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*  BIO-SYNTHESIS - Custom Antibody Custom Peptide Synthesis Custom SiRNA Synthesis: Small Interfering RNA
Small Interfering RNA. Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, are a class of ... Most notably, siRNA is involved in the RNA interference (RNAi) pathway where the siRNA interferes with the expression of a ... "A species of small antisense RNA in posttranscriptional gene silencing in plants". Shortly thereafter, in 2001, synthetic ... 20-25 nucleotide-long double-stranded RNA molecules that play a variety of roles in biology. ...
http://bio-synthesis.blogspot.com/2011/03/small-interfering-rna_14.html
*  Small interfering RNA - Wikipedia
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA ... Jensen, Kirsty; Anderson, Jennifer A.; Glass, Elizabeth J. (2014-04-15). "Comparison of small interfering RNA (siRNA) delivery ... Li LC (2008). "Small RNA-Mediated Gene Activation". RNA and the Regulation of Gene Expression: A Hidden Layer of Complexity. ... Dicer cuts the long dsRNA to form short interfering RNA or siRNA; this is what enables the molecules to form the RNA-Induced ...
https://en.wikipedia.org/wiki/Small_interfering_RNA
*  Phys.org - small interfering rna
Small interfering RNA. Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of ... Approval of first RNA interference drug - why the excitement?. Small interfering RNA sounds like something from a science ... attaching antibody-like RNA nanoparticles to microvesicles can deliver effective RNA therapeutics such as small interfering RNA ... The group published their findings in Science in a paper titled "A species of small antisense RNA in posttranscriptional gene ...
https://phys.org/tags/small+interfering+rna/
*  Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway |...
Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway. ... Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway ... Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway ... Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway ...
http://cancerres.aacrjournals.org/content/67/22/10782?ijkey=e0bf2cc376d210b31ea4aa9c4ea4aad5a6cfc272&keytype2=tf_ipsecsha
*  Poly(Ester Amine)-Mediated, Aerosol-Delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis - Redorbit
Poly(ester amine) carrier may serve as an effective carrier, and aerosol delivery of Akt1 small interfering RNA may be a ... Poly(Ester Amine)-Mediated, Aerosol-Delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis. by Sam Savage ... were used for in vivo effects of aerosol-delivered Akt1 small interfering RNA (siRNA) in lung tumorigenesis. In K-ras^sup LA1^ ... To demonstrate the feasibility and emphasize the importance of noninvasive aerosol delivery of Akt1 small interfering RNA ( ...
http://www.redorbit.com/news/health/1459846/polyester_aminemediated_aerosoldelivered_akt1_small_interfering_rna_suppresses_lung_tumorigenesis/
*  Testing Novel Compounds for Noninvasive Delivery of Small Interfering RNA into CNS | Parkinson's Disease
Small interfering RNA (siRNA) molecules have been successfully used to target specific genes in cell culture. However, the lack ... Testing Novel Compounds for Noninvasive Delivery of Small Interfering RNA into CNS. Rapid Response Innovation Awards, 2011. ... Gene expression can be specifically modulated by molecules named small interfering RNAs (siRNAs). Although siRNAs have emerged ... Recently, we have designed non-viral vectors that can deliver functional small interfering siRNAs specifically into cultured ...
https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=929
*  IJMS | Free Full-Text | Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs | HTML
Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral ... RNA interference (RNAi) is an evolutionarily conserved process in which cells employ small interfering RNA (siRNA) duplexes to ... Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs. Hongjiang Ruan †, Shen Liu †, Fengfeng Li, Xujun Li and Cunyi ... Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral ...
http://www.mdpi.com/1422-0067/14/2/4361/htm
*  IJMS | Free Full-Text | Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs | Notes
Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral ... Small Regulatory RNAs in the Control of Motility and Biofilm Formation in E. coli and Salmonella ...
http://www.mdpi.com/1422-0067/14/2/4361/notes
*  Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation | Diabetes
Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation. ... Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation ... Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation ... Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation ...
http://diabetes.diabetesjournals.org/content/60/2/565
*  Systematic coarse-grained modeling of complexation between small interfering RNA and polycations (Journal Article) | SciTech...
