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*  Catalytic RNA - Latest research and news | Nature
Catalytic RNA. Definition. Catalytic RNA (ribonucleic acid) are RNA molecules that have enzyme activity. The classic example is ... Discovery of catalytic RNA contributed to the hypothesis of an 'RNA world', describing the origin of life as starting from RNA ... Catalytic RNAs are involved in a number of biological processes, including RNA processing and protein synthesis. ... Topological constraints of structural elements in regulation of catalytic activity in HDV-like self-cleaving ribozymes *Chiu-Ho ...
http://www.nature.com/subjects/catalytic-rna?error=cookies_not_supported&code=8c8fff1d-47b2-4f08-90fe-c3ab3ccf701c
*  Catalytic RNA and Structure
These catalytic RNA sequences are called ribozymes. The function of a ribozyme depends upon the primary sequence of the RNA ... Catalytic RNA and Structure *. Please ensure you have JavaScript enabled in your browser. If you leave JavaScript disabled, you ... p023/biotechnology-techniques/catalytic-rna-and-structure. You may print and distribute up to 200 copies of this document ... "Catalytic RNA and Structure" Science Buddies. Science Buddies, 28 July 2017. Web. 24 Mar. 2018 ,https://www.sciencebuddies.org/ ...
https://www.sciencebuddies.org/science-fair-projects/project-ideas/BioChem_p023/biotechnology-techniques/catalytic-rna-and-structure
*  RCSB PDB - 488D: CATALYTIC RNA ENZYME-PRODUCT COMPLEX Structure Summary Page
Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic ... RNA RIBOZYME STRAND A. 16 synthetic 16-MER FIRST RNA FRAGMENT OF CLEAVED SUBSTRATE B. 20 synthetic 20-MER, 3'-END CYCLIC ... RNA LINKING C9 H13 N3 O10 P2 C ... CATALYTIC RNA ENZYME-PRODUCT COMPLEX. *DOI: 10.2210/pdb488d/pdb ...
http://www.rcsb.org/pdb/explore/explore.do?structureId=488D
*  Environmental epistasis in catalytic RNA | Proceedings of the Royal Society of London B: Biological Sciences
Environmental change exposes beneficial epistatic interactions in a catalytic RNA Message Subject (Your Name) has sent you a ... Environmental change exposes beneficial epistatic interactions in a catalytic RNA. Eric J. Hayden, Andreas Wagner ... Here, we reconstruct the fitness landscape of a catalytic RNA molecule (ribozyme), including all possible intermediates that ... 1997 Equally parsimonious pathways through an RNA sequence space are not equally likely. J. Mol. Evol. 45, 278-284. doi:10.1007 ...
http://rspb.royalsocietypublishing.org/content/279/1742/3418
*  PB1 - RNA-directed RNA polymerase catalytic subunit - Influenza D virus (D/swine/Oklahoma/1334/2011) - PB1 gene & protein
RNA-directed RNA polymerase catalytic subunit (Fragment). Influenza C virus (C/Eastern India/1202/2011) ... RNA-directed RNA polymerase catalytic subunitUniRule annotation. Automatic assertion according to rulesi ... RNA-directed RNA polymerase catalytic subunit. Influenza D virus (D/bovine/Mexico/S62/2015) ... RNA-directed RNA polymerase catalytic subunit. Influenza D virus (D/bovine/Mexico/S7/2015) ...
https://www.uniprot.org/uniprot/K9LH03
*  PB1 - RNA-directed RNA polymerase catalytic subunit - Influenza A virus (strain A/USA:Iowa/1943 H1N1) - PB1 gene & protein
During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a ... In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. ... RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of ... help/catalytic_activity' target='_top'>More...,/a>,/p>Catalytic activityi. Nucleoside triphosphate + RNA(n) = diphosphate + RNA ...
http://www.uniprot.org/uniprot/A4GCL6
*  Growth rate regulation of 4.5 S RNA and M1 RNA, the catalytic subunit of Escherichia coli RNase P
... Dong, Hengjiang Uppsala ... We have studied the expression of 4.5 S RNA and Fv Il RNA, the catalytic subunit of Escherchia coli RNase P, under various ... but has little effect on the expression of M1 RNA. These data suggest that the expression of both 4.5 S RNA and M1 RNA genes ... Both RNA species increase in abundance as a function of growth rate. There are roughly 450 molecules of 4.5 S RNA and 80 ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:400904
*  Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA | Science
Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA ... Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA ... Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA ... Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA ...
http://science.sciencemag.org/content/260/5113/1500
*  7 - Structural and Catalytic Roles of Metal Ions in RNA (RSC Publishing)
Since the discovery of catalytic RNA molecules (ribozymes), intense research has been devoted to understand their structure and ... Among RNA molecules, the large ribozymes, namely group I and group II introns and RNase P, are of special importance. The first ... allow clarifying and rationalizing both the structural and catalytic roles of metal ions in large ribozymes. In particular, the ...
