Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.. 2ox9. Mouse Scavenger Receptor C-type Lectin ... and plant toxins and mitogens. The structural basis for selective sugar recognition by members of all of these groups has been ... Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex. 1ypu. Human Oxidized Low Density Lipoprotein Receptor ... NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [ (PUBMED: ...

The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of ... epidermal growth factor receptor during decidualization. Primary human endometrial stromal cells (HESCs) were subjected to ... Furthermore, mitogen-activated protein kinase 7 (MAPK7), a known downstream target of WNK1, was activated during ... and migration in part through mitogen-activated protein kinase 7," Biology of Reproduction, 97(3), 400-412, (30 August 2017) ...

Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ... The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB ... Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These ... The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular ...

Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of ... Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation. Journal of cell science, 115 ... The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes. ... The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation. Pigment cell research / sponsored by the ...

... induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen- ... including ligands for G protein-coupled receptors and growth factor receptors, and exogenous lipoproteins. The group uses in ... Fortunato T, Vara D, Wheeler-Jones C* and Pula G*. Expression of protease-activated receptor 1 and 2 and anti-vasculogenic ... Protease-activated receptors, cyclo-oxygenases and pro-angiogenic signalling in endothelial cells. Biochem Soc Trans 37: 1179- ...

Fellowship - Do G-protein coupled receptors regulate pathogenesis any mycotoxin biosynthesis in filamentous phytopathogenic ... The mitogen-activated protein kinase (MAPK) signaling pathways are essential to the adaptation to the human host. Fungal cell ... The mitogen-activated protein kinase (MAPK) signaling pathways are essential to the adaptation to the human host. Fungal cell ... The mitogen-activated protein kinase (MAPK) signaling pathways are essential to the adaptation to the human host. Fungal cell ...

... on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation was examined using RAW 264.7 macrophage- ... including NF-κB and mitogen-activated protein kinases (MAPKs). PQQ augmented the expression of type I interferon receptor ( ... Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine ( ... The effect of pyrroloquinoline quinine (PQQ) on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast ...

Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase ... Type 1 Ins-Like Growth Factor Receptor/Ins Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells ... receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways. Authors: Mou Et al.. Respir Res 2011;176: ... DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent ...

B Cell Receptor Signaling Pathway. PIK3R3;ACTR2;CD72;NFATC2;CDK6;TTC6;PIK3CB;RAC1;GSK3B. ... MAPK4; mitogen-activated protein kinase 4; PRKM4; Erk3 related; Erk4; ERK-4; MAPK 4; p63-MAPK; Erk3-related; MAP kinase 4; MAP ... We selected most pathways MAPK4 participated on our site, such as B Cell Receptor Signaling Pathway, Focal Adhesion, Insulin ...

RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus; Wnt signaling pathway. ... mitogen activated protein kinase 8; protein kinase mitogen-activated 8; EC 2.7.11.24; OTTMUSP00000019790. ... Mapk8; mitogen-activated protein kinase 8; JNK; JNK1; Prkm8; SAPK1; AI849689; c-Jun N-terminal kinase; JNK1 beta1 protein ... Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged. Cat.No. : Mapk8-1051M. ...

Basal p38 Mitogen-Activated Protein Kinase Regulates Unliganded Glucocorticoid Receptor Function in Airway Smooth Muscle Cells. ... Transient receptor potential vanilloid 4 activation constricts the human bronchus via the release of cysteinyl leukotrienes. ...

Machado RD, Aldred MA, James V, et al. Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension. Hum ... A detrimental role for oestrogens in FPAH is supported by studies that show oestrogen is a potent mitogen of pulmonary vascular ... Data suggest that, unlike the weak mitogen 2-OHE, 16α-OHE1 stimulates cellular proliferation by constitutively activating the ... Mutations in bone morphogenetic protein receptor type 2 (BMPR2) cause familial pulmonary arterial hypertension (FPAH), but the ...

Caspase, Dual Specificity Mitogen Activated Protein Kinase Kinase 4, Toll Like Receptor 4, Tumor Necrosis Factor, and Androgen ... Caspase Inhibitor, Dual Specificity Mitogen Activated Protein Kinase Kinase 4 Inhibitor, Toll Like Receptor 4 Antagonist, and ... Toll Like Receptor 4, Tumor Necrosis Factor, and Androgen Receptor among others. Caspase leads this segment of the Liver ... Toll Like Receptor 4, Tumor Necrosis Factor, and Androgen Receptor among others. ...

09/01/2000 - "Gastrin-releasing peptide (GRP) is a mitogen and morphogen important in the development of human colon cancers. " ... 06/01/2006 - "Gastrin-releasing peptide (GRP) and its receptor (GRPR) are aberrantly up-regulated in colon cancer. ". ... 07/01/2000 - "We herein demonstrate that the mitogen gastrin-releasing peptide (GRP) is a morphogen, critically important in ... 09/01/2000 - "Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell ...

AT1, AT2, AT4, and mitochondrial assembly receptor (MasR) are found to be plentiful in the brain. The brain RAS system exhibits ... and specific receptors (ATR). AGT acts as the precursor molecule for Ang peptides—I, II, III, and IV—while the ... K. Bedecs, N. Elbaz, M. Sutren et al., "Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase ... Mas receptor; AT1: angiotensin receptor subtype 1; AT2: angiotensin receptor subtype 2; AT4: angiotensin receptor subtype 4; PD ...

