90-kDa Ribosomal Protein S6 Kinases - Ribosomal Protein S6 Kinases, 90 kDa Summary Report | CureHunter
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their ... Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and ... of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN. ... apparent molecular size and the fact they contain two functional kinase domains. ...http://www.curehunter.com/public/keywordSummaryD038744-90-kDa-Ribosomal-Protein-S6-Kinases-Ribosomal-Protein-S6-Kinases--90-kDa.do
The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia | Disease Models & Mechanisms
Ribosomal biogenesis involves the processing of pre-ribosomal RNA. A deficiency of some ribosomal proteins (RPs) impairs ... ATP shortage leads to activation of the energy sensor AMP-activated protein kinase (AMPK) (Hardie et al., 2012). Activated AMPK ... S6). These data indicate that RP-deficient cells function under conditions of chronic DNA damage. ... encodes a ribosomal protein required for the maturation of 40S ribosomal subunits. Blood 109, 980-986. ...http://dmm.biologists.org/content/7/7/895
BI-D1870 | CAS#501437-28-1 | RSK inhibitor | MedKoo Biosciences
... the p90 ribosomal S6 kinase), which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10Â-30 nM. BI-D1870 exhibited a ... BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401( ... 16 Protein Tyrosine Kinase * c-Kit * c-Met * c-RET * CSF-1R ... The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents ... Description: BI-D1870 is a potent and specific RSK inhibitor (the p90 ribosomal S6 kinase), which inhibits RSK1, RSK2, RSK3 and ...http://www.medkoo.com/products/4600
RPS6KA6 - Ribosomal protein S6 kinase - Pan troglodytes (Chimpanzee) - RPS6KA6 gene & protein
IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR016239. Ribosomal_S6_kinase_II. IPR008271. Ser/Thr_kinase_AS. ... IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR016239. Ribosomal_S6_kinase_II. IPR008271. Ser/Thr_kinase_AS. ... Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.UniRule annotation. ,p> ... View protein in PROSITE. PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 2 hits. PS50011. PROTEIN_KINASE_DOM. 2 ...http://www.uniprot.org/uniprot/K7D2H3
Rps6kl1 MGI Mouse Gene Detail - MGI:2443413 - ribosomal protein S6 kinase-like 1
IPR000719 Protein kinase domain. IPR011009 Protein kinase-like domain superfamily. IPR035050 Ribosomal protein S6 kinase-like 1 ... protein coding gene. Chr12:85135249-85151275 (-). 129S1/SvImJ MGP_129S1SvImJ_G0019953. protein coding gene. Chr12:85894557- ... protein coding gene. Chr12:84866806-84886134 (-). BALB/cJ MGP_BALBcJ_G0019890. protein coding gene. Chr12:82976279-82995588 (-) ... protein coding gene. Chr12:84476525-84493139 (-). PWK/PhJ MGP_PWKPhJ_G0019009. protein coding gene. Chr12:76646372-76662342 (-) ...http://www.informatics.jax.org/marker/MGI:2443413
Ribosomal Protein S6 Kinases - S6 Kinase Summary | CureHunter Mobile
Drugs Related to Ribosomal Protein S6 Kinases. * 70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa) ... Also Known As: S6 Kinase; Ribosomal Protein S6 Kinase; S6-H4 Kinase; S6 H4 Kinase. Networked: 292 relevant articles (4 outcomes ... Ribosomal Protein S6 Kinases (S6 Kinase) Summary Description: A family of protein serine/threonine kinases which act as ... Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. ...http://www.curehunter.com/m/keywordSummaryD019893.do
p70 Ribosomal protein S6 kinase (Rps6kb1): an update | Journal of Clinical Pathology
The Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by ... Upon activation, this kinase phosphorylates S6 protein of ribosomal subunit 40S resulting in selective translation of unique ... TOP mRNAs are coding the components of translational apparatus including ribosomal proteins and elongation factors. Due to the ... proliferation and metabolism and is the central regulator of translation of some components of protein synthesis system. ...http://jcp.bmj.com/content/67/12/1019
Myc-DDK-tagged ORF clone of Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3) as transfection-ready DNA ...
... home , products , origene , myc-ddk-tagged orf clone of homo sapiens ribosomal protein s6 kinase, 90kda, polypeptide 3 (rps6ka3 ... Myc-DDK-tagged ORF clone of Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3) as transfection-ready DNA ... Myc-DDK-tagged ORF clone of Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3) as transfection-ready DNA ...https://www.bioscience.co.uk/product~161379
Bcr-Abl Kinase Modulates the Translation Regulators Ribosomal Protein S6 and 4E-BP1 in Chronic Myelogenous Leukemia Cells via...
