Anticerebral Ischemia-Reperfusion Injury Activity of Synthesized Puerarin Derivatives
The mouse model of cerebral artery ischemia/reperfusion injury was established to test the anticerebral ischemia-reperfusion ... derivatives of puerarin may serve as promising approach to improve neuron function in ischemia-reperfusion brain injury-related ... improving the protective effects against cerebral ischemia/reperfusion injury. Therefore, ... Puerarin has shown protective effect on injury of neural cell. In order to enhance this protective effect of puerarin, puerarin ...
Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection
... collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and ... While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, ... while myocardial reperfusion is well established, the process itself can trigger myocardial reperfusion injury by causing ... D. M. Yellon and D. J. Hausenloy, "Myocardial reperfusion injury," New England Journal of Medicine, vol. 357, no. 11, pp. 1121- ...
The Effect of Botulinum Toxin A on Ischemia-Reperfusion Injury in a Rat Model
... injury are becoming increasingly common, studies on the effects of botulinum toxin A (BoTA) on IR injury in musculocutaneous ... this study was to examine our hypotheses that BoTA provide protection of musculocutaneous flap from ischemia-reperfusion injury ... we found that local BoTA preconditioning yielded significant protection against IR injury in a rat musculocutaneous flap model ... i,Introduction,/i,. While studies using various materials to overcome ischemia-reperfusion (IR) ...
Table of Contents 2017 | Oxidative Medicine and Cellular Longevity | Hindawi
RTA-408 Protects Kidney from Ischemia-Reperfusion Injury in Mice via Activating Nrf2 and Downstream GSH Biosynthesis Gene. Peng ... Idh2 Deficiency Exacerbates Acrolein-Induced Lung Injury through Mitochondrial Redox Environment Deterioration. Jung Hyun Park ... Capsaicin Protects Cardiomyocytes against Anoxia/Reoxygenation Injury via Preventing Mitochondrial Dysfunction Mediated by ...
Oxidative Stress in the Critically Ill Patients: Pathophysiology and Potential Interventions | Hindawi
Pathophysiology of oxidative stress in reperfusion injury. *Therapeutic interventions targeting increased oxidative burden in ... Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms-Biomarkers-Interventions, and Future ... radicals contributes to an increased burden of oxidative stress that may be implicated in the pathophysiology of tissue injury ...
Mas Receptor Blockade Promotes Renal Vascular Response to Ang II after Partial Kidney Ischemia/Reperfusion in a Two-Kidney-One...
... injury is the principal cause of acute kidney injury. The renin-angiotensin system (RAS) and hypertension also may be ... IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for ... influenced by renal IR injury. In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas ... i,Background,/i,. Partial kidney ischemia-reperfusion (IR) ... Kidney partial ischemia-reperfusion (IR) injury is defined as a ...
Surgical Removal of a Canine Aortic Thromboembolism Secondary to Pancreatitis
Ischemia-reperfusion injury is a concern after ATE [29]. After a period of decreased or absent tissue oxygenation, reactive ... M. McMichael and R. M. Moore, "Ischemia-reperfusion injury pathophysiology, part I," Journal of Veterinary Emergency and ... B. H. Cassutto and R. W. Gfeller, "Use of intravenous lidocaine to prevent reperfusion injury and subsequent multiple organ ... Lidocaine has been purported to be helpful in prevention of ischemia/reperfusion injury. Its mechanisms of action are ...
Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation
... injury.,i, Objective,/i,. To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery ... Simvastatin reduced the generation of autophagosomes and the ultrastructural injuries to myocardium.,i, Conclusion,/i,. ... Perioperative statin therapy reduced myocardial injury by regulating myocardial autophagy and activating the phosphorylation of ... i,Background,/i,. Cardiopulmonary bypass (CPB) causes systemic inflammatory response and ischemia-reperfusion (IR) ...
Nanoparticle Enhanced MRI Scanning to Detect Cellular Inflammation in Experimental Chronic Renal Allograft Rejection
... these effects may have been due to ischaemia reperfusion injury [28, 29]. We hypothesized that they could be used to identify ... Allograft Injury: Histology. Kidneys were divided and fixed fresh frozen or in methyl Carnoys solution and embedded in ... Allograft Injury: Cellular Infiltrate. Macrophage infiltration was identified by F4/80+ (Abcam, Cambridge, UK) staining by ... opposing roles during liver injury and repair," The Journal of Clinical Investigation, vol. 115, no. 1, pp. 56-65, 2005. ...
Perioperative Dynamics of TLR2, TLR4, and TREM-1 Expression in Monocyte Subpopulations in the Setting of On-Pump Coronary...
