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*  Somatostatin receptor type 5
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G ... Somatostatin receptor 1 (SSTR1) and somatostatin receptor 5 (SSTR5)expression in hepatocellular carcinoma.. ... Data indicate that somatostatin receptor scintigraphy (SRS) and immunohistochemical results for somatostatin and dopamine ... Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic Neuroendocrine Tumors.. 25962406. 2015. An immunohistochemical ...
https://pharos.nih.gov/idg/targets/P35346
*  Response to Cabergoline and Pasireotide in Non-functioning Pituitary Adenomas and Resistant Prolactinomas - Full Text View -...
Somatostatin and Dopamine Receptors Expression in Non-functioning Pituitary Adenomas and Resistant Prolactinomas: Correlation ... Somatostatin. Cardiotonic Agents. Sympathomimetics. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects ... The study of the receptors by quantitative messenger ribonucleic acid (mRNA) expression levels and immunohistochemistry ... These responses will be compared with the receptor expressions which may be a tool as a predicting element of the response to ...
https://clinicaltrials.gov/ct2/show/NCT01620138?recr=Open&cond=%22Adenoma%22&rank=16
*  Neuroendocrine Tumors Guidelines: Grading and Staging, Gastrointestinal and Pulmonary Carcinoid Tumors, Neuroendocrine Tumors...
Somatostatin scintigraphy to assess sites of metastases and somatostatin receptor status if octreotide or lanreotide is being ... Somatostatin receptor scintigraphy is not routinely indicated but may be considered in tumors with proliferative indexes in the ... In patients with a functioning NET, all liver-directed therapies require prior initiation of somatostatin analog therapy (or ... cholecystectomy is recommended during surgical resection if treatment with a somatostatin analog (ie, octreotide, lanreotide) ...
https://emedicine.medscape.com/article/2500010-overview
*  Therapy of metastatic pancreatic neuroendocrine tumors (pNETs): recent insights and advances | SpringerLink
Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and ... Value of somatostatin receptor scintigraphy: a prospective study in gastrinoma of its effect on clinical management. ... Oberg K. Gallium-68 somatostatin receptor PET/CT: Is it time to replace (111)Indium DTPA octreotide for patients with ... Somatostatin-receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors. Endocr Relat Cancer. 2010;17: ...
https://link.springer.com/article/10.1007%2Fs00535-012-0642-8
*  Molecular Imaging Radiotherapy: Theranostics for Personalized Patient Management of Neuroendocrine Tumors (NETs)
... but peptide hormone receptors such as somatostatin receptors as well as CCK receptors, GRP receptors and so forth. These ... Somatostatin receptors are G-protein coupled membrane glycoproteins at the moment five subtypes of human somatostatin receptors ... Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype- ... Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic ...
http://thno.org/v02p0448.htm
*  Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Treatment - Patient Information [NCI] - North Kansas...
Somatostatin receptor scintigraphy: A type of radionuclide scan that may be used to find small pancreatic NETs. A small amount ... Somatostatin receptor scintigraphy: A type of radionuclide scan that may be used to find small pancreatic NETs. A small amount ... Somatostatin receptor scintigraphy: A type of radionuclide scan that may be used to find small pancreatic NETs. A small amount ... Fasting serum somatostatin test: A test in which a blood sample is checked to measure the amount of somatostatin in the blood. ...
https://www.nkch.org/patients-visitors/health-library/healthwise-document-viewer/?id=ncicdr0000062678
*  Somatostatin binding in human gastrointestinal tissues: effect of cations and somatostatin analogues. | Gut
... with no change in receptor affinity. Displacement studies were then performed with somatostatin-14 and somatostatin analogues ... Somatostatin binding in human gastrointestinal tissues: effect of cations and somatostatin analogues. ... Somatostatin binding in human gastrointestinal tissues: effect of cations and somatostatin analogues. ... This study characterises the somatostatin binding site in human gastrointestinal cancer and mucosa in terms of cationic ...
http://gut.bmj.com/content/34/10/1351
*  Peptide receptor radionuclide therapy and NETs: how to select patients?
NETs strongly express somatostatin receptors (SSTRs) of five different subtypes (SSTRs1 5) with SSTR2 being the most common. ... Imaging with radiolabelled receptor binding somatostatin analogues and meta isobenzyl guanidine (MIBG) can be used to select ... Diagnostic workup requires imaging; both anatomical (ultrasound, CT, MRI) and functional (somatostatin receptor scintigraphy, ... Peptide receptor radionuclide therapy and NETs: how to select patients?. Rupa Ahluwalia2, Gail McKane1,2, Jiten Vora2 & Sobhan ...
http://www.endocrine-abstracts.org/ea/0022/ea0022p454.htm
*  Improving quality of life in patients with pancreatic neuroendocrine tumor following peptide receptor radionuclide therapy...
