The retinal pigment epithelium also degenerates. Over time, the abnormal accumulation of this substance can damage the cells ... localizes to the basolateral plasma membrane of the retinal pigment epithelium". Proceedings of the National Academy of ... Mutations in the RDS gene disrupt the structures in these cells that contain light-sensing pigments, leading to vision loss. It ... Vitelliform macular dystrophy causes a fatty yellow pigment (lipofuscin) to build up in cells underlying the macula. ...

"Transport mechanisms in the retinal pigment epithelium". In: The retinal pigment epithelium: function and disease. Marmor MF, ... "Light-induced responses of the Retinal pigment epithelium". In: M. F. Marmor and T. J. Wolfensberger, eds. The Retinal Pigment ... "Clinical electrophysiology of the retinal pigment epithelium". In: M. F. Marmor and T. J. Wolfensberger, eds. The Retinal ... "Light-evoked modulation of basolateral membrane Cl− conductance in chick retinal-pigment epithelium - the light peak and fast ...

Retinal pigment epithelium (RPE) helps absorb light through binding to photoreceptors helping to regulate light exposure. S163R ... Yang, Song; Zhou, Jun; Li, Dengwen (2021-07-28). "Functions and Diseases of the Retinal Pigment Epithelium". Frontiers in ... The C1QTNF5 gene secreted and membrane-linked to a protein which is strongly expressed in retinal pigment epithelium cells. The ... Expression in Murine Retinal Pigment Epithelium". Investigative Ophthalmology & Visual Science. 56 (11): 6971-80. doi:10.1167/ ...

Strauss O The retinal pigment epithelium in visual function. Physiological Reviews. July 2005; 85(3): 845-881. Quote from p. ... Aspects of vitamin A metabolism in sensory epithelia (inner ear, olfactory bulbus, pineal gland).Int J Vitam Nutr Res Suppl. ... These subjects also have night blindness and retinal dystrophy but few other signs of vitamin A deficiency." ... the role of retinyl esters as systemic and local sources for retinol in mucous epithelia. J Nutr. 2004 Dec;134(12 Suppl):3453S- ...

... a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium". Proceedings of the ... "Entrez Gene: RRH retinal pigment epithelium-derived rhodopsin homolog". Gühmann M, Porter ML, Bok MJ (August 2022). "The ... In mice, a peropsin is localized to the apical microvilli of the retinal pigment epithelium (RPE). There, it regulates storage ... Rivolta C, Berson EL, Dryja TP (December 2006). "Mutation screening of the peropsin gene, a retinal pigment epithelium specific ...

... group was studying human retinal cell development by identifying secreted factors produced by the retinal pigmented epithelium ... In humans, pigment epithelium-derived factor is encoded by the SERPINF1 gene. Pigment epithelium-derived factor (PEDF) was ... pigment epithelium derived factor), member 1". Steele FR, Chader GJ, Johnson LV, Tombran-Tink J (Feb 1993). "Pigment epithelium ... "Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth ...

"Combined hamartoma of sensory retina and retinal pigment epithelium". Retina. 9 (4): 302-311. doi:10.1097/00006982-198909040- ... She founded the Retinal Research Foundation and the McPherson Eye Research Institute. She was awarded the University of ... At the time she was training, there were not many cures for retinal detachment. McPherson was the first woman fellow to work in ... In 1969, McPherson founded the Retina Research Foundation, which looked to eradicate retinal disease worldwide. The Foundation ...

Robert Machemer - Helen Keller Foundation (with video) Machemer R; Laqua H (1975). "Pigment epithelium proliferation in retinal ... He is sometimes called the "father of modern retinal surgery." Helmut Machemer, Roberts father, was an ophthalmologist who ... He established an animal model of retinal detachment and used this model to study proliferative vitreoretinopathy (PVR), which ...