F. Arslan, M. B. Smeets, L. A. J. ONeill et al., "Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like ... It is considered to develop due to a massive alarmin release in response to ischemia reperfusion, mechanical injury, and ... Those factors include mechanical and reperfusion injuries, ischemia, various burns, UV rays, and radiation [4-6]. Adverse ... Nowadays, TLR2 receptors are inseparably linked with the progression of ischemic and reperfusion myocardial injuries [25]. TLR2 ...
Total Flavonoids from Carya cathayensis Sarg. Leaves Alleviate H9c2 Cells Hypoxia/Reoxygenation Injury via Effects on miR-21...
leaves alleviate hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes and to explore potential mechanisms. H9c2 cells ... The results indicated that TFs significantly alleviate H/R injury, which include inhibiting apoptosis and enhancing antioxidant ... miR-21 expression with miR-21 inhibitor effectively suppressed the protective effects of TFs against H/R-induced injury. Our ... Cardiac ischemia/reperfusion (I/R) injury is a serious disease and threatens human health [1]. Reperfusion treatment has a ...
miR-217 Is a Useful Diagnostic Biomarker and Regulates Human Podocyte Cells Apoptosis via Targeting TNFSF11 in Membranous...
... miR-320 could be a novel diagnosis and treatment target in renal ischemic reperfusion injury [19]. miR-193b-3p could also be a ... P. Fan, C. Chen, Y. Chen, Y. Chang, and P. Chu, "MicroRNAs in acute kidney injury," Human Genomics, vol. 10, no. 1, 2016. ... M. Nangaku, S. J. Shankland, and W. G. Couser, "Cellular response to injury in membranous nephropathy," Journal of the American ... M. D. Sanchez-Nio, A. Benito-Martin, S. Gonalves et al., "TNF superfamily: a growing saga of kidney injury modulators," ...
Relation of Fibrinogen-to-Albumin Ratio to Severity of Coronary Artery Disease and Long-Term Prognosis in Patients with Non-ST...
showed that hypoproteinemia might aggravate ischemia and reperfusion injury in patients with coronary no-reflow phenomenon [28 ...
Cerebral Endothelial Function Determined by Cerebrovascular Reactivity to L-Arginine
In fact NOS inhibitors have been shown to minimize the ischemic reperfusion injury after acute stroke [39, 40]. Further studies ... C. Iadecola, "Bright and dark sides of nitric oxide in ischemic brain injury," Trends in Neurosciences, vol. 20, no. 3, pp. 132 ...
Gpx3 and Egr1 Are Involved in Regulating the Differentiation Fate of Cardiac Fibroblasts under Pressure Overload
Overexpression of Atf, for example, can alleviate ischemia-reperfusion injury in the heart by reducing oxidative stress [78]. ... Q. Jin, R. Li, N. Hu et al., "DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff- required ... H. Liu, L. Wang, X. Weng et al., "Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and ... "Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice," Journal of ...
Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation
F. Arslan, M. B. Smeets, L. A. J. ONeill et al., "Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like ... J. Yang, H. Jiang, J. Yang et al., "Valsartan preconditioning protects against myocardial ischemia-reperfusion injury through ... "Inhibition of toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury," Circulation, vol. 114, no ... "Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury," Circulation, vol. 123 ...
Leukotrienes in Atherosclerosis: New Target Insights and Future Therapy Perspectives
Many studies regarding myocardial ischemia and reperfusion show that leukotriene signaling may be involved in the development ... of ischemic injury. For these, reasons both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been ... myocardial ischemia and reperfusion show that leukotriene signaling may be involved in the development of ischemic injury. For ...
Atorvastatin and Conditioned Media from Atorvastatin-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show...
... and protect kidneys from ischemia-reperfusion injury [9]. Microvesicles from phenotypical EPC enhance vascularization in ... "Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA- ...
Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and...
L. Liu, W. Zhang, L. Wang et al., "Curcumin prevents cerebral ischemia reperfusion injury via increase of mitochondrial ... Rats submitted to ischemic reperfusion injury after curcumin pretreatment exhibited a better developed mitochondrial network in ... J. Athale, A. Ulrich, N. Chou MacGarvey et al., "Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury ... protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and ...
Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects...
K. Song, M. Zhang, J. Hu et al., "Methane-rich saline attenuates ischemia/reperfusion injury of abdominal skin flaps in rats ... and apoptotic injury in many diseases, including acute pancreatitis [10], spinal cord injury [16, 17], acute lung injury [18], ... L. Wang, Y. Yao, R. He et al., "Methane ameliorates spinal cord ischemia-reperfusion injury in rats: antioxidant, anti- ... and apoptotic injury during spinal cord injury in rats," Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID ...
