RNA-binding protein EWS - Wikipedia
RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. ... "Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins". ... "Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS". Curr. Biol. ... The normal EWS gene encodes an RNA binding protein closely related to FUS (gene) and TAF15, all of which have been associated ...
MedlinePlus: Genes: E
SMART: IQ domain annotation
RNA binding to EWS interferes with PKC phosphorylation. Several other RNA-binding proteins, including TLS/FUS and PSF, co- ... These data suggest that PKC may regulate interactions of EWS and other RNA-binding proteins with their RNA targets and that IQ ... purify with EWS. PKC phosphorylation of these proteins also inhibits their binding to RNA in vitro. ... The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain. ...
Precision medicine for human cancers with Notch signaling dysregulation (Review)
... sarcoma due to repression of JAG1 by RNA binding protein EWS-friend leukemia integration 1 transcription factor fusion protein ... receptor-type tyrosine-protein phosphatase F and TRIO and F-actin-binding protein, which activates RAC1 to maintain vascular ... disintegrin and metalloproteinase domain-containing protein 10; ATM, serine-protein kinase ATM; MAML, mastermind like protein; ... CT, computed tomography; GI, gastrointestinal; FISH, fluorescence in situ hybridization; RNA-ISH, RNA in situ hybridization; ...
EWSR1 and SERP2 Interaction - Wiki-Pi
It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations ... a web resource for human protein-protein interactions. ... EWS RNA-binding protein 1. stress-associated endoplasmic ... Protein-Protein Interactions. 159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 ...
Int Med - Digestv & Liver Dis - Research output - University of Texas Southwestern Medical Center
RNA-Binding Protein EWS 27% 2 Scopus citations * ACG Clinical Guideline: Diagnosis and Management of Biliary Strictures. ... Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma. Wang, S., Huo, X., Yang, Y., Mo, Y., ... A Combined DNA/RNA-based Next-Generation Sequencing Platform to Improve the Classification of Pancreatic Cysts and Early ...
EWSR1 and VPS72 - Wiki-MPM
School of Medicine - Research output - University of Texas Southwestern Medical Center
RNA-Binding Protein EWS 27% 2 Scopus citations * Abnormal bolus reflux on impedance-pH testing independently predicts 3-year ... Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma. Wang, S., Huo, X., Yang, Y., Mo, Y., ... Carbohydrate-containing Clear Liquids with or without Protein, Chewing Gum, and Pediatric Fasting Duration - A Modular Update ...
Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. | Broad...
Proto-Oncogene Protein c-fli-1. RNA-Binding Protein EWS. Sarcoma, Ewing ... Screening identified cytosine arabinoside (ARA-C) as a modulator of EWS/FLI. ARA-C reduced EWS/FLI protein abundance and ... the EWS/FLI off state was determined with microarray expression profiling of Ewing sarcoma cell lines with EWS/FLI-directed RNA ... Although the EWS/FLI oncoprotein, present in the vast majority of Ewing tumors, was characterized over ten years ago, it has ...
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Ewing Sarcoma: Practice Essentials, Etiology, Epidemiology
A small molecule that binds to EWS-FLI1, YK-4-279, blocks its interaction with a key partner protein, RNA Helicase A (RHA), ... Fusion protein. The EWS-FLI1 fusion transcript encodes a 68-kd protein with 2 primary domains. The EWS domain is a potent ... A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewings sarcoma. Nat ... EWS-ETV t(7;22), and EWS-FEV t(2;22), all of which involve the ETS family protein. Approximately 4% of Ewing sarcomas have been ...
Neuroscience
EWS, EWS oncogene, EWSR1, RNA binding protein EWS. Catalogue No.: FNab10142. Host: Rabbit. Reactivity: Human, Mouse. Test ... Monkey IGFBP-3(Insulin-like growth factor-binding protein 3) ELISA Kit ... BSAP, BSAP,PAX5, paired box 5, Paired box protein Pax 5, PAX5. Catalogue No.: FNab10180. Host: Rabbit. Reactivity: Human. Test ... ETS related protein Tel1, ETS translocation variant 6, ets variant 6, ETV6, TEL, TEL/ABL, TEL1, Transcription factor ETV6. ...