"Entrez Gene: RPE65 retinal pigment epithelium-specific protein 65kDa". Wolf G (Mar 2005). "Function of the protein RPE65 in the ... Retinal pigment epithelium-specific 65 kDa protein, also known as retinoid isomerohydrolase, is an enzyme of the vertebrate ... RPE65 is a critical enzyme in the vertebrate visual cycle found in the retinal pigmented epithelium. It is also found in rods ... Jin M, Li S, Moghrabi WN, Sun H, Travis GH (Aug 2005). "Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium". ...

... and other retinal diseases, and the retinal pigment epithelium (RPE), which supports the photoreceptors and is also implicated ... 2001). "Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization". J Cell Physiol. 188 (2): 253-263 ... Pigment epithelium-derived factor (PEDF) also acts as an inhibitor of angiogenesis. The secretion of PEDF is noticeably ... Ogata N, Tombran-Tink J, Jo N, Mrazek D, Matsumura M (2001). "Upregulation of pigment epithelium-derived factor after laser ...

16 The tapetum lucidum is within the retinal pigment epithelium; in the other three types the tapetum is within the choroid ... Nightjars use a retinal tapetum lucidum composed of lipids. Like humans, some animals lack a tapetum lucidum and they usually ... A classification of anatomical variants of tapeta lucida defines four types: Retinal tapetum, as seen in teleosts (with a ... The brownsnout spookfish has an extraordinary focusing mirror derived from a retinal tapetum. Choroidal guainine tapetum, as ...

β-carotene content is confirmed in human retinal pigment epithelium. Reviews reported mixed results for observational studies, ... Carotene to Retinal Pigment". Conversion of β-carotene to retinal pigment. Vitamins & Hormones. Vol. 75. pp. 117-30. doi: ... Once taken up by peripheral tissue cells, the major usage of absorbed β-carotene is as a precursor to retinal via symmetric ... β-Carotene (beta-carotene) is an organic, strongly coloured red-orange pigment abundant in fungi, plants, and fruits. It is a ...

"OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium". Biochemical and Biophysical Research ... Otx2 also represses specific retinal fates (such as subtypes of retinal ganglion and horizontal cells) of sister cells to ... "OTX2 activates the molecular network underlying retina pigment epithelium differentiation". The Journal of Biological Chemistry ... "Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development". ...

April 2003). "A novel function for Hedgehog signalling in retinal pigment epithelium differentiation". Development. 130 (8): ...

They went on to use fundus autofluorescence to image the retinal pigment epithelium over the course of a year, this allowed ... Since the choriocapillaris is the main blood supply of the retinal pigment epithelium, it is leading some to believe that ... However, more recent data suggest that photoreceptor degeneration is not limited to the area of retinal pigment epithelium ... Multiple imaging methods can be applied to quantify this area of retinal pigment epithelium atrophy including short-wavelength ...

Julien, S; Schraermeyer, U (Oct 2012). "Lipofuscin can be removed from the retinal pigment epithelium of monkeys". Neurobiol ... "Reversible accumulation of lipofuscin-like inclusions in the retinal pigment epithelium". Investigative Ophthalmology & Visual ... Soraprazan (remofuscin) has been found to remove lipofuscin from retinal pigment epithelial cells in animals. This opens up a ... It is considered to be one of the aging or "wear-and-tear" pigments, found in the liver, kidney, heart muscle, retina, adrenals ...

Radu RA, Hu J, Peng J, Bok D, Mata NL, Travis GH (July 2008). "Retinal pigment epithelium-retinal G protein receptor-opsin ... RPE, retinal pigment epithelium; ipRGC, intrinsically photosensitive retinal ganglion cells; OPL, outer plexiform layer; IPL, ... RGR-opsins, also known as Retinal G protein coupled receptors are expressed in the retinal pigment epithelium (RPE) and Müller ... a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium". Proceedings of the ...

Blumenthal EZ; Papamichael G; Merin S (1998). "Combined hamartoma of the retina and retinal pigment epithelium: a bilateral ... "A pilot study of topical treatment with an alpha2-agonist in patients with retinal dystrophies". J Ocul Pharmacol Ther. 24 (1 ... was an Israeli ophthalmologist specializing in the diagnosis and treatment of retinal and genetic eye diseases. Saul Merin was ...

