Retinoblastoma-binding protein 5 is a protein that in humans is encoded by the RBBP5 gene. The protein encoded by this gene is ... The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. ... It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. ... "Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping". Genomics. 27 (3): 511-9 ...
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. ... The binding site on SV40 DNA for a T antigen-related protein. Cell 13: 165-179.. Joseph F. Sambrook. Gluzman Y. 1981. SV40- ... cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF. Cell 56: 829-838.. ... The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 239: 1150-1153.. ...
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. ... The binding site on SV40 DNA for a T antigen-related protein. Cell 13: 165-179.. Joseph F. Sambrook. Gluzman Y. 1981. SV40- ... cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF. Cell 56: 829-838.. ... The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 239: 1150-1153.. ...
... lunch proteins form protein shake recipes protein shakes proteins in a membrane are proteins in bacon proteins in eggs proteins ... lunch proteins form protein shake recipes protein shakes proteins in a membrane are proteins in bacon proteins in eggs proteins ... proteins on keto proteins per day proteins play in the body proteins polar or nonpolar proteins transport recombinant proteins ... proteins on keto proteins per day proteins play in the body proteins polar or nonpolar proteins transport recombinant proteins ...
Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa human protein known to play an essential role in mRNA 3-end processing, ... Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa RING finger-containing protein that plays a role in 3-end poly- ... Retinoblastoma Binding Protein 6 (RBBP6) is a RING finger-containing protein which plays a critical role in the 3-end ... Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa RING finger-containing protein whose function is known to be mediated ...
The retinoblastoma binding protein 2 (RBP2) is a member of the JARID family of proteins, which has a histone demethylase ... The Retinoblastoma Binding Protein Rbp2 Is an H3k4 Demethylase. Cell. 2007;128(5):889-900. ... by inducing the survival factor PIM1 and suppressing the binding between the translational regulator poly(rC)-binding protein ... For instance, the retinoblastoma-interacting zinc-finger protein 1 (RIZ1) and H3K9 histone methyltransferase, are downregulated ...
Another lead SNP is located in RBBP8 which encodes Retinoblastoma-binding protein 8 (RBBP8, CtIP), an endonuclease involved in ... Chen Z, Tao S, Gao Y, et al. Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in ... Regulation of Steroid Hormone Receptor Function By the 52-kDa FK506-Binding Protein (FKBP52). Curr Opin Pharmacol. 2011;11(4): ... Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J ...
RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts ... Rbl2 protein, rat 0 *Retinoblastoma-Like Protein p130. Rbl2 protein, mouse 0 *Retinoblastoma-Like Protein p130. RBL2 protein, ... and PAPILLOMAVIRUS E7 PROTEINS. Other names p130, Retinoblastoma-. Like Protein; Retinoblastoma Like Protein 2; Retinoblastoma ... Retinoblastoma-Like Protein p130. To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste ...
... retinoblastoma binding protein 7, chromatin remodeling factor; SAR: selective autophagy receptor; SCARB2: scavenger receptor ... Here we show that a recently identified protein termed LD-associated protein [LDAP]-interacting protein (LDIP) works together ... binding protein 1; TFEB: transcription factor EB; TOLLIP: toll interacting protein; UBE2G2: ubiquitin conjugating enzyme E2 G2 ... heat shock protein family A (Hsp70) member 5; HSPA8: heat shock protein 8; HSPB1: heat shock protein 1; HSPH1: heat shock ...
Retinoblastoma-binding protein 2 homolog 1, RBP2-H1, KDM5B, JARID1B, PLU1, RBBP2H1Species Reactivity: MouseTested Applications ... Jumonji/ARID domain-containing protein 1B, PLU-1, Retinoblastoma-binding protein 2 homolog 1, RBP2-H1, KDM5B, JARID1B, PLU1, ... Jumonji/ARID domain-containing protein 1B, PLU-1, Retinoblastoma-binding protein 2 homolog 1, RBP2-H1, KDM5B, JARID1B, PLU1, ... Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.. Physicalstate: ...