http://pubs.rsc.org/en/Content/Chapter/9781849732512-00197/978-1-84973-251-2
*  Nanomechanical constraints acting on the catalytic site of cellular RNA polymerases | Biochemical Society Transactions
2008) An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II. Nat. Struct. Mol. Biol ... Nanomechanical constraints acting on the catalytic site of cellular RNA polymerases Message Subject (Your Name) has forwarded a ... Nanomechanical constraints acting on the catalytic site of cellular RNA polymerases. Robert O.J. Weinzierl ... 2003) Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase. EMBO J. 22:2234-2244. ...
http://www.biochemsoctrans.org/content/38/2/428
*  Empirical demonstration of environmental sensing in catalytic RNA: evolution of interpretive behavior at the origins of life |...
Here, we present data that certain catalytic RNA sequences have properties that would enable interpretation of divalent cation ... We have shown that RNA molecules in a test tube can meet the minimum criteria for the evolution of interpretive behaviour in ... Interpretation in RNA molecules provides a property entirely dependent on natural physico-chemical interactions, but capable of ... we show an empirical proof-of-principle that interpretation can be an evolvable trait in RNA, often suggested as a model system ...
https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-014-0248-2
*  Catalytic effects of Murchison Material: Prebiotic Synthesis and Degradation of RNA Precursors | SpringerLink
Mineral components of the Murchison meteorite were investigated in terms of potential catalytic effects on synthetic and ... Cech TR (1987) The chemistry of self-splicing RNA and RNA enzymes. Science 236:1532-1539PubMedCrossRefGoogle Scholar ... Catalytic effects of Murchison Material: Prebiotic Synthesis and Degradation of RNA Precursors. ... Cheng LK, Unrau PJ (2010) Closing the circle: replicating RNA with RNA. In: Deamer D, Szostak J (eds) Origins of Life. Cold ...
https://link.springer.com/article/10.1007%2Fs11084-011-9239-0
*  RCSB PDB - 3ULD: High resolution structure of DNA/RNA hybrid in complex with RNase H catalytic domain D132N mutant...
RNA/DNA hybrid in complex with RNase H catalytic domain mutant D132N ... High resolution structure of DNA/RNA hybrid in complex with RNase H catalytic domain D132N mutant. ...
http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=3ULD
*  Catalytic activation of multimeric RNase E and RNase G by 5′-monophosphorylated RNA | PNAS
Catalytic activation of multimeric RNase E and RNase G by 5′-monophosphorylated RNA. Xunqing Jiang and Joel G. Belasco ... Within the catalytic domain of these enzymes, there presumably is a site that can interact productively with RNA 5′ ends that ... 3B ). In the case of RNase G, the increase in k cat for the monophosphorylated RNA (2.1 ± 0.1 min-1) versus the hydroxyl RNA ( ... Catalytic activation of multimeric RNase E and RNase G by 5′-monophosphorylated RNA ...
https://www.pnas.org/content/101/25/9211
*  Adrian R. Ferré-D'Amaré, Ph.D. Research | National Heart, Lung, and Blood Institute (NHLBI)
Catalytic RNAs. Ribozymes are non-coding RNAs that can precisely position reactants and accelerate chemical reactions by ... catalytic RNAs) and the interactions between RNA and proteins at the level of atomic structure. Dr. Ferré-D'Amaré is also ... New tools for RNA cell biology. Tens of thousands of non-coding RNAs have been discovered in the human transcriptome, and new ... Ferré-D'Amaré's second translational research focus is on the role of a catalytic RNA-glmS-in controlling the synthesis of the ...
https://www.nhlbi.nih.gov/node/83041
*  Adrian R. Ferré-D'Amaré, Ph.D. Research | National Heart, Lung, and Blood Institute (NHLBI)
Catalytic RNAs. - Adrian R. Ferré-D'Amaré, Ph.D. Research Ribozymes are non-coding RNAs that can precisely position reactants ... RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures. ... catalytic RNAs) and the interactions between RNA and proteins at the level of atomic structure. Dr. Ferré-D'Amaré is also ... New tools for RNA cell biology. - Adrian R. Ferré-D'Amaré, Ph.D. Research Tens of thousands of non-coding RNAs have been ...
https://www.nhlbi.nih.gov/node/83041?page=1
*  'Dual' peptidyl-oligonucleotide conjugates: Role of conformational flexibility in catalytic cleavage of RNA - PE...