... phospho-S6 ribosomal protein (Ser235/236), S6 ribosomal protein, and 4E-BP1. All antibodies were from Cell Signaling Technology ... The 236 position of S6 ribosomal protein is known to be phosphorylated by p70 S6 kinase in a PI3K- and rapamycin-dependent ... These results strongly suggested that the Mr 30,000 protein detected by the AKT-pSub antibody was S6. S6 ribosomal protein is ... S6 ribosomal protein and 4E-BP1 are constitutively phosphorylated in a Bcr-Abl kinase-dependent manner, and occurs via mTOR. A ...http://cancerres.aacrjournals.org/content/63/18/5716?ijkey=d7261532f7dd4e43d52827741c4045d596fb7a11&keytype2=tf_ipsecsha
Ribosomal protein S6 kinase alpha-3
... ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and ... Data show that the 90 kDa ribosomal protein S6 kinases RSK1 and RSK2 play a key role in the homing of ovarian cancer cells in ... Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade 29 ... Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and ...https://pharos.nih.gov/idg/targets/P51812
rps6ka3, ribosomal protein S6 kinase a, polypeptide 3a - Creative Biogene
... ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase, polypeptide 3; ribosomal protein S6 kinase, polypeptide 3a ... RPS6KA3A; ribosomal protein S6 kinase a, polypeptide 3a; rps6ka3; zgc:56006; id:ibd1103; wu:fk86e02; si:ch211-114c12.12; ... Profiling ServicesKinase Screening & Profiling ServicesProtease Screening & Profiling ServicesNuclear Receptor Screening & ... Creative Biogene Introduces Innovative Expression Vectors for High Level of Protein Production ...https://www.creative-biogene.com/symbolsearch_rps6ka3.html
The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus |...
Recently, ribosomal protein S6 kinase 4 (RSK4), a member of serine/threomine (Ser/Thr) kinase family and p53-related gene, is ... Recently, ribosomal protein S6 kinase 4 (RSK4), a member of serine/threomine (Ser/Thr) kinase family and p53-related gene, is ... RSK4, ribosomal protein S6 kinase 4, is firstly found as an X-linked gene in patients with mental retardation and most ... The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus. ...https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-11-12
Ribosomal protein S6 kinase 1 (S6K1) is usually a serine/threonine protein | Melatonin membrane receptors in peripheral tissues
Ribosomal protein S6 kinase 1 (S6K1) is usually a serine/threonine protein. Ribosomal protein S6 kinase 1 (S6K1) is usually a ... The protein was reloaded around the HisTrap column to remove the undigested protein, and the flow-through fractions were ... The target protein was eluted and treated with protein phosphatase, to remove nonspecific phosphorylation, and the N-terminal 6 ... serine/threonine protein kinase that plays an important role in the PIK3/mTOR signaling pathway, and is implicated in diseases ...http://cancer-basics.com/ribosomal-protein-s6-kinase-1-s6k1-is-usually-a-serine-threonine-protein/
PI3K-Akt Signaling | www.antibodies-online.com
ATG13 Proteins RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2): RPS6KB2 antibodies RPS6KB2 ELISA Kits RPS6KB2 ... and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein ... This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR ... MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8): MAP3K8 antibodies MAP3K8 ELISA Kits MAP3K8 Proteins ...https://www.antibodies-online.com/pi3k-akt-signaling-pathway-4/
Sarcopenia and Age-Related Endocrine Function
... p70 ribosomal protein S6 kinase) signaling. Although the transgenic approach of upregulating IGF-I expression in skeletal ... and PI3-kinase protein contents in the C57BL/6 mouse," Mechanisms of Ageing and Development, vol. 106, no. 3, pp. 217-232, 1999 ... of the myostatin protein that circulates in blood also appears to exist in an inactive complex with a variety of proteins, ... 24] hypothesized that abundant nuclear factor-κB (NF-κB) protein induced age-related increases in IL-6 and TNF-α. Moreover, ...https://www.hindawi.com/journals/ije/2012/127362/
RCSB PDB - 3WF5: Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-benzimidazol...
Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-benzimidazol-2-yl)piperidin-1- ... Ribosomal protein S6 kinase 1 (S6K1) is a serine/threonine protein kinase that plays an important role in the PIK3/mTOR ... Ribosomal protein S6 kinase 1 (S6K1) is a serine/threonine protein kinase that plays an important role in the PIK3/mTOR ... Protein Workshop , Ligand Explorer. Global Symmetry: Asymmetric - C1 Global Stoichiometry: Monomer - A Biological assembly 1& ...https://www.rcsb.org/structure/3WF5
KEGG BRITE: KEGG Orthology (KO) - Pelodiscus sinensis (Chinese soft-shelled turtle)
... ribosomal protein S6 kinase B1 102460281 RPS6KB2; ribosomal protein S6 kinase B2 102451367 RPS6; ribosomal protein S6 102459901 ... ribosomal protein S6 kinase beta [EC:22.214.171.124] K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:126.96.36.199] K02991 RP-S6e; ... 102443595 MAP2K1; mitogen-activated protein kinase kinase 1 102457075 MAP2K2; mitogen-activated protein kinase kinase 2 ... protein kinase A [EC:188.8.131.52] K04345 PKA; protein kinase A [EC:184.108.40.206] K04739 PRKAR; cAMP-dependent protein kinase ...http://www.genome.jp/kegg-bin/get_htext?pss00001+102462946
KEGG ENZYME: 220.127.116.11
protein-serine kinase;. Prp4 protein kinase;. Raf kinase;. Raf-1;. ribosomal protein S6 kinase II;. ribosomal S6 protein kinase ... protein kinase A;. protein kinase CK2;. protein kinase p58;. protein phosphokinase;. protein serine kinase;. protein serine- ... mitogen-activated S6 kinase;. p82 kinase;. phosphorylase b kinase kinase;. PKA;. protein glutamyl kinase;. protein kinase ( ... serine protein kinase;. serine-specific protein kinase;. serine(threonine) protein kinase;. serine/threonine protein kinase;. ...http://www.genome.jp/dbget-bin/www_bget?enzyme+18.104.22.168
... ribosomal protein S6 kinase. ... Phosphoinositide 3-kinase (PI3K) is part of a larger family of ... Among these are the activation of PI3K and mitogen-activated protein kinase (MAPK) signaling pathways in the setting of mTOR- ... and kinase (H1047R) domains and result in constitutive activation of the kinase (7). Mutations in PIK3CA are also mutually ... proteins (14). Activated mTOR forms two unique complexes with other proteins (TORC1 and TORC2; 15). TORC2 containing rictor ...http://clincancerres.aacrjournals.org/content/19/14/3738
... ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kD, polypeptide 5; ribosomal protein S6 kinase, 90kDa, ... 90 kDa ribosomal protein S6 kinase 5; MSK1; MSPK1; RLPK; RSK-like protein kinase; RSKL; S6K-alpha-5; nuclear mitogen- and ... ribosomal protein S6 kinase, 90kDa, polypeptide 5 (RPS6KA5(Kin.Dom.1-N-terminal)). Target Class. Kinase. Family. AGC. Official ... Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors ...https://discoverx.com/target-data-sheets/kinase/rps6ka5
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) Antikörper</span>
... serine/threonine-protein kinase 14B , ribosomal protein S6 kinase, 70kDa, polypeptide 2 , S6 kinase 2 , ribosomal protein S6 ... 70 kDa ribosomal protein S6 kinase 2 , P70S6K2 , S6 kinase-related kinase , S6K-beta , S6K-beta-2 , p70 S6 kinase beta , p70 ... p70 ribosomal S6 kinase beta , p70-S6K 2 , ribosomal protein S6 kinase beta-2 , serine/threonine-protein kinase 14 beta , ... anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 Antikörper * anti-Ribosomal Protein S6 Kinase, 52kDa, Polypeptide 1 ...http://www.antikoerper-online.de/pi3k-akt-signalweg-pathway-4/rps6kb2-antibody-8074/
Frontiers | A pivotal role of GSK-3 in synaptic plasticity | Frontiers in Molecular Neuroscience
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain ... Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain ... p90 ribosomal protein S6 kinase (RSK; Valerio et al., 2006) and Integrin-linked kinase (ILK; Naska et al., 2006) also regulate ... OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl ...https://www.frontiersin.org/articles/10.3389/fnmol.2012.00013/full
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated...
phosphoinositide-3-kinase;. S6K1,. ribosomal protein S6 kinase 1;. 4E-BP1,. eIF4E-binding protein;. HEK,. human embryonic ... mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1). ... The Mammalian Target of Rapamycin-p70 Ribosomal S6 Kinase but Not Phosphatidylinositol 3-Kinase-Akt Signaling Is Responsible ... with these Akt phosphorylation sites mutated to alanine dominantly inhibited the activation of ribosomal protein S6 kinase 1 ( ...https://www.pnas.org/content/99/21/13571.long
alpha kinase 1 ELISA Kits | Biocompare.com
Compare alpha kinase 1 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and ... ribosomal protein S6 kinase alpha-1. *. Reactivity: Human. *. Quantity: 1x96 well plate ... PRKAA1(5'-AMP-activated protein kinase catalytic subunit alpha-1) BioAssay™ ELISA Kit (Human) ... Immunotag™ Human PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1) ELISA ...https://www.biocompare.com/pfu/110627/soids/2-2268684/ELISA_Kit/ELISA_alpha_kinase_1
GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy | Springer for Research &...
Background Ligand-dependent activation of the G-protein coupled receptor 119 (GPR119) lowers blood glucose via glucose- ... phosphorylation of ribosomal protein S6 kinase β-1 (p70S6K) and eukaryotic translation initiation factor 4E-binding protein 1 ( ... Mitogen-activated protein kinase kinase (MEK) inhibitor could increase the effect of cetuximab through blocking Ras-Raf pathway ... 6a), but the activation of upstream kinases such as liver kinase B1 (LKB1) and transforming growth factor-β-activating kinase 1 ...https://rd.springer.com/article/10.1186%2Fs13046-018-0949-2