Pathogenesis of Cognitive Dysfunction in Patients with Obstructive Sleep Apnea: A Hypothesis with Emphasis on the Nucleus...
M. Bliksøen, M. L. Kaljusto, J. Vaage, and K. O. Stensløkken, "Effects of hydrogen sulphide on ischaemia-reperfusion injury and ... In OSA, repeated intermittent arterial oxygen desaturation and reoxygenation and ischemia-reperfusion injury to the vascular ... Depressive symptoms accompanying OSA exacerbated injury. When MRI maps were compared between OSA and control groups, injury ... analogous to peripheral nerve injury resulting from low-frequency vibration [135]. Neural injury and dysfunction in OSA ...
Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin
D. Zhao, J. Yang, and L. Yang, "Insights for oxidative stress and mTOR signaling in myocardial ischemia/reperfusion injury ... Reduction in oxidative stress caused by ischemia-reperfusion injury is clearly an appropriate countermeasure to the major ... "The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: revisited," Oxidative Medicine and ... of yam family in myocardial ischemic reperfusion injury," Food & Function, vol. 1, no. 3, pp. 278-283, 2010. ...
Infiltration of Blood-Derived Macrophages Contributes to the Development of Diabetic Neuropathy
... to the spinal cord plays a pivotal role in different models of central nervous system injury. Therefore, the present study ... "Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice," Stroke, vol. 38, no. 4, ... "Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats," Diabetologia, vol. 49, no. ... some studies have shown that these cells initiate secondary injury in models of ischemic stroke and traumatic brain injury [25 ...
Involvement of Nrf2 in Ocular Diseases
... promotes neuronal survival in both the retinal ischemia/reperfusion and the optic nerve injury models [163, 165]. The Nrf2 ... "Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury," Free Radical ... Depletion of Nrf2 aggravates RGC death induced by optic nerve injury [163]. Similar results have been reported in mice ... Since the depletion of GSH is directly correlated to oxidative injury and cell death via apoptosis, Nrf2 thus serves as an ...
HD-13 Induces Swine Pneumonia Progression via Activation of TLR9
"Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates hepatic ischemia/reperfusion injury by ...
Emerging Roles of Impaired Autophagy in Fatty Liver Disease and Hepatocellular Carcinoma
"Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury," Cell Death & ... P. D. Schneider and C. M. Gorschboth, "Limiting ischemic liver injury by interfering with lysosomal autophagy," The Journal of ... H. Yang, H. M. Ni, and W. X. Ding, "Emerging players in autophagy deficiency-induced liver injury and tumorigenesis," Gene ... Acute and chronic alcohol consumption can result in liver injury since this organ is the primary site of alcohol metabolism [68 ...
MIF mRNA Expression and Soluble Levels in Acute Coronary Syndrome
T. Rassaf, C. Weber, and J. Bernhagen, "Macrophage migration inhibitory factor in myocardial ischaemia/reperfusion injury," ... mention that upon ischaemia injury, MIF is rapidly released from the myocardium and mediates cardioprotection; however, with ... the severity of ischaemic injury, and the time after acute MI [18]. Regarding the MIF soluble levels, we found significantly ... and it is already known that their elevated levels are associated with cardiac injury and myonecrosis [28]. Regarding ...
Human Bone Marrow Mesenchymal Stem Cell (hBMSCs)-Derived miR-29a-3p-Containing Exosomes Impede Laryngocarcinoma Cell Malignant...
R. Tian, X. Guan, H. Qian et al., "Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating ... S. He, Z. Wang, Y. Li et al., "MicroRNA-92a-3p enhances functional recovery and suppresses apoptosis after spinal cord injury ...
Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends
... was found to inhibit human keratinocytes and ameliorate the ischemia/reperfusion injury acting on AQP3 [64] and AQP4 [143], ... M. H. M. Shimizu, A. Danilovic, L. Andrade et al., "N-Acetylcysteine protects against renal injury following bilateral ureteral ... lung injuries (AQP1) [136], and Sjögren syndrome-associated xerostomia (AQP5) [137], to inhibit ovarian tumor growth (AQP5) [89 ... "Curcumin improves the recovery of motor function and reduces spinal cord edema in a rat acute spinal cord injury model by ...
Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension
"A long-term and slow-releasing hydrogen sulfide donor protects against myocardial ischemia/reperfusion injury," Scientific ... sulfide inhibits autophagic neuronal cell death by reducing oxidative stress in spinal cord ischemia reperfusion injury," ... limits ventilator-induced lung injury," Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 3715037, 2017. ... "Cardioprotective effect of hydrogen sulfide in ischemic reperfusion experimental rats and its influence on expression of ...