Effects of Poststroke Losartan Versus Captopril Treatment on Myogenic and Endothelial Function in the Cerebrovasculature of...
SHRsp capable of developing stroke have an overactive renin-angiotensin system1,6 and high blood aldosterone levels.1 Captopril ... is associated with the presence of an overactive renin-angiotensin II (AII)-aldosterone system1 and rapid death.1,2 Treatment ... that cerebrovascular defects associated with hemorrhagic stroke have a capacity to be reversed in SHRsp by altering renin- ...http://stroke.ahajournals.org/content/38/5/1590
Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phox-dependent...
Inhibitors of the renin-angiotensin system (RAS) and nonspecific vasodilators normalized blood pressure and inhibited EPC ... Inhibitors of the renin-angiotensin system (RAS) and nonspecific vasodilators normalized blood pressure and inhibited EPC ...http://www.zora.uzh.ch/id/eprint/12156/
The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in mice.
Activation of the renin-angiotensin-aldosterone system impairs PAC function. The effects of the direct renin inhibitor ... Activation of the renin-angiotensin-aldosterone system impairs PAC function. The effects of the direct renin inhibitor ...http://www.biomedsearch.com/nih/renin-inhibitor-aliskiren-upregulates-pro/20857126.html
Malignant hypertensive crisis induced by chronic intrarenal norepinephrine infusion. | Hypertension
... and increases in plasma renin activity (PRA), mean arterial pressure (MAP), and filtration fraction. At the end of this period ... marked activation of the renin-angiotensin-aldosterone system, increased plasma cortisol concentration, hemolysis, marked ...http://hyper.ahajournals.org/content/6/2_Pt_2/I177
Effects of Human Renin in the Vasculature of Rats Transgenic for Human Angiotensinogen | Hypertension
Identification of vascular renin-binding proteins by chemical cross-linking: inhibition of binding of renin by renin inhibitors ... We also observed the effect of renin inhibition during renin infusion. In four separate experiments human renin (10 ng/mL) was ... since the effects of renin were still present after cessation of renin infusion, when renin activity in the perfusate was ... We conclude that renin acts on angiotensinogen at a site in the vascular wall. The cleavage depends on renin and not on other ...http://hyper.ahajournals.org/content/26/2/272
Tissue renin-angiotensin systems in renal hypertension. | Hypertension
Tissue renin-angiotensin systems in renal hypertension.. M Nishimura, A Milsted, C H Block, K B Brosnihan, C M Ferrario ... Renin mRNA levels of the ischemic kidney remained elevated at both the early and later phases, whereas in both ischemic and ... We also measured renin mRNA in the kidneys of these renal hypertensive rats. The early phase of hypertension (day 6) was ... The circulating renin-angiotensin system was not activated in the later phase of hypertension (day 24). Angiotensinogen mRNA ...http://hyper.ahajournals.org/content/20/2/158
The lack of association between angiotensin-converting enzyme gene insertion/deletion polymorphism and nicotine dependence in...
Blood-borne angiotensin II is generated from angiotensinogen via cleavage by renin and angiotensin-converting enzyme (ACE), an ... enzymatic cascade known as the renin-angiotensin system (RAS). Several lines of evidence indicate that ACE, beyond its ...https://repository.medri.uniri.hr/en/islandora/object/medri%3A1447
Plasma immunoreactive endothelin-1 in experimental malignant hypertension. | Hypertension
Six weeks of caffeine administration increased blood pressure, blood urea nitrogen, serum creatinine, plasma renin activity, ...http://hyper.ahajournals.org/content/18/1/93
Racial Difference in the Relationship of an Angiotensin I-Converting Enzyme Gene Polymorphism to Serum Angiotensin I-...
Brunner HR, Laragh JH, Baer L. Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med. 1972;286: ... Low renin-aldosterone in 'prehypertensive' young adults. J Clin Endocrinol Metab. 1982;54:808-814. ... Since ACE activity is an integral component of the renin-angiotensin system, ACE has been considered a candidate gene for ... In addition, there are well-established racial differences in the renin-angiotensin system, such as the lower PRA that ...http://hyper.ahajournals.org/content/27/1/62
Influence of Nitric Oxide in the Chronic Phase of Two-Kidney, One Clip Renovascular Hypertension | Hypertension
Lin L, Mistry M, Stier CT, Nasjletti A. Role of prostanoids in renin-dependent and renin-independent hypertension. Hypertension ... Kidney renin mRNA levels in the early and chronic phase of two-kidney, one clip hypertension in rats. J Hypertens. 1989;7:105- ... Plasma renin activity and the renal response to nitric oxide synthesis inhibition. J Am Soc Nephrol. 1992;3:1288-1294. ... Plasma renin activity and the renal response to nitric oxide synthesis inhibition. J Am Soc Nephrol. 1992;3:1288-1294. ...http://hyper.ahajournals.org/content/31/2/649
Renin-angiotensin system - Wikipedia
The renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS) is a hormone system that regulates blood ... Fetal renin-angiotensin system. In the fetus, the renin-angiotensin system is predominantly a sodium-losing system,[ ... Direct renin inhibitors can also be used for hypertension. The drugs that inhibit renin are aliskiren and the ... Local renin-angiotensin systems. Locally expressed renin-angiotensin systems have been found in a number of tissues, ...https://en.wikipedia.org/wiki/RAA_system
Aldosterone and Renin | SpringerLink
Plasma Renin Activity Congenital Adrenal Hyperplasia Primary Aldosteronism Plasma Aldosterone Zona Glomer These keywords were ... Homer, J. M., Hintz, R. L., and Luetscher, J. A., 1979, The role of renin and angiotensin in salt-losing, 21-hydroxylase ... Lemal, J. M., Rapaport, R., and Bayard, F., 1976, Plasma aldosterone, renin activity, and 17a-hydroxyprogesterone in salt- ... Biglieri E.G. (1985) Aldosterone and Renin. In: Ingbar S.H. (eds) Contemporary Endocrinology. Contemporary Endocrinology (( ...https://link.springer.com/chapter/10.1007/978-1-4684-4817-7_5
