Long non-coding RNA - Wikipedia
Long non-coding RNAs (long ncRNAs, lncRNA) are defined as transcripts longer than 200 nucleotides that are not translated into ... "On the classification of long non-coding RNAs". RNA Biology. 10 (6): 924-933. doi:10.4161/rna.24604. PMC 4111732 . PMID ... "We're calling long noncoding RNAs a class, when actually the only definition is that they are longer than 200 bp," says Ana ... "Intergenic" refers to long non-coding RNAs that are transcribed from non-coding DNA sequences between protein-coding genes, ...https://en.wikipedia.org/wiki/Long_non-coding_RNA
Tag: long noncoding RNA | Highlight HEALTH
Long stretches of DNA once considered inert "dark matter" of the genome - the over 98% of DNA that doesn't code for proteins - ...http://www.highlighthealth.com/tag/long-noncoding-rna/
Clusters of Internally Primed Transcripts Reveal Novel Long Noncoding RNAs
We detected several known long ncRNAs within these regions, supporting the basic rationale of our approach. In silico analysis ... and were most likely primed from internal adenine-rich regions within longer parental transcripts. We therefore conducted a ... Non-protein-coding RNAs (ncRNAs) are increasingly being recognized as having important regulatory roles. Although much recent ... for experimental validation by northern blot and RT-PCR and found that the majority represent previously unrecognized noncoding ...http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0020037&imageURI=info:doi/10.1371/journal.pgen.0020037.g001
Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness...
Furthermore, the role of long noncoding RNAs (lncRNAs) in the cellular response to stiffening has never been explored. This ... Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness ... Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness ... Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness ...http://atvb.ahajournals.org/content/38/1/164
The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells | Garvan Institute of Medical Research
Expression of the long noncoding RNA (lncRNA) SPRY4-IT1 is low in normal human melanocytes but high in melanoma cells. siRNA ... Expression of the long noncoding RNA (lncRNA) SPRY4-IT1 is low in normal human melanocytes but high in melanoma cells. siRNA ... The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells. Abstract. Expression of the long ... The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells ...https://www.garvan.org.au/research/publications/12621
Systematic Characterization of Long Noncoding RNAs Reveals the Contrasting Coordination of Cis- and Trans-Molecular Regulation...
Interestingly, a relatively new class of noncoding RNAs, long noncoding RNAs (lncRNA), has recently been shown to also regulate ... As a class of important regulatory RNAs, the role of long noncoding RNAs (lncRNAs) in human heart development is still poorly ... Long noncoding RNA: a new player of heart failure? J Cardiovasc Transl Res. 2013;6:876-883. doi: 10.1007/s12265-013-9488-6.. ... Long noncoding RNAs expression profile of the developing mouse heart. J Cell Biochem. 2014;115:910-918. doi: 10.1002/jcb.24733. ...http://circgenetics.ahajournals.org/content/9/2/110
Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes | Genome Biology | Full Text
Mercer TR, Dinger ME, Sunkin SM, Mehler MF, Mattick JS: Specific expression of long noncoding RNAs in the mouse brain. Proc ... Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF: Long noncoding RNAs in neuronal-glial fate ... Ponting CP, Oliver PL, Reik W: Evolution and functions of long noncoding RNAs. Cell. 2009, 136: 629-641. 10.1016/j.cell.2009.02 ... Sheik Mohamed J, Gaughwin PM, Lim B, Robson P, Lipovich L: Conserved long noncoding RNAs transcriptionally regulated by Oct4 ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2010-11-7-r72
The p53‐inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation | The EMBO Journal
The p53‐inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation. View ORCID Profile ... The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in ...http://emboj.embopress.org/content/early/2017/10/18/embj.201696239.figures-only