We report a novel class of catalytic biomaterials, comprising amphipathic RNA-cleaving peptides placed between two RNA ... Upstream catalytic targeting of specific RNA sequences offers an alternative platform for drug discovery to achieve more potent ... Dual' peptidyl-oligonucleotide conjugates: Role of conformational flexibility in catalytic cleavage of RNA novelconjugates ... This study provides the strong position for future development of highly selective RNA-targeting agents that can potentially be ...
http://novelconjugates.com/dual-peptidyl-oligonucleotide-conjugates-role-of-conformational-flexibility-in-catalytic-cleavage-of-rna/
*  Progress in Nucleic Acid Research and Molecular Biology: Volume 79 : Kivie Moldave : 9780125400800
Catalytic RNA: Volume 120 Garrett A. Soukup 12 Dec 2013. Hardback. US$177.83 ... Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular ... Structure and Function in Promoter Escape by T7 RNA Polymerase. Ribonuclease Inhibitor: Structure and Function. show more ...
https://www.bookdepository.com/Progress-Nucleic-Acid-Research-Molecular-Biology-79-Kivie-Moldave/9780125400800?ref=bd_ser_1_1
*  Nucleotide sequence and structural analysis of two satellite RNAs associated with chicory yellow mottle virus. - Semantic...
Both linear and circular forms of this satellite RNA were detected in infected tissues. Comparison of the sCYMV-S1 primary ... coding for a protein of Mr 39,636 resembling in composition those of other large nepovirus satellite RNAs, a 5' leader sequence ... The two satellite RNAs associated with CYMV infections were sequenced. The larger (sCYMV-L1) has only linear molecules 1145 ... RNA catalytic properties of the minimum (-)sTRSV sequence.. *A Hampel, R Tritz ...
https://www.semanticscholar.org/paper/Nucleotide-sequence-and-structural-analysis-of-two-Rubino-Tousignant/5c8bf1953e5d767c4cd54cf8c8004aaa76f5221f
*  Biological Chemistry
25 years of catalytic RNA: looking younger than ever!. Hammann, Christian / Hartmann, Roland K. / Marchfelder, Anita ... On the occasion of the 25th anniversary of the discovery of catalytic RNA. Cech, Thomas R. ... Highlight: RNA Catalysis. Group II introns: structure, folding and splicing mechanism. Fedorova, Olga / Zingler, Nora ... RNA self-processing towards changed topology and sequence oligomerization. Pieper, Stefan / Vauléon, Stéphanie / Müller, Sabine ...
https://www.degruyter.com/view/j/bchm.2007.388.issue-7/issue-files/bchm.2007.388.issue-7.xml
*  US9072766B2 - Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT) - Google Patents
Chimeric dna-rna catalytic sequences US5427908A (en) 1990-05-01. 1995-06-27. Affymax Technologies N.V.. Recombinant library ... binding to a target RNA (e.g., an RNA having the complementary sequence) and causing the RNA to be degraded by ... RNA Extraction and Quantitative PCR. For RNA extraction, tissues were homogenized in Tri reagent (Molecular Re-search Center, ... After a ribozyme has cleaved its RNA target, it is released from that target RNA and thereafter can bind and cleave another ...
https://patents.google.com/patent/US9072766B2/en
*  RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit | eLife
Ubiquitination close to the active site of RNAPII occurs in response to RNA processing events and is linked to transcriptional ... RNA-seq. RNA was extracted as previously described (Tollervey, 1987). The RNA samples were either enriched for mRNA using ... Bre5 binds RNA in vitro and in vivo.. (A) Bre5 and Ubp3 plus Bre5 bind RNA in vitro. Recombinant Bre5 and Ubp3 were expressed ... RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit. ...
https://elifesciences.org/articles/27082
*  Structural diversity of self-cleaving ribozymes | PNAS
Using droplet-based microfluidics to improve the catalytic properties of RNA under multiple-turnover conditions ... Frequency of RNA-RNA interaction in a model of the RNA World. ... Engineered Catalytic RNA and DNA. David Steele, Alexis ... Revitalization of Six Abandoned Catalytic DNA Species Reveals a Common Three-way Junction Framework and Diverse Catalytic Cores ... Folding of small RNAs displaying the GNC base-pattern: implications for the self-organization of the genetic system ...
http://www.pnas.org/content/97/11/5784/tab-article-info
*  Glossary of biotechnology and genetic engineering
cf catalytic antibody; catalytic RNA.. catalytic antibody (= abzyme) An antibody selected for its ability to catalyse a ... catalytic RNA (= ribozyme; gene shears) A natural or synthetic RNA molecule that cuts an RNA substrate. ... C Cytosine residue in either DNA or RNA.. CAAT box (also CAT box) A conserved sequence found within the promoter region of the ... cytosine A pyrimidine base found in DNA and RNA.. cytosol The fluid portion of the cytoplasm, i.e., the cytoplasm minus its ...
http://www.fao.org/docrep/003/X3910E/X3910E06.htm