Here, we systematically develop such a model for the complexation of small interfering RNA (siRNA) and grafted ... Journal Article: Systematic coarse-grained modeling of complexation between small interfering RNA and polycations ... Title: Systematic coarse-grained modeling of complexation between small interfering RNA and polycations ...
https://www.osti.gov/scitech/biblio/22493384-systematic-coarse-grained-modeling-complexation-between-small-interfering-rna-polycations
*  Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference | The Journal of Immunology
Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference. John Capodici, Katalin Karikó and Drew ... Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference ... Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference ... Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference ...
http://www.jimmunol.org/content/169/9/5196
*  Characterization and evaluation of amphipathic, cationic peptides for small interfering RNA delivery
... ... Baoling Chen (2015). Characterization and evaluation of amphipathic, cationic peptides for small interfering RNA delivery. ... which can be triggered by small interfering RNA. The efficiency and specificity of this process makes siRNA a powerful tool for ... In the human non-small cell lung tumor xenograft model, the STR-HK-siRNA complexes induced the highest tumor inhibition rate ( ...
https://uwspace.uwaterloo.ca/handle/10012/9447
*  A Theranostic Small Interfering RNA Nanoprobe Protects Pancreatic Islet Grafts From Adoptively Transferred Immune Rejection |...
Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation. Diabetes 2011;60:565- ... A Theranostic Small Interfering RNA Nanoprobe Protects Pancreatic Islet Grafts From Adoptively Transferred Immune Rejection. ... A Theranostic Small Interfering RNA Nanoprobe Protects Pancreatic Islet Grafts From Adoptively Transferred Immune Rejection ... Here, we used a dual-purpose therapy/imaging small interfering (si)RNA magnetic nanoparticle (MN) probe that targets β2 ...
http://diabetes.diabetesjournals.org/content/61/12/3247
*  Phased, Secondary, Small Interfering RNAs in Posttranscriptional Regulatory Networks | Plant Cell
... small interfering RNAs (phasiRNAs), originally designated as trans-acting small interfering RNAs or tasiRNAs. PhasiRNA ... small interfering RNAs (phasiRNAs); and natural antisense transcript small interfering RNAs (NAT-siRNAs). These categories are ... Small interfering RNAs (siRNAs) are defined by the dependency of their biogenesis on an RNA-dependent RNA polymerase (RDR). The ... 2012). RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. ...
http://www.plantcell.org/content/25/7/2400.full
*  Oral History | CSHL | Research | Ron Plasterk on Small Interfering RNAs
Actually I think that at the core of it more important that double-stranded RNA are the small interfering RNAs - the SiRNAs - ... Small Interfering RNAs (Ron Plasterk) Then use your browser's back button to return ... these small RNAs that were made by the dicer-protein so you have long double stranded RNA which is diced by these dicer-RNAs ... RNA Induced Silencing Complex - and that can find the messenger RNA and base pair to it. And if it base pairs to it ...
http://library.cshl.edu/oralhistory/interview/cshl/research/small-interfering-rnas/
*  Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression | Cancer Research
We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX) for RNA interference (RNAi) in the ... Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression. Manuela Aleku, ... Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res 2005; 65: 6910-8. ... Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo. ...
http://cancerres.aacrjournals.org/content/68/23/9788?ijkey=e1f1d94f19d9e6d8e880c828e46770cf9c308c82&keytype2=tf_ipsecsha
*  Chemical Modification Patterns Compatible with High Potency Dicer-Substrate Small Interfering RNAs
Dicer-substrate small interfering RNAs (DsiRNAs) are synthetic RNA duplexes that are processed by Dicer into 21-mer species and ... O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res. 2003;31:3185-3193. [PMC free article] [PubMed] ... called small interfering RNAs (siRNAs), are the actual molecular triggers of RNAi and direct target specificity of the RNA- ... and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2582043/
*  Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo | Molecular Cancer Therapeutics
RNA interference has become widely used as an experimental tool to study gene function. In addition, small interfering RNA ( ... ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 2001;107:309-21. ... Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene ... Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Olaf R. Mook, Frank Baas, Marit B. de ...
