Cdh11 Acts as a Tumor Suppressor in a Murine Retinoblastoma Model by Facilitating Tumor Cell Death
p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 1998;12:1599-1609. [PubMed] ... Protein isolation and immunoblot. Protein isolation and immunoblot analysis were performed as described previously . ... Effects of celecoxib in human retinoblastoma cell lines and in a transgenic murine model of retinoblastoma. Br J Ophthalmol. ... CDH11 gene copy number and expression are frequently lost in human retinoblastomas and in retinoblastomas arising in TAg-RB ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2858707/
Molecular Sequelae of Histone Deacetylase Inhibition in Human Retinoblastoma Cell Lines: Clinical Implications | IOVS | ARVO...
Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature. 1998;391:597-601. [CrossRef] [PubMed] ... RBL1 (p107). 0.73. 0.46. 0.64. 1.07. 0.47. 0.42. 1.89. 0.98. 2.48. 1.84. 2.07. 1.07. ... We evaluated the effect of vorinostat on p53 expression in retinoblastoma cells. We found that vorinostat increased p53 protein ... Absence of the Rb protein in retinoblastoma causes the release of free, transcriptionally active E2F-1, thus permitting ...http://iovs.arvojournals.org/article.aspx?articleid=2186218
Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. - PubMed - NCBI
The cellular protein p107 and the retinoblastoma protein (pRB) have many features in common. Most strikingly, they contain ... Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.. Cao L1, Faha B, Dembski M, Tsai LH ... Here, we report that p107 is found in the cyclin A/E2F complex and that this complex also contains p33cdk2. These observations ... Thus, by binding to pRB and p107, E1A and large-T antigen target two distinct aspects of E2F regulation. ...https://www.ncbi.nlm.nih.gov/pubmed/1530885?dopt=Abstract
Retinoblastoma family proteins induce differentiation and regulate B-myb expression in neuroblastoma cells.
The retinoblastoma family proteins, pRb, p107 and pRb2/p130, act in the repression of proliferation genes, interacting mainly ... 0/Recombinant Fusion Proteins; 0/Retinoblastoma Protein; 0/Retinoblastoma-Like Protein p107; 0/Retinoblastoma-Like Protein p130 ... Proteins*. Recombinant Fusion Proteins / biosynthesis. Retinoblastoma Protein / physiology*. Retinoblastoma-Like Protein p107. ... 0/Nuclear Proteins; 0/Phosphoproteins; 0/Proteins; 0/RBL1 protein, human; 0/RBL2 protein, human; 0/Rbl1 protein, mouse; 0/Rbl2 ...http://www.biomedsearch.com/nih/Retinoblastoma-family-proteins-induce-differentiation/11464857.html
Similar articles for PubMed (Select 8446173) - PubMed - NCBI
Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. ... Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. ... Molecular characterization of Xenopus laevis DP proteins.. Girling R, Bandara LR, Ormondroyd E, Lam EW, Kotecha S, Mohun T, La ... A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=8446173
Oligodendrocyte Regeneration after Neonatal Hypoxia Requires FoxO1-Mediated p27Kip1 Expression | Journal of Neuroscience
1995) Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev 9:1340-1353. ... Precipitated proteins were analyzed by immunoblotting with an anti-Rb Abs (Cell Signaling) for white matter and anti-p107 ... In hypoxic SVZ, a reduction in p107-E2F4 was detected, indicating higher levels of unbound E2F4 protein as a mechanism ... The Role of Cysteine String Protein α Phosphorylation at Serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance ...http://www.jneurosci.org/content/32/42/14775.long
The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family Proteins | Molecular and...
1996) Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. USA ... 1993) Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7:1111-1125. ... 1995) Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 9:1340-1353. ... 1997) Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc. Natl. Acad. Sci. USA 94:6933- ...https://mcb.asm.org/content/18/3/1408?ijkey=ce30b10c58d844f3e702233298b911df050f998f&keytype2=tf_ipsecsha
Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone | JCB
Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 9:1340-1353. ... microtubule-associated protein 2; P, postnatal day; Rb, retinoblastoma protein; RMS, rostral migratory stream; SCM, stem cell ... The Rb-like protein p107 also binds the E2F family of transcription factors and is phosphorylated by Cdk4 but not by Cdk2 ( ... Precipitated proteins were analyzed by immunoblotting with anti-p107 antibody (Sigma-Aldrich). Bands were detected by using HRP ...http://jcb.rupress.org/content/179/6/1231.full
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate | JCB
The Retinoblastoma protein p107 regulates the neural precursor pool in both the developing and adult brain. As p107-deficient ... p107−/−, n = 3; Hes1+/−:p107−/−, n = 6; Hes1−/−:p107−/−, n = 5; Hes1−/−, n = 3; Hes1+/−:p107+/−, n = 4; Hes1+/−:p107+/+, n = 4 ... p107−/− (n = 6), and p107−/− (n = 4) embryos revealed that loss of a single Hes1 allele could restore neurogenesis in p107- ... p107−/− and Hes1+/−:p107−/−. Therefore, a reduction in Hes1 expression in p107−/− mice restores the number of neural precursors ...http://jcb.rupress.org/content/178/1/129
A Screen for New Trithorax Group Genes Identified little imaginal discs, the Drosophila melanogaster Homologue of Human...
