The recruitment of this machinery results in the production of viroid-derived small RNAs (vd-sRNAs) that mediate RNA ... Members of the Pospiviroidae family replicate in the nucleus through double-stranded RNA intermediates, attracting the host RNA ... Viroids are pathogenic circular, non-coding, single-stranded RNA molecules. ... At least in plants, DNA regions that become de novo methylated can be defined by homologous RNA molecules in a process termed ...

... into the catalytic pocket, such as thiol, carboxylic acid, or any other acidic hydrogen atoms. One of the best examples is the ... Systematically differentiating functions for alternatively spliced isoforms through integrating RNA-seq data. PLoS Comput Biol ... Because of a different catalytic mechanism compared to SBLs, the SBL inhibitors are inefficient on MBLs and there is no ... of inhibitors are zinc-chelating agents targeting the fundamental zinc atom requirement of the metallo-enzyme for its catalytic ...