http://mct.aacrjournals.org/content/6/3/833.long
*  Kallikrein gene 'knock-down' by small interfering RNA transfection induces a profibrotic phenotype in rat mesangial cells.
RNA, Messenger / antagonists & inhibitors, genetics. RNA, Small Interfering / pharmacology*. Rats. Rats, Wistar. Receptor, ... 0/Culture Media, Conditioned; 0/Fibronectins; 0/LDL-Receptor Related Protein 1; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/ ... its expression using specific small interfering RNAs (siRNA). METHODS: Rat mesangial cells were treated with 12, 60, 120 nmol/l ...
http://www.biomedsearch.com/nih/Kallikrein-gene-knock-down-by/18090545.html
*  Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema - Full Text View -...
Cand5 is a small interfering RNA molecule that selectively silences the mRNA encoding for VEGF. The target population are ... Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema. This study has been ... The molecule is a duplex formed by the hybridization of two partially complementary single strand RNAs in which the 3' end are ... Cand5 is a synthetic double stranded RNA (dsRNA) oligonucleotide. ...
https://clinicaltrials.gov/ct2/show/NCT00306904
*  Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer | Clinical Cancer Research
Although the RNA interference effect, which is mediated by small interfering RNA (siRNA) or micro-RNA, has potential ... Small interfering RNAs (siRNAs), which are small double-stranded RNA (dsRNA) oligonucleotides with or without overhangs, are ... Small interfering RNA functions by binding to RNA-induced silencing complex in the cytosol, so that the delivery of siRNA ... Vickers TA, Koo S, Bennet CF, et al Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense ...
http://clincancerres.aacrjournals.org/content/10/22/7721
*  Leicester Research Archive: Fighting against kidney diseases with small interfering RNA: opportunities and challenges
Fighting against kidney diseases with small interfering RNA: opportunities and challenges. Authors: Yang, C.. Zhang, C.. Zhao, ... Fighting against kidney diseases with small interfering RNA: opportunities and challenges..pdf. Published (publisher PDF). 1.1 ...
https://lra.le.ac.uk/handle/2381/36465
*  Identification of Chemosensitivity Nodes for Vinblastine through Small Interfering RNA High-Throughput Screens | Journal of...
Identification of Chemosensitivity Nodes for Vinblastine through Small Interfering RNA High-Throughput Screens. Carolyn A. ... Therefore, we implemented a small interfering RNA (siRNA) synthetic lethal screen targeting 5520 unique druggable genes to ... Identification of Chemosensitivity Nodes for Vinblastine through Small Interfering RNA High-Throughput Screens ... Small interfering (siRNA) technology has been used to identify genes that are essential for cancer cell survival (Kaelin, 2005 ...
http://jpet.aspetjournals.org/content/339/3/851
*  Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma...
This study was to explore the effects of specific small interfering RNA (siRNA) targeting HPA-1 com ... 0/RNA, Messenger; 0/RNA, Small Interfering; 9005-49-6/Heparin; EC 3.2.1.-/heparanase; EC 3.2.1.31/Glucuronidase ... Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma ... This study was to explore the effects of specific small interfering RNA (siRNA) targeting HPA-1 combined with heparin on ...
http://www.biomedsearch.com/nih/Effects-small-interfering-RNA-targeting/20800024.html
*  Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human...
Small interfering RNAs (siRNAs) are double-stranded RNA molecules that induce sequence-specific degradation of homologous ... Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ... Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ... Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ...
http://mct.aacrjournals.org/content/3/7/833.full