution, and molecular genetics". J. Lipid Res. 33 (9): 1255-67. doi:10.1016/S0022-2275(20) ...
This could have been caused by accumulation of PSAP and saposins in DA neurons over time, Moreover, we believe that part of ... PSAP is cleaved to saposins in the lysosome, which, in turn, regulate a subset of lysosomal sphingolipid related hydrolases5. ... Magenta arrows are metabolic pathways modulated by saposins. L Graph showing gangliosides in DRN of two genotypes. Students t- ... It should be noted that the cleavage of PSAP into saposins varies between cell types and more studies are needed to ...
The individual saposins are found in cellular structures called lysosomes, which are the cells recycling centers. The saposins ...
Saposins and saposin-like proteins (SAPLIP) are among these proteins. In plants, two types of proteins contain saposin B-like ... Saposins and saposin-like proteins (SAPLIP) are among these proteins. In plants, two types of proteins contain saposin B-like ...
... causing saposins A and D to accumulate in the lysosomes. ...
The mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains two saposin A-type domains in ... The saposin B-type domain is a ~80 amino acid domain present in saposins and related proteins that interact with lipids. The ... the extremities that are removed in the activation reaction, and four saposin B-type domains yielding the active saposins A, B ... domain is named after the small lysosomal proteins, saposins, which serve as sphingolipid hydrolase activator proteins in ...
The N-terminal domains of these proteins are close to saposins, lipid and membrane binding proteins, some of which are shown to ...
Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with ... Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, ... This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each ... Saposins; Sgp1; Sphingolipid activator protein 1; Sphingolipid activator protein 2; Sulfated glycoprotein 1; Sulfatide/GM1 ...
Shigemoto, K., Kubo, S., Jie, C., Hato, N., Abe, Y., Ueda, N., Kobayashi, N., Kameda, K., Mominoki, K., Miyazawa, A., Ishigami, A., Matsuda, S. & Maruyama, N., Jun 2008, Myasthenia Gravis and Related Disorders 11th International Conference. Blackwell Publishing Inc., p. 93-98 6 p. (Annals of the New York Academy of Sciences; vol. 1132).. Research output: Chapter in Book/Report/Conference proceeding › Conference contribution ...
Aevarsson, A., Kaczorowska, A-K., Adalsteinsson, B. T., Ahlqvist, J., Al-Karadaghi, S., Altenbuchner, J., Arsin, H., Átlasson, Ú. Á., Brandt, D., Cichowicz-Cieślak, M., Cornish, K. A. S., Courtin, J., Dabrowski, S., Dahle, H., Djeffane, S., Dorawa, S., Dusaucy, J., Enault, F., Fedøy, A-E., Freitag-Pohl, S., & 32 othersFridjonsson, O. H., Galiez, C., Glomsaker, E., Guérin, M., Gundesø, S. E., Gudmundsdóttir, E. E., Gudmundsson, H., Håkansson, M., Henke, C., Helleux, A., Henriksen, J. R., Hjörleifdóttir, S., Hreggvidsson, G. O., Jasilionis, A., Jochheim, A., Jónsdóttir, I., Jónsdóttir, L. B., Jurczak-Kurek, A., Kaczorowski, T., Kalinowski, J., Kozlowski, L. P., Krupovic, M., Kwiatkowska-Semrau, K., Lanes, O., Linares-Pastén, J., Karlsson, E. N., Skírnisdóttir, S., Svensson, A., Walse, B., Welin, M., Zhang, R. & Virus-X, 2021 Jun 24, In: FEMS Microbiology Letters. 368, 12, 16 p., fnab067.. Research output: Contribution to journal › Review article › peer-review ...
Both saposins and PS are widely contained in various tissues. The brain, skeletal muscle, and heart cells predominantly contain ... Neurotrophic factor prosaposin (PS) is a precursor for saposins A, B, C, and D, which are activators for specific sphingolipid ... Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A-D. Accumulating evidence suggests that PSAP is ... unprocessed PS rather than saposins. PS and PS-derived peptides stimulate neuritogenesis and increase choline acetyltransferase ...
The saposin B-type domain is a ~80 amino acid domain present in saposins and related proteins that interact with lipids. In ...
Diese Methode lieferte die drei Glycoformen 44a-c des Saposins D in guten Ausbeuten. Die Kristallisation von Saposin D (GlcNAc ... 44a und eine röntgenkristallographische Analyse zeigten die native Struktur des synthetischen Saposins D. Durch Struktur- ...
SAP 1 Sphingolipid Activator use Saposins Sap 1a Ets Domain Protein use ets-Domain Protein Elk-4 ...
SAP 1 Sphingolipid Activator use Saposins Sap 1a Ets Domain Protein use ets-Domain Protein Elk-4 ...
SAP 1 Sphingolipid Activator use Saposins Sap 1a Ets Domain Protein use ets-Domain Protein Elk-4 ...
SAP 1 Sphingolipid Activator use Saposins Sap 1a Ets Domain Protein use ets-Domain Protein Elk-4 ...
SAP 1 Sphingolipid Activator use Saposins Sap 1a Ets Domain Protein use ets-Domain Protein Elk-4 ...
Crystal structures of human saposins C and D: implications for lipid recognition and membrane interactions.. Rossmann, M. and ...
This highly conserved glycoprotein is a precursor for 4 cleavage products: saposins A, B, C, and D. ...
The large subunit contains the active site serine, while the smaller subunit has striking sequence similarity to the saposins, ... The large subunit contains the active site serine, while the smaller subunit has striking sequence similarity to the saposins, ... The large subunit contains the active site serine, while the smaller subunit has striking sequence similarity to the saposins, ... The large subunit contains the active site serine, while the smaller subunit has striking sequence similarity to the saposins, ...
... cathelicidin and saposins. The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their ...
This highly conserved glycoprotein rapid fire crossfire a precursor for 4 cleavage products: saposins A, B, C, and D. He was 65 ...
Saposins Saposinas Saposinas Serine-Type D-Ala-D-Ala Carboxypeptidase D-Ala-D-Ala Carboxipeptidase Tipo Serina Serina ...
Saposins Saposinas D09 - Carboidratos. beta-Glucanas beta-Glucans beta-Glucanos D12 - Aminoácidos, Peptídeos e Proteínas. ...
Saposins Saposinas Saposinas Serine-Type D-Ala-D-Ala Carboxypeptidase D-Ala-D-Ala Carboxipeptidase Tipo Serina Serina ...
Saposins Saposinas Saposinas Serine-Type D-Ala-D-Ala Carboxypeptidase D-Ala-D-Ala Carboxipeptidase Tipo Serina Serina ...
Saposins Saposinas Saposinas Serine-Type D-Ala-D-Ala Carboxypeptidase D-Ala-D-Ala Carboxipeptidase Tipo Serina Serina ...
Saposins Saposinas Saposinas Serine-Type D-Ala-D-Ala Carboxypeptidase D-Ala-D-Ala Carboxipeptidase Tipo Serina Serina ...