... Version 05 February 2006 (temporary). http://tolweb.org/Double-stranded_RNA_Viruses/21833/2006.02. ... Double-stranded RNA Viruses Click on an image to view larger version & data in a new window ... Transmission electron micrograph of intact rotavirus particles, double-shelled. Distinctive rim of radiating capsomeres. ... Double-stranded RNA Viruses Page Content. *Title Illustrations. *About This Page. articles & notes. *Double-stranded RNA ...
Small nucleolar RNA interference induced by antisense or double-stranded RNA in trypanosomatids ... double-stranded RNA;. GFP,. green fluorescent protein;. PFR,. paraflagellar rod;. 5′ UTR,. 5′ untranslated region. ... Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Huân Ngô, Christian Tschudi, Keith Gull, and Elisabetta ... Double-stranded RNA induces mRNA degradation in Trypanosoma brucei Message Subject (Your Name) has sent you a message from PNAS ...
The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the ... The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. ... A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The ... duplex region of the RNA and of a portion of the target gene are identical. ...
This serine/threonine-specific protein kinase is activated by double-stranded RNA by a mechanism involving autophosphorylation ... PKR--a protein kinase regulated by double-stranded RNA.. Clemens MJ1. ... The RNA-regulated protein kinase, (PKR) is an interferon-inducible enzyme of widespread occurrence in eukaryotic organisms. ...
... dubbed Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO)... Patton, John T., ed. (2008). Segmented Double- ... Double-stranded (ds) RNA viruses are a diverse group of viruses that vary widely in host range (humans, animals, plants, fungi ... It is a double-stranded RNA non-enveloped virus The members of genus Orbivirus within the Reoviridae family are arthropod borne ... 2008). "The Yeast dsRNA Virus L-A Resembles Mammalian dsRNA Virus Cores". Segmented Double-stranded RNA Viruses: Structure and ...
... it seems possible that cellular RNA-dependent RNA polymerase could be involved in the conversion of single-stranded RNA to ... Double-stranded RNA (dsRNA)-mediated interference with expression of specific genes has been observed in a number of organisms ... Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana. Chiou-Fen Chuang and Elliot M. ... We investigated the potential of double-stranded RNA interference (RNAi) with gene activity in Arabidopsis thaliana. To ...
... it seems possible that cellular RNA-dependent RNA polymerase could be involved in the conversion of single-stranded RNA to ... Double-stranded RNA (dsRNA)-mediated interference with expression of specific genes has been observed in a number of organisms ... Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana. Chiou-Fen Chuang and Elliot M. ... An Intron Sense Suppression Construct Targeting Soybean FAD2-1 Requires a Double-Stranded RNA-Producing Inverted Repeat T-DNA ...
double-stranded RNA;. PKR,. dsRNA-activated protein kinase;. MEF,. mouse embryo fibroblast;. IRF,. IFN regulatory factor;. TNF- ... A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Sandy D. Der, Yi-Li Yang, ... The interferon-induced, double-stranded RNA-activated protein kinase (PKR) has been implicated in processes that rely on ... A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis ...
Double stranded RNA (dsRNA) can effectively reduce house fly fertility, and shows promise as a pest control method, according ... Double stranded RNA treatment can reduce fertility of adult house fly pests Fly-specific dsRNA interfered with gene expression ... Double Stranded RNA treatment Can Reduce Fertility of Adult House Fly Pests (IMAGE) view more ... Double stranded RNA (dsRNA) can effectively reduce house fly fertility, and shows promise as a pest control method, according ...
Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.. Kibler KV1, Shors T, Perkins KB, Zeman CC, ... The vaccinia virus E3L gene codes for double-stranded RNA (dsRNA) binding proteins which can prevent activation of the dsRNA- ...
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Mary K. Montgomery, SiQun Xu, ... RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans ... RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans ... RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans ...
RNA interference (RNAi) is widely used as a reverse genetic approach for functional analysis of plant genes. Constitutive or ... 1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.PubMed ... Double-stranded (ds) RNA interference (RNAi) is widely used as a reverse genetic approach for functional analysis of plant ... Jung H., Zhai Z., Vatamaniuk O.K. (2011) Direct Transfer of Synthetic Double-Stranded RNA into Protoplasts of Arabidopsis ...
