Pharos : Target Details - ICMT
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in ... Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. ... Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. This gene encodes the third of ... three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those ...
Pharos : Target Details - PRMT3
The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ... the guanidino nitrogens of arginyl residues in some proteins. This gene belongs to the protein arginine methyltransferase (PRMT ... The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ... Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. This gene belongs ...
Pharos : Target Details - FBLL1
Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). ... Involved in pre-rRNA processing by catalyzing the site-specific 2-hydroxyl methylation of ribose moieties in pre-ribosomal RNA ... Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity).. ... Involved in pre-rRNA processing by catalyzing the site-specific 2-hydroxyl methylation of ribose moieties in pre-ribosomal RNA ...
Pharos : Target Details - PRMT5
Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with ... and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction ... such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, ... Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1 ...
Pharos : Target Details - NSD3
This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced ... H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation, while Lys-27 is a mark for ... H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation, while Lys-27 is a mark for ... This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced ...
Pharos : Target Details - DPH5
The four successive methylation reactions represent the second step of diphthamide biosynthesis. This gene encodes a component ... The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation ... Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved ... S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue ...
Pharos : Target Details - PRMT7
Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such ... The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as ... such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric ... Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1 ...
Pharos : Target Details - TRDMT1
... specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) ... This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, ... This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 ... residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar ...
Pharos : Target Details - MGMT
Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, ... Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the ... Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the ... Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, ...
Pharos : Target Details - PRMT6
Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription ... catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues ... Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading ... H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on ...
Pharos : Target Details - SETD1A
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization ... residue is already methylated. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. The ...
Pharos : Target Details - TRMT61A
... methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, ... which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) ... which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place ...
Pharos : Target Details - TRMT61B
... methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with ... methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with ...
Pharos : Target Details - TRMT6
... methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, ... methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1 ... methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1 ... methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, ...
Pharos : Target Details - SETD1B
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization ... residue is already methylated. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. The ...
Pharos : Target Details - NTMT1
Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the ... Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal ... Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, ... Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [ ...
Pharos : Target Details - METTL14
... m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation ... m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By ... The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of ... The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of ...
Pharos : Target Details - TRMT10C
... methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). This ...
Pharos : Target Details - DNMT3L
... by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of ... but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for ... However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the ... Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear ...
Pharos : Target Details - FBL
Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a ... The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins ... Involved in pre-rRNA processing by catalyzing the site-specific 2-hydroxyl methylation of ribose moieties in pre-ribosomal RNA ... protein methyltransferase by mediating methylation of Gln-105 of histone H2A (H2AQ104me), a modification that impairs binding ...
Pharos : Target Details - EHMT2
This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this ... the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function ... Also weakly methylates Lys-27 of histone H3 (H3K27me). Also required for DNA methylation, ... Also weakly methylates Lys-27 of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase ...
Pharos : Target Details - CARM1
The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts ... Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing ... Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved ... the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA ...
Pharos : Target Details - PRMT1
The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased ... whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino ... Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). ... the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, ...
Pharos : Target Details - POLR2A
Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (By ... These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In ... Methylation and dimethylation have a repressive effect on target genes expression (By similarity). (Microbial infection) Acts ...
Pharos : Target Details - SETD2
This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is ... also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates Lys- ...