A Transcriptional Response To Replication Stress Selectively Expands A Subset Of Brca2-Mutant Mammary Epithelial Cells. ... A Transcriptional Response To Replication Stress Selectively Expands A Subset Of Brca2-Mutant Mammary Epithelial Cells. Nov-22. ...

Estrogen receptor α (ERα) is a key transcriptional element in the. Estrogen receptor α (ERα) is a key transcriptional element ...

... wild-type mice with a membrane-impermeable MMP-12 inhibitor elevates systemic IFN-α levels and reduces viral replication in ... A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity Nat Med. 2014 May;20(5):493-502. doi: 10.1038/ ...

... mutations are associated with transcriptional up-regulation of genes involved in cell cycle progression and DNA replication. To ... 2: The transcriptome of ASXL1MT CMML is characterized by transcriptional up-regulation of key mitotic pathways and leukemogenic ... 3: ASXL1MT CMML is associated with permissive promoter chromatin states supporting transcriptional up-regulation.. ... Transcriptional up-regulation in ASXL1MT CMML is independent of gene body (hydroxy)methylation. Given this heterogeneity of ...

Non-transcriptional control of DNA replication by c-Myc p.445 doi: 10.1038/nature05953 ...

July 2007). "Non-transcriptional control of DNA replication by c-Myc". Nature. 448 (7152): 445-451. Bibcode:2007Natur.448..445D ... There are instances where transcriptional factors, such as the Yamanaka factors, are still needed to aid in heterokaryon cell ... 2007-12-06). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 2006). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ...

origin of replication (6). transcriptional cis regulatory region (8). DNA segment (20,382). pseudogenic region (15,940). ... Examples: vir* AND replication gaba AND NOT inhibitory synapse GO:0005794 OR GO:0005783 Browse Gene Ontology (GO) Molecular ...

Transcriptional responses to loss of RNase H2 in Saccharomyces cerevisiae. DNA repair. 2012 11(12):933-41. [Abstract Arana ME, ... Kunkel, T.A. (2004) DNA Replication Fidelity. J. Biol. Chem.279, 16895-16898. [Abstract Kunkel, T.A. (2004) DNA Replication ... Abstract Kunkel, T.A. (2011) Balancing eukaryotic replication asymmetry with replication fidelity. Curr. Opin. Chem. Biol. 15, ... Kunkel, T.A. (2011) Balancing eukaryotic replication asymmetry with replication fidelity. Curr. Opin. Chem. Biol. 15, 620-626 ...

It has been reported that creatinine inhibits bacterial replication. C. glutamicum can resist creatinine stress in the ... Citation: Zhang H, Ouyang Z, Zhao N, Han S and Zheng S (2022) Transcriptional Regulation of the Creatine Utilization Genes of ... Transcriptional Regulation of the Creatine Utilization Genes of Corynebacterium glutamicum ATCC 14067 by AmtR, a Central ... Blue dotted line: transcriptional repression by AmtR; black arrows: creatine and creatinine degradation pathway; red arrows: ...

Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication by transcriptional activation at the long ... transcriptional and post-transcriptional mechanisms. J Exp Med 1990;172:151-8. ... These data suggest that pulmonary TB might act as a potent stimulus for the cellular-level replication of HIV. In summary, ... Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication in the lung. Am J Respir Crit Care Med 1997;155: ...

The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. . Proc Natl Acad Sci U S A, 102. ... The pre-replication complex (pre-RC) assembly or the DNA replication licensing is the first step in DNA replication initiation ... Many DNA replication proteins at the replication forks including RPC (replication factor C complex), RPA1/2, the MCM2-7 complex ... 2.2.3. The roles of DNA replication licensing proteins in coordination of DNA replication with mitosis. Many DNA replication ...

Cell growth & replication. (concentrated in cell nucleus). • Bone formation. Due to. transcriptional. • Skin integrity. ...

... its transcriptional activation and its replication during early S-phase. Together, these results provide a unified model that ... Conclusions We identified the replication licencing factor CDC6 as a new partner of the Polycomb group member BMI1. Our results ... Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic ... Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication ...

Transcriptional repression is epigenetically marked by H3k9 methylation during SV40 replication. Clin. Epigenet. 2014, 6, 21. [ ... To exist as a stable episome, the virus must be able to coordinate its own replication with that of the cell and to segregate ... Mizzen, C.A.; Allis, C.D. Linking histone acetylation to transcriptional regulation. Cell. Mol. Life Sci. 1998, 54, 6-20. [ ... Varshavsky, A.J.; Sundin, O.H.; Bohn, M.J. SV40 viral minichromosome: Preferential exposure of the origin of replication as ...

