TNF-Related Apoptosis-Inducing LigandApoptosis Regulatory ProteinsApoptosisLigandsCaspasesCaspase 3Fas Ligand ProteinInhibitor of Apoptosis ProteinsProto-Oncogene Proteins c-bcl-2Tumor Necrosis Factor-alphaSignal TransductionDNA FragmentationCell Line, TumorIn Situ Nick-End Labelingbcl-2-Associated X ProteinCells, CulturedCell SurvivalX-Linked Inhibitor of Apoptosis ProteinCD40 LigandCASP8 and FADD-Like Apoptosis Regulating ProteinApoptosis Inducing FactorCell LineCaspase 9Caspase InhibitorsCaspase 8Tumor Cells, CulturedEnzyme ActivationReceptors, Tumor Necrosis FactorMitochondriaMembrane GlycoproteinsTumor Suppressor Protein p53Flow CytometryCytochromes cCell ProliferationBlotting, WesternProtein Bindingbcl-X ProteinTransfectionMice, Inbred C57BLAnnexin A5Proto-Oncogene ProteinsRNA, MessengerMolecular Sequence DataAmino Acid Chloromethyl KetonesAntineoplastic AgentsDose-Response Relationship, DrugCysteine Proteinase InhibitorsJurkat CellsNF-kappa BCell DivisionCell CycleDown-RegulationEnzyme InhibitorsReceptors, Tumor Necrosis Factor, Type IMice, KnockoutUp-RegulationPoly(ADP-ribose) PolymerasesPhosphorylationAmino Acid SequenceRNA, Small InterferingReactive Oxygen SpeciesMembrane ProteinsCarrier ProteinsCell DeathTime FactorsReverse Transcriptase Polymerase Chain ReactionBinding SitesRecombinant ProteinsHL-60 CellsGene Expression RegulationReceptors, TNF-Related Apoptosis-Inducing LigandCaspase 7Membrane Potential, MitochondrialCytochrome c GroupNecrosisGene ExpressionGenes, bcl-2ImmunohistochemistryRANK LigandProto-Oncogene Proteins c-aktDrug SynergismTumor Necrosis FactorsProtein Structure, TertiaryProteinsbcl-2 Homologous Antagonist-Killer ProteinBH3 Interacting Domain Death Agonist ProteinMutationHeLa CellsModels, BiologicalGene Expression Regulation, NeoplasticT-LymphocytesKineticsMyeloid Cell Leukemia Sequence 1 ProteinModels, MolecularDNA DamageCell DifferentiationReceptors, Tumor Necrosis Factor, Type IIProtein-Serine-Threonine KinasesBase SequenceMitogen-Activated Protein Kinases