January 12, 2023 - Joanna Wysocka: Cis-regulatory elements and transcription factor dosage as drivers of human disease and ... November 17, 2022 - Benoit Bruneau: Transcriptional regulation of heart development and disease. William H. Younger ...
Transcriptional Activation 11% * Alitretinoin 11% * Sterol Regulatory Element Binding Protein 1 11% ...
Combinatorial gene regulatory functions underlie ultraconserved elements in Drosophila. M Warnefors, B Hartmann, S Thomsen, CR ... Evolution of Hox Post-Transcriptional Regulation by Alternative Polyadenylation and MicroRNA Modulation Within 12 Drosophila ... Transposable elements: insertion pattern and impact on gene expression evolution in hominids. M Warnefors, V Pereira, A Eyre- ... Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation ...
Chang, W- (1998) Identification of transcriptional regulatory elements in muscle promoter of Ca++-activated potassium channel, ... Brenner, R, Atkinson, N (1996) Developmental and Eye-specific transcriptional control elements in an intronic region of a Ca2+- ... Tissue-specific expression of a Ca2+-activated K+ channel is controlled by multiple upstream regulatory elements. J. Neurosci ... 2016) A DNA element in the slo gene modulates ethanol tolerance. Alcohol. 2016 Mar;51:37-42. PMID: 26992698 ...
In this review, we discuss regulatory elements found in the 5′ untranslated region (UTR) and their influence on protein ... Most synthetic biology tools to tune pathway expression focus on controlling transcription, whereas post‐transcriptional ...
The objective of this study was to identify transcriptional regulatory proteins that mediate EBNA- 1 expression via the viral ... family may regulate EBNA-1 transcription by targeting an essential cis-regulatory element of Qp, QRE-2. Further investigation ... The objective of this study was to identify transcriptional regulatory proteins that mediate EBNA- 1 expression via the viral ... The objective of this study was to identify transcriptional regulatory proteins that mediate EBNA- 1 expression via the viral ...
Singh LN, Hannenhalli S. 2010. Correlated Changes Between Regulatory Cis Elements and Condition-Specific Expression in ... Hannenhalli S, Levy S. 2003. Transcriptional regulation of protein complexes and biological pathways. Mammalian Genome. 14(9): ... Systems Biology and Regulatory GenomicsSystems Biology and Regulatory Genomics. 4023:225-234.*Google Scholar ... Identification and cross-species comparison of canine osteoarthritic gene regulatory cis-elements. Osteoarthritis and Cartilage ...
GENOME-WIDE CHARACTERIZATION OF TRANSCRIPTIONAL REGULATORY ELEMENTS, PATHWAYS AND ASSOCIATED GENETIC VARIATIONS INVOLVED IN THE ... GENOME-WIDE CHARACTERIZATION OF TRANSCRIPTIONAL REGULATORY ELEMENTS, PATHWAYS AND ASSOCIATED GENETIC VARIATIONS INVOLVED IN THE ...
... is a database with genome-wide annotations of regulatory sites. All predictions are made using the PhyloGibbs ... CREMA The Cis-Regulatory Element Motif Activity analysis infers key transcriptional regulators driving chromatin changes across ... Phylogibbs: An algorithm for inferring regulatory motifs and regulatory sites from collections of DNA sequences, including ... SwissRegulon: A database of genome-wide annotations of regulatory sites. We currently have annotations for 17 prokaryotes and 3 ...
CREs (i.e., enhancers/promoters) typically consist of multiple clustered binding sites for both transcriptional activators and ... Montana, C. L., Myers, C. A., & Corbo, J. C. (2011). Quantifying the activity of cis-regulatory elements in the mouse retina by ... Montana, Cynthia L. ; Myers, Connie A. ; Corbo, Joseph C. / Quantifying the activity of cis-regulatory elements in the mouse ... Montana, CL, Myers, CA & Corbo, JC 2011, Quantifying the activity of cis-regulatory elements in the mouse retina by explant ...
Promoters are dependent on additional regulatory elements • Transcription may be activated, enhanced or repressed by regulatory ... The transcriptional machinery is capable of recognize Promoters in contrast with present statistical data that suggest that the ... Many regulatory factors have not been characterized yet ... regulatory elements do not contain sufficient information to do ... proteins/protein complex • Transcriptional activators and repressors act very specifically both in terms of the cell type and ...
Transcriptional Regulatory Elements === :Insulators (modENCODE, class I) Insulators identified by ChIP-chip of Cp190, ... Transcriptional Regulatory Regions (REDfly) Locations of regulatory regions reported in the literature, as compiled by ... An arrow pointing to the right indicates a transposable element with its conventional 5 terminus to the left (assuming view is ... An arrow pointing to the right indicates a transposable element with its conventional 5 terminus to the left (assuming view is ...
These results are suggestive of a complex regulatory element that mediates fine control rather than acting as a simple on-off ... We show that the transcriptional activity of this complex is highly sensitive to the p65:p50 ratio that is expressed. We ... Transcriptional activation of the human TNF gene involves multiple regulatory elements whose functional properties vary between ... to dissect the transactivating potential of NF-kappaB binding sites in the human TNF promoter region from other regulatory ...
