Maeda T, Gupta MP, Stewart AF (Jun 2002). "TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters ... MEF2C is a transcription factor in the Mef2 family. The gene is located at 5q14.3 on the minus (Crick) strand and is 200,723 ... Lu J, McKinsey TA, Nicol RL, Olson EN (Apr 2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation ... Yang SH, Galanis A, Sharrocks AD (Jun 1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors ...
Regulation of synapse development by the activity-regulated transcription factor MEF2 Advisor: Michael Greenberg. ... Neurotrophic Factor Regulation of Immediate Early Gene Expression. Advisor: Michael Greenberg. Cole, Rebecca Leah. ... Glucocorticoids regulate kisspeptin neurons during stress and contribute to infertility and obesity in leptin-deficient mice. ... TLF is a Functional Regulator or Transcription with Targets that are Distinct from the TATA-Box Binding Protein (TBP). Advisor ...
... while a loss-of-function study of the activity-regulated MEF2 transcription factor also revealed a role for MEF2 in suppression ... 2012) The transcription factor MEF2 directs developmental visually driven functional and structural metaplasticity. Cell 151:41 ... 2006) AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc. Nat Neurosci 9:887-895, doi: ... 2011) Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol 94:259-295, doi:10.1016/j. ...
In the mammalian nervous system, neuronal activity regulates the strength and number of synapses formed. The genetic program ... We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity ... We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity ... We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity ...
MEF2 transcription factors are key regulators of sprouting angiogenesis. Journal article Sacilotto N. et al, (2016), Genes Dev ... our ability to manipulate vessel growth for therapeutic aims is hampered by a poor understanding of the mechanisms regulating ... Corrigendum: MEF2 transcription factors are key regulators of sprouting angiogenesis. Journal article ... Enhancers are densely clustered groups of transcription factor binding motifs and are the principal regulators of spatio- ...
Furthermore, transcription factors can bind accessible regions and recruit other factors important for transcription to occur. ... Using single and double conditional knockout of MEF2 family TFs, we find that MEF2A and MEF2D play functionally redundant roles ... Upon assessing transcriptomic and epigenomic functions of CHD7, we find CHD7 to regulate gene programs implicated in human ... The recruitment of chromatin remodelers to specific regions is accomplished by multiple factors including transcription factors ...
We found that transcription factor MEF2 regulates basal Mfn2 expression in neurons and that excitotoxicity-dependent ... animal model of stroke (Barsoum and models of excitotoxicity via MEF2 degradation that by acting on the Mfn2 promoter regulates ... degradation of MEF2 causes Mfn2 downregulation. Thus Mfn2 reduction is a late event in excitotoxicity and its targeting may ...
Mef2) transcription factor family, is a critical regulator of this process. In CD4 T cells, Mef2d negatively regulates ... The transcription factor Mef2d regulates B:T synapse-dependent GC-TFH differentiation and IL-21-mediated humoral immunity. ... Fatores de Transcrição MEF2/genética , Fatores de Transcrição MEF2/metabolismo ... In particular, since the heart reflects complex factors, it is necessary to develop HOs that can be simulated in depth. In this ...
Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science. 1996 Jun 7;272(5267):1476-80. ... Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn. 2006 May;235(5):1345-57. PMID:16502419 doi: ...
... and how many target genes do MADS proteins really regulate? Recently, several studies reported on the genome-wide ... it appears that MADS proteins may directly regulate thousands of target genes (Figure 1a), and may ser... ... MADS domain transcription factors are key regulators in yeast, animals, and plants. They guide important developmental ... High-confidence targets were enriched in transcription factors, including those known to regulate AP1 itself. As with the ...
It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible ... The expression of miR-1 and miR-133 in the embryonic heart is regulated by transcription factors SRF, MEF2, myogenic regulatory ... thus modifying the transcription factors and regulating cardiomyocyte development [40]. The molecular mechanisms regulating ... RE1 silencing transcription factor, Sfrp5 - secreted frizzled related protein 5, Sox6 - SRY-box transcription factor 6, Sp3 - ...
... to stroke as CaMKK β or CaMK IV KO mice had increased levels of the pro-inflammatory serum cytokines tumor necrosis factor ... The CaMKK pathway regulates the activity of several transcription factors such as CREB, activator protein-1 (AP-1), myocyte ... enhancer factor-2 (MEF2), and members of the retinoid orphan receptor (ROR) family, which are all proteins that play pivotal ... Next, we examined the levels of p-CREB, which is a neuroprotective transcription factor that is activated by CaMK IV [14]. At 6 ...
The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA ... YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression. J Biol Chem. 2003;278: ... by phosphorylation and activation of transcription factors (MyoD) and cofactors (MEF2) or of different components of the muscle ... Balda MS, Matter K. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J ...
MEF2 and multiple other activity-regulated transcription factors - including SRF, Fos27 and NPAS428 - induces the transcription ... CREB is a cellular transcription factor that regulates numerous genes including c-fos, BDNF, tyrosine hydroxylase, numerous ... calcium influx into neurons triggers the dephosphorylation of the transcription factor myocyte enhancer factor 2 (MEF2) by ... For example, activity-regulated MEF2 by activating Arc suppresses the number of excitatory synapses26,29, whereas CREB and ...
Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in ... phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and ... Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition ... Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca( ...
The MEF2 domain binds isoforms of the Myocyte Enhancer Factor 2 (MEF2) family of transcription factors, while Domain I binds ... MEF2 isoforms and GEF form a protein complex in vivo;however, the function of this complex in regulating gene transcription is ... that regulates GLUT4 gene transcription in vivo. Preliminary evidence suggests that changes in lipid metabolism and/or cAMP ... To understand the mechanisms by which GEF and MEF2 proteins regulate the GLUT4 promoter;3) ) To determine the nature of the ...