1994 Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. Mol. Cell ... The protein encoded by the little imaginal discs gene is the Drosophila homologue of human retinoblastoma binding protein 2. ... 1995 The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex. ... RBP-2 was discovered in a screen for proteins that interact with the pocket domain of the retinoblastoma protein (pRB; Defeo-J ...http://www.genetics.org/content/156/2/645
Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. - Semantic Scholar
Studies of these viruses have been invaluable in uncovering the central role of the Rb family of pocket proteins in cell cycle ... simple equilibrium dissociation of pRb from cellular pRb-binding factors to chaperone-mediated alterations in pocket protein ... Small DNA tumor viruses have evolved different mechanisms to abrogate the function of the retinoblastoma tumor suppressor (pRb ... UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.. Satoko Iwahori, Angie C Umaña, ...https://www.semanticscholar.org/paper/Mechanisms-by-which-DNA-tumor-virus-oncoproteins-Rb-Helt-Galloway/0e58fdd7b89d175a56b22a42f283948cb3138a4b
One Function-Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor
... thereby triggering hypophosphorylation of retinoblastoma proteins and formation of repressive pocket protein-E2F complexes on ... Furthermore, the knockdown of the Rb, p130 and p107 proteins significantly reduced the p53-mediated repression . Therefore ... Usually, the retinoblastoma protein gets hyperphosphorylated by CDKs in G1/S-Phase of the cell-cycle which leads to release of ... Analyses of the cdc2 promoter showed that its repression is dependent on both p21CIP1 and the retinoblastoma proteins (Rb, p130 ...https://www.hindawi.com/journals/bmri/2011/464916/
Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71...
The retinoblastoma protein (p105), p107, and p130 are each targeted for degradation by the pp71 protein, which is encoded by ... The HCMV pp71 protein binds directly to Rb, p107 and p130 through an Rb-binding LxCxD motif, targeting them for degradation (23 ... Here, we describe the degradation of the retinoblastoma family of tumor suppressor proteins by the proteasome in the absence of ... While the pp71-mediated degradation of the retinoblastoma family of proteins requires proteasome function, it occurs without ...https://www.pnas.org/content/100/6/3263?ijkey=72cbb94c1c833509e028ca84ad9a4d26b0dcfba2&keytype2=tf_ipsecsha
Retinoblastoma-like protein 1 - Wikipedia
Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene. The protein encoded ... Xiao ZX, Ginsberg D, Ewen M, Livingston DM (May 1996). "Regulation of the retinoblastoma protein-related protein p107 by G1 ... "Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins". ... "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Molecular and ...https://en.wikipedia.org/wiki/Retinoblastoma-like_protein_1
Searle Scholars Program : Rene Bernards (1989)
... is the retinoblastoma family of growth-inhibitory proteins that includes the retinoblastoma protein pRb and the related p107 ... We have shown previously that the retinoblastoma protein-related p107 can form a specific complex with the MYC transactivation ... To study cell cycle regulation by pocket proteins, we have isolated cDNAs for cellular proteins that interact with p107 and 130 ... Adenovirus transforming proteins Adenovirus E1A proteins disrupt cell cycle control by binding to a number of cellular proteins ...https://searlescholars.net/person/300
A model for FGF regulation of p107 phosphorylation in R | Open-i
A model for FGF regulation of p107 phosphorylation in RCS cells.FGF signaling activates a regulatory B subunit that targets the ... This phenomenon requires the function of the p107 and p130 members of the Rb protein family, and p107 dephosphorylation is one ... This phenomenon requires the function of the p107 and p130 members of the Rb protein family, and p107 dephosphorylation is one ... Furthermore, an association between p107 and PP2A was induced by FGF treatment. Our data show that p107 dephosphorylation is a ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2562983_pone.0003447.g007&req=4
Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth -- Smith et al. 9 (4):...
Retinoblastoma-related p107 and pRb2/p130 Proteins in Malignant Lymphomas: Distinct Mechanisms of Cell Growth Control. Clin. ... The p130 protein is found in quiescent cells but not in growing cells, whereas the inverse is true for the p107 protein. ... E1A Blocks Hyperphosphorylation of p130 and p107 without Affecting the Phosphorylation Status of the Retinoblastoma Protein. J ... Whereas the Rb protein is found in both growing and quiescent cells, the accumulation of p130 and p107 is tightly regulated ...http://cgd.aacrjournals.org/cgi/content/abstract/9/4/297?ijkey=015fbcaba9dcb563da61bf2ad36b969aaa44854a&keytype2=tf_ipsecsha
A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F | Molecular and Cellular Biology
1993) Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7:1111-1125. ... 1997) The retinoblastoma protein and cancer. in Protein dysfunction in human genetic disease. eds Swallow D. M., Edwards Y. H. ... 1993) TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein ... from a p107-overexpressing stable cell line, U2OS-p107 (74), was used in binding reactions as described above. Bound proteins ...https://mcb.asm.org/content/18/9/5032
Recent progress in the study of brown adipose tissue | Cell & Bioscience | Full Text
Pocket proteins include retinoblastoma protein (pRb), p107 and p130. pRb has been shown to influence adipocyte differentiation ... Alteration of p107, another member of the pocket proteins, can also affect the differentiation of adipocytes. As reported by ... Pocket protein. Pocket proteins play key roles in cell cycle progression [48, 49]. They can bind to E2F family and inhibit the ... Wnt proteins are found to be downregulated in the course of brown adipocyte formation, suggesting that these Wnt proteins ...https://0-cellandbioscience-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/2045-3701-1-35
Table of Contents | Cancer Research
Protein Represses Osteocalcin Gene Transcription and Forms Complexes with the Retinoblastoma Protein-related Protein p107 and ... Parathyroid Hormone-related Protein as a Growth Regulator of Prostate Carcinoma. Kristiann M. Dougherty, Eric A. G. Blomme, Amy ... Expression of Multidrug Resistance Protein-3 (Multispecific Organic Anion Transporter-D) in Human Embryonic Kidney 293 Cells ... Combination Therapy with the Farnesyl Protein Transferase Inhibitor SCH66336 and SCH58500 (p53 Adenovirus) in Preclinical ...http://cancerres.aacrjournals.org/content/59/23