Genome-wide analysis of long noncoding RNA stability. - Department of Psychiatry
... and cis-antisense long noncoding RNAs (lncRNAs) that are expressed from mammalian genomes. Despite progress in functional ... Utilizing a custom noncoding RNA array, we determined the half-lives of ∼800 lncRNAs and ∼12,000 mRNAs in the mouse Neuro-2a ... Surprisingly, one of the least stable lncRNAs is the well-characterized paraspeckle RNA Neat1, suggesting Neat1 instability ... Analysis of lncRNA features revealed that intergenic and cis-antisense RNAs are more stable than those derived from introns, as ...https://www.psych.ox.ac.uk/publications/482396
HOTAIR Long Noncoding RNA is not a Biomarker for Acute Myeloid Leukemia (AML) in Iranian Patients
The role of HOX transcript antisense RNA in acute myeloid leukemia (AML) was investigated in the present case control study. ... "HOTAIR Long Noncoding RNA is not a Biomarker for Acute Myeloid Leukemia (AML) in Iranian Patients". Asian Pacific Journal of ... HOTAIR Long Noncoding RNA is not a Biomarker for Acute Myeloid Leukemia (AML) in Iranian Patients. ... Sayad, A., Hajifathali, A., Hamidieh, A., Roshandel, E., Taheri, M. HOTAIR Long Noncoding RNA is not a Biomarker for Acute ...http://journal.waocp.org/article_46977.html
Circulating Long Noncoding RNA as a Potential Target for Prostate Cancer - pdf descargar
Circulating Long Noncoding RNA as a Potential Target for Prostate Cancer. . Biblioteca virtual para leer y descargar libros, ... Keywords: long noncoding RNA; prostate cancer; biomarker; therapeutic target long noncoding RNA; prostate cancer; biomarker; ... Circulating Long Noncoding RNA as a Potential Target for Prostate Cancer - Descarga este documento en PDF. Documentación en PDF ... Its emergence is largely due to the coordination of a malignant network, and long noncoding RNA has been recently demonstrated ...http://libros.duhnnae.com/2017/jun5/149741775864-Circulating-Long-Noncoding-RNA-as-a-Potential-Target-for-Prostate-Cancer.php
Long noncoding RNA repertoire in chicken liver and adipose tissue | Genetics Selection Evolution | Full Text
Long noncoding RNA prediction. lncRNA annotation was performed by the FEELnc program (FlExible Extraction of Long noncoding ... Analyses of long non-coding RNA and mRNA profiling using RNA sequencing during the pre-implantation phases in pig endometrium. ... Comparison of splice sites reveals that long noncoding RNAs are evolutionarily well conserved. RNA. 2015;21:801-12.View Article ... SINEUPs: a new class of natural and synthetic antisense long non-coding RNAs that activate translation. RNA Biol. 2015;12:771-9 ...https://gsejournal.biomedcentral.com/articles/10.1186/s12711-016-0275-0
Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. - Nuffield Department of...
... study of four highly conserved and brain-expressed transcripts selected from a list of mouse long intergenic noncoding RNA ( ... This dearth of information is partially attributable to a lack of established non-protein-coding RNA (ncRNA) orthologs among ... Indeed, more of the human genome is transcribed into noncoding sequence than into protein-coding sequence. Nevertheless, whilst ... their pattern of brain expression during embryonic and early postnatal stages together indicate that these are functional RNA ...https://www.ndcn.ox.ac.uk/publications/106551
Over-expression of long noncoding RNA BANCR inhibits malignant phenotypes of human bladder cancer | Journal of Experimental &...
Peng W, Si S, Zhang Q, Li C, Zhao F, Wang F, Yu J, Ma R. Long non-coding rna meg3 functions as a competing endogenous rna to ... Geisler S, Coller J. Rna in unexpected places: long non-coding rna functions in diverse cellular contexts. Nat Rev Mol Cell ... Long noncoding rnas and the genetics of cancer. Br J Cancer. 2013;108:2419-25.View ArticlePubMedPubMed CentralGoogle Scholar. ... Long noncoding rna in prostate, bladder, and kidney cancer. Eur Urol. 2014;65:1140-51.View ArticlePubMedGoogle Scholar. ...https://jeccr.biomedcentral.com/articles/10.1186/s13046-016-0397-9
Long noncoding RNA expression profile in HLE B-3 cells during TGF-β2-induced epithelial-mesenchymal transition | BMC...
Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009;23(13):1494-504.View ArticlePubMedPubMed Central ... Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell. 2009;136(4):629-41.View ArticlePubMed ... Genome regulation by long noncoding RNAs. Annu Rev Biochem. 2013;81:145-66.View ArticleGoogle Scholar. ... Long noncoding RNAs (lncRNAs) are transcripts of more than 200 nucleotides, that do not have the ability to encode proteins, ...https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-017-0461-z
Advances in understanding chromosome silencing by the long non-coding RNA Xist. - Oxford Neuroscience
Here, we provide an overview of the current state of our knowledge, what is known about Xist RNA and how it may trigger ... The Xist gene produces a non-coding RNA that functions as the primary switch for X-inactivation, coating the X chromosome from ... but our understanding of the molecular basis of silencing mediated by Xist RNA has progressed more slowly. A picture has, ... Advances in understanding chromosome silencing by the long non-coding RNA Xist. ...https://www.neuroscience.ox.ac.uk/publications/366790
Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk : Carcinogenesis - oi
Long non-coding RNAs (lncRNAs), representing a large proportion of non-coding transcripts across the human genome, are ... Long non-coding RNAs (lncRNAs), representing a large proportion of non-coding transcripts across the human genome, are ... At least one-third of the phenotype-related loci identified by genome-wide association studies (GWAS) are mapped to non-coding ... At least one-third of the phenotype-related loci identified by genome-wide association studies (GWAS) are mapped to non-coding ...http://oxfordindex.oup.com/view/10.1093/carcin/bgr187
Functionality or transcriptional noise? evidence for selection within long noncoding RNAs. Genome Research. 17(5):556-565. ... A large intergenic noncoding RNA induced by p53 mediates global gene repression in thep53 response. Cell. 142(3):409-419. DOI: ... Large intergenic non-coding RNA-RoR modeulates reprogramming of human induced pluripotent stem cells. NATURE Genetics. 42(12): ... Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129(7):1311-1323. ...http://librarynews.rockefeller.edu/?tag=lincrna
Staff Profile - Institute for Cell and Molecular Biosciences - Newcastle University
... have shown that much of the noncoding regions of the genome are actively transcribed. The resulting noncoding RNAs have emerged ... NATs are long regulatory RNAs that are transcribed in the opposite direction of protein-coding transcripts and potentially ... Moreover, we are interested in the function of noncoding RNAs in the organisation of the genome and the regulation of ... Non-coding RNAs and Epigenetic Regulation of Gene Expression: Drivers of Natural Selection. Norfolk: Caister Academic Press, ...http://www.ncl.ac.uk/camb/staff/profile/andreaswerner.html
Telomerase and Long Noncoding RNA-Protein Complexes | HHMI.org
Tom Cech and his research group are studying the structure and mechanism of long noncoding RNAs and RNA-protein complexes, ... We have now moved out of this RNA world to investigate other long noncoding RNAs, where catalysis is carried out by RNPs (RNA- ... Tom Cech and his research group are studying the structure and mechanism of long noncoding RNAs and RNA-protein complexes, ... Long Noncoding RNAs Regulating Transcription. While previous research has suggested the specific binding of the histone ...https://www.hhmi.org/research/telomerase-and-long-noncoding-rna-protein-complexes
Long Noncoding RNAs and Cancer
Long noncoding RNAs (lncRNAs), products of pervasive transcription of the human genome, have emerged as important epigenetic ... Molecular mechanisms of long noncoding RNAs. Molecular Cell 43: 904-914.. Wapinski O and Chang HY(2011) Long noncoding RNAs and ... 2011) The long noncoding MALAT‐1 RNA indicates a poor prognosis in non‐small cell lung cancer and induces migration and tumor ... Long Noncoding RNAs and Cancer. Ramiro Garzon, The Ohio State University, Columbus, Ohio, USA Parvathi Ranganathan, The Ohio ...http://www.els.net/WileyCDA/ElsArticle/refId-a0025252.html
2.7 Noncoding RNAs - long noncoding RNAs introduction - Week 2 - Epigenetic Modifications and Organisation of the Nucleus |...
JCI - Investigating long noncoding RNAs using animal models
... long noncoding RNAs (lncRNAs), represents a large family of noncoding RNA molecules with potentially broad implications for ... Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol Cell. 2011;44(4):667-678. ... RNA-targeted approaches and animal models. RNA-targeted strategies introduce an exogenous RNA or an RNA analog that ... Investigating long noncoding RNAs using animal models. Michael Feyder1,2 and Loyal A. Goff1,2,3 1McKusick-Nathans Institute for ...https://www.jci.org/articles/view/84422
An inducible long noncoding RNA amplifies DNA damage signaling. - PubMed - NCBI
An inducible long noncoding RNA amplifies DNA damage signaling.. Schmitt AM1,2, Garcia JT1, Hung T1, Flynn RA1, Shen Y1, Qu K1 ... Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but mostly unknown functions. Here we ... Right: RNA chromatography using 6 pmol RNA and 1 ug of each recombinant protein as indicated.. (b) RNA IP of p53 in human ... DNA damage activated transcription of the DINO (Damage Induced Noncoding) lncRNA via p53. DINO was required for p53-dependent ...https://www.ncbi.nlm.nih.gov/pubmed/27668660
Predicting Long Noncoding RNA and Protein Interactions Using Heterogeneous Network Model
... Ao Li,1,2 Mengqu Ge,1 Yao Zhang,1 ... C. Xie, J. Yuan, H. Li et al., "NONCODEv4: exploring the world of long non-coding RNA genes," Nucleic Acids Research, vol. 42, ... O. Wapinski and H. Y. Chang, "Long noncoding RNAs and human disease," Trends in Cell Biology, vol. 21, no. 6, pp. 354-361, 2011 ... K. C. Wang and H. Y. Chang, "Molecular mechanisms of long noncoding RNAs," Molecular Cell, vol. 43, no. 6, pp. 904-914, 2011. ...https://www.hindawi.com/journals/bmri/2015/671950/ref/