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5: ... Microglia Recognize Double-Stranded RNA via TLR3. Terrence Town, David Jeng, Lena Alexopoulou, Jun Tan and Richard A. Flavell ... Microglia Recognize Double-Stranded RNA via TLR3 Message Subject (Your Name) has forwarded a page to you from The Journal of ... Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413: 732-738. ...
... we found that double-stranded RNA was substantially more effective at producing interference than was either strand ... Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.. Fire A1, Xu S, Montgomery MK, ... Only a few molecules of injected double-stranded RNA were required per affected cell, arguing against stochiometric ... After injection into adult animals, purified single strands had at most a modest effect, whereas double-stranded mixtures ...
siRNA is a type of double stranded RNA (dsRNA).. The author stirred fears down under last year with well-publicized warnings ... RNA engineered to maintain toxic traits could also enter the natural environment to harm plants and animals, Heinemann argued. ... The papers authors, led by John Heinemann, warn that small interfering RNA (siRNA) used to silence genes could disrupt human ... Instead of adding genetic material for desirable traits, certain undesirable traits are "silenced" by inhibiting RNA from ...
RIG-I and MDA5 are cytosolic RNA sensors that play a critical role in innate antiviral responses. Major advances have been made ... IFN-α/β production does not rely on plus-strand RNA synthesis and thus generation of the partially double-stranded replicative ... Our results show that the incoming genomic plus-strand RNA does not activate MDA5, but minus-strand RNA synthesis and ... MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells Cell Rep. 2012 Nov 29;2(5):1187-96. doi: ...
The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo. R C Patel, P ... The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo ... The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo ... The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo ...
Monoclonal antibodies to double-stranded RNA as probes of RNA structure in crude nucleic acid extracts.. Schönborn J1, ... We describe four monoclonal antibodies (MAB) which specifically recognize double-stranded RNA (dsRNA) together with their use ... only background levels of binding were obtained on single-stranded RNA species which contain double-helical secondary ... no binding to single-stranded RNA homopolymers or to DNA or RNA-DNA hybrids was observed. The apparent affinity of the ...
The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase.. Galabru J1, Katze MG, ... The protein kinase from human cells dependent on double-stranded (ds) RNA is a 68-kDa protein (p68 kinase), the level of which ... In spite of its lower affinity of binding, VAI RNA cannot be displaced by poly(I).poly(C) or reovirus dsRNA. These data confirm ... We have also investigated the binding of adenoviral VAI RNA to the purified p68 kinase and have found that the affinity of this ...
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. G P Cosentino, S ... Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo ... Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo ... Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo ...
Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV ... Microbial infection) Interacts with human herpes simplex virus 1 (HHV-1) protein US11 in an RNA-dependent manner (PubMed: ...
... edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult ... Has A-to-I RNA editing activity on extended dsRNA: ... Double-stranded RNA-specific editase AdarAdd BLAST. 676. ... Cluster: Double-stranded RNA-specific editase Adar. 4. Q9NII1-2. M9NGI0. Q9NII1-6. M9NFQ6. Drosophila melanogaster (Fruit fly) ... Cluster: Double-stranded RNA-specific editase Adar. 55. Q9NII1-2. M9NGI0. Q9NII1-6. M9NFQ6. UPI00078ADFB4. A0A0Q5T786. ...
... double stranded RNA (dsRNA)-activated serine/threonine kinase, PKR, is a potent negative regulator of cell growth when ... RNA, Double-Stranded / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured. eIF-2 Kinase / ... 0/Cell Cycle Proteins; 0/DNA Primers; 0/NF-kappa B; 0/RNA, Double-Stranded; EC 2.7.11.1/eIF-2 Kinase ... The interferon (IFN)-induced, double stranded RNA (dsRNA)-activated serine/threonine kinase, PKR, is a potent negative ...
Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot- ... double-stranded RNA binding Source: MGI ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the function, ... Interferon-induced, double-stranded RNA-activated protein kinaseAdd BLAST. 514. Amino acid modifications. Feature key. Position ... "Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.". Nie Y., Hammond G.L., Yang J.H.. J. ...
RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As ... Double-stranded RNA-binding protein Staufen homolog 2Add BLAST. 570. Amino acid modifications. Feature key. Position(s). ... double-stranded RNA binding Source: MGI ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the function, ... sp,Q9NUL3,STAU2_HUMAN Double-stranded RNA-binding protein Staufen homolog 2 OS=Homo sapiens OX=9606 GN=STAU2 PE=1 SV=2 ...