Our study provides high-resolution structures of medically relevant FluPolA, as well as insights into the replication ... Furthermore, the molecular mechanisms of genomic viral RNA (vRNA) replication-which proceeds through a complementary RNA (cRNA ... and in vitro assays to show that the interface of the FluPolA dimer is required for vRNA synthesis during replication of the ... reveal that the interface of the RNA polymerase dimer is required to initiate viral RNA synthesis in viral genome replication. ...

Phosphoserine- and DNA replication origin-binding protein involved in many signaling pathways and processes including the DNA ... 14-3-3 protein, major isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, ... 14-3-3 protein, major isoform; protein abundance and relative distribution to the nucleus increase upon DNA replication stress ... including replication origins; regulates exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling, aggresome ...

... involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ... involved in pre-replicative complex assembly involved in nuclear cell cycle DNA replication (IDA, IMP) ... ATP binding protein involved in DNA replication initiation, maintenance of rDNA and silent mating-type cassette heterochromatin ... a form of dwarfism caused by recessive mutations in genes encoding components of the pre-replication complex. Manually Curated ...

3. DNA replication in the cell cycle, for one. 4. Presence of two or more cell lineages in the same organism. 5. Protein in the ... GRAS family of transcriptional regulators. 6. Part of a clinical trial control arm, often. 7. -NH2. 11. Jupiter or Saturn, for ...

The origin recognition complex links replication, sister chromatid cohesion, and transcriptional silencing ... Spatial and temporal control of mammalian chromosome replication during the cell-cycle and development ...

I think of it as similar function to a frame shift on DNA replication.. So even though only the exons get translated it is ... Post-transcriptional regulation occurs in eukaryotes, stabilizing mRNA for translation. DNA transcribes into RNA, with exons ... I thought that the addition of the poly-A tail was done as a post-transcriptional modification via polyadenylate polymerase. Is ... Voiceover: Lets talk about post-transcriptional regulation which is regulation basically once DNA has been transcribed into ...

Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We ... Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals ...

Effect of AhR activation on HIV-1 replication.. (A-H) HIV-1 replication in CD4+ T cells (A) PBMCs (B-D) or macrophages (E-H), ... IFN-γ inhibits HIV-1 replication in macrophages.. (A and B) HIV-1NLYU2 replication in macrophages (A) or PBMCs (B) treated with ... AhR activation inhibits HIV-1 replication in macrophages.. (A and B) HIV-1NLYU2 replication in CD4+ T cells (A) or macrophages ... Effect of IFN-γ on HIV-1 replication and microarray analysis of IFN-γ-induced changes in mRNA levels.. (A and B) HIV-1NLYU2 ...

However, the transcriptional mechanisms for proviral replication control remain unclear. In this study, we show that, apart ... Transcriptional status determines the HIV replicative state in infected patients. ... thereby impairing transcriptional reactivation for latency reversal. These findings, therefore, provide a mechanistic ...

Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila. ...

... involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ... DNA replication origin binding [IDA]*chromatin binding [IDA]. Gene Ontology Cellular Component. *DNA replication preinitiation ... nuclear origin of replication recognition complex [IDA, IMP]*nuclear pre-replicative complex [IDA]*nucleus [IDA] ... DNA replication initiation [IMP]*chromatin silencing at silent mating-type cassette [IDA, IGI]*pre-replicative complex assembly ...

Background: May act as transcriptional regulator. Induces apoptosis in infected cells.Element of infectious replication cycle. ...

Following early exposure to transcriptional analyses (P. Singer), chemical synthesis (T. Nguyen), and viral replication (R. ...

Relations Between Replication and Transcription. In: Kušić-Tišma, J, ed. Fundamental Aspects of DNA Replication. Rijeka, ... Zenkin, N*., Yuzenkova, Y. and Severinov, K. (2006) Transcript-assisted transcriptional proofreading. SCIENCE, 313:518-20. ... Castro-Roa D, Zenkin N. Relations Between Replication and Transcription . In: Kušić-Tišma, J, ed. Fundamental Aspects of DNA ... Zenkin N, Naryshkina T, Kuznedelov K, Severinov K. The mechanism of DNA replication primer synthesis by RNA polymerase. Nature ...