Pesquisa | Biblioteca Virtual em Saúde
O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and ... Developmental dynamics of RNA translation in the human brain. Duffy, Erin E; Finander, Benjamin; Choi, GiHun; Carter, Ava C; ... Automatic structure-based NMR methyl resonance assignment in large proteins. Pritisanac, Iva; Würz, Julia M; Alderson, T Reid; ... Whence Blobs? Phylogenetics of functional protein condensates. Pritisanac, Iva; Zarin, Taraneh; Forman-Kay, Julie D; Moses, ...
Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous...
Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice 2018; 27(2 ... Nakamura N, Kimura Y, Tokuda M, Honda S, Hirose S. MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change ... Several regulatory proteins such as dynamin-related protein 1 (Drp1) are required to maintain mitochondrial morphology via a ... MiD49 and MiD51 (MIEF1) also binds to Drp1, but these bindings inhibit mitochondrial fission [37, 38]. ...
Genetics of Amyotrophic Lateral Sclerosis | Encyclopedia MDPI
Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice. Exp. ... 2) The loss of nuclear TDP-43 function leads to inhibition of TDP-43 binding to STMN2 RNA and mis-splicing of STMN2 RNA, which ... RNA metabolism and protein metabolism have been indicated as commonly proposed ALS pathogenic mechanisms [11]. ... Inlet) Moreover, mFUS binds to mature mRNAs in the cytoplasm and affects mRNA translation. Suppressed protein translation ...
Ewing Sarcoma: Practice Essentials, Etiology, Epidemiology
A small molecule that binds to EWS-FLI1, YK-4-279, blocks its interaction with a key partner protein, RNA Helicase A (RHA), ... Fusion protein. The EWS-FLI1 fusion transcript encodes a 68-kd protein with 2 primary domains. The EWS domain is a potent ... A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewings sarcoma. Nat ... EWS-ETV t(7;22), and EWS-FEV t(2;22), all of which involve the ETS family protein. Approximately 4% of Ewing sarcomas have been ...
"Ewing Sarcoma Transcriptome: Identification of FOXN3 as a Novel Target" by Natasha Kreiling
... a better understanding of FOXN3 and its ability to act as a tumor suppressor in EWS will unravel novel mechanisms of EWS ... EWS-FLI1 promotes tumor growth by dysregulating several genes and pathways. We have identified FOXN3, an important gene in cell ... The most common fusion gene is EWS-FLI1 a potent oncogenic transcription factor responsible for initiating genome instability. ... Ewing Sarcoma is an aggressive cancer characterized by a fusion gene formed from a chromosomal translocation between a RNA ...
ALSF Childhood Cancer Research Grants | Page 3 | Alex's Lemonade Stand Foundation for Childhood Cancer
Ewing Sarcoma: Diagnosis, Treatment, Research and Support
Inhibitory RNA techniques were used to identify insulin-like growth factor binding protein 3 (Prieur 2004) and cyclin D1 ( ... Their research showed that EWS-FLI binds a molecule called RNA Helicase A which functions in the regulation of genetic ... described a non-viral delivery system for administering small inhibitory RNA directed against the EWS-FLI fusion protein (Hu- ... A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewings sarcoma. Nat ...
Gene Detail
UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM - Terms starting with 'W' - MEDINDEX.AM
Ubiquitous nuclear and cytoplasmic RNA Binding Protein EWS belongs to the TET family of RNP proteins, contains an RNA ... The RNA-binding activity is localized to a C-terminal RGG box. EWS binds RNA, calmodulin, and the RNA polymerase II 33 kD ... EWS contains a transcription activation domain, but the RNA-binding domain can repress trans-activation by the activation ... EWS interacts with FAK2 and relocates from cytoplasm to ribosomes upon FAK2 activation. Two isoforms of the EWS protein are ...
MH DELETED MN ADDED MN
RNA, Chloroplast D13.444.735.476 RNA, Double-Stranded G2.111.570.790.486.775 G2.111.570.820.486.775 RNA-Binding Protein EWS ... Retinoblastoma-Binding Protein 4 D12.776.930.700.890.200.500 D12.776.930.780.890.200.500 Retinoblastoma-Binding Protein 7 ... RNA-Binding Protein FUS D12.776.157.725.500.500.905 D12.776.157.725.813.750.905 D12.776.664.962.500.500.902 D12.776.664.962. ... Chlorophyll Binding Proteins D12.776.183.750.750.490.500 Chlorophyllides D23.767.727.220.180 Chloroplast Proteins D12.776.183 ...