... regulates melanosome biogenesis and localization in the retinal pigment epithelium". Development. 133 (20): 4109-18. doi: ... Shroom2 is both necessary and sufficient to govern the localization of pigment granules at the apical surface of epithelial ...

"Membrane receptors for retinol-binding protein in cultured human retinal pigment epithelium". Investigative Ophthalmology & ... "Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of ... lipofuscin-based retinal diseases". Investigative Ophthalmology & Visual Science. 46 (12): 4393-401. doi:10.1167/iovs.05-0820. ...

In zebrafish and lamprey, CYP27C1 is expressed in the retinal pigment epithelium. The replacement of A1 by A2 broadens the ... as TH receptors have been shown to regulate CYP27C1 within the retinal pigment epithelium. TH nuclear receptors thraa-I-, thrab ... In Pacific salmonids in particular, Coho salmon parr shift vitamin A1/A2 ratio in their rod visual pigments in accordance with ... The catalytic efficiency of CYP27C1 was assessed for all trans-retinol, retinal, and retinoic acid, and was highest for retinol ...

This mutation results in defective retinal pigment epithelium phagocytosis of photoreceptor outer segments. The shaking rat ... The Royal College of Surgeons rat (or RCS rat) is the first known animal with inherited retinal degeneration. Although the ... "Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat". Human Molecular Genetics. 9 (4): 645- ...

DJ-1 is expressed in both the neural retina and retinal pigment epithelium of mammals, where it exerts a neuroprotective role ... "DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)". PLoS One. 8 (7): e67983. Bibcode: ...

It occurs due to proliferation of retinal pigment epithelium associated with choroidal hemorrhage. The size of the spots are ... It is named after the two persons who first described it: Ernst Fuchs, who described a pigmented lesion in 1901, and Forster, ... "Forster-Fuchs Retinal Spot". patient.info. Retrieved 24 December 2012. "Pathologic myopia (myopic degeneration) - EyeWiki". ... and a pigmented scar remains. As in macular degeneration, central sight is affected. Atrophy leads to the loss of two or more ...

"The influence of pro-inflammatory cytokines on human retinal pigment epithelium cell receptors". Graefes Arch. Clin. Exp. ...

Syed N, Smith JE, John SK, Seabra MC, Aguirre GD, Milam AH (2001). "Evaluation of retinal photoreceptors and pigment epithelium ... retinal pigment epithelium and retina. Rab (G-protein) GRCh38: Ensembl release 89: ENSG00000188419 - Ensembl, May 2017 GRCm38: ... Seabra MC, Brown MS, Goldstein JL (1993). "Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase ...

"Claudin 5 is transiently expressed during the development of the retinal pigment epithelium". J. Membr. Biol. 186 (2): 81-8. ...

Induced stem cells Retinal pigment epithelium Spinal cord injury research Alper, J. (2009). "Geron gets Green Light for Human ... Phase I/II clinical trials involving retinal pigment epithelial (RPE) cells, derived from human embryonic stem cells, for the ... Patients eyes were injected with retinal pigmented epithelial cells derived from human embryonic stem cells. While no ...

... and trypan blue on the human retinal pigmented epithelium". Graefes Archive for Clinical and Experimental Ophthalmology = ... "Safety Testing of Infracyanine Green Using Retinal Pigment Epithelium and Glial Cell Cultures". Investigative Ophthalmology & ... "Safety Testing of Infracyanine Green Using Retinal Pigment Epithelium and Glial Cell Cultures". Investigative Ophthalmology & ... But the retinal phototoxicity caused by IFCG is lesser compared to Indocyanine green in one study in cell cultures. Jackson, ...

... between Bruchs membrane and retinal pigment epithelium, or between the retinal pigment epithelium and photoreceptors. Despite ... The white dots are small and located in the posterior pole at the level of the retinal pigment epithelium. The white dots may ... There are yellow-white placoid lesions in the posterior pole at the level of the retinal pigment epithelium. Some suggest a ... The fundus presents with yellow or gray lesions (white dots) at the level of the choroid and retinal pigment epithelium. The ...