Aldosterone and Renin
Renin is an enzyme that controls aldosterone production. Aldosterone and renin tests help diagnose primary (Conn syndrome) and ... Renin is an enzyme that controls aldosterone production. These tests measure the levels of aldosterone and renin in the blood ... blood levels of aldosterone and renin are measured and a calculation is done by dividing the aldosterone result by the renin ... The kidneys release renin when there is a drop in blood pressure or a decrease in sodium chloride concentration in the tubules ...https://labtestsonline.org/tests/aldosterone-and-renin
Renin-1 (P06281) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.http://www.ebi.ac.uk/interpro/protein/P06281
Renin in Experimental Hypertension | The BMJ
Renin in Experimental Hypertension. Br Med J 1942; 2 doi: https://doi.org/10.1136/bmj.2.4258.179 (Published 15 August 1942) ...http://www.bmj.com/content/2/4258/179
Evolution of renin. | Hypertension
In this way, they discovered renin. This paper covers the methods by which its mode of action was uncovered, as well as its ...http://hyper.ahajournals.org/content/18/5_Suppl/III100
Renin, Genes, and Beyond | Hypertension
Renin, Genes, and Beyond. 40 Years of Molecular Discoveries in the Hypertension Field. Brian J. Morris ...http://hyper.ahajournals.org/content/early/2011/01/10/HYPERTENSIONAHA.110.166967
Aldosterone and Renin
... and what the results of aldosterone and renin tests might mean ... Describes when aldosterone and renin tests are requested, how ... Normally when renin increases, aldosterone increases; when renin is low, aldosterone decreases. ... the most important of these being renin and angiotensin II. Renin, produced by the kidney, stimulates production of angiotensin ... Renin is then measured in these blood samples. If the value is significantly higher in one side, this indicates the site of the ...https://labtestsonline.org.uk/tests/aldosterone-and-renin
Renin | Disease Models & Mechanisms
Summary: Using a mouse model of precursor B-cell leukemia, we have investigated influencing factors on leukemia genesis, including genetic background, cell of origin and deletion efficiency. ...http://dmm.biologists.org/keyword/renin
Go to Renin.
Though renin itself has no effect on blood pressure, angiotensin II does. An excess of angiotensin II can lead to hypertension ... Through a series of chemical reactions, renin converts angiotensinogen (a protein released into the blood by the liver) to ... Some studies have shown an association between increased renin activity and a cluster of cardiovascular disease risk factors ... and inhibiting renin secretion by the kidney. ...https://www.diabetesselfmanagement.com/diabetes-resources/definitions/renin/
Renin FRET Substrate I
... also called Renin Substrate I in some literature) contains a renin cleavage site that occurs in the N-terminal peptide of human ... The kinetics of renin-catalyzed hydrolysis of this substrate is shown to be consistent with a simple substrate inhibition model ... The substrate can detect renin as low as 30 ng/mL after an incubation of only 3-5 min.; Minimum Purity: 95%; DABCYL-g-Abu- ... Cleavage of the substrate occurs specifically at the Leu-Val bond and corresponds to the renin cleavage site of angiotensinogen ...https://www.anaspec.com/products/product.asp?id=48589&productid=17790
WikiGenes - REN - renin
Renin and aldosterone levels were evaluated by using a radioimmunoassay .. *The cAMP mechanisms that regulate renin mRNA ... HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. ... The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Morimoto, S., Cassell ... RnBP has been shown to bind and inactivate renin, a key player of the blood pressure regulating renin-angiotensin system . ...http://www.wikigenes.org/e/gene/e/5972.html
The Local Cardiac Renin-Angiotensin Aldosterone System | SpringerLink
Second Edition updates new findings on the local renin-angiotensin systems (RAS) with a focus on the local RAASs of the ... The Local Cardiac Renin-Angiotensin Aldosterone System, Second Edition updates new findings on the local renin-angiotensin ... Renin Cell Identity and Homeostasis R. Ariel Gómez, Maria Luisa S. Sequeira Lopez, Xuan Jin, Magali Cordaillat, Ellen Steward ... Renin-Angiotensin-Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease Arantxa González, Susana Ravassa ...https://link.springer.com/book/10.1007%2F978-1-4419-0528-4
Renin Angiotensin System in Cognitive Function and Dementia
"Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice ... 2. Systemic and Brain Renin Angiotensin System. The renin angiotensin system (RAS) is a peptide hormone cascade that controls ... S. Inaba, M. Iwai, M. Furuno et al., "Continuous activation of renin-angiotensin system impairs cognitive function in renin/ ... Figure 4: A schematic representation of the renin-angiotensin system. Additional components of the renin-angiotensin system ( ...https://www.hindawi.com/journals/ajn/2013/102602/
Control of Renin Synthesis and Secretion.
Renin is synthesized as an enzymatically inactive proenzyme which is constitutively secreted from several tissues. Only renin- ... The aspartyl protease renin is the rate limiting activity of the renin-angiotensin-aldosterone system (RAAS). ... The aspartyl protease renin is the rate limiting activity of the renin-angiotensin-aldosterone system (RAAS). Renin is ... Only renin-expressing cells in the kidney are capable of generating active renin from prorenin, which is stored in prominent ...http://www.biomedsearch.com/nih/Control-Renin-Synthesis-Secretion/22237158.html