A major effort of Corbo lab is directed toward understanding the transcriptional regulatory networks that orchestrate the ... parallel reporter assay called CRE-seq to further interrogate the architecture of photoreceptor cis-regulatory elements. Our ... quantitative model of photoreceptor transcriptional regulation including a detailed cis-regulatory grammar. This model will ... During her PhD, Abhi elucidated the regulatory role of cytokine signaling pathways in the function of lipid antigen presenting ...
... and the regulatory regions of Oct4. This major H3.3 deposition occurs in absence of DNA replication, and is HIRA-and ... found to be especially enriched in the coding region of transcriptionally active genes as well as in gene regulatory elements [ ... A HIRA- and transcription- dependent H3.3 incorporation onto transplanted chromatin is required for transcriptional ... To confirm transcriptional reprogramming of these genomic regions we have directly measured whether their rate of transcription ...
Regulatory MicroRNAs in Aberrant Cholesterol Transport and Metabolism Curator: Marzan Khan, B.Sc Aberrant levels of lipids and ... regulatory elements approximately 22 nucleotides long, with the ability to control post-transcriptional expression of genes(3 ... Further examination of miR-148 established that Liver-X-Receptor (LXR) activation of the Sterol regulatory element-binding ... Regulatory T cells (Tregs) are important for sperm tolerance and male fertility September 11, 2023 ...
Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of ... The TP53 regulatory pathway was predicted to be the most inhibited with a z-score of −3.113 and a p-value of 4.05E-19 (Table 1 ... Transcriptional targets of NRF2 include genes involved in alcohol metabolism such as ADH7, AKR1B1, ALDH3A1, and ALDH7A1, all of ... The upstream regulatory role of RABL6 was predicted in six out of eight ESCC datasets. RABL6 gene encodes a member of the Ras ...
The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. ... Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes ... The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. ... The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. ...
... play a crucial role in establishing and maintaining the GSC transcriptional program. This review focuses on the relevance of ... Alterations on chromatin insulator elements (IEs) might lead to aberrant chromatin remodeling via DNA loop formation, causing ... While many efforts have been made to study transcriptional regulatory elements in cancer, most of these focused on promoters ... Genetic and epigenetic alterations on insulator elements (IEs), an essential type of cis-regulatory element involved in ...
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes ...
INTRODUCTION Transcriptional regulation is accomplished mainly by the regulatory elements such as promoters and enhancers those ... promoters containing sequence motifs known as IFN-stimulated response element (ISRE) are the binding sites of the sequence- ... 1 STAT2 and IFN regulatory factor 9 (IRF9) bind to ISREs in the promoters facilitating transcription initiation complex ... KD did not show the additive effect in ISG transcription suggesting that TAF-I and histone H1 may act on the same regulatory ...
... transcriptional, mRNA stability, translational, and posttranslational). Iron regulatory proteins (IRPs) 1 and 2 post- ... transcriptionally control mammalian iron homeostasis by binding to iron-responsive elements (IREs), conserved RNA stem-loop ... This would improve our understanding of an iron regulatory network. For these purposes we used microarray gene expression data ... Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, ...
Studies on active TEs have suggested that the elements could alter gene expression by providing cis-regulatory elements, such ... as promoters, enhancers, and transcription factor binding sites [10]. Through these mechanisms, altered transcriptional ... Keywords: Alu elements (1) DNA transposable elements (1) endogenous retroviruses (1) long interspersed nucleotide elements (1) ... ABSTRACT Transposable Elements: No More Junk DNA. Since the advent of whole-genome sequencing, transposable elements (TEs), ...
Regulatory Elements, Transcriptional. *RNA 3 Polyadenylation Signals. *RNA 5 Terminal Oligopyrimidine Sequence ... A users guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol. 2011 Apr; 9(4):e1001046. ... molecular cloning and assessment of transcriptional regulation by a polydnavirus. Arch Insect Biochem Physiol. 2008 Apr; 67(4): ...
liver X receptors (LXR) that act in synergy with sterol regulatory element binding protein (SREBP1) in promoting hepatic ... 4. In wild-type mice, during fasting, (a) transcriptional genetic activators (GA) of FAs oxidation are synthetized; (b) ... Ntambi, Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated ... Then, the reduction of each element of the model was considered: (a) A reaction R was removed from the model if the compendium ...
Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and ... increases their transcriptional activities. Facilitates binding of TP53 to DNA. Proposed to be involved in mitochondrial ... In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory ... In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells ...
... which involves various cis-regulatory elements and trans-acting factors at transcriptional level. In addition, DNA methylation ... can either activate gene expression by facilitating the interactions between enhancers or other cis-regulatory elements and ...
The MYB binding sites (AACTAAA/C) in TaGAPCp2P/3P were identified as the key cis-elements for responding to drought stress and ... contained enhancer elements that increased gene expression levels under drought stress. We used an effector and a reporter to ... were the target cis-elements of TaMYB. The deletion of the specific MYB binding sites in the promoter fragments significantly ... The aim of this experiment was to identify the core cis-regulatory elements that may respond to drought stress in the GAPCp2 ...