MH DELETED MN ADDED MN
RNA, Chloroplast D13.444.735.476 RNA, Double-Stranded G2.111.570.790.486.775 G2.111.570.820.486.775 RNA-Binding Protein EWS ... Retinoblastoma-Binding Protein 4 D12.776.930.700.890.200.500 D12.776.930.780.890.200.500 Retinoblastoma-Binding Protein 7 ... RNA-Binding Protein FUS D12.776.157.725.500.500.905 D12.776.157.725.813.750.905 D12.776.664.962.500.500.902 D12.776.664.962. ... Chlorophyll Binding Proteins D12.776.183.750.750.490.500 Chlorophyllides D23.767.727.220.180 Chloroplast Proteins D12.776.183 ...
MH DELETED MN ADDED MN
RNA, Chloroplast D13.444.735.476 RNA, Double-Stranded G2.111.570.790.486.775 G2.111.570.820.486.775 RNA-Binding Protein EWS ... Retinoblastoma-Binding Protein 4 D12.776.930.700.890.200.500 D12.776.930.780.890.200.500 Retinoblastoma-Binding Protein 7 ... RNA-Binding Protein FUS D12.776.157.725.500.500.905 D12.776.157.725.813.750.905 D12.776.664.962.500.500.902 D12.776.664.962. ... Chlorophyll Binding Proteins D12.776.183.750.750.490.500 Chlorophyllides D23.767.727.220.180 Chloroplast Proteins D12.776.183 ...
MH DELETED MN ADDED MN
RNA, Chloroplast D13.444.735.476 RNA, Double-Stranded G2.111.570.790.486.775 G2.111.570.820.486.775 RNA-Binding Protein EWS ... Retinoblastoma-Binding Protein 4 D12.776.930.700.890.200.500 D12.776.930.780.890.200.500 Retinoblastoma-Binding Protein 7 ... RNA-Binding Protein FUS D12.776.157.725.500.500.905 D12.776.157.725.813.750.905 D12.776.664.962.500.500.902 D12.776.664.962. ... Chlorophyll Binding Proteins D12.776.183.750.750.490.500 Chlorophyllides D23.767.727.220.180 Chloroplast Proteins D12.776.183 ...
MH DELETED MN ADDED MN
RNA, Chloroplast D13.444.735.476 RNA, Double-Stranded G2.111.570.790.486.775 G2.111.570.820.486.775 RNA-Binding Protein EWS ... Retinoblastoma-Binding Protein 4 D12.776.930.700.890.200.500 D12.776.930.780.890.200.500 Retinoblastoma-Binding Protein 7 ... RNA-Binding Protein FUS D12.776.157.725.500.500.905 D12.776.157.725.813.750.905 D12.776.664.962.500.500.902 D12.776.664.962. ... Chlorophyll Binding Proteins D12.776.183.750.750.490.500 Chlorophyllides D23.767.727.220.180 Chloroplast Proteins D12.776.183 ...
Proto-Oncogene Proteins c-mdm2 | Profiles RNS
RNA-Binding Protein EWS. *RNA-Binding Protein FUS. *RUNX1 Translocation Partner 1 Protein ... "Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by ... An E3 UBIQUITIN LIGASE that interacts with and inhibits TUMOR SUPPRESSOR PROTEIN P53. Its ability to ubiquitinate p53 is ...
Ewing's sarcoma
It involves fusions between EWSR1, a gene encoding an RNA-binding protein and E26 transformation-specific transcription factors ... Characterized most frequently by a specific translocation of EWS-FLI1, but other EWS translocations exist. ...
Proto-Oncogene Proteins c-abl | Profiles RNS
RNA-Binding Protein EWS. *RNA-Binding Protein FUS. *Stathmin. *Wnt1 Protein. *Wnt2 Protein ... "Proto-Oncogene Proteins c-abl" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Proto-Oncogene Proteins c-abl" by people in this website by ... Below are the most recent publications written about "Proto-Oncogene Proteins c-abl" by people in Profiles. ...
Ewing Sarcoma: Practice Essentials, Background, Etiology
A small molecule that binds to EWS-FLI1, YK-4-279, blocks its interaction with a key partner protein, RNA Helicase A (RHA), ... Fusion protein. The EWS-FLI1 fusion transcript encodes a 68-kd protein with 2 primary domains. The EWS domain is a potent ... A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewings sarcoma. Nat ... EWS-ETV t(7;22), and EWS-FEV t(2;22), all of which involve the ETS family protein. Recently, approximately 4% of Ewing sarcoma ...