In the presence of amphoterin they activate the mitogen-activated protein kinase pathway components p38, stress-activated ... Multiligand receptors * Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouses tale Nick Platt et ... Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems Monty Krieger ... Krieger, M, Herz, J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL ...

Progestin and G protein-coupled receptor 30 inhibit mitogen-activated protein kinase activity in MCF-7 breast cancer cells. ... Differential regulation of alpha-adrenergic receptor subclasses by gonadal steroids in human myometrium. Bottari, S.P., Vokaer ... Provera administered in vivo had no effect on either dehydrogenase activity in soluble estradiol receptor-poor carcinomata, ... This allowed characterization of both receptor subclasses individually and study of them in various physiological and ...

Cerebral ischemia causes tissue death owing to occlusion of the cerebral blood vessels, and cerebral ischemia activates mitogen ... In order to confirm the participation of the adenosine A2A receptor in the effects mediated by PDRN, 8 mg/kg 7-dimethyl-1- ... Adenosine A2A receptor agonist, polydeoxyribonucleotide (PDRN), suppresses the secretion of pro-inflammatory cytokines and ... Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ...

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med. 205:1491-1503. ... All nucleated cells are thought to have RLR and PKR receptors for viral nucleic acids, while toll-like receptors (TLRs) are ... IFN-α/β receptor (IFNAR) receptor ablation or neutrophil depletion avoided lethal infection but did not affect the viral load. ... binds the SARS-CoV-2 receptor ACE2 and also is a selective 5-HT1B/1D receptor antagonist, making it useful in patients with ...

Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response ... NTS and its receptors have been implicated in the progression of a broad range of human cancers. These include cancers of the ... Maoret JJ, Pospai D, Rouyer-Fessard C, Couvineau A, Laboisse C, Voisin T et al (1994) Neurotensin receptor and its mRNA are ... Souaze F, Viardot-Foucault V, Roullet N, Toy-Miou-Leong M, Gompel A, Bruyneel E et al (2006) Neurotensin receptor 1 gene ...

For patients with EGFR mutations, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) such as osimertinib ... and downstream mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinases (PI3K) signaling pathways. These ... Cetuximab and necitumumab are epidermal growth factor receptor (EGFR) inhibitors. *Maintenance therapy after first-line ... tyrosine kinase receptor, which are sensitive to ALK inhibitors, and amplification of MET (mesenchymal epithelial transition ...

... pathway and the mitogen-activated protein kinase (MAPK) pathways. In reactive conditions, CD30 receptor and ligand (CD30L, ... CD30 is a transmembrane glycoprotein receptor of the tumor necrosis factor receptor super family 8 (TNFRSF8), mediating its ... Stimulation of CD30 leads signal mediation through tumor necrosis factor receptor-associated proteins (TRAF), thereby ...

Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and ... induced mitogen-activated protein kinase-ERK1/2, p38 and c-Jun N-terminal kinase phosphorylation) (74) that may sensitize it to ... A and B forms of the androgen receptor are expressed in a variety of human tissues. Mol Cell Endocrinol. 1996;120(1):51-7.. * ... Phosphorylation of androgen receptor isoforms. Biochem J. 2004;383(Pt 2):267-76.. * Cited Here , ...

... epidermal growth factor and its receptor, EGFR; mitogen-activated protein [MAP] kinase, but it is usually secondary (small ...

The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear. Download ... the cAMP-dependent protein kinase and the mitogen-activated protein kinase pathways) and two other mechanisms that become ... The Role of NMDA Glutamate Receptors, PKA, MAPK, and CAMKII in the Hippocampus in Extinction of Conditioned Fear. Hippocampus. ... The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear.. Hippocampus ...

p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen- ...

... and mitogen-activated protein kinase (MAPK) signaling in normal physiology and cancer. ... Johan Lennartssons research focuses on platelet-derived growth factor receptor (PDGFR) ... His research focuses on platelet-derived growth factor receptor (PDGFR) and mitogen-activated protein kinase (MAPK) signaling ... Johan Lennartssons research focuses on platelet-derived growth factor receptor (PDGFR) and mitogen-activated protein kinase ( ...

... a soluble form of the IL-6 receptor has also been described. The IL-6 receptor is expressed on T cells, mitogen activated B ... The IL-6 receptor is a strongly glycosylated 80 kDa protein of 449 amino acids. Two different forms of the receptor have been ... Tumour necrosis factor receptor I is one of two specific, high affinity cell surface receptors that function as transducing ... Tumour necrosis factor receptor II (TNFRII) is one of two specific, high affinity cell surface receptors that function as ...

A few examples are RAS (receptor associated) targeted therapy, mTOR (mechanistic target of rapamycin) inhibitors,7 interferon,8 ... promising preliminary results were published10 demonstrating a response to treatment with mitogen-activated protein kinase ...

Activation of mitogen-activated protein kinases by peroxisome proliferator-activated receptor ligands: an example of nongenomic ... 2003) The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278: 11303- ... Furthermore, the related receptor GPR41 that responds only to less hydrophobic, short-chain fatty acids (Brown et al., 2003) ... Brown AJ, Jupe S, and Briscoe CP (2005) A family of fatty acid binding receptors. DNA Cell Biol 24: 54-61. ...