Houben R, Adam C, Baeurle A, Hesbacher S, Grimm J, Angermeyer S. An intact retinoblastoma protein-binding site in Merkel cell ... 38] Other proteins are the target of experimental vaccines. [39] Further exploration of virus-specific therapy will provide ... 8] Research into the genome of MCV is expanding and specific proteins are being explored for their clinical utility. For ... The absence of S-100 protein and homatropine methylbromide marker essentially excludes the diagnosis of malignant melanoma. ...
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol. 1990;64:1353-6 . ... However, the sT-Ag of MCPyV constructs altered to lack a functional PP2A binding domain still initiates cell transformation (29 ... including the LXCXE motif necessary for LT-Ag association with the retinoblastoma protein and the Walker A box GPXXXGKT, which ... glial fibrillary acidic protein, vimentin, pancytokeratin, neuron-specific nuclear protein, Olig2, synaptophysin, and laminin. ...
... the histone methyltransferase family and the Retinoblastoma-binding protein family (which contains TUDOR and BRIGHT domains), ... The CD is 60-90 amino acids long and has been proposed to be a protein-protein interaction module, an RNA and/or DNA-binding ... These CD-containing proteins can be classified into protein families based on other domains contained in the protein, for ... We also found that the CD contained within the proteins in the same family is almost invariably of the same subclass, and that ...
guanine nucleotide binding protein (G protein), gamma 2 subunit ...
CDK4:cyclin D complexes phosphorylate and inactivate the retinoblastoma (Rb) tumor-suppressor protein, releasing E2F ... that harbor FOXO1 binding element motifs (refs. 39, 43, 48, and Figure 6A), and revealed that FOXO1 binding was augmented in Eμ ... A) Levels of the indicated proteins were determined by immunoblotting lysates of Eμ-Myc Cdk4+/+ versus Eμ-Myc Cdk4-/- lymphomas ... Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A. 2006;103(47):17834- ...
The activated cyclin D1/CDK4 and cyclin D1/CDK6 complex phosphorylates the retinoblastoma protein to induce the expression of ... IGF-binding protein 3; IKK, IkB kinase; IRS, insulin receptor substrate; MCL-1, myeloid cell leukemia 1; MMPs, matrix ... IGF-binding protein 3; IKK, IkB kinase; IRS, insulin receptor substrate; MCL-1, myeloid cell leukemia 1; MMPs, matrix ... DNA binding, and gene transcription in myeloid and leukemic cells. Nimbolide significantly decreased the protein expression of ...
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) Title : Oxime ... covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) - Bachovchin_2010_Bioorg.Med.Chem.Lett_20_ ... A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors Title : A substrate- ... 8. DPP9s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation Title : DPP9s Enzymatic Activity ...
Solution structure of the zinc finger CCHC domain from the human retinoblastoma-binding protein 6 (Retinoblastoma-binding Q ... This motif is present in a number of nucleic acid-binding proteins including the nucleocapsid protein of retroviruses. In ... How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription. ... It is also found in eukaryotic proteins involved in RNA binding or single-stranded DNA binding [ (PUBMED:15937226) ]. ...
2.10 Nucleocapsid Protein. The nucleocapsid (N) protein of coronaviruses is a structural protein that binds directly to viral ... Inactivation of the cyclin-CDK complex results in hypophosphorylation of the retinoblastoma protein and in turn inhibits S ... The four structural proteins of coronaviruses are: S protein, M protein, E protein, and N protein [50]. The E protein has been ... ADPr binding, G-quadruplex binding, ssRNA binding, protease (papain-like protease), and NSP4 binding), and transmembrane domain ...
We demonstrate that the lack of functional BRCA1 protein correlates to higher aromatase levels in 85% of BRCA1 mutation ... Kijima I, Ye J, Glackin C, Chen S: CCAAT/enhancer binding protein delta up-regulates aromatase promoters I.3/II in breast ... D1 promotes progression through the G1-S phase of the cell cycle by phosphorylating and inactivating the retinoblastoma protein ... and CCAAT/enhancer binding protein δ (C/EBPδ) increase aromatase levels within the epithelial cells and surrounding adipose ...
Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein. J Biol ... 4] The E6 protein product of these high-risk HPVs binds to the tumor suppressor protein p53, which is thought to disrupt the ... The E7 protein causes an inactivation of the tumor suppressor retinoblastoma gene (Rb) via its interaction with the Rb protein ... 2] The death rate from cervical cancer has decreased dramatically since the American Cancer Society recommended the use of the ...
... and E7 binds and inhibits the function of the retinoblastoma protein (Rb) (3). The L1 protein can self-assemble into virus-like ... codes for the L1 and L2 viral capsid proteins and for the E1-E2 and E4-E7 proteins, which play major roles in gene regulation, ... E6 and E7 deregulate cell cycle control by E6 binding and degradation of p53, ... Together, these 2 cancers account for 90% of all OSCCs (6,9). Patients usually do not seek counseling until the tumors are ...
The proliferation- and glycolysis-associated proteins were assessed using immunofluorescence staining in vivo. We found that ... The regulatory effect of transcription factors of specificity protein 1 (SP1) on RBBP7 mRNA expression was confirmed in dual- ... we focused on retinoblastoma-binding protein 7 (RBBP7), which is a highly conserved in WD-repeat subfamily that are primarily ... Protein concentrations were determined using the BCA Protein Assay Kit (Beyotime, Shanghai, China). The proteins were ...
The indirect antitumor activities of PEDF were uncovered from the early findings that it stimulates retinoblastoma cell ... Recently, a new ~60-kDa PEDF binding protein has been purified from membrane extracts of bovine retina tissues, retinoblastoma ... GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays. 2007;29(4):356-70. doi: ... Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF ...
Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma. Mol Med Report 2012. ... The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci 1996; 21:134-40. ... Furthermore, protein expression studies have detected increased levels of S100-like proteins, such as Cal A, in a variety of ... The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene11, ...
... protein N myristoyl transferase (NMT), at a glycine, with a consensus site: G (EDRKHPFYW) x x (STAGCN) P. This allows ... Many proteins in eukaryotes are covalently attached to myristic acid in membranes through amide linkages formed by myristoyl ... bound to the host Retinoblastoma protein (dark grey)(PDB 1gux) In molecular biology Short Linear Motifs (also known as SLiMs, ... Many proteins in eukaryotes are covalently attached to myristic acid in membranes through amide linkages formed by myristoyl ...
The AhR protein is predominantly cytoplasmic in the majority of normal tissues and binding to exogenous ligands such as PAHs, ... AhR was significantly repressed in tumors from both mice with a liver-specific retinoblastoma protein ablation and their wild- ... The binding of kaempferol may block the binding of AhR ligands, and thus inhibit the activity of other ligands such as TCDD [ ... AhR protein and mRNA expression is associated with phases of rapid proliferation and differentiation in certain tissues. AhR- ...
This article discusses what was formerly referred to as incontinentia pigmenti type 2, also known as Bloch-Sulzberger syndrome ... Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. NEMO binds to Lys 63-linked ... and retinoblastoma. ... The NEMO protein is required for the activation of the kinase ... NEMO is an ubiquitous protein that becomes active during embryogenesis. The skin, eyes, and hair all are affected. In the mouse ...
Over the last 2 decades, induced pluripotent stem cells (iPSCs) have had various potential applications in various medical ... The role of telomere-binding modulators in pluripotent stem cells. Protein Cell. 2020;11(1):60-70. ... Generation of induced pluripotent stem cells (iPSCs) from a retinoblastoma patient carrying a c.2663G,A mutation in RB1 gene. ... Some reprogramming modulators include tumor suppressor protein, cell signaling modifiers, and hypoxia [59,60,61,62,63,64]. ...