We found that HDAC7 specifically interacted with the transcription factor MEF2C in pre-B cells and was recruited to MEF2 ... To date, the central role of specific transcription factors in positively regulating these distinct differentiation processes ... We report that the histone deacetylase HDAC7 was highly expressed in pre-B cells but dramatically down-regulated during ... genetic transcription, macrophage, microarray analysis, molecular mechanics, nonlymphoid gene, phagocytosis, pre B lymphocyte, ...
The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos. 1994 ... GATA transcription factors and cardiac development. 1999, Pubmed , Xenbase Chomczynski, Single-step method of RNA isolation by ... Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. 2005, Pubmed , Xenbase Foley, Multiple ... Carboxy terminus of GATA4 transcription factor is required for its cardiogenic activity and interaction with CDK4. 2015, Pubmed ...
... a role in caspase-independent cell death by activation of the ERK pathway and increased activity of MEF2 transcription factors ... Also NR4A1 has linked not only to cell apoptosis but also proliferation in response to growth factor. It plays ... and other key factors. Antibodies used to identify and locate intracellular and extracellular proteins in common applications ... NR4A1 is an orphan nuclear receptor that act concomitantly with NURR1 in regulating the expression of delay-early genes during ...
Regulation of the MEF2 family of transcription factors by p38. Mol. Cell. Biol. ... Myocyte enhancer factor 2C and myogenin up-regulate each others expression and induce the development of skeletal muscle in ... Regulation of the MEF2 family of transcription factors by p38. Mol. Cell. Biol. ... Several extracellular factors modulate expression of the MRFs and/or MEF2 factors. Signal transducers such as the mitogen- ...
ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells. ... MEF2 transcription factors in human placenta and involvement in cytotrophoblast invasion and differentiation. ... The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos. ... Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho- ...
and Meyer, Magdalena (2020) Anxiolytic and Anxiogenic? How the Transcription Factor MEF2 Might Explain the Manifold Behavioral ... 2020) Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in ...
Similarly, the constant expression of CCAAT/enhancer binding protein (C/EBPβ), a transcription factor that positively regulates ... Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell ... found that miR-432 can negatively regulate myoblast proliferation through the downregulation of E2F transcription factor 3 ( ... BHLH transcription factor (MYC). Adult skeletal muscle. [119]. miR-345-5p. ↑. DLK1. GREM1. CYR61. NOV. COL1A1. SOD2. BLNK. ...
Transcription Factors - MEF2 Transcription Factors * Transcription Factors - MEF2 Transcription Factors * Transcription Factors ... SUMO-1 modification of MEF2A regulates its transcriptional activity Journal Article * Best Open Access ... DNA-Binding Proteins - MEF2 Transcription Factors * DNA-Binding Proteins - Myogenic Regulatory Factors ...
Transcription Factors - MEF2 Transcription Factors * Transcription Factors - MEF2 Transcription Factors * Transcription Factors ... SUMO-1 modification of MEF2A regulates its transcriptional activity Journal Article * Best Open Access ... DNA-Binding Proteins - MEF2 Transcription Factors * DNA-Binding Proteins - Myogenic Regulatory Factors ...
Brehm A., Miska E., Reid J., Bannister A., Kouzarides T., 1999 The cell cycle-regulating transcription factors E2F-RB. Br J ... HDAC4 deacetylase associates with and represses the MEF2 transcription factor. Embo J 18: 5099-5107. PDF ... Bannister A. J., Miska E. A., 2000 Regulation of gene expression by transcription factor acetylation. Cell. Mol. Life Sci. 57: ... Involvement of circulating factors in the transmission of paternal experiences through the germline. EMBO J. 2020 Oct 9:e104579 ...
... and myocyte enhancer factor-2 (MEF2) as critical TFs in regulating longitudinal stretch-induced gene changes whose activity is ... Gene ontology (GO) term analysis indicated enrichment of transcription factor (TF) activity and protein kinase activity by both ... Analysis of this network identified serum response factor (SRF) ... with the RNA-Seq data to identify the mechanisms regulating ... By altering the major axis of biaxial, mechanical stretch, I hypothesized that different signaling pathways and transcription ...
MEF2, GLI, FOXO, STAT3, NFAT, NFKB. In a further embodiment, the transcription factor is NFAT. Reporter gene assays are ... which in turn regulates the expression of the reporter protein chosen by the user. Expression of the reporter, in one ... For example, reporter gene expression can be coupled to a responsive element for one of the following transcription factors: ... The calcium activates specific calcium responsive transcription vectors such as nuclear factor of activated T-cells (NFAT). ...
Animals , Rats , Contusions , Gastrointestinal Tract , Gene Expression Regulation , MEF2 Transcription Factors , Genetics , ... It can be seen that XZZTO can promote the expression of MEF2. At the same time, XZZTO can regulate the regeneration and repair ... Sex Factors , Incidence , Prevalence , Retrospective Studies , Risk Factors , Contusions/etiology , Contusions/epidemiology , ... The expression level of MEF2 shows an upward trend. Even 21 days after injury, the expression of MEF2 dose not show a ...
The whole adipogenic process was driven by a coordinated activation of transcription factors and epigenetic modulators. Overall ... Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ... Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was ... E2F, C/EBP, Krüppel-like factor (KLF) and GATA families. The E2F family of transcription factors is known to regulate cell ...