Integrases and their protein co-factors, the recombination directionality factor (RDF) can change the orientation of a specific ... module that generates different outputs in response to the same input signal and a fundamental step towards building a genetic ... in which gp3 transcription was inhibited by a state-based repressor during recombination requiring the absence of Gp3. Placing ... DNA segment flanked by two recombination sites. Integrase alone switches the orientation in one direction, and this ...