THP1-Dual™ KO-RIG-I / KO-MDA5 / KO-MAVS cells | Reporter Monocytes | InvivoGen
RIG-I and MDA5 are two distinct sensors of viral double-stranded RNA (dsRNA), a replication intermediate for RNA viruses [1-3 ... The stability for 20 passages, following thawing, has been verified. * These cells are guaranteed mycoplasma-free. ... RIG-I is a cytoplasmic RNA helicase that is critical for host antiviral responses. It senses double-stranded RNA (dsRNA), a ... MDA5 is a cytoplasmic RNA helicase that plays an important role in antiviral response. It senses long double-stranded RNA ( ...
ssPolyU/LyoVec - TLR8 Agonist - RNA homopolymer / LyoVec™ | InvivoGen
10 ml endotoxin-free water Storage and stability: ssPolyU/LyoVec™ is provided lyophilized and shipped at room temperature. ... TLR7 and TLR8 can recognize both self and viral RNA but seem able to distinguish the presence of viral RNA by detecting their ... TLR8 Agonist - RNA homopolymer / LyoVec™. ssPolyU is a lyophilized preparation of single-stranded poly-uridine (polyU) ... PolyU is a synthetic ssRNA which when complexed to cationic lipids can substitute for viral RNAs in inducing IFN-α production ...
A549-Dual™ cells | NF-κB & IRF Reporter Lung Carcinoma
Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism.. Sikorska J. et al ... The stability of this cell line for 20 passages following thawing has been verified. ... RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells. PLoS One. 8(4):e62872.. 3 ...
Blasticidin | Selection Antibiotic | InvivoGen
Multiple myeloma-associatedhDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a ... Please note that we cannot guarantee the stability of the product if aliquots are made at less than 10 mg/ml. Importantly, ...
A549-ASC-GFP-NLRP1 Reporter Cells for COVID-19 Studies | Inflammasomes | InvivoGen
Bauernfried et al., 2022. Human NLRP1 is a sensor for double-stranded RNA. Science. 2021 Jan 29;371(6528):eabd0811. doi: ... The stability for 20 passages, following thawing, has been verified. * These cells are guaranteed mycoplasma-free. ... Upon SARS-CoV-2 infection, viral RNA is released in target cells and immediately translated to produce viral polyprotein ...