... as the majority of these slow-growing malignancies overexpress somatostatin receptors. The aim of this study was to evaluate ... Improving quality of life in patients with pancreatic neuroendocrine tumor following peptide receptor radionuclide therapy ... Neuroendocrine tumors (NETs) have proven to be appropriate neoplasms for peptide receptor radionuclide therapy (PRRT), ...
https://oncology.medicinematters.com/neuroendocrine-tumors/palliative-care/improving-quality-of-life-in-patients-with-pancreatic/15123284
*  Treatment of the carcinoid syndrome
Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas ... Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial ... The antitumoral effect of the long-acting somatostatin analog lanreotide in neuroendocrine tumors. Am J Gastroenterol 2000; 95: ... Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic ...
http://www.uptodate.com/contents/treatment-of-the-carcinoid-syndrome
*  Mahvash Disease: Pancreatic Neuroendocrine Tumor Syndrome Caused by Inactivating Glucagon Receptor Mutation | OMICS...
Mahvash disease is a novel pancreatic neuroendocrine tumor syndrome caused by inactivating glucagon receptor mutations. Its ... Although somatostatin analogs decrease glucagon levels, the clinical utility of somatostatin analogs in patients without gross ... The glucagon receptor family. Pharmacol Rev 55: 167-194.. *Jiang G, Zhang BB (2003) Glucagon and regulation of glucose ... Zhou C, Dhall D, Nissen NN, Chen CR, Yu R (2009) Homozygous P86S mutation of the human glucagon receptor is associated with ...
https://www.omicsonline.org/open-access/mahvash-disease-pancreatic-neuroendocrine-tumor-syndrome-glucagon-receptor-mutation-1747-0862.1000084.php?aid=19904
*  Receptors, pancreatic hormone | Article about Receptors, pancreatic hormone by The Free Dictionary
Find out information about Receptors, pancreatic hormone. glandular organ that secretes digestive enzymes and hormones. In ... which produce the regulatory agent somatostatin. These hormones are secreted directly into the bloodstream, and together, they ... redirected from Receptors, pancreatic hormone). Also found in: Dictionary, Thesaurus, Medical. pancreas. (păn`krēəs), glandular ... Receptors, pancreatic hormone , Article about Receptors, pancreatic hormone by The Free Dictionary https://encyclopedia2. ...
https://encyclopedia2.thefreedictionary.com/Receptors%2C+pancreatic+hormone
*  A Case of Recurrent Acromegaly: Medical Management of the Disease | MedCrave
Somatostatin analogues have proven to be effective in cases like ours, yet its efficacy varies among studies. ... growth hormone receptor antagonists are available either alone or in combination and radiation therapy is also available. ... Somatostatin analogues remain first line medical therapy, especially for cases like ours, which have recurred after failed ... 2007) Long-Term Efficacy and Safety of Combined Treatment of Somatostatin Analogs and Pegvisomant in Acromegaly. J Clin ...
http://googlescholar.medcraveonline.com/scholars/article_fulltext/3916
*  GH-secreting pituitary macroadenoma (acromegaly) associated with progressive dental malocclusion and refractory CPAP treatment ...
Combined treatment of somatostatin analogues with pegvisomant in acromegaly. Endocrine. 2016;52:206-13.View ArticlePubMedGoogle ... GH receptor antagonists such as pegvisomant [10]. ... Three types of drugs are available: somatostatin analogs (SSA) ... combining a long-acting SSA and pegvisomant in patients in whom GH and IGF-1 levels did not decrease with somatostatin agonists ...
https://head-face-med.biomedcentral.com/articles/10.1186/s13005-017-0140-6
*  RheumaKnowledgy » Acromegaly
Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm. J Clin ... There are several categories of pharmacotherapy, including: 1) somatostatin analogues (octreotide, lanreotide), 2) dopamine ... growth hormone receptor antagonist (pegvisomant). These approaches are often successful at normalizing GH activity; they can ...
http://www.rheumaknowledgy.com/acromegaly/
*  "Overgrowth: Missing a Tumor" Acromegaly without Imaging Evidence of Pituitary Adenoma and No Ectopic Source: A Case Report |...
Pegvisomant, a human GH receptor antagonist, competes with GH for binding at its receptor and block production of IGF-1. ... Other treatment options include somatostatin analogues (octreotide and lanreotide), dopamine agonists (bromocriptine and ... Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med. 2000;342(16):1171-7. PubMed DOI ... Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet. 2001;358(9295):1754-9. PubMed ...
http://www.asean-endocrinejournal.org/index.php/JAFES/article/view/419/855
*  Anti-Somatostatin Receptor 3 antibody (ab28680) | Abcam
Rabbit polyclonal Somatostatin Receptor 3 antibody validated for WB, IHC, ICC and tested in Human. Referenced in 3 publications ... Anti-Somatostatin Receptor 3 antibody. See all Somatostatin Receptor 3 primary antibodies. ... Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of ... Somatostatin receptor subtype 2 in high-grade gliomas: PET/CT with (68)Ga-DOTA-peptides, correlation to prognostic markers, and ...
http://www.abcam.com/somatostatin-receptor-3-antibody-ab28680.html
*  Somatostatin Receptors - GPCR / G Protein
somatostatin receptor antagonist Octreotide is a peptide agonist for sst2, sst3 and sst5 somatostatin receptors. IC50/Kd values ... somatostatin receptor 2 antagonist CYN-154806 is a potent selective somatostatin receptor 2 (sst2) antagonist. ... Somatostatin - Somatostatin is an endogenous peptide noted to inhibit the release of growth hormone, insulin and glucagon. ... nM) at cloned human somatostatin receptors are: 290 - 1140 (sst1), 0.4 - 2.1 (sst2), 4.4 - 34.5 (sst3), > 1000 (sst4), and 5.6 ...
https://www.adooq.com/somatostatin-receptors.html
*  Somatostatin Receptor 2 (SSTR2) ELISA Kits
... somatostatin receptor subtype 2 , somatotropin release-inhibiting factor receptor , somatostatin receptor 2 , somatostatin type ... More ELISA Kits for Somatostatin Receptor 2 Interaction Partners. Human Somatostatin Receptor 2 (SSTR2) interaction partners ... Additionally we are shipping Somatostatin Receptor 2 Antibodies (87) and Somatostatin Receptor 2 Proteins (8) and many more ... Somatostatin Receptor 2 (SSTR2) Antigen Profile Antigen Summary Somatostatin acts at many sites to inhibit the release of many ...
https://www.antibodies-online.com/abstract/Somatostatin+Receptor+2+
*  SS4R - Somatostatin receptor 4 - Gallus gallus (Chicken) - SS4R gene & protein
... somatostatin receptor activity, cellular response to glucocorticoid stimulus, chemical synaptic transmission, G-protein coupled ... receptor signaling pathway, coupled to cyclic nucleotide second messenger, negative regulation of cell proliferation ... Somatostatin receptor 4Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> , ... Somatostatin receptor type 4Imported. ,p>Information which has been imported from another database using automatic procedures ...
http://www.uniprot.org/uniprot/Q4PLA6
*  Anti-Somatostatin receptor 2 antibody (GTX29550) | GeneTex
Rabbit Polyclonal Somatostatin receptor 2 antibody. Validated in WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP. Tested in Human, Mouse, ... A synthetic peptide made to the C-terminus of rat Somatostatin Receptor 2 [UniProt# P30680] ... IHC-P analysis of mouse pancreas tissue using GTX29550 Somatostatin receptor 2 antibody.. ... IHC-P analysis of rat pancreas tissue using GTX29550 Somatostatin receptor 2 antibody.. ...
https://www.genetex.com/Product/Detail/Somatostatin-receptor-2-antibody/GTX29550
*  Solubilization of active somatostatin receptors from rat brain. | Molecular Pharmacology
Solubilization of active somatostatin receptors from rat brain.. H T He, S Rens-Domiano, J M Martin, S F Law, S Borislow, M ... Solubilization of active somatostatin receptors from rat brain.. H T He, S Rens-Domiano, J M Martin, S F Law, S Borislow, M ... Solubilization of active somatostatin receptors from rat brain.. H T He, S Rens-Domiano, J M Martin, S F Law, S Borislow, M ... Solubilization of active somatostatin receptors from rat brain. Message Subject (Your Name) has forwarded a page to you from ...
http://molpharm.aspetjournals.org/content/37/5/614
*  177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine Neoplasms
This is a phase II treatment protocol offering 177Lu-DOTATATE therapy for somatostatin receptor expressing cancers including, ... Presence of somatostatin-receptors on the known tumor lesions demonstrated by. OctreoScan within 6 months of the first dose of ... 177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine Neoplasms. Trial Phase:. Phase 2. ... 177)Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine. Neoplasms. First Annual Report on ...
http://www.knowcancer.com/cancer-trials/NCT01237457/
*  Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats | Diabetes
Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats. Diabetes 2003;52:1176-1181pmid: ... Systemic distribution of somatostatin receptor subtypes in human: an immunohistochemical study. Endocr J 2005;52:605-611pmid: ... Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from ... Function and expression of somatostatin receptors of the endocrine pancreas. Mol Cell Endocrinol 2008;286:169-179pmid:18375050 ...
http://diabetes.diabetesjournals.org/content/62/8/2968
*  Somatostatin receptor - Wikipedia
There are five known somatostatin receptors: SST1 (SSTR1) SST2 (SSTR2) SST3 (SSTR3) SST4 (SSTR4) SST5 (SSTR5) All are G protein ... Somatostatin Receptor at the US National Library of Medicine Medical Subject Headings (MeSH). ... "Classification and nomenclature of somatostatin receptors". Trends Pharmacol. Sci. 16 (3): 86-8. doi:10.1016/S0165-6147(00) ... seven transmembrane receptors. Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, ...
https://en.wikipedia.org/